UNITED STATES

                       SECURITIES AND EXCHANGE COMMISSION

                             WASHINGTON, D.C. 20549

                    ----------------------------------------

                                   FORM 8-K/A
                                 Amendment No. 2

                                 CURRENT REPORT



                     Pursuant to Section 13 or 15 (d) of the
                         Securities Exchange Act of 1934

                         Date of Report - March 12, 2003
                            (March 11, 2003) (Date of
                            earliest event reported)


                           Hemispherx Biopharma, Inc.
             (Exact name of registrant as specified in its charter)



        Delaware                     0-27072                   52-0845822
      (State or other jurisdiction  (Commission File Number)  (IRS Employer
       of incorporation)                                      Identification
                                                              Number)




       1617 JFK Boulevard                                 19103
    (Address of principal executive offices)            (Zip Code)


                            Area Code (215) 988-0080
                         (Registrant's telephone number)





ITEM 2.  ACQUISITION OR DISPOSITION OF ASSETS.

         As noted in the previous  Current Report on Form 8-K filed On March 13,
2003,  Hemispherx  Biopharma,  Inc. (the "Company") executed two agreements with
Interferon  Sciences,  Inc.  ("ISI") to purchase  certain assets of ISI (the two
asset  purchase  transactions  are  hereinafter  referred to as the "First Asset
Purchase"  and the "Second  Asset  Purchase")  and  consummated  the First Asset
Purchase.

         In  the  second   agreement   with  ISI  (the  "Second  Asset  Purchase
Agreement"),  ISI agreed to sell to the  Company  all of its rights to ALFERON N
Injection(R),  a pharmaceutical  product used for the treatment of certain types
of genital  warts in adults  (the  "Product")  and other  assets  related to the
Product  including,  but not limited to,  real estate and  machinery.  For these
assets, the Company agreed to:

     (i) issue  424,528  shares of its Common Stock which has a Market Value (as
defined in the Second  Asset  Purchase  Agreement)  of $675,000 and a guaranteed
value of $675,000;

     (ii) issue an additional 62,500 shares of Common Stock without a guaranteed
value;

     (iii) continue to pay ISI 6 % of the net sales of the Product; and

     (iv) satisfy certain obligations of ISI.

         On March 17, 2004, the Company consummated the Second Asset Purchase.


Item 7.       Financial Statements and Exhibits.


              (a)     Financial Statements.

None.
              (b)     Unaudited Pro forma Financial Information.

The  required  Pro  Forma  Financial  Information  related  to the  Registrant's
acquisition of certain assets of Interferon Sciences, Inc. on March 17, 2004 are
attached hereto as Exhibit 99.1.

              (c)          Exhibits.

None.






                                                               SIGNATURE


Pursuant  to the  requirements  of the  Securities  Exchange  Act of  1934,  the
registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned hereunto duly authorized.


                                          Hemispherx Biopharma, Inc.



                                      By:  /s/ William A. Carter
                                          ------------------------
March 26, 2004                            William A. Carter, M.D., President







                                                                   Exhibit 99.1

              Unaudited Pro Forma Consolidated Financial Statements

On March 11, 2003 the Company executed two agreements with Interferon  Sciences,
Inc. ("ISI") to purchase certain of its assets.

In the first agreement with ISI, the Company effectively acquired the operations
of ISI including its inventory of Alferon N Injection(R),  and a limited license
for the production,  manufacture use,  marketing and sale of this product.  This
transaction was completed on March 11, 2003. For these assets, the Company:

i)       Issued 487,028 shares of its common stock, and
ii)      Agreed to pay ISI 6% of the net sales of the Product

The  Company  also is required to pay ISI a service fee and pay certain of ISI's
obligation related to the product.

In the second agreement with ISI,  effectively an asset acquisition,  ISI agreed
to sell to the  Company  all of ISI's  rights to the  product  and other  assets
related to the product including, but not limited to, real estate and machinery.
This transaction was completed on March 17, 2004. For these assets, the Company:

i)  Issued on March 17, 2004 an additional 487,028 shares of its common stock;
    and will
ii) Continue to pay ISI 6% of the net sales of the product


Pro Forma Condensed Consolidated Statement of Operations (Unaudited) of
the Company

The following  unaudited pro forma  consolidated  statement of operations of the
Company for the year ended December 31, 2003 presents the results of the Company
assuming  the  above-mentioned  two  agreements  between the Company and ISI had
occurred on January 1, 2003.

The unaudited pro forma  consolidated  statement of operations should be read in
conjunction  with the consolidated  financial  statements of the Company for the
year ended  December  31, 2003,  including  the notes  thereto,  included in the
Company's Annual Report on Form 10-K/A.  The pro forma data is for informational
purposes  only  and  may  not  necessarily  reflect  the  Company's  results  of
operations for the year ended December 31, 2003 had the Company  consummated the
two agreements on January 1, 2003.




                                              Hemispherx Biopharma, Inc. and Subsidiaries
                                       Unaudited Pro Forma Consolidated Statement of Operations
                                                     Year Ended December 31, 2003
                                                 (in thousands, except per share data)

                                                                                        (4)        Pro Forma
                                                           (3)                       Pro Forma     As Further
                                                        Pro Forma      Pro Forma     Further       Adjusted
                      (1)             (2)               Adjustments    as Adjusted   Adjustment    For
                  Hemispherx       Interferon           For First      For First     For Second    Second
                 Biopharma, Inc.  Sciences, Inc.                       Asset         Asset         Asset
                     And              Asset
                 Subsidiaries     And Subsidiary       Acquisition     Acquisition  Acquisition   Acquisition
                 ------------     --------------       -----------     -----------  -----------   ------------
                     2003             2003
                    ------           ------
                                                                                     
Revenues:
Sales of product
                          $509            $ 242         $                  $ 751      $                   $ 751
Clinical
treatment
programs                   148                -                -             148         -                  148
                 --------------  ---------------  ---------------     -----------   -------      ---------------
Total Revenues
                           657              242                              899                            899
                 --------------  ---------------  ---------------     -----------   -------      ---------------
Costs and
expenses:
Production
costs/Cost of
Goods Sold                 502              267               47 (a)         816        60 (d)              876
Research and
development              3,150              176              (7) (a)       3,319         8 (d)            3,327
General and
administrative           4,257              963            (675) (a)       4,545         8 (d)            4,553
Royalty Expense
                                                              45 (b)          45                             45

                 --------------  ---------------  ---------------     -----------   -------      ---------------
Total cost and
expenses                 7,909            1,406            (590)           8,725        76                8,801
                 --------------  ---------------  ---------------     -----------   -------      ---------------

Interest and
other income                80               13             (13) (a)         80                             80
Interest
Expense and
Financing Costs                                             (68) (c)
                       (7,598)            (274)              274 (a)     (7,666)                        (7,666)

Metacine
Settlement                                1,550          (1,550) (a)

Service fee
income                                      451            (451) (a)
Other income                                 14             (14) (a)
Bulk sale of
Alferon
inventory                                 1,149          (1,149) (a)

                 --------------  ---------------  ---------------     -----------   -------      ---------------
Net loss            $ (14,770)          $ 1,739        $ (2,381)      $ (15,412)    $ (76)           $ (15,488)
                 --------------  ---------------  ---------------     -----------   -------      ---------------

Basic and
diluted loss
per share              $ (.42)                                           $ (.43)                        $ (.43)
                 --------------                                       -----------                ---------------
Basic and
diluted weighted
Average common
shares
outstanding
                        35,235                                            35,327                         36,056
                 --------------                                       -----------   -------      ---------------


See accompanying notes to consolidated statement of operations.





                           NOTES TO UNAUDITED PROFORMA
                      CONSOLIDATED STATEMENT OF OPERATIONS

The  following  notes  describe the column  headings in the  unaudited pro forma
consolidated  statement of operations  and the pro forma  adjustments  that have
been made to this statement:

     (1) Reflects the unaudited consolidated historical statement of operations
     of Hemispherx Biopharma, Inc. and subsidiaries for the year ended December
     31, 2003.

     (2) Reflects the unaudited consolidated  historical statement of operations
     for ISI for the period ended September 30, 2003,  which date represents its
     most recent available financial statements.

     (3) Reflects pro forma  adjustments  relating to the first  acquisition  on
     March 11, 2003 of certain assets of ISI and the related funding as follows:

                      (a) Adjustments to reflect the following:

                           Production  cost  related  to sales of product by ISI
                           are  based  on  the   Company's   cost  of  inventory
                           purchased from ISI in the First Asset Acquisition.  A
                           portion of the Company's total cost of the net assets
                           was  allocated to inventory in  accordance  with FASB
                           141.

                           ISI debt was not assumed by the Company,  interest on
                           the debt has been eliminated.

                           The ISI  building  was  acquired in the Second  Asset
                           Acquisition.  Depreciation  expense  related  to  the
                           building  has  been  included  for  the  First  Asset
                           Acquisition  adjustments.  The  depreciation  of  the
                           building,  based  on the  cost  of the  Second  Asset
                           Acquisition, is recorded in entry 4(e) below.

                           Service  fee income paid to ISI by the  Company,  the
                           gain on the bulk sale of the Alferon inventory to the
                           Company  and  the  Metacine   settlement   have  been
                           eliminated.

                           General and administrative  expenses beyond March 11,
                           2003 have been  eliminated  because ISI's general and
                           administrative  expenses  subsequent to that date are
                           not related to the  Alferon  business.  All  expenses
                           related to the Alferon  business  subsequent to March
                           11,  2003  have  been   included  in  the   Company's
                           historical results for the period from March 11, 2003
                           through December 31, 2003.







                                                                                 
                                          Production
                                          Cost / Cost
                                          of Sold Goods      R&D       G&A         Other          Total
           ---------------------------- ------------------- ------- --------- ------------ --------------
           Inventory                                $(109)                                        $(109)
           ---------------------------- ------------------- ------- --------- ------------ --------------
           ---------------------------- ------------------- ------- --------- ------------ --------------
           Interest  expense                                                         $274            274
           ---------------------------- ------------------- ------- --------- ------------ --------------
           ---------------------------- ------------------- ------- --------- ------------ --------------
           Interest income                                                           (13)           (13)
           ---------------------------- ------------------- ------- --------- ------------ --------------
           ---------------------------- ------------------- ------- --------- ------------ --------------
           Depreciation                                 62      $7        $7                          76
           ---------------------------- ------------------- ------- --------- ------------ --------------
           ---------------------------- ------------------- ------- --------- ------------ --------------
           Service fee income                                                       (451)          (451)
           ---------------------------- ------------------- ------- --------- ------------ --------------
           ---------------------------- ------------------- ------- --------- ------------ --------------
           Other income                                                              (14)           (14)
           ---------------------------- ------------------- ------- --------- ------------ --------------
           ---------------------------- ------------------- ------- --------- ------------ --------------
           Bulk sale of Alferon
           inventory                                                              (1,149)        (1,149)
           ---------------------------- ------------------- ------- --------- ------------ --------------
           ---------------------------- ------------------- ------- --------- ------------ --------------
           G&A after
           March 11, 2003                                                668                         668
           ---------------------------- ------------------- ------- --------- ------------ --------------
           ---------------------------- ------------------- ------- --------- ------------ --------------
           Metacine Settlement                           -       -         -      (1,550)        (1,550)
           ---------------------------- ------------------- ------- --------- ------------ --------------
           ---------------------------- ------------------- ------- --------- ------------ --------------
           Totals                                    $(47)      $7      $675     $(2,903)       $(2,268)
           ---------------------------- ------------------- ------- --------- ------------ --------------


         (b) Increase in general and  administrative  costs  resulting  from the
         recognition  of 6%  royalty  charges  on the net sales of the  acquired
         ALFERON N injection product.

         (c) Increase in interest for period from January 1, 2003 through  March
         11, 2003 for issuance of 6% Senior Convertible  Debentures on March 12,
         2003.

     (4) Reflects pro forma  adjustments  relating to the second  acquisition of
certain assets of ISI as follows:

         (d) Adjustments reflect  depreciation  expense relating to the acquired
         building as result of the second acquisition of certain assets of ISI.

Pro Forma Condensed Consolidated Balance Sheet (Unaudited) of the Company

The following  unaudited pro forma condensed  consolidated  balance sheet of the
Company as of December 31, 2003 presents the  financial  position of the Company
assuming the asset sale had occurred on December 31,  2003.  The  unaudited  pro
forma condensed  consolidated  balance sheet should be read in conjunction  with
the  consolidated  financial  statements  of the  Company,  including  the notes
thereto for the year ended December 31, 2003,  included in the Company's  Annual
Report on Form 10-K/A. The pro forma data is for informational purposes only and
may not  necessarily  reflect  the  Company's  financial  position  or what  the
Company's  financial  position would have been had the Company  consummated  the
asset sale on December 31, 2003.








                                              Hemispherx Biopharma, Inc. and Subsidiaries
                                            Unaudited Pro Forma Consolidated Balance Sheet
                                                           December 31, 2003
                                                            (in thousands)

                                                                                    PRO FORMA
                                                                (2)                 AS
                                             (1)              PRO FORMA             ADJUSTED
                                         HEMISPHERX           ADJUSTMENTS           FOR
                                         BIOPHARMA,           FOR SECOND            SECOND
                                         INC. AND             ASSET                 ASSET
                                         SUBSIDIARIES         ACQUISITION           ACQUISITION
                                         ------------         -----------           -----------
                                                                               
                ASSETS
Current Assets:
    Cash and cash equivalents               $ 3,764           $                              $3,764
                                                                          -
    Short term investments                    1,495                       -                   1,495
    Inventory                                 2,896                       -                   2,896
    Accounts and other receivables              282                       -                     282
    Prepaid and other current assets            170                       -                     170
                                      --------------   ---------------------   ---------------------
    Total current assets                      8,607                                           8,607
                                      --------------   ---------------------   ---------------------
    Property, plant and equipment,               94                3,212(2)                   3,306
    net
    Patent and trademark rights, net          1,027                                           1,027

    Investments in unconsolidated
    affiliates                                  408                                             408
    Deferred financing costs                    393                                             393
    Deferred acquisition costs                1,546              (1,546)(2)
    Advance receivable                        1,300                                           1,300
    Other assets                                 29                                              29
                                      --------------   ---------------------   ---------------------
    Total assets                            $13,404              $1,666                     $15,070
                                      ==============   =====================   =====================
             LIABILITIES
Current liabilities:
    Accounts payable                           $488    $                  -                    $488
    Accrued expenses                          1,119                       -                   1,119
                                      --------------   ---------------------   ---------------------
    Total current liabilities                 1,607                       -                   1,607
                                      --------------   ---------------------   ---------------------
Long term debt-net of
current portion                               2,058                                           2,058

Redeemable common stock                         491               1,452 (2)                   1,943
Stockholders' equity :
    Common stock                                 39                                              39
                                                                    214 (2)
    Additional paid-in capital              123,054               1,769 (3)                 125,037
    Accumulated deficit                   (113,843)              (1,769)(3)                (115,612)
    Treasury stock                              (2)                                              (2)
                                      --------------   ---------------------   ---------------------

    Total stockholders' equity                9,248                 214                       9,462
                                      --------------   ---------------------   ---------------------
    Total liabilities and                  $ 13,404             $ 1,666                     $15,070
    stockholders' equity
                                      ==============   =====================   =====================

See accompanying notes to consolidated balance sheet


                           NOTES TO UNAUDITED PROFORMA
                           CONSOLIDATED BALANCE SHEET

The following  notes  describe the column  headings in the  unaudited  pro-forma
consolidated  balance sheet and the pro forma adjustments that have been made to
this balance sheet:

     (1)Reflects the consolidated balance sheet of Hemispherx Biopharma Inc. and
     subsidiaries as of December 31, 2003.

     (2) Reflects pro forma  adjustments  for the second  acquisition of certain
     assets  of  ISI  totaling  $3.1  million  and  the  assumption  of  certain
     obligations,  including  those  settled  via the  issuance of shares of the
     Company's  common  stock.  The  value of the  common  shares  issued to ISI
     approximated  $1.7  million,   of  which   approximately  $1.5  million  is
     redeemable and reflected as such.

As a result of the  acquisition,  the following  table  summarizes the estimated
fair values of the property acquired.

                                                         (AMOUNTS IN THOUSANDS)
                               Second Acquisition
                Cost of Building and Equipment :
                Issued 487,028 shares to ISI                           $1,666
                Issued 581,761 shares to ISI Creditors         $907
                Assumed Liability for Tax Lien                  639     1,546
                                                               ----   ---------
                    Total Cost of Property Acquired                    $3,212
                                                                      ========

The shares  issued to ISI were  valued at $3.42 per share  which was the closing
price of the  Company's  shares on the American  Stock  Exchange as of March 17,
2004.  The shares issued to ISI  creditors  were values at $1.56 per share which
was the closing price of the Company's  shares on the American Stock Exchange as
of March 12, 2003.

     (3) Represents the estimated  intrinsic  value of 1,450,000  stock warrants
     granted to the Company's Chief Executive  Officer during October 2003, that
     became vested upon the second acquisition of certain assets from ISI.