Filed Pursuant to Rule 424(b)(3) and (c)
                                                              File No. 333-53678


                           PROSPECTUS SUPPLEMENT NO. 1

                        INHALE THERAPEUTIC SYSTEMS, INC.

                                  $230,000,000
                                       OF
                       3.5% CONVERTIBLE SUBORDINATED NOTES
                              DUE OCTOBER 17, 2007
                                       AND
                        4,558,065 SHARES OF COMMON STOCK
                      ISSUABLE UPON CONVERSION OF THE NOTES


         This prospectus supplement supplements the prospectus dated February 2,
2001 of Inhale Therapeutic Systems, Inc. relating to the public offering and
sale by selling security holders described below. This prospectus supplement
contains information on ownership of principal amount of notes beneficially
owned and offered and shares of our common stock issuable upon conversion of the
notes. This prospectus supplement should be read in conjunction with the
prospectus, and this prospectus supplement is qualified by reference to the
prospectus, except to the extent that the information provided by this
prospectus supplement supersedes the information contained in the prospectus.



         SEE "RISK FACTORS" BEGINNING ON PAGE 5 OF THE PROSPECTUS TO READ ABOUT
FACTORS YOU SHOULD CONSIDER BEFORE BUYING THE NOTES OR OUR COMMON STOCK.

                ------------------------------------------------

         Neither the Securities and Exchange Commission nor any other regulatory
body has approved or disapproved of these securities or passed upon the adequacy
or accuracy of this prospectus. Any representation to the contrary is a criminal
offense.







The table and related notes, and the paragraphs immediately following the table
and related notes, appearing in the prospectus under the heading "Selling
Security Holders" is amended by the addition of the following table and related
notes, and the following paragraph immediately following the table and related
notes:




---------------------------------------------- --------------------- ------------------ ------------ --------------------
           NAME                                PRINCIPAL AMOUNT OF     COMMON STOCK       COMMON     COMMON STOCK OWNED
                                                NOTES BENEFICIALLY     ISSUABLE UPON       STOCK      AFTER COMPLETION
                                                OWNED AND OFFERED      CONVERSION OF      OFFERED      OF THE OFFERING
                                                      (1)(2)           THE NOTES (2)
---------------------------------------------- --------------------- ------------------ ------------ --------------------

                                                                                         

Allstate Life Insurance Company                       200,000              3,963           3,963              --
---------------------------------------------- --------------------- ------------------ ------------ --------------------
City of New Orleans                                   174,000              3,448           3,448              --
---------------------------------------------- --------------------- ------------------ ------------ --------------------
JMG Capital Partners, LP                            2,000,000             39,635          39,635              --
---------------------------------------------- --------------------- ------------------ ------------ --------------------
JMG Triton Offshore Fund, Ltd.                      6,500,000            128,814         128,814              --
---------------------------------------------- --------------------- ------------------ ------------ --------------------
KBC Financial Products USA                          2,500,000             49,544          49,544              --
---------------------------------------------- --------------------- ------------------ ------------ --------------------
Merrill Lynch Pierce Fenner & Smith Inc.            5,690,000            112,762         112,762              --
---------------------------------------------- --------------------- ------------------ ------------ --------------------
Onyx Fund Holding, LDC                              3,000,000             59,453          59,453              --
---------------------------------------------- --------------------- ------------------ ------------ --------------------
Pro Mutual                                            651,000             12,901          12,901              --
---------------------------------------------- --------------------- ------------------ ------------ --------------------
Raytheon Master Pension Trust                         470,000              9,314           9,314              --
---------------------------------------------- --------------------- ------------------ ------------ --------------------
Shell Pension Trust                                   376,000              7,451           7,451              --
---------------------------------------------- --------------------- ------------------ ------------ --------------------



   ------------------

   (1)  Amounts indicated may be in excess of the total amount registered due to
        sales or transfers exempt from the registration requirements of the
        Securities Act since the date upon which the selling holders provided to
        us in the information regarding their notes.

   (2)  Amounts listed include additional amounts now being registered by the
        selling holder for notes beneficially owned and offered and common stock
        issuable upon conversion of the notes that were already included in the
        prospectus dated February 2, 2001.

     Additional information regarding selling holders will be provided by
amendment or supplement to this prospectus.

     With the exception of Merrill Lynch Pierce Fenner & Smith Inc. and Deutsche
Bank Securities Inc., none of the selling holders nor any of their affiliates,
officers, directors or principal equity holders has held any position or office
or has had any material relationship with us within the past three years,
although the selling holders may hold additional securities of Inhale. Merrill
Lynch Pierce Fenner & Smith Inc. and Deutsche Bank Securities Inc. were initial
purchasers of the notes. The selling holders purchased the notes in private
transactions on or after October 27, 2000. All of the notes were "restricted
securities" under the Securities Act prior to this registration.

     Information concerning the selling holders may change from time to time and
any changed information will be set forth in supplements to this prospectus if
and when necessary. In addition, the conversion rate and therefore, the number
of shares of common stock issuable upon conversion of the notes, is subject to
adjustment under certain circumstances. Accordingly, the aggregate principal
amount of notes and the number of shares of common stock into which the notes
are convertible may increase or decrease.

            The date of this prospectus supplement is March 16, 2001.