As filed with the Securities and Exchange Commission on December 18, 2013
Registration 333-192210
 
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

Pre-Effective Amendment No. 3
FORM S-4
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933

THERMOGENESIS CORP.
(Exact name of registrant as specified in its charter)

Delaware
 
3821
 
94-3018487
(State or other jurisdiction of incorporation or organization)
 
(Primary Standard Industrial Classification Code Number)
 
(I.R.S.  Employer Identification Number)

2711 Citrus Road
Rancho Cordova, California 95742
(916) 858-5100
 (Address, including zip code, and telephone number, including area code, of registrant’s principal executive offices)

Matthew T. Plavan
Chief Executive Officer
ThermoGenesis Corp.
2711 Citrus Road
Rancho Cordova, California 95742
(916) 858-5100
(Name, address, including zip code, and telephone number, including area code, of agent for service)

Copies to:
David C. Adams, Esq.
Weintraub Tobin Chediak Coleman Grodin
400 Capitol Mall, Eleventh Floor
Sacramento, California 95814
(916) 558-6000
Kenneth L. Harris
Chief Executive Officer
TotipotentRX Corporation
548 South Spring Street, Suite 210
Los Angeles, CA 90013
(213) 221-7373
Alan B. Spatz, Esq.
Troy Gould PC
1801 Century Park East, Suite 1600
Los Angeles, CA 90067
(310) 553-4441

Approximate date of commencement of proposed sale to the public: As soon as practicable after this Registration Statement becomes effective.
 
If the securities being registered on this Form are being offered in connection with the formation of a holding company and there is compliance with General Instruction G, check the following box.  o
 
If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering.  o
 
If this Form is a post-effective amendment filed pursuant to Rule 462(d) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering.  o
 
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions of “large accelerated filer,” “accelerated filer,” and “smaller reporting company” in Rule 12b-2 of the Exchange Act.

Large accelerated filer o
Accelerated filer o
Non-accelerated filer o
Smaller reporting company x
If applicable, place an X in the box to designate the appropriate rule provision relied upon in conducting this transaction:
 
Exchange Act Rule 13e-4(i) (Cross-Border Issuer Tender Offer) o
 
Exchange Act Rule 14d-1(d) (Cross-Border Third-Party Tender Offer) o

CALCULATION OF REGISTRATION FEE
Title of each class of
securities to be registered
 
Amount to be
registered(1)
   
Proposed maximum
offering price per share
   
Proposed maximum
aggregate offering price(2)
   
Amount of
registration fee(2)(3)
 
Common Stock, $0.001 par value per share
   
12,490,841
     
N/A
 
$
10,742,123
   
$
1,384
 
 
                               

(1)
Relates to common stock, $0.001 par value per share, of ThermoGenesis Corp., or ThermoGenesis, issuable to holders of common stock, no par value per share, of TotipotentRX Corporation, or TotipotentRX, in the proposed merger of TotipotentRX with and into ThermoGenesis.  The amount of ThermoGenesis common stock to be registered is based on the maximum number of shares of ThermoGenesis common stock that are expected to be issued pursuant to the merger. The actual number of shares issued pursuant to the merger transaction may be less than the number of shares being registered.
 
(2)
Pursuant to Rule 457 under the Securities Act of 1933, as amended and solely for the purpose of calculating the registration fee, the proposed maximum aggregate offering price was calculated as the product of $0.86 (the average high and low price of ThermoGenesis common stock on November 5, 2013) and 12,490,841 (the maximum possible number of shares of ThermoGenesis common stock which may be exchanged in the merger) times $128.80 per million.
 
(3)
The total registration fee of $1,384 was previously paid for the registration of $10,742,123 proposed maximum aggregate offering price in the filing of the Registration Statement on November 8, 2013.

The registrant hereby amends this Registration Statement on such date or dates as may be necessary to delay its effective date until the registrant shall file a further amendment which specifically states that this Registration Statement shall thereafter become effective in accordance with Section 8(a) of the Securities Act of 1933 or until this Registration Statement shall become effective on such date as the Securities and Exchange Commission, acting pursuant to said Section 8(a), may determine.

SUBJECT TO COMPLETION, DATED DECEMBER 18, 2013
 
The information in this prospectus is not complete and may be changed.  ThermoGenesis may not issue the securities being offered by use of this prospectus until the registration statement filed with the Securities and Exchange Commission, of which this prospectus is a part, is effective.   This prospectus is not an offer to sell these securities, nor is it soliciting offers to buy these securities, in any jurisdiction where the offer or sale is not permitted.

 
To the stockholders of ThermoGenesis Corp. and shareholders of TotipotentRX Corporation:

The boards of directors of ThermoGenesis Corp., referred to herein as ThermoGenesis, and TotipotentRX Corporation, referred to herein as TotipotentRX, have each unanimously approved an Agreement and Plan of Merger and Reorganization dated July 15, 2013 by and among ThermoGenesis, TotipotentRX, Kenneth L. Harris and Mitchel Sivilotti (“Merger Agreement”), pursuant to which TotipotentRX will merge with and into ThermoGenesis and ThermoGenesis will survive the merger, and in connection therewith change its name to Cesca Therapeutics Corp.

ThermoGenesis is soliciting proxies for use at a special meeting of stockholders to consider and vote upon (i) to adopt and approve the Merger Agreement including the contemplated merger and transactions related thereto, and (ii) a proposal to adjourn the special meeting, if necessary, if a quorum is present, to solicit additional proxies if there are not sufficient votes in favor to approve the Merger Agreement.

TotipotentRX is soliciting written consents from its shareholders to consider and vote on a proposal to adopt and approve the Merger Agreement including the contemplated merger and transactions completed thereby.

If the merger is consummated, each TotipotentRX shareholder will receive, in exchange for each share of TotipotentRX common stock held immediately before the closing of the merger, 30.283 shares of ThermoGenesis common stock, representing in the aggregate approximately 12,490,800 shares of common stock or approximately 43.0% of the outstanding common stock of the combined company assuming all TotipotentRX outstanding options are exercised.

The Merger Agreement, among other things, further provides that each outstanding warrant to acquire the common stock of TotipotentRX will be assumed by ThermoGenesis and will become a warrant to acquire shares of common stock of ThermoGenesis, with the number of shares and exercise price proportionately adjusted based on the exchange ratio of the merger.

ThermoGenesis’ common stock is listed on the NASDAQ Capital Market under the ticker “KOOL”.  On December 19, 2013, the last trading day before the date of this proxy statement/prospectus/consent solicitation, the closing price of the ThermoGenesis common stock was $[____] per share.  TotipotentRX is a privately-held company and there is no public market for its securities.

This proxy statement/prospectus/consent solicitation provides you with detailed information concerning ThermoGenesis, TotipotentRX and the merger.  Please give all of the information contained in this proxy statement/prospectus/consent solicitation your careful attention.

In particular, you should carefully consider the discussion in the section entitled “Risk Factors” beginning on page 20 of this proxy statement/prospectus/consent solicitation.
 
Matthew Plavan
Chief Executive Officer
ThermoGenesis Corp.
Kenneth L. Harris
Chief Executive Officer
TotipotentRX Corporation
 

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of the shares to be issued under this proxy statement/prospectus/consent solicitation or passed upon the adequacy or accuracy of this proxy statement/prospectus/consent solicitation.  Any representation to the contrary is a criminal offense.

This proxy statement/prospectus/consent solicitation is dated December 20, 2013 and was first mailed to stockholders of ThermoGenesis and shareholders of TotipotentRX on or about December 26, 2013.

ThermoGenesis Corp.
2711 Citrus Road
Rancho Cordova, CA 95742
(916) 858-5100
NOTICE OF SPECIAL MEETING OF STOCKHOLDERS
TO BE HELD ON FEBRUARY 13, 2014

 TO THE THERMOGENESIS STOCKHOLDERS:

NOTICE IS HEREBY GIVEN that ThermoGenesis Corp. will hold a special meeting of its stockholders on Thursday, February 13, 2014 at 10:00 a.m., Pacific Standard Time, at the law offices of Weintraub Tobin, 400 Capitol Mall, Suite 1100, Sacramento, CA  95814, for the following purposes:
 
1.  To consider and vote upon a proposal to approve and adopt the Agreement and Plan of Merger and Reorganization dated July 15, 2013, by and among ThermoGenesis Corp., TotipotentRX Corporation, Kenneth Harris and Mitchel Sivilotti, a copy of which is attached as Annex A to the accompanying proxy statement/prospectus/consent solicitation, and related transactions therein, pursuant to which among other things  ThermoGenesis will issue shares of common stock to the shareholders of TotipotentRX Corporation and TotipotentRX Corporation will merge with and into ThermoGenesis, with ThermoGenesis surviving the merger and changing its name to Cesca Therapeutics Corp.
 
2.  To consider and vote upon a proposal to adjourn the special meeting, if necessary, if a quorum is present, to solicit additional proxies if there are not sufficient votes in favor to approve the Merger Agreement.
 
3.  To consider and act upon such other business and matters or proposals as may properly come before the special meeting or any adjournments or postponements thereof.
 
The board of directors of ThermoGenesis has fixed December 20, 2013 as the record date for determining which stockholders have the right to receive notice of and to vote at the ThermoGenesis special meeting or any adjournments or postponements thereof.  Only holders of record of shares of ThermoGenesis common stock at the close of business on the record date have the right to receive notice of and to vote at the ThermoGenesis special meeting.  At the close of business on the record date, ThermoGenesis had 16,677,909 shares of common stock outstanding and entitled to vote.
 
Your vote is important.  The affirmative vote of the holders of a majority of the outstanding shares of ThermoGenesis common stock having voting power on the record date for the ThermoGenesis special meeting is required for approval of Proposal No. 1.  The affirmative vote of the holders of a majority of the shares of ThermoGenesis common stock having voting power present in person or represented by proxy at the ThermoGenesis special meeting is required for approval of Proposal No. 2, if necessary.
 
Whether or not you plan to attend the ThermoGenesis special meeting, please complete, sign and date the enclosed proxy and return it promptly in the enclosed postage-paid return envelope.  You may revoke the proxy at any time before its exercise in the manner described in the accompanying proxy statement/prospectus/consent solicitation.  Any stockholder present at the ThermoGenesis special meeting, including any adjournment or postponement of the meeting, may revoke such stockholder’s proxy and vote personally on the matters to be considered at the ThermoGenesis special meeting.  Executed proxies with no instructions indicated thereon will be voted “FOR” each of the proposals outlined above.
 
THE THERMOGENESIS BOARD OF DIRECTORS HAS DETERMINED THAT EACH OF THE PROPOSALS OUTLINED ABOVE IS ADVISABLE TO AND IN THE BEST INTERESTS OF THERMOGENESIS AND ITS STOCKHOLDERS AND HAS APPROVED EACH SUCH PROPOSAL.  THE THERMOGENESIS BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS THAT THERMOGENESIS STOCKHOLDERS VOTE “FOR” EACH SUCH PROPOSAL.
 
 
BY ORDER OF THE BOARD OF DIRECTORS
 
 
Rancho Cordova, California
David C. Adams
December 20, 2013
Corporate Secretary


The accompanying proxy statement/prospectus/consent solicitation provides a detailed description of the Merger Agreement including the Merger and the transactions contemplated thereby to be considered at the special meeting of stockholders. We urge you to read the accompanying proxy statement/prospectus/consent solicitation and its annexes carefully and in their entirety, including the section entitled “Risk Factors” beginning on page 20. If you have any questions concerning the Merger Agreement including the Merger and the transactions contemplated thereby, or the accompanying proxy statement/prospectus/consent solicitation, would like additional copies of the accompanying proxy statement/prospectus/consent solicitation, or need help voting your shares, please contact ThermoGenesis’ proxy solicitor:

Georgeson Inc.
480 Washington Blvd., 26th Floor
Jersey City, NJ 07310
(866) 203-9401 (Toll Free)

TotipotentRX Corporation
548 South Spring Street, Suite 210
Los Angeles, CA 90013

NOTICE OF SOLICITATION OF WRITTEN CONSENT
 
TO THE TOTIPOTENTRX SHAREHOLDERS:
 
TotipotentRX Corporation has entered into the Agreement and Plan of Merger and Reorganization, dated July 15, 2013, by and among ThermoGenesis Corp., TotipotentRX, Kenneth L. Harris and Mitchel Sivilotti (“Merger Agreement”), a copy of which is attached as Annex A to the accompanying proxy statement/prospectus/consent solicitation, pursuant to which TotipotentRX will merge with and into ThermoGenesis with ThermoGenesis surviving the merger and change its name to Cesca Therapeutics Corp. and ThermoGenesis will issue common stock to the shareholders of TotipotentRX.

This proxy statement/prospectus/consent solicitation is being delivered to you on behalf of the TotipotentRX board of directors to request that holders of TotipotentRX common stock as of December 20, 2013, or the record date, execute and return written consents to adopt and approve the Merger Agreement including the merger and transactions completed thereby.  At the close of business on the record date, TotipotentRX had 401,563 shares of common stock outstanding and entitled to vote.

As a record holder of outstanding TotipotentRX common stock on the record date, you are urged to complete, date and sign the enclosed written consent and promptly return it to TotipotentRX.  The TotipotentRX board of directors has set January 31, 2013 as the target final date for receipt of written consents. TotipotentRX reserves the right to extend the final date for receipt of written consents without any prior notice to shareholder.

This proxy statement/prospectus/consent solicitation describes the merger agreement and the actions to be taken in connection with the merger and provides additional information about the parties involved.  Please give this information your careful attention.  A summary of the dissenters’ rights that may be available to you is provided in the section entitled “The Merger—Appraisal and Dissenters’ Rights” on page 66 of this proxy statement/prospectus/consent solicitation.

Written consents from the holders of a majority of the shares of TotipotentRX common stock outstanding on the applicable record date are required to adopt and approve the Merger Agreement, including the merger and transactions contemplated thereby.

Regardless of the number of shares you own, your written consent is important.  Please complete, date and sign the written consent furnished with this proxy statement/prospectus/consent solicitation and return it promptly to TotipotentRX by one of the means described in “Solicitation of TotipotentRX Written Consent—Submission of Consents” on page 37 of this proxy statement/prospectus/consent solicitation. You may change or revoke your consent to a proposal at any time before the consents of holders of a sufficient number of shares to approve and adopt such proposal have been filed with the corporate secretary of TotipotentRX.

THE TOTIPOTENTRX BOARD OF DIRECTORS HAS CAREFULLY CONSIDERED THE MERGER AND THE TERMS OF THE MERGER AGREEMENT AND HAS DETERMINED THAT THE MERGER IS FAIR, ADVISABLE AND IN THE BEST INTERESTS OF TOTIPOTENTRX AND ITS SHAREHOLDERS. ACCORDINGLY, THE TOTIPOTENTRX BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS THAT TOTIPOTENTRX SHAREHOLDERS APPROVE THE MERGER AND ADOPT AND APPROVE THE MERGER AGREEMENT AND THE TRANSACTIONS CONTEMPLATED THEREBY BY EXECUTING AND DELIVERING THE WRITTEN CONSENT FURNISHED WITH THIS PROXY STATEMENT/PROSPECTUS/CONSENT SOLICITATION.

 
BY ORDER OF THE BOARD OF DIRECTORS
 
 
Los Angeles, California
Kenneth L. Harris
December 20, 2013
Chief Executive Officer

TABLE OF CONTENTS

1
 
 
8
 
 
15
 
 
19
 
 
20
 
 
33
 
 
34
 
 
34
 
 
34
 
 
34
 
 
35
 
 
35
 
 
36
 
 
36
 
 
36
 
 
37
 
 
39
 
 
39
 
 
54
 
 
63
 
 
63
 
 
63
 
 
63
 
 
63
 
 
66
 
 
69
 
 
80
 
 
95
 
 
100
 
 
101
 
 
102
 
 
103

104
 
 
104
 
 
105
 
 
105
 
 
106
 
 
106
 
 
107
 
 
113
 
 
113
 
 
113
 
 
113
 
 
114
 
 
114
 
 
118
 
 
119
 
 
120
 
 
133
 
 
142
 
 
142
 
 
142
 
 
F-2
 
 
F-33
 
 
F-56

Annex A Agreement and Plan of Merger and Reorganization dated July 15, 2013
 
Annex B Chapter 13 of the California General Corporation Law
 
Annex C Opinion of Roth Capital Partners, LLC.
QUESTIONS AND ANSWERS ABOUT THE MERGER

The following section provides answers to frequently asked questions about the Agreement and Plan of Merger and Reorganization, dated July 15, 2013, by and among ThermoGenesis Corp., TotipotentRX, Kenneth L. Harris and Mitchel Sivilotti (“Merger Agreement”) and the merger (“Merger”) and transactions contemplated thereby and the effect of the Merger on holders of ThermoGenesis common stock and TotipotentRX common stock, the ThermoGenesis special meeting of stockholders and the TotipotentRX shareholder action by written consent.  This section, however, only provides summary information.  ThermoGenesis and TotipotentRX urge you to read carefully the remainder of this proxy statement/prospectus/consent solicitation, including the annexes to this proxy statement/prospectus/consent solicitation, because the information in this section does not provide all the information that might be important to you regarding the Merger and the other matters being considered at the ThermoGenesis special meeting of stockholders and by the TotipotentRX shareholder action by written consent.

As used in this proxy statement/prospectus/consent solicitation, references to “ThermoGenesis” refer collectively to ThermoGenesis Corp. and its subsidiary unless the context requires otherwise, references to “TotipotentRX” refers to TotipotentRX Corporation and its subsidiaries, and references to the “combined company” refer to ThermoGenesis following the proposed merger described in this proxy statement/prospectus/consent solicitation and the name change to “Cesca Therapeutics Corp.”

Questions and Answers Regarding the Merger
 
Q: What is the transaction?
A:  The transaction is the Merger of TotipotentRX with and into ThermoGenesis with ThermoGenesis surviving the Merger.  As a result, each outstanding share of TotipotentRX common stock will be converted into 30.283 shares of ThermoGenesis common stock.

Q: Why am I receiving this proxy statement/prospectus/consent solicitation?
A:  You are receiving this proxy statement/prospectus/consent solicitation because you have been identified as a stockholder of ThermoGenesis or shareholder of TotipotentRX.  If you are a stockholder of ThermoGenesis, you are entitled to vote at ThermoGenesis’ special meeting of stockholders.  If you are a shareholder of TotipotentRX, you are entitled to vote by signing the TotipotentRX shareholder action by written consent.  This document serves as a proxy statement of ThermoGenesis used to solicit proxies for ThermoGenesis’ special meeting of stockholders, as a consent solicitation of TotipotentRX shareholders, and as a prospectus of ThermoGenesis used to offer shares of ThermoGenesis common stock to TotipotentRX shareholders in exchange for their shares of TotipotentRX common stock pursuant to the terms of the Merger Agreement.  This document contains important information about the Merger Agreement, Merger, the shares of ThermoGenesis common stock to be issued in the Merger, the special meeting of ThermoGenesis stockholders, and consent solicitation of the holders of common stock of TotipotentRX and you should read it carefully.

Q: What is required to approve the Merger Agreement and consummate the Merger?
A:  To consummate the Merger, ThermoGenesis stockholders must approve and adopt the Merger Agreement including the Merger and transactions contemplated thereby, including but not limited to, the issuance of shares of common stock in the Merger, and TotipotentRX stockholders must approve and adopt the Merger Agreement including the Merger and transactions contemplated thereby.

The approval of the Merger Agreement by the stockholders of ThermoGenesis requires the affirmative vote of the holders of a majority of the common stock having voting power outstanding on the record date of the ThermoGenesis special meeting.  The approval of the Merger Agreement by the stockholders of TotipotentRX requires the affirmative vote of the holders of at least a majority of the common stock having voting power outstanding on the applicable record date.

In addition to the requirement of obtaining such stockholder and shareholder approvals, each of the other closing conditions set forth in the Merger Agreement must be satisfied or waived.  For a more complete description of the closing conditions under the Merger Agreement, we urge you to read the section entitled “The Merger Agreement—Conditions to Completion of the Merger” on page 74 of this proxy statement/prospectus/consent solicitation.
QWhat happens to ThermoGenesis if the Merger is not ultimately completed?
A:  ThermoGenesis will continue as it currently is. ThermoGenesis believes that the Merger with TotipotentRX will enable the combined company to capture additional gains and growth in the regenerative medicine industry rather than a stand-alone because currently each company’s business focuses on complementary parts of the regenerative medicine industry; however, ThermoGenesis believes that its current business would continue to grow even without the Merger.

Q: When do ThermoGenesis and TotipotentRX expect to complete the Merger?
A: ThermoGenesis and TotipotentRX are working to complete the Merger during the first quarter of 2014 or as soon thereafter as reasonably possible.  ThermoGenesis and TotipotentRX must first obtain the necessary approvals, including, but not limited to, the approval of each company’s stockholders, and satisfy the closing conditions described in the Merger Agreement.  ThermoGenesis cannot assure as to if or whether all the conditions to the Merger will be met nor can ThermoGenesis predict the exact timing of the closing of the Merger.  It is possible neither ThermoGenesis nor TotipotentRX will be able to complete the Merger.

Q: What are the material U.S. federal income tax consequences of the Merger to me?
A: The Merger has been structured to qualify as a tax-free reorganization within the meaning of Section 368(a) of the Internal Revenue Code of 1986, as amended, or the Code.  As a result of the Merger’s qualification as a reorganization, it is anticipated that TotipotentRX shareholders will not recognize a gain or loss for U.S. federal income tax purposes upon the exchange of shares of TotipotentRX common stock for shares of ThermoGenesis common stock, except with respect to cash received in lieu of fractional shares of ThermoGenesis common stock and except for TotipotentRX shareholders who exercise their appraisal rights with respect to the Merger.

Tax matters are very complicated, and the tax consequences of the Merger to a particular stockholder will depend in part on such stockholder’s circumstances.  Accordingly, you should consult your tax advisor for a full understanding of the tax consequences of the Merger to you, including the applicability and effect of federal, state, local and foreign income and other tax consequences.  For more information, please see the section entitled “The Merger—Material United States Federal Income Tax Consequences of the Merger” beginning on page 63 of this proxy statement/prospectus/consent solicitation.

Q:  What risks should I consider in deciding whether to vote in favor of the proposals?
A:  You should carefully review the section of this proxy statement/prospectus/consent solicitation entitled “Risk Factors” beginning on page 20, which sets forth certain risks and uncertainties related to the Merger, risks and uncertainties to which the combined company’s business will be subject, and risks and uncertainties to which each of ThermoGenesis and TotipotentRX, as an independent company, is subject.

Q:  Will a proxy solicitor be used?
A: Yes. ThermoGenesis has engaged Georgeson Inc. to assist in the solicitation of proxies for the ThermoGenesis special meeting and ThermoGenesis estimates it will pay Georgeson a fee of $8,500. ThermoGenesis has also agreed to reimburse Georgeson for reasonable out-of-pocket expenses and disbursements incurred in connection with the proxy solicitation and to indemnify Georgeson against certain losses, costs, and expenses. In addition to soliciting proxies through the mail, ThermoGenesis may solicit proxies through its directors, officers, and employees in person, by email, telephone, and facsimile.

Q: Who is paying for this proxy solicitation and consent solicitation?
A:  ThermoGenesis and TotipotentRX are conducting this proxy statement/prospectus/consent solicitation and will each bear their own costs of the proxy statement/prospectus/consent solicitation, including the preparation, assembly, printing and mailing of this proxy statement/prospectus/consent solicitation, the proxy card and any additional information furnished to ThermoGenesis stockholders or TotipotentRX shareholders.

Questions and Answers for ThermoGenesis Stockholders

Q:  What do I need to do now?
A: After you have carefully read and considered this proxy statement/prospectus/consent solicitation, if you are the stockholder of record, you may instruct the proxy holders how to vote your shares by completing, signing, dating and returning a requested proxy card in the provided, postage pre-paid envelope or by using the Internet voting site or the toll-free telephone number listed on the proxy card.  Specific instructions for using the Internet and telephone voting systems are on the website and proxy card (and repeated in the box below). The Internet and telephone voting systems for ThermoGenesis stockholders of record will be available until 1:00 a.m., Central Time, on February 13, 2014 (the morning of the special meeting).  Please indicate on your proxy card how you want your shares to be voted, then sign, date and mail the proxy card in the enclosed prepaid return envelope as soon as possible so that your shares may be represented and voted at the ThermoGenesis special meeting.
 
If you are the beneficial owner of shares of ThermoGenesis common stock held in street name, you have the right to direct your broker, bank or nominee on how to vote your shares.  Your broker, bank or nominee has provided a voting instruction card for you to use in directing the broker, bank or nominee regarding how to vote your shares.

ThermoGenesis stockholders may also attend the ThermoGenesis special meeting and vote in person.

VOTE BY INTERNET
 
Shares Held of Record:
www.envisionreports.com/KOOL
Shares Held Through Broker, Bank or Nominee:
Internet: www.proxyvote.com
24 hours a day/7 days a week
Through 1:00 am Central Time, February 13, 2014
 
INSTRUCTIONS:
 
Read this Proxy Statement/Prospectus/Consent Solicitation.
Go to the applicable website listed above.
Have your proxy card or voting instruction card in hand (including the control number specified on that notice or card) and follow the instructions.
VOTE BY TELEPHONE
 
Shares Held of Record:
1-800-652-VOTE (8683)
Shares Held Through Broker, Bank or Nominee:
1-800-579-1639
Toll-free 24 hours a day/7 days a week
Through 1:00 am Central Time, February 13, 2014
 
INSTRUCTIONS:
 
Read this Proxy Statement/Prospectus/Consent Solicitation.
Call the applicable toll-free number above.
Have your proxy card or voting instruction card in hand (including the control number specified on that notice or card) and follow the instructions.

Q: Why is my vote important?
A: If you do not return your proxy card at or before the special meeting, it will be more difficult for ThermoGenesis to obtain the necessary quorum to hold the special stockholder meeting.  In addition, if you fail to vote by proxy or in person, it will have the same effect as a vote against the Merger Agreement including the Merger and transactions contemplated thereby.

Q:  How many votes do I have?
A:   You are entitled to one vote for each share of ThermoGenesis common stock you owned at the close of business on the record date, provided that those shares are either held directly in your name as the stockholder of record or were held for you as the beneficial owner through a broker, bank or other nominee.

Q:  What should I do if I receive more than one set of voting materials?
A:  You may receive more than one notice or set of voting materials, including multiple copies of this proxy statement/prospectus/consent solicitation and multiple proxy cards or voting instruction cards.  For example, if you hold your shares in more than one brokerage account, you may receive a separate voting instruction card for each brokerage account in which you hold shares.  If you are a stockholder of record and your shares are registered in more than one name, you will receive more than one proxy card.  Please vote by telephone or the Internet with respect to each proxy card that you receive, or complete, sign, date and return each proxy card and voting instruction card that you receive, to ensure that all of your shares are voted at the special meeting.

Q:   If my shares are held in “street name” by my broker, will my broker automatically vote my shares for me?
A:   No.  Your broker cannot automatically vote your shares without instructions from you.  If your shares are held in street name, you should instruct your broker as to how to vote your shares, following the instructions contained in the voting instructions card that your broker provides to you.  Without instructions, your shares will not be voted, which will have the same effect as if you voted against approval of the Merger Agreement.

Q:   What happens if I do not return a proxy card or otherwise provide proxy instructions?
A:   The failure to return your proxy card will have the same effect as voting against the Merger Agreement and your shares will not be counted for purposes of determining whether a quorum is present at the ThermoGenesis special meeting.  Executed proxies without instructions will be voted for Merger Agreement and other proposals outlined in ThermoGenesis’ special meeting notice.

Q:   Can I change or revoke my vote after I return a proxy card or voting instruction card?
A:  If you are the stockholder of record, you may revoke your proxy or change your vote by:

· delivering to the Corporate Secretary of ThermoGenesis, prior to your shares being voted at the special meeting, a written notice of revocation or a duly executed proxy card, in either case dated later than the prior proxy card relating to the same shares (such written notice should be hand delivered to ThermoGenesis' Assistant Corporate Secretary or should be sent so as to be delivered to ThermoGenesis Corp., 2711 Citrus Rd., Rancho Cordova, CA 95742, Attn: Corporate Secretary);
· attending the special meeting and voting in person; or
· making a timely and valid later Internet or telephone vote, as the case may be, if you have previously voted on the Internet or by telephone in connection with the special meeting.

If you are the beneficial owner of shares held in street name, you may change your vote by:

· submitting new voting instructions to your broker, bank or other nominee in a timely manner; or
· attending the special meeting and voting in person, if you have obtained a legal proxy from the broker, bank or nominee that holds your shares giving you the right to vote the shares.

Questions and Answers for TotipotentRX Shareholders

Q:  Who is soliciting my written consent?
A:   The TotipotentRX board of directors is providing these consent solicitation materials to you to seek action by written consent to approve the Merger Agreement including the Merger and the transactions contemplated thereby.  These materials also constitute a prospectus with respect to the ThermoGenesis common stock to be issued to TotipotentRX stockholders in connection with the Merger.
Q: What am I being asked to approve?
A: You are being asked to approve the Merger Agreement including the Merger and transactions contemplated thereby.  The approval of the Merger Agreement by the shareholders of TotipotentRX requires the affirmative vote of the holders of at least a majority of the common stock having voting power outstanding on the applicable record date.  Mr. Kenneth L. Harris and Mitchel Sivilotti, TotipotentRX’s Chief Executive Officer and Chief Biologist, respectively, own, in the aggregate, 300,000 shares of common stock representing approximately 74.0% of TotipotentRX.

Q: What happens to TotipotentRX if the Merger is not ultimately completed?
A: If the Merger is not completed, TotipotentRX is likely to continue as an independent privately held company for the foreseeable future.   TotipotentRX believes that the Merger with ThermoGenesis will enable the combined company to capture additional gains and growth in the regenerative medicine industry rather than a stand-alone because currently each company’s business focuses on complementary parts of the regenerative medicine industry; however, TotipotentRX is confident that its current business would continue to grow even without the Merger.

Q:  Who is entitled to give a written consent?
A:  The TotipotentRX board of directors has set December 20, 2013, as the record date for determining holders of TotipotentRX common stock entitled to execute and deliver written consent with respect to this solicitation.  Holders of TotipotentRX common stock on the record date will be entitled to give a consent using the written consent furnished with this proxy statement/prospectus/consent solicitation.  If you are a TotipotentRX shareholder on the record date, you will be able to give or withhold a consent, or abstain, on the proposal on which you are entitled to vote, using the written consent furnished with this proxy statement/prospectus/consent solicitation.

Q:  What do TotipotentRX shareholders need to do now?
A:  TotipotentRX urges you to read this proxy statement/prospectus/consent solicitation carefully, including its annexes, and consider how the Merger affects you.  TotipotentRX shareholders are being asked to sign and return the written consent. TotipotentRX is not asking TotipotentRX shareholders for a proxy and TotipotentRX shareholders are not requested to send TotipotentRX a proxy.

Q:  What options do I have with respect to the Merger Agreement proposal?
A:  With respect to the shares of TotipotentRX common stock that you hold, you may execute a written consent to approve the Merger Agreement, including the Merger and transactions contemplated thereby (which is equivalent to a vote for the Merger Agreement) or to disapprove such proposal (which is equivalent to a vote against the Merger Agreement).  If you fail to execute and return your written consent, it has the same effect as voting against the Merger Agreement.

Q:  How can I return my TotipotentRX written consent?
A:  If you hold shares of TotipotentRX common stock as of the record date and you wish to submit your consent, you must fill out the enclosed written consent, date and sign it, and promptly return it to TotipotentRX.  Once you have completed, dated and signed your written consent, deliver it to TotipotentRX by faxing it, by emailing a pdf copy of your written consent to proxyvote@totipotentrx.com, or by mailing your written consent to TotipotentRX, 548 S. Spring Street, Suite 210, Los Angeles, CA 90013; Fax number (213) 341-2415.  TotipotentRX will not be holding a shareholders’ meeting to consider the Merger Agreement, and therefore you will be unable to vote by attending a shareholders’ meeting.

Q: What happens if I do not return my TotipotentRX written consent?
A: If you are a record holder of shares of TotipotentRX common stock and you do not return your written consent, that will have the same effect as a vote against the Merger Agreement.

Q:  Will my rights as a ThermoGenesis stockholder be different from my rights as a TotipotentRX shareholder?
A:  Yes. Upon completion of the Merger, each shareholder of TotipotentRX, a California corporation, will become a stockholder of ThermoGenesis, a Delaware corporation.  There are important differences between the rights of stockholders of ThermoGenesis and shareholders of TotipotentRX.  Please carefully review the description of these differences in the section of this proxy statement/prospectus/consent solicitation entitled “Comparison of Rights of Holders of ThermoGenesis Stock and TotipotentRX Stock” beginning on page 107.
Q:  Should I send in my share certificates now?
A:  No.  If you are a TotipotentRX shareholder, after the Merger is consummated, you will receive written instructions from ThermoGenesis’ exchange agent for exchanging your certificates representing shares of TotipotentRX common stock for certificates representing shares of ThermoGenesis common stock.

Q:  As a TotipotentRX shareholder, how does TotipotentRX’s board of directors recommend that I vote?
A:  After careful consideration, TotipotentRX’s board of directors has approved the terms of the Merger Agreement, including the Merger and transactions contemplated thereby, and has determined that they are advisable, fair to and in the best interests of TotipotentRX shareholders. Accordingly, TotipotentRX’s board of directors recommends that TotipotentRX’s shareholders approve Merger Agreement by written consent.

Q:  Are TotipotentRX shareholders entitled to dissenters’ rights?
A:  Under California law, holders of TotipotentRX common stock are entitled to dissenters’ rights in connection with the Merger.  If you do not wish to accept shares of ThermoGenesis common stock in the Merger and you do not approve the Merger Agreement by the TotipotentRX shareholder action by written consent, you have the right under California law to seek from TotipotentRX the “fair market value” of your shares in lieu of the ThermoGenesis common stock you would receive if the Merger is completed.  TotipotentRX refers you to the information under the heading “The Merger—Appraisal and Dissenters’ Rights” on page 63 of this proxy statement/prospectus/consent solicitation and to the applicable California statute attached as Annex B to this proxy statement/prospectus/consent solicitation for information on how to exercise your dissenters’ rights.  Failure to follow all of the steps required under California law will result in the loss of your dissenters’ rights.  In addition, if holders of more than two and one-half percent (2.5%) of the outstanding shares of TotipotentRX decide to exercise their dissenters’ rights, ThermoGenesis will have the right to terminate the Merger Agreement.

Q:  What will TotipotentRX shareholders receive in the Merger?
A:  ThermoGenesis has agreed to issue, and holders of TotipotentRX common stock will receive, shares of ThermoGenesis common stock such that following the consummation of the transactions contemplated by the Merger Agreement, current stockholders of ThermoGenesis are expected to own approximately 57.0% of the common stock of the combined company, and current TotipotentRX shareholders are expected to own approximately 43.0% of the combined company.  If the Merger is consummated, each share of TotipotentRX common stock is expected to convert into the right to receive 30.283 shares of ThermoGenesis common stock.

Q:  How will the Merger affect stock options and warrants for TotipotentRX common stock?
A:  ThermoGenesis will assume each outstanding warrant to purchase shares of TotipotentRX common stock, which will become exercisable for shares of ThermoGenesis common stock with the same terms, exercisability, vesting schedule and other provisions, but with the number of shares and exercise price being appropriately adjusted based on the exchange ratio of the Merger.  In connection with the Merger, each outstanding option held by TotipotentRX shareholders to purchase common stock of TotipotentRX will be cancelled.

Q:  What if I am a record holder of TotipotentRX Common Stock and I don’t indicate a decision with respect to the Merger Agreement proposal?
A:  If you are a record holder on the record date of shares of TotipotentRX common stock and you return a signed written consent without indicating your decision on a proposal, you will have given your consent to adopt and approve the Merger Agreement including the Merger and other transactions contemplated thereby.

Q:  What is the deadline for returning my written consent?
A:  The TotipotentRX board of directors has set January 31, 2014 as the targeted final date for receipt of written consents.  TotipotentRX reserves the right to extend the final date for receipt of written consents beyond January 31, 2014, in the event that consents adopting and approving the Merger Agreement including the Merger and the transactions contemplated thereby have not been obtained by that date from holders of a sufficient number of shares of TotipotentRX common stock to satisfy the conditions to the Merger.  Any such extension may be made without notice to shareholders.  Once TotipotentRX has received written consents from holders owning more than a majority of outstanding shares of common stock of TotipotentRX, the consent solicitation will conclude.
Q: Can I change or revoke my written consent?
A: Yes, if you are a record holder on the record date of shares of TotipotentRX common stock, you may change or revoke your consent to the Merger Agreement at any time before the consents of a sufficient number of shares to approve and adopt such proposal have been received by TotipotentRX.  If you wish to change or revoke your consent before that time, you may do so by sending in a new written consent with a later date by one of the means described in the section entitled “Solicitation of TotipotentRX Written Consent—Submission of Consents” on page 37, or delivering a notice of revocation to the corporate secretary of TotipotentRX.
SUMMARY

The following summary highlights selected information from this proxy statement/prospectus/consent solicitation and may not contain all of the information that is important to you.  To better understand the Merger Agreement, including the Merger and other transactions contemplated thereby being considered at the ThermoGenesis special meeting and by written consent by the TotipotentRX shareholders, you should carefully read this entire proxy statement/prospectus/consent solicitation, including the Merger Agreement attached as Annex A to this proxy statement/prospectus/consent solicitation.   For purposes of this proxy statement/prospectus/consent solicitation, the term “Merger Agreement” will refer to the Merger Agreement, as the same may be amended.

The Companies

ThermoGenesis Corp.
2711 Citrus Road
Rancho Cordova, CA 95742
(916) 858-5100

ThermoGenesis is a leading designer and supplier of clinical technologies for processing and storing stem cells used in the practice of regenerative medicine.  Regenerative medicine is an emerging field using cell-based therapies to address a number of clinical indications, including the repair or restoration of diseased or damaged tissue and cell function.  ThermoGenesis’ products isolate and automate the volume reduction and cryopreservation of adult stem cell concentrates from cord blood, bone marrow and peripheral blood for use in laboratory and point of care settings.  ThermoGenesis’ primary business model is based on the sale of medical devices and the recurring revenues generated from their companion single-use, sterile disposable products. ThermoGenesis currently sells its products in over 30 countries throughout the world to customers that include private and public cord blood banks, surgeons, hospitals and research institutions. ThermoGenesis’ worldwide commercialization strategy relies primarily on the utilization of distributors.  Founded in 1986, ThermoGenesis has approximately 55 employees and is located in Rancho Cordova, California.

ThermoGenesis’ growth strategy is to expand its offerings in regenerative medicine while partnering with other pioneers in the stem cell arena to accelerate our worldwide penetration of this potentially explosive market.  ThermoGenesis plans to have a product line that will facilitate the processing of an increasing number of therapeutic cell sources and to leverage our technological investments into profitable adjacent markets.

ThermoGenesis’ common stock is listed on the NASDAQ Capital Market under the symbol KOOL.

TotipotentRX Corporation
548 S. Spring Street, Suite 210
Los Angeles, CA 90013
(213) 221-7373

TotipotentRX Corporation, formerly known as MK Alliance, Inc., is engaged in the research, development, and commercialization of cell-based therapeutics for use in regenerative medicine.  In addition, TotipotentRX sells medical devices and equipment for collection, transportation, and processing of cord blood, cord tissue, bone marrow, and peripheral blood stem cells; reagents for culturing and assaying stem cells; and services to hospital and surgeons for processing autologous cellular therapies at the point of care.  Founded in November 2007, TotipotentRX has approximately 46 employees and is headquartered in Los Angeles, California.

TotipotentRX Corporation is the surviving corporation of a merger between MK Alliance Inc., and TotipotentRX.  Prior to the merger, MK Alliance owned approximately 77.0% of the outstanding shares of common stock of TotipotentRX.   TotipotentRX merged with and into MK Alliance Inc. with the surviving corporation changing its name to TotipotentRX.  TotipotentRX also has two wholly-owned subsidiaries: TotipotentRX Cell Therapy, Pvt. Ltd. (cellular therapeutics) including its joint collaboration Fortis-TotipotentRX Centre for Cellular Medicine (cellular clinical trials), and TotipotentSC Scientific Product Pvt. Ltd. (medical devices).  Unless otherwise indicated, reference to TotipotentRX includes its predecessor and its subsidiaries TotipotentRX Cell Therapy Pvt. Ltd., Fortis-TotipotentRX Centre for Cellular Medicine, and TotipotentSC Scientific Product Pvt. Ltd.
TotipotentRX operates four lines of business and serves patients, physicians and partners:

 
Therapeutics Division;
 
Medical Devices Division;
 
Contract Services Division; and
 
Cell Manufacturing and Banking Division

TotipotentRX’s general business strategy is to attempt to increase sales of existing and proposed products and services from its TotipotentRX operations in order to generate cash flow to help support the cardiovascular and orthopedic autologous cell therapy point-of-care combination product development efforts of TotipotentRX.  TotipotentRX also operates a medical device assembly and supply business at its Gurgaon, a suburb of New Delhi, facility in India.  This facility was designed to house the sales and operations departments, which cater specifically to the design, assembly and supply of medical devices and kits to the regenerative medicine market, primarily private cord blood banks.

The Merger

A copy of the Merger Agreement is attached as Annex A to this proxy statement/prospectus/consent solicitation.  ThermoGenesis and TotipotentRX encourage you to read the entire Merger Agreement carefully because it is the principal document governing the Merger and the transactions contemplated thereby.

Merger Consideration (see page 69)

If the Merger is completed, TotipotentRX will merge with and into ThermoGenesis, and ThermoGenesis will be the surviving entity.  A TotipotentRX shareholder will receive, in exchange for each share of TotipotentRX common stock held by such shareholder immediately before the effective date of the Merger, 30.283 shares of ThermoGenesis common stock (the “Merger Consideration”), excluding TotipotentRX dissenting shares.  As a result, immediately after the Merger TotipotentRX shareholders are expected to own in the aggregate approximately 43.0% of the outstanding shares of ThermoGenesis after giving effect of the Merger without taking into account any outstanding ThermoGenesis’ options or TotipotentRX warrants that will be assumed by ThermoGenesis to acquire shares of common stock.  For a more complete description of the Merger Consideration to be issued by ThermoGenesis, please see the section entitled “The Merger Agreement” in this proxy statement/prospectus/consent solicitation.

Treatment of TotipotentRX Options and Warrants (see page 69)

In connection with the Merger, each outstanding option to purchase common stock of TotipotentRX not exercised will be cancelled and each warrant to purchase the common stock of TotipotentRX will be assumed by ThermoGenesis and will become a warrant to purchase shares of common stock of ThermoGenesis, with the number of shares of common stock and exercise price adjusted to reflect the exchange ratio in the Merger.  As of the date of this proxy statement/prospectus/consent solicitation, there were outstanding options to purchase 10,901 shares and warrants to acquire 2,004 shares of TotipotentRX common stock.  After giving effect to the exchange ratio, it is assumed that 330,115 shares of ThermoGenesis common stock will be issued to TotipotentRX option holders assuming the exercise thereof and TotipotentRX warrants will be assumed by ThermoGenesis to purchase 60,687 shares of ThermoGenesis common stock.  For a more complete description of the treatment of TotipotentRX options and warrants, please see the section entitled “The Merger Agreement” in this proxy statement/prospectus/consent solicitation.

Reasons for the Merger (see page 39)

ThermoGenesis and TotipotentRX anticipate that the combined company resulting from the Merger will be a fully integrated regenerative medicine company with the ability and expertise to research, design, and develop devices and disposables necessary to facilitate, or integrate into the design of clinical protocols and applications directed at cell therapies at the point of care, managing both risk of regulatory approval, and channel distribution.  The combined company will have the ability to develop new products, devices, and disposables, and support existing products, while directing new development of products and services to clinical trials.  ThermoGenesis and TotipotentRX believe the combined company will have the following strategic benefits:
One of the First Integrated Regenerative Medicine Companies.  The combined company will be one of the first companies to bring together cell-therapy-related devices, patented platform technology, proprietary cell formulations and treatment protocols and a cell-therapy-specific clinical research organization increasing the likelihood that a safe and effective therapy can reach full commercialization.
Practical, Commercializable Cell Therapies.  The combined company will offer safe and effective therapies backed by clinical evidence, including eight clinical trials in osteoarthritis, avascular necrosis, cardiac and critical limb ischemia, among others, using patient and regulator friendly autologous cells and at the bedside, 60-90 minute protocol.
Ability to Rapidly and Cost-Effectively Implement New Clinical Trials.  The combined company will have the ability to rapidly initiate early clinical development of new cell therapies at its U.S. Food and Drug Administration (FDA)-registered clinical research organization in India and generate high quality data at a fraction of the cost of clinical trials undertaken in the U.S. or Europe.
Positioned to Commercialize in Both Developed and Emerging Markets. The combined company's existing U.S. and Asian footprints uniquely position it to meet the needs of patients, hospitals and physicians across the globe. This footprint allows flexibility to meet the variable market demands in service and price.
Significant Value Creation.  The combined company should support a higher valuation than either company alone, with the potential to create additional, near and long-term shareholder value through the development of new protocols in major therapeutic areas.

For a more complete description of the factors on which the ThermoGenesis board of directors based its decision to approve the Merger Agreement including the issuance of ThermoGenesis common stock to TotipotentRX shareholders in connection with the Merger discussed in this proxy statement/prospectus/consent solicitation, please see the section entitled “The Merger—ThermoGenesis’ Reasons for the Merger” in this proxy statement/prospectus/consent solicitation.  For a more complete description of the factors on which the TotipotentRX board of directors based its decision to approve the Merger Agreement discussed in this proxy statement/prospectus/consent solicitation, please see the section entitled “The Merger—TotipotentRX “Reasons for the Merger” in this proxy statement/prospectus/consent solicitation.

Overview of the Merger Agreement (see page 39)

Conditions to completion of the Merger.

ThermoGenesis and TotipotentRX are required to complete the Merger only if certain customary conditions are satisfied or waived, including:

· the Merger Agreement must be approved by the TotipotentRX shareholders and ThermoGenesis stockholders;
· the registration statement on Form S-4, of which this proxy statement/prospectus/consent solicitation is a part, must have been declared effective by the SEC;
· ThermoGenesis and TotipotentRX shall each have the written opinion from ThermoGenesis' counsel to the effect that the Merger will constitute a “reorganization” within the meaning of Section 368(a) of the Code; and
· ThermoGenesis shares of common stock to be issued in connection with the Merger shall have been authorized for listing on the NASDAQ Capital Market.

In addition, the obligation of ThermoGenesis to complete the Merger is further subject to the satisfaction or waiver of the following conditions:

· the representations and warranties of TotipotentRX and Messrs. Kenneth Harris and Mitchel Sivilotti (the “Principal Stockholders”) contained in the Merger Agreement shall have been true and correct as of the date of the Merger Agreement and the closing date;
· TotipotentRX and the Principal Stockholders shall have performed or complied in all material respects with all agreements and covenants to be performed or complied with by them;
·
the employment agreements with the Principal Stockholders shall be in full force and effect;
·
each of the non-competition agreements shall be in full force and effect;
· TotipotentRX shall have paid less than $300,000 to satisfy appraisal rights in connection with the merger involving TotipotentRX and MK Alliance, Inc.; and
· holders of no more than two and one half percent (2.5%) of the outstanding shares of TotipotentRX common stock shall have exercised dissenters’ rights.
 
In addition, the obligation of TotipotentRX to complete the Merger is further subject to the satisfaction or waiver of the following conditions:

· the representations and warranties of ThermoGenesis contained in the Merger Agreement shall have been true and correct as of the date of the Merger Agreement, and as of the closing date;
· ThermoGenesis shall have performed or complied in all material respects with all agreements and covenants required by the Merger Agreement to be performed or complied with by them on or prior to the closing;
· Kenneth L. Harris and another TotipotentRX  nominee shall have been appointed as directors of ThermoGenesis and there shall be no more than seven directors serving on ThermoGenesis’ board of directors; and
· Holders of no more than two percent (2.0%) of the outstanding shares of ThermoGenesis common stock shall have exercised dissenters’ rights under applicable law with respect to their shares by virtue of the Merger.  Holders of ThermoGenesis common stock, however, have no dissenters’ rights.

Termination of the Merger Agreement (see page 76)

The Merger Agreement may be terminated at any time before the completion of the Merger by the mutual consent of ThermoGenesis and TotipotentRX.

Under certain circumstances specified in the Merger Agreement, the Merger Agreement may be terminated if:

· by ThermoGenesis or TotipotentRX if the Merger has not been consummated by (i) December 15, 2013, provided however, that if the SEC does not declare the registration statement effective by October 31, 2013, then either party may extend the termination date by an additional 60 days (which termination date has been extended by ThermoGenesis and TotipotentRX for an additional 60 days in accordance with the Merger Agreement);
· by ThermoGenesis or TotipotentRX if a court of competent jurisdiction or any governmental entity prohibits the Merger;
· by either ThermoGenesis or TotipotentRX if the Merger shall not have been approved by the ThermoGenesis’ stockholders at its stockholders’ meeting or by written consent from the TotipotentRX shareholders;
· by TotipotentRX if (i) the board of directors of ThermoGenesis shall have failed to recommend to approve the Merger; (ii) ThermoGenesis shall have failed to file the registration statement with the SEC within 60 days of receipt of TotipotentRX’s financial statements; (iii) ThermoGenesis shall have failed to hold its stockholders’ meeting within 60 days after the registration statement is declared effective;  (iv) ThermoGenesis shall have entered into any letter of intent or similar document to any acquisition proposal; or (v) ThermoGenesis shall have breached the no solicitation provisions set forth in the Merger Agreement;
· by ThermoGenesis if (i) the board of directors of TotipotentRX shall have failed to recommend approval of the Merger; (ii) the board of directors of TotipotentRX shall have endorsed any acquisition proposal; (iii) TotipotentRX shall have entered into any letter of intent or similar document relating to any acquisition proposal; or (iv) TotipotentRX shall have breached the no solicitation provisions set forth in the Merger Agreement;
· by ThermoGenesis (i) if TotipotentRX GAAP financial statements are not delivered to ThermoGenesis by July 30, 2013; or (ii) if, excluding differences related to non-cash charges for deferred revenue, compensation expenses and the reduction in the value of securities held by TotipotentRX for investment, TotipotentRX audited (A) consolidated net income before interest, taxes, depreciation and amortization (EBITDA) for each of the years ended December 31, 2012 and 2011 is more than $100,000 less than the EBITDA of the TotipotentRX unaudited annual financial statements for the corresponding year; (B) consolidated revenue for the year ended December 31, 2012 is more than $100,000 less than the consolidated revenue as set forth in the TotipotentRX unaudited annual financial statements for such year; (C) shareholders' equity for TotipotentRX and its subsidiaries as of December 31, 2012 is more than $250,000 less than the shareholders' equity for TotipotentRX and its subsidiaries at December 31, 2012 as set forth in the TotipotentRX unaudited annual financial statements; or (D) financial statements are qualified by TotipotentRX’s auditors other than a going concern.  ThermoGenesis has waived the deadline and certain financial conditions that were not met by TotipotentRX,  See “The Merger Agreement-Termination” on page 77;
· by TotipotentRX upon a breach of any representation, warranty, covenant or agreement on the part of ThermoGenesis set forth in the Merger Agreement;  or
· by ThermoGenesis upon a breach of any representation, warranty, covenant or agreement on the part of TotipotentRX set forth in the Merger Agreement.

Opinion of Roth Capital Partners (see page 54)

Roth Capital Partners, LLC rendered its opinion to the board of directors of ThermoGenesis, based upon and subject to the assumptions, factors, qualifications and limitations set forth in the written opinion described herein, to the effect that, as of July 15, 2013, the total consideration to be paid by ThermoGenesis in connection with the Merger, including the Merger Consideration, is fair to ThermoGenesis from a financial point of view.

Lock-up Agreements (see page 78)

Kenneth Harris and Mitchel Sivilotti, each of whom will sometimes be referred to collectively in this proxy statement/prospectus/consent solicitation as the Principal Stockholders, have each entered into a stockholder lock-up agreement pursuant to which, among other things, such Principal Stockholder agrees not to transfer his TotipotentRX shares of common stock except pursuant to the Merger or transfers of less than 4.0% of the outstanding common stock of TotipotentRX to other shareholders of TotipotentRX, and not to exercise his dissenters’ rights related to the Merger.

In addition, each Principal Stockholder has agreed that until the second anniversary of the effective date of the Merger, such Principal Stockholder will not pledge, sell, sell any option or warrant related to or otherwise transfer or dispose of, directly or indirectly, any ThermoGenesis shares of common stock received in the Merger.  During each of the first and second year of the lock-up agreement, each Principal Stockholder may sell up to 25.0% of the outstanding shares of ThermoGenesis common stock that such Principal Stockholder received in the Merger without restriction.

As of the date of the Merger Agreement, the Principal Stockholders beneficially owned an aggregate of approximately 300,000 shares of TotipotentRX common stock, representing approximately 74.7% of the outstanding shares of TotipotentRX common stock, and the Principal Stockholders will beneficially own approximately 9,331,500 shares of ThermoGenesis common stock representing approximately 32.0 % of the outstanding shares of ThermoGenesis common stock after giving effect to the Merger.

Board of Directors; Management of the Combined Company Following the Merger (see page 100)

The Merger Agreement provides that TotipotentRX shall appoint two directors, one of whom must be an independent director, to ThermoGenesis’ board of directors.  TotipotentRX intends to appoint Mr. Kenneth L. Harris as one of the two directors to ThermoGenesis’ board.  It is anticipated that all current members of ThermoGenesis’ directors shall remain on the board.
If the Merger is completed, Matthew T. Plavan will serve of Chief Executive Officer; Kenneth L. Harris shall serve as President; Dan T. Bessey shall serve as Chief Financial Officer; and Mitchel Sivilotti shall serve as Chief Biologist, Senior Vice President of the combined company.  Mr. Harris and Mr. Sivilotti have each entered into employment agreements with ThermoGenesis which will become effective upon the effective date of the Merger.

Interests of Certain Persons in the Merger (see page 63)

In considering the recommendation of the TotipotentRX board of directors with respect to approving the Merger Agreement, TotipotentRX shareholders should be aware that certain members of the board of directors and executive officers of TotipotentRX have interests in the Merger Agreement that may be different from, or in addition to, interests they have as TotipotentRX shareholders.  For example, upon the effective date of the Merger, Mr. Harris will serve on the board of directors of the combined company; Mr. Harris and Mr. Sivilotti will also serve as executive officers of the combined company.  In addition, upon the effective date of the Merger, ThermoGenesis’ employment agreements with Mr. Harris and Mr. Sivilotti will become effective, and ThermoGenesis will payoff certain loans due to Messrs. Harris and Sivilotti by TotipotentRX.

Accounting Treatment (see page F-56)

The Merger will be accounted for as a “purchase,” as that term is used under generally accepted accounting principles, for accounting and financial reporting purposes.  Under purchase accounting, the assets (including identifiable intangible assets) and liabilities (including executory contracts and other commitments) of TotipotentRX as of the effective date of the Merger will be recorded at their respective fair values and added to those of ThermoGenesis. Any excess of purchase price over the fair values is recorded as goodwill. Consolidated financial statements of ThermoGenesis issued after the Merger would reflect these fair values and would not be restated retroactively to reflect the historical consolidated financial position or results of operations of TotipotentRX.  The purchase method of accounting is based on ASC 805 “Business Combinations.”

Material U.S. Federal Income Tax Consequences (see page 63)

Each of ThermoGenesis and TotipotentRX will receive an opinion of Weintraub Tobin Chediak Coleman Grodin, counsel to ThermoGenesis, that the Merger will qualify as a reorganization within the meaning of Section 368(a) of the Internal Revenue Code of 1986, as amended, sometimes referred to herein as the Code or the IRC.  In general, TotipotentRX shareholder will not recognize gain or loss for United States federal income tax purposes upon the exchange of shares of TotipotentRX common stock for shares of ThermoGenesis common stock, except for TotipotentRX shareholders who exercise their dissenters’ rights with respect to the Merger. In addition, ThermoGenesis stockholders will not recognize gain or loss for United States federal income tax purposes in connection with the Merger.  Tax matters are very complicated, and the tax consequences of the Merger to a particular shareholder will depend in part on such shareholder’s circumstances.  Accordingly, you are urged to consult your own tax advisor for a full understanding of the tax consequences of the Merger to you, including the applicability and effect of federal, state, local and foreign income and other tax laws.  For more information on the federal income tax effect of the Merger, see the section entitled “Material Federal Income Tax Consequences of the Merger.”

Comparison of Stockholder Rights (see page 107)

Upon consummation of the Merger, the holders of issued and outstanding TotipotentRX common stock will be entitled to receive ThermoGenesis common stock. The rights of the holders of ThermoGenesis common stock are governed by ThermoGenesis’ Certificate of Incorporation, ThermoGenesis’ Bylaws and Delaware General Corporation Law, while the rights of holders of TotipotentRX common stock are generally governed by TotipotentRX’s Articles of Incorporation, TotipotentRX’s Bylaws and California law.  There are difference in rights afforded by under Delaware law and California law.   See “Comparison of Rights of Holders of ThermoGenesis Stock and TotipotentRX Stock’’ in this proxy statement/prospectus/consent solicitation for more information.
Appraisal and Dissenters’ Rights in Connection with the Merger (see page 66)

Under Delaware law, holders of ThermoGenesis common stock are not entitled to appraisal rights in connection with the Merger because ThermoGenesis’ shares of common stock are listed on a national securities exchange.

If the Merger Agreement is approved by written consent from required vote of TotipotentRX shareholders and is not abandoned or terminated, holders of TotipotentRX common stock who did not approve the Merger Agreement via written consent may, by complying with Sections 1300 through 1313 of the California General Corporation Law or CGCL, be entitled to dissenters’ rights as described herein and receive cash for the fair market value of their TotipotentRX common stock.  For more information about dissenters’ rights, see Sections 1300 through 1313 of the CGCL, attached as Annex B to this proxy statement/prospectus/consent solicitation, and the section entitled “Appraisal and Dissenter’s Rights” in this proxy statement/prospectus/consent solicitation.

Risks Associated with the Merger (see page 20)

Both ThermoGenesis and TotipotentRX are subject to various risks associated with their businesses and industries.  In addition, the Merger poses a number of risks to each company and its respective stockholders or shareholders, including, but not limited to, the following:

· if the proposed Merger is not completed, both ThermoGenesis and TotipotentRX may experience negative publicity and a negative impression in the investment community since each party has spent a substantial amount of effort, time and money to consummate the Merger;
· failure to complete the Merger may result in ThermoGenesis or TotipotentRX paying a termination fee or expenses to the other party;
· the combined company may not be able to obtain necessary financing after the effective date of the Merger adversely affecting its business plan;
· the market price of ThermoGenesis’ common stock may decline as a result of the Merger;
· ThermoGenesis and TotipotentRX stockholders may not realize a benefit from the Merger commensurate with the ownership dilution they will experience in connection with the Merger;
· certain provisions of the Merger Agreement may discourage third parties from submitting alternative business proposals, including proposals that may be superior to the financial arrangements contemplated by the Merger Agreement; and
· ThermoGenesis and TotipotentRX may not be able to successfully integrate their operations.

These risks are discussed in greater detail under the section entitled “Risk Factors” in this proxy statement/prospectus/consent solicitation.  ThermoGenesis and TotipotentRX encourage you to read and consider all of these risks carefully.

SELECTED HISTORICAL AND UNAUDITED PRO FORMA COMBINED CONDENSED CONSOLIDATED FINANCIAL STATEMENTS

The following tables present summary historical and unaudited pro forma condensed combined financial data for ThermoGenesis and TotipotentRX.

Selected Historical Financial Data of ThermoGenesis

The following selected financial data should be read together with ThermoGenesis’ financial statements and accompanying notes and “ThermoGenesis’ Management’s Discussion and Analysis of Financial Condition and Results of Operations” included elsewhere in this proxy statement/prospectus/consent solicitation. The selected financial data in this section is not intended to replace ThermoGenesis’ financial statements and the accompanying notes.  Historical results are not necessarily indicative of operating results to be expected in the future.
 
The statement of operations data for the years ended June 30, 2013 and 2012 and the balance sheet data as of June 30, 2013 and 2012 was derived from ThermoGenesis’ audited financial statements contained in its Annual Report on Form 10-K for the year ended June 30, 2013, which is included in this proxy statement/prospectus/consent solicitation. The statement of operations data for the years ended June 30, 2011, 2010 and 2009 and balance sheet data as of June 30, 2011, 2010 and 2009 was derived from audited financial statements not included in this proxy statement/prospectus/consent solicitation.  The statement of operations data for the three months ended September 30, 2013 and 2012 and the balance sheet data as of September 30, 2013 was derived from unaudited condensed financial statements also included in this proxy statement/prospectus/consent solicitation. The unaudited financial statements include all adjustments, consisting of normal recurring accruals, which ThermoGenesis considers necessary for a fair presentation of the financial position and the results of operations for these periods. Operating results for the three months ended September 30, 2013 are not necessarily indicative of the results that may be expected in future periods.

 
 
Year Ended June 30,
   
(Unaudited)
Three Months Ended
September 30,
 
Summary of Operations
 
2013
   
2012
   
2011
   
2010
   
2009
   
2013
   
2012
 
Net revenues
 
$
17,963,000
   
$
19,023,000
   
$
23,400,000
   
$
23,088,000
   
$
19,799,000
   
$
3,644,000
   
$
4,122,000
 
 
                                                       
Cost of revenues
   
(11,598,000
)
   
(12,690,000
)
   
(14,563,000
)
   
(15,643,000
)
   
(14,106,000
)
   
(2,253,000
)
   
(2,496,000
)
 
                                                       
Gross profit
   
6,365,000
     
6,333,000
     
8,837,000
     
7,445,000
     
5,693,000
     
1,391,000
     
1,626,000
 
 
                                                       
Sales and marketing
   
(2,955,000
)
   
(2,761,000
)
   
(3,195,000
)
   
(2,889,000
)
   
(3,808,000
)
   
(715,000
)
   
(656,000
)
Research and development
   
(2,991,000
)
   
(3,729,000
)
   
(3,003,000
)
   
(5,013,000
)
   
(5,222,000
)
   
(833,000
)
   
(838,000
)
General and administrative
   
(5,645,000
)
   
(5,222,000
)
   
(5,474,000
)
   
(4,797,000
)
   
(5,441,000
)
   
(2,142,000
)
   
(1,140,000
)
Gain on sale of product lines
   
2,161,000
     
--
     
--
     
--
     
--
     
--
     
2,000,000
 
 
                                                       
Income (loss) from operations
   
(3,065,000
)
   
(5,379,000
)
   
(2,835,000
)
   
(5,254,000
)
   
(8,778,000
)
   
(2,299,000
)
   
992,000
 
Interest and other income  (expense), net
   
(21,000
)
   
393,000
     
268,000
     
61,000
     
228,000
     
--
     
3,000
 
Net income (loss)
 
(3,086,000
)
 
(4,986,000
)
 
(2,567,000
)
 
(5,193,000
)
 
(8,550,000
)
 
(2,299,000
)
 
$
995,000
 
Per share data:
                                                       
Basic and diluted net income (loss) per common share
 
(0.19
)
 
(0.30
)
 
(0.17
)
 
(0.37
)
 
(0.61
)
 
(0.14
)
 
$
0.06
 

 
 
   
(Unaudited)
 
 
 
As of June 30,
   
As of September 30,
 
Balance Sheet Data
 
2013
   
2012
   
2011
   
2010
   
2009
   
2013
 
Cash, cash equivalents and short term investments
 
$
6,884,000
   
$
7,879,000
   
$
12,309,000
   
$
10,731,000
   
$
15,631,000
   
$
5,306,000
 
Working capital
 
$
11,125,000
   
$
14,034,000
   
$
18,976,000
   
$
16,587,000
   
$
20,923,000
   
$
8,959,000
 
Total assets
 
$
18,529,000
   
$
21,080,000
   
$
24,399,000
   
$
24,030,000
   
$
27,655,000
   
$
16,484,000
 
Total liabilities
 
$
5,211,000
   
$
5,182,000
   
$
4,306,000
   
$
6,251,000
   
$
5,201,000
   
$
5,364,000
 
Total stockholders’ equity
 
$
13,318,000
   
$
15,898,000
   
$
20,093,000
   
$
17,779,000
   
$
22,454,000
   
$
11,120,000
 

 
 
   
(Unaudited)
 
 
 
Year Ended June 30,
   
Three Months Ended September 30,
 
Other Data
 
2013
   
2012
   
2011
   
2010
   
2009
   
2013
   
2012
 
Adjusted EBITDA(1)
 
(3,961,000
)
 
(3,984,000
)
 
(1,409,000
)
 
(4,244,000
)
 
(7,825,000
)
 
(1,974,000
)
 
(731,000
)
 

(1)
Adjusted EBITDA represents loss from operations excluding amounts for depreciation and amortization, stock-based compensation expense, impairment of intangible asset and gain on sale of product lines.  Adjusted EBITDA is a common measure of operating performance and helps us evaluate our performance by removing from our operating results non-cash items and items which do not relate to our core operating performance.

Non-GAAP Measures
 
In addition to the results reported in accordance with US GAAP, we also use a non-GAAP measure, adjusted EBITDA, to evaluate operating performance and to facilitate the comparison of our historical results and trends.  This financial measure is not a measure of financial performance under US GAAP and should not be considered in isolation or as a substitute for loss as a measure of performance.  The calculation of this non-GAAP measure may not be comparable to similarly titled measures used by other companies.  Reconciliations to the most directly comparable GAAP measure are provided below.

 
 
   
(Unaudited)
 
 
 
Year Ended June 30,
   
Three Months Ended September 30,
 
 
 
2013
   
2012
   
2011
   
2010
   
2009
   
2013
   
2012
 
Income (loss) from operations
 
(3,065,000
)
 
(5,379,000
)
 
(2,835,000
)
 
(5,254,000
)
 
(8,778,000
)
 
(2,299,000
)
 
$
992,000
 
 
                                                       
Add (subtract):
                                                       
Depreciation and amortization
   
538,000
     
604,000
     
466,000
     
492,000
     
474,000
     
156,000
     
134,000
 
Stock-based compensation expense
   
563,000
     
791,000
     
960,000
     
518,000
     
479,000
     
169,000
     
143,000
 
Impairment of intangible asset
   
164,000
     
--
     
--
     
--
     
--
     
--
     
--
 
Gain on sale of product lines
   
(2,161,000
)
   
--
     
--
     
--
     
--
     
--
     
(2,000,000
)
Adjusted EBITDA loss
 
(3,961,000
)
 
(3,984,000
)
 
(1,409,000
)
 
(4,244,000
)
 
(7,825,000
)
 
(1,974,000
)
 
(731,000
)

Selected Historical Financial Data of TotipotentRX

The following selected financial data should be read together with TotipotentRX’s financial statements and accompanying notes and “TotipotentRX’s Management’s Discussion and Analysis of Financial Condition and Results of Operations” included elsewhere in this proxy statement/prospectus/consent solicitation. The selected financial data in this section is not intended to replace TotipotentRX’s financial statements and the accompanying notes. Historical results are not necessarily indicative of operating results to be expected in the future.

The statement of operations data for the years ended December 31, 2012 and 2011 and the balance sheet data as of December 31, 2012 and 2011 were derived from TotipotentRX’s audited financial statements that are included in this proxy statement/prospectus/consent solicitation.  The statement of operations data for the nine months ended September 30, 2013 and 2012 and the balance sheet data as of September 30, 2013 was derived from unaudited condensed financial statements also included in this proxy statement/prospectus/consent solicitation. The unaudited financial statements include all adjustments, consisting of normal recurring accruals, which TotipotentRX considers necessary for a fair presentation of the financial position and the results of operations for these periods. Operating results for the nine months ended September 30, 2013 are not necessarily indicative of the results that may be expected in future periods.
 
 
   
(Unaudited)
 
 
 
Year Ended December 31,
   
Nine Months Ended September 30,
 
Summary of Operations
 
2012
   
2011
   
2013
   
2012
 
Net revenues
 
$
1,177,000
   
$
1,839,000
   
$
1,130,000
   
$
791,000
 
Gross profit
 
$
401,000
   
$
830,000
   
$
301,000
   
$
275,000
 
Loss from operations
 
(1,117,000
)
 
(228,000
)
 
(879,000
)
 
(615,000
)
Net loss
 
(1,157,000
)
 
(322,000
)
 
(891,000
)
 
(653,000
)

 
 
   
(Unaudited)
 
 
 
December 31,
   
September 30,
 
Balance Sheet Data
 
2012
   
2011
   
2013
 
Cash and cash equivalents
 
$
1,035,000
   
$
1,174,000
   
$
509,000
 
Working capital
 
$
809,000
   
$
713,000
   
$
44,000
 
Total assets
 
$
1,842,000
   
$
2,097,000
   
$
1,323,000
 
Total liabilities
 
$
1,028,000
   
$
987,000
   
$
1,445,000
 
Total stockholders’ equity(deficit)
 
$
814,000
   
$
1,110,000
   
(122,000
)

 
 
   
(Unaudited)
 
 
 
Year Ended December 31,
   
Nine Months Ended
September 30,
 
Other Data
 
2012
   
2011
   
2013
   
2012
 
Adjusted EBITDA(1)
 
(777,000
)
 
(63,000
)
 
(806,000
)
 
(551,000
)
 

(1)
Adjusted EBITDA represents loss from operations excluding amounts for depreciation and amortization, stock-based compensation expense and impairment of investment in private corporation.  Adjusted EBITDA is a common measure of operating performance and helps evaluate performance by removing from operating results non-cash items and items which do not relate to core operating performance.

Non-GAAP Measures
 
In addition to the results reported in accordance with US GAAP, TotipotentRX also uses a non-GAAP measure, adjusted EBITDA, to evaluate operating performance and to facilitate the comparison of historical results and trends.  This financial measure is not a measure of financial performance under US GAAP and should not be considered in isolation or as a substitute for loss as a measure of performance.  The calculation of this non-GAAP measure may not be comparable to similarly titled measures used by other companies.  Reconciliations to the most directly comparable GAAP measure are provided below.

(Unaudited)
 
Year Ended December 31,
   
Nine Months Ended
September 30,
 
 
 
2012
   
2011
   
2013
   
2012
 
Loss from operations
 
(1,117,000
)
 
(228,000
)
 
(879,000
)
 
(615,000
)
 
                               
Add:
                               
Depreciation and amortization
   
89,000
     
60,000
     
72,000
     
63,000
 
Stock-based compensation expense
   
1,000
     
105,000
     
1,000
     
1,000
 
Impairment of investment in private corporation
   
250,000
     
--
     
--
     
--
 
Adjusted EBITDA
 
(777,000
)
 
(63,000
)
 
(806,000
)
 
(551,000
)

Selected Unaudited Pro Forma Condensed Combined Financial Data of ThermoGenesis and TotipotentRX

The following unaudited pro forma condensed combined financial data should be read in conjunction with the historical financial statements and the accompanying notes of ThermoGenesis and TotipotentRX, and “ThermoGenesis’ Management’s Discussion and Analysis of Financial Condition and Results of Operations” and “TotipotentRX’s Management’s Discussion and Analysis of Financial Condition and Results of Operations,” which are included elsewhere in this proxy statement/prospectus/consent solicitation, and the other information contained in this proxy statement/prospectus/consent solicitation. See the financial statements of ThermoGenesis and TotipotentRX beginning on pages F-2 and F-33, respectively.

The following selected unaudited pro forma condensed combined financial information was prepared using the purchase method of accounting under ASC 805, Business Combinations. For accounting purposes, ThermoGenesis is considered to be purchasing TotipotentRX in this merger. The ThermoGenesis and TotipotentRX unaudited pro forma condensed combined balance sheet data assume that the merger of ThermoGenesis and TotipotentRX took place on September 30, 2013, and combines ThermoGenesis’ historical balance sheet at September 30, 2013 with TotipotentRX’s historical balance sheet at September 30, 2013. The ThermoGenesis and TotipotentRX unaudited pro forma condensed combined statement of operations data assume that the merger of ThermoGenesis and TotipotentRX took place as of the beginning of the periods presented.

The selected unaudited pro forma condensed combined financial data are presented for illustrative purposes only and are not necessarily indicative of the combined financial position or results of operations of future periods or the results that actually would have been realized had the entities been a single entity during these periods. The selected unaudited pro forma condensed combined financial data as of and for the three months ended September 30, 2013 and year ended June 30, 2013 are derived from the unaudited pro forma condensed combined financial information starting at page F-56 of this proxy statement/prospectus/consent solicitation and should be read in conjunction with those statements and the related notes. See “Unaudited Pro Forma Condensed Combined Financial Information.”

(Unaudited)
 
For the Year
Ended June 30,
2013
   
For the Three
Months Ended
September 30,
2013
 
Statement of Operations:
 
   
 
Net revenues
 
$
19,280,000
   
$
3,951,000
 
Gross profit
 
$
6,791,000
   
$
1,519,000
 
Loss from operations
 
(4,614,000
)
 
(2,086,000
)
Net loss
 
(4,645,000
)
 
(2,092,000
)
Net loss per common share
 
(0.16
)
 
(0.07
)
 
               
Balance Sheet Data:
         
As of September
30, 2013
 
Cash and cash equivalents
         
$
7,038,000
 
Working capital
         
$
10,267,000
 
Total assets
         
$
26,893,000
 
Total liabilities
         
$
6,113,000
 
Total stockholders’ equity
         
$
20,780,000
 

MARKET PRICE DATA AND DIVIDEND INFORMATION

ThermoGenesis

ThermoGenesis’ common stock is listed on the NASDAQ Capital Market under the symbol KOOL.  The following table sets forth the range of high and low closing sales prices for the common stock as reported on the NASDAQ Capital Market for the periods indicated below.

Fiscal 2014
 
High
   
Low
 
Fiscal 2013
 
High
   
Low
 
Fiscal 2012
 
High
   
Low
 
First Quarter (Sep. 30)
 
$
1.52
   
$
1.01
 
First Quarter (Sep. 30)
 
$
1.29
   
$
0.88
 
First Quarter (Sep. 30)
 
$
2.13
   
$
1.20
 
 
               
Second Quarter (Dec. 31)
 
$
1.01
   
$
0.67
 
Second Quarter (Dec. 31)
 
$
1.29
   
$
0.71
 
 
               
Third Quarter (Mar. 31)
 
$
1.00
   
$
0.82
 
Third Quarter (Mar. 31)
 
$
1.15
   
$
0.70
 
 
               
Fourth Quarter (June 30)
 
$
1.53
   
$
0.77
 
Fourth Quarter (June 30)
 
$
0.95
   
$
0.80
 

On July 16, 2013, the date of  the public announcement of the signing of the Merger Agreement and on December 19, 2013, the date preceding the date of this proxy statement/prospectus/consent solicitation the last sales prices reported on the NASDAQ Capital Market for ThermoGenesis common stock were $1.26 per share and [$__] per share, respectively.  As of December 20, 2013, the record date for the ThermoGenesis special meeting, there were 16,677,909 shares of ThermoGenesis common stock outstanding and approximately 266 holders of record of ThermoGenesis common stock.

On December 11, 2013, ThermoGenesis received notice from the NASDAQ Listing Qualifications Department informing it that ThermoGenesis failed to maintain the $1.00 per share minimum bid listing requirement and we must regain compliance with listing requirements or face delisting.  In order to regain compliance, the bid price of ThermoGenesis common stock must close at a price of at least $1.00 per share for a minimum of 10 consecutive business days at any time before June 9, 2014.  If compliance cannot be demonstrated by June 9, 2014, then NASDAQ will decide whether ThermoGenesis meets all applicable standards for initial listing on the Capital Market (except the bid price requirement) based on our most recent public filings and market information.  If ThermoGenesis meets these standards, then it will be granted an additional 180 calendar day compliance period.  NASDAQ can deny the extension if it does not appear to them that it is possible for ThermoGenesis to cure the deficiency.

ThermoGenesis has never declared or paid any cash dividends on its common stock nor does it intend to do so in the foreseeable future.  Any future determination to pay cash dividends will be at the discretion of ThermoGenesis’ board of directors and will depend upon its financial condition, operating results, capital requirements, any applicable contractual restrictions and such other factors as ThermoGenesis’ board of directors deems relevant.
 
TotipotentRX

TotipotentRX is a privately-held company and there is no established public trading market for its common stock.  As of December 20, 2013, the record date for seeking TotipotentRX shareholder consent, there were 401,563 shares of TotipotentRX common stock outstanding and twelve holders of record of TotipotentRX common stock.

TotipotentRX has never declared or paid any cash dividends on its common stock nor does it intend to do so in the foreseeable future.

RISK FACTORS
 
ThermoGenesis stockholders and TotipotentRX shareholders should carefully consider the following factors, in addition to the other information contained in this proxy statement/prospectus/consent solicitation, before deciding how to vote their shares of common stock.  The risk factors relating to TotipotentRX will also apply to the combined company going forward because the business of the combined company will primarily be TotipotentRX’s business.

Risks Related to the Merger

Consummation of the Merger is Subject to Various Closing Conditions and the Failure to Complete the Merger Could Negatively Impact the Perception of ThermoGenesis and TotipotentRX.

The consummation of the Merger is subject to the satisfaction of a number of conditions, including, but not limited to approval by ThermoGenesis’ stockholders and TotipotentRX’s shareholders.   No assurance can be given that the Merger will occur on the terms and timeline currently contemplated or at all.  If the proposed Merger is not completed, the share price of ThermoGenesis common stock may decline to the extent that the current market price of ThermoGenesis common stock reflects an assumption that the Merger will be completed.  Further, a failed Merger may result in negative publicity and a negative impression of both ThermoGenesis and TotipotentRX in the investment community since both parties have spent a substantial amount of effort, time and money to explain the benefits of the Merger.

Some of TotipotentRX’s Officers and Directors May Have Conflicts of Interests in Recommending that You Vote in Favor of the Merger that May Influence Them to Support or Approve the Merger Without Regard to Your Interests.

Certain officers and directors of TotipotentRX have entered into employment contracts with ThermoGenesis that become effective upon the effective date of the Merger and that provide them with interests in the Merger that are different from other shareholders of TotipotentRX, including, among others, the service as an officer or director of the combined company.  In addition, ThermoGenesis will payoff certain loans due to Mr. Harris and Mr. Sivilotti by TotipotentRX.  These employment contracts and assumption of loans by ThermoGenesis may influence the officers and directors of TotipotentRX to support and approve the Merger. 

The Market Price of the Combined Company’s Common Stock May Decline As a Result Of the Merger.

The market price of the combined company’s common stock may decline as a result of the Merger for a number of reasons, including the following:

· the combined company does not achieve the perceived benefits of the Merger as rapidly or to the extent anticipated by financial or industry analysts or the investment community; or
· the combined company is unable to obtain required financing.

ThermoGenesis Stockholders and TotipotentRX Shareholders May Not Realize a Benefit From the Merger Commensurate With the Ownership Dilution They Will Experience In Connection With the Merger.

If the combined company is unable to realize the strategic and financial benefits currently anticipated from the Merger, ThermoGenesis stockholders will have experienced an approximately 43.0% dilution of their ownership interests in ThermoGenesis, and TotipotentRX shareholders will have experienced an approximately 57.0% dilution of their ownership interests in TotipotentRX without receiving any commensurate benefit.
Certain Provisions Of the Merger Agreement May Discourage Third Parties From Submitting Alternative Takeover Proposals, Including Proposals That May Be Superior to the Merger Consideration Contemplated By the Merger Agreement.

The terms of the Merger Agreement prohibit each of ThermoGenesis and TotipotentRX from soliciting alternative takeover proposals or cooperating with persons making unsolicited takeover proposals.  In addition, under certain circumstances ThermoGenesis or TotipotentRX would be required to pay a termination fee of $500,000 to the other party if the Merger Agreement is terminated.  This termination fee may discourage third parties from submitting alternative takeover proposals to ThermoGenesis or TotipotentRX or their respective stockholders or shareholders, and may cause the respective boards of directors to be less likely to recommend an alternative proposal.

ThermoGenesis’ and TotipotentRX’s Inability to Successfully Integrate Their Operations Could Adversely Affect the Combined Business.

The ability of ThermoGenesis and TotipotentRX to fulfill their strategy and business plan is dependent on their ability to successfully integrate their operations.  Failure to quickly and adequately integrate their operations and personnel could adversely affect the combined company’s business and its ability to achieve its objectives and strategy.

ThermoGenesis and TotipotentRX May Not Be Able to Successfully Integrate Their Business, or to Realize the Anticipated Synergies of the Combined Businesses.

The Merger between ThermoGenesis and TotipotentRX represents a significant investment by both companies.   The Merger will require significant attention and resources of both ThermoGenesis and TotipotentRX which could reduce the likelihood of achievement of other corporate goals. The additional financing needs created by the combined company will also require additional management time to address. There is no assurance that ThermoGenesis will realize synergies in the scientific, clinical, regulatory, or other areas as the parties currently contemplate.

Upon Completion of the Merger, ThermoGenesis Will Need to Raise Additional Capital in Furtherance of its Business Plan.

Upon completion of the Merger, management estimates a need for $15 million to $20 million of additional growth capital to execute the Cesca Therapeutic business plan over the next 24 to 36 months. The proposed financing may include shares of common stock and warrants to purchase additional shares of common stock, equity investments from strategic development partners or some combination of each.  Any additional equity financings may be financially dilutive to, and will be dilutive from an ownership perspective to, the combined company’s stockholders.

Lack of demonstrated clinical utility of cord blood derived stem cells beyond hematopoietic transplantation may result in a decline in demand for cord blood banking services, adversely affecting sales of ThermoGenesis’ products

Transplants using stem cells derived from cord blood and cord tissue have become a standard procedure for treating blood cell lineage disorders including leukemia, lymphoma and anemia. However, clinical research demonstrating the utility of cord blood stem cells for use in treating other diseases or injury has been minimal, leaving claims of broad clinical utility of cord blood stem cells by cord blood banks largely unsubstantiated. The low utilization rate of banked cord blood samples coupled with the lack of demonstrated clinical results for multiple treatment indications has led to consumer skepticism regarding the benefits of cord blood banking and in turn, a significant reduction in collection rates in a number of geographies in Europe and the US.  A continued lack of investment in the research and development of supporting clinical data for additional applications may lead to greater skepticism globally, further adversely affecting demand for cord blood banking services and revenues to ThermoGenesis.
Risks Related to ThermoGenesis’ Business and Operations

ThermoGenesis’ Future Revenue Growth is Dependent on its New Products and its Existing Products being accepted for New Indications or into New Markets.

The acceptance of ThermoGenesis’ products into new markets or for new indications will depend upon the medical community and third-party payers accepting the products as clinically useful, reliable, accurate, and cost effective compared to existing and future products or procedures.  Acceptance will also depend on ThermoGenesis’ ability to adequately train technicians on how to use its existing and future products.  Even if its products are released for sale, their use may not be recommended by the medical profession or hospitals unless acceptable reimbursement from healthcare and third-party payers is available.  Failure of these products to achieve significant market share could have material adverse effects on ThermoGenesis long term business, financial condition, and results of operation.

Outcomes of Pending or Future Clinical Trials or Evaluations May be Negative and the Regenerative Medicine Market May not Expand, or May Not Expand in the Areas Targeted by ThermoGenesis’ Products.

The marketing and sales of new products may depend on successful clinical trials or evaluation outcomes in the regenerative medicine areas targeted by ThermoGenesis’ products and the approval of regulators.  Clinical trials also represent a significant expenditure of resources. Negative clinical trial results in connection with ThermoGenesis’ products or in the areas targeted by it could negatively impact regulatory approval or market acceptance of ThermoGenesis’ products.  Unfavorable clinical trials or failure of study results to obtain regulatory approval in a targeted clinical application and/or geographical area even with successful clinical trials, could have material adverse effects on ThermoGenesis’ long term business, financial condition, and results of operations.

A Significant Portion of ThermoGenesis’ Revenue is Derived from Customers in Foreign Countries.  ThermoGenesis May Lose Revenues, Market Share, and Profits Due to Exchange Rate Fluctuations, Political and Economic Changes Related to Its Foreign Business.

For the years ended June 30, 2013 and 2012, sales to customers in foreign countries comprised approximately 55.0% and 43.0%, respectively, of ThermoGenesis’ revenues.  ThermoGenesis’ foreign business is subject to economic, political and regulatory uncertainties and risks that are unique to each area of the world.  Fluctuations in exchange rates may also affect the product prices that ThermoGenesis’ foreign customers are willing to pay, and may put it at a price disadvantage compared to other competitors.  Potentially volatile shifts in exchange rates may negatively affect ThermoGenesis’ financial position and results.

The Loss of a Significant Distributor or End User Customer May Adversely Affect ThermoGenesis’ Financial Condition and Results of Operations.

Revenues from four significant distributors comprised 56.0% of ThermoGenesis’ revenues for the fiscal year ended June 30, 2013, and a significant portion of its largest distributor’s revenue came from one customer.  The loss of a large end user customer or distributor may decrease ThermoGenesis’ revenues.

ThermoGenesis is Reliant on Highly Specialized Distributors and Regulatory Approval to Market and Sell Its Bone Marrow Processing System.

Although ThermoGenesis has added distributors in other territories, ThermoGenesis may not be able to expand its sales of in vivo applications utilizing bone marrow processing devices until clinical trials are conducted.  Since the MXP, Res-Q, and VXP products are projected as a significant portion of ThermoGenesis’ revenue growth, a delay in finding competent distributors in the clinical space and/or a delay or failure to complete clinical trials and each on-label regulatory approval may adversely affect its future revenues and competitive advantage.
ThermoGenesis’ Inability to Protect Its Patents, Trademarks, Trade Secrets and Other Proprietary Rights Could Adversely Impact Our Competitive Position.

ThermoGenesis believes that its patents, trademarks, trade secrets and other proprietary rights are important to its success and its competitive position.  Accordingly, ThermoGenesis devotes substantial resources to the establishment and protection of its patents, trademarks, trade secrets and proprietary rights.  If ThermoGenesis’ products are challenged as infringing upon patents of other parties, ThermoGenesis may be required to modify the design of the product, obtain a license, or litigate the issues, all of which may have an adverse business effect on ThermoGenesis.

ThermoGenesis May Be Subject to Claims That Its Products or Processes Infringe the Intellectual Property Rights of Others, Which May Cause ThermoGenesis to Pay Unexpected Litigation Costs or Damages, Modify Its Products or Processes or Prevent Us From Selling Its Products.

Although it is ThermoGenesis’ intention to avoid infringing or otherwise violating the intellectual property rights of others, third parties may nevertheless claim that ThermoGenesis’ processes and products infringe their intellectual property and other rights.  ThermoGenesis competes with other companies for contracts in some small or specialized industries, which increases the risk that the other companies will develop overlapping technologies leading to an increased possibility that infringement claims will arise. ThermoGenesis may be subject to costly and time-consuming legal proceedings, and this could divert ThermoGenesis’ management’s attention from operating its business.  In order to resolve such proceedings, ThermoGenesis may need to obtain licenses from these third parties or substantially re-engineer or rename our products in order to avoid infringement.  In addition, ThermoGenesis might not be able to obtain the necessary licenses on acceptable terms, or at all, or be able to re-engineer or rename its products successfully.

Adverse Results of Legal Proceedings could have a Material Adverse Effect on ThermoGenesis.

ThermoGenesis is currently subject to, and may in the future be subject to, a variety of legal proceedings and claims that arise out of the ordinary conduct of business.  Results of legal proceedings cannot be predicted with certainty.  Irrespective of their merits, legal proceedings may be both lengthy and disruptive to operations and may cause significant expenditure and diversion of management attention.  ThermoGenesis may be faced with significant monetary damages or injunctive relief against us that could have a material adverse effect on a portion of business operations or a material adverse effect on the financial condition and results of operations.  See “ThermoGenesis’ Business-Legal Proceedings”.

ThermoGenesis May Not Be Able to Protect Its Intellectual Property In Countries Outside the United States.  Intellectual Property Law Outside the United States Is Uncertain and In Many Countries Is Currently Undergoing Review and Revisions.

The laws of some countries do not protect ThermoGenesis’ patent and other intellectual property rights to the same extent as United States laws.  This is particularly relevant to ThermoGenesis as a significant amount of its current and projected future sales are outside of the United States.  Third parties may attempt to oppose the issuance of patents to ThermoGenesis in foreign countries by initiating opposition proceedings.  Opposition proceedings against any of our patent filings in a foreign country could have an adverse effect on its corresponding patents that are issued or pending in the United States.  It may be necessary or useful for ThermoGenesis to participate in proceedings to determine the validity of its patents or its competitors’ patents that have been issued in countries other than the U.S.  This could result in substantial costs, divert ThermoGenesis’ efforts and attention from other aspects of its business, and could have a material adverse effect on our results of operations and financial condition.

Any Failure to Achieve and Maintain the High Design and Manufacturing Standards That ThermoGenesis’ Products Require May Seriously Harm Its Business.

ThermoGenesis’ products require precise, high-quality manufacturing.  Achieving precision and quality control requires skill and diligence by our personnel as well as our vendors.  Our failure to achieve and maintain these high manufacturing standards, including the incidence of manufacturing errors, design defects or component failures could result in patient injury or death, product recalls or withdrawals, delays or failures in product testing or delivery, cost overruns or other problems that could seriously hurt ThermoGenesis’ business.  Additionally, the large amount of AXP disposable inventory certain distributors and end-users maintain may delay the identification of a manufacturing error and expand the financial impact.  A manufacturing error or defect, or previously undetected design defect, or uncorrected impurity or variation in a raw material component, either unknown or undetected, could affect the product.  Despite ThermoGenesis’ very high manufacturing standards, ThermoGenesis cannot completely eliminate the risk of errors, defects or failures. If ThermoGenesis or its vendors are unable to manufacture ThermoGenesis’ products in accordance with necessary quality standards, ThermoGenesis’ business and results of operations may be negatively affected.
ThermoGenesis’ Revenues and Operating Results May Be Adversely Affected As A Result of Its Required Compliance With the Adopted European Union Directive On the Restriction Of the Use of Hazardous Substances In Electrical and Electronic Equipment, As Well As Other Standards Around the World.

A number of domestic and foreign jurisdictions seek to restrict the use of various substances, a number of which have been or are currently used in ThermoGenesis’ products or processes.  For example, the European Union Restriction of Hazardous Substances in Electrical and Electronic Equipment (RoHS) Directive now requires that certain substances, which may be found in certain products ThermoGenesis has manufactured in the past, be removed from all electronics components.  Eliminating such substances from its manufacturing processes requires the expenditure of additional research and development funds to seek alternative substances for its products, as well as increased testing by third parties to ensure the quality of its products and compliance with the RoHS Directive.  Other countries, such as China, have enacted or may enact laws or regulations similar to RoHS.  While ThermoGenesis has implemented a compliance program to ensure its product offering meets these regulations, there may be instances where alternative substances will not be available or commercially feasible, or may only be available from a single source, or may be significantly more expensive than its restricted counterparts.  Additionally, if ThermoGenesis was founded to be non-compliant with any such rule or regulation, ThermoGenesis could be subject to fines, penalties and/or restrictions imposed by government agencies that could adversely affect its operating results.

ThermoGenesis’ Products May Be Subject to Product Recalls Which May Harm Its Reputation And Divert Its Managerial And Financial Resources.

The FDA and similar governmental authorities in other countries have the authority to order the mandatory recall of ThermoGenesis’ products or order their removal from the market if the governmental entity finds ThermoGenesis’ products might cause adverse health consequences or death.  The FDA may also seize product or prevent further distribution.  A government-mandated or voluntary recall by ThermoGenesis could occur as a result of component failures, manufacturing errors or design defects (including labeling defects).  In the past ThermoGenesis has initiated voluntary recalls of some of its products and it could do so in the future.  Any recall of ThermoGenesis’ products may harm its reputation with customers, divert managerial and financial resources and negatively impact our profitability.

ThermoGenesis Is Dependent On Its Suppliers And Manufacturers to Meet Existing Regulations.

Certain of ThermoGenesis’ suppliers and manufacturers are subject to heavy government regulations, including FDA QSR compliance, in the operation of its facilities, products and manufacturing processes.  Any adverse action by the FDA against ThermoGenesis’ suppliers or manufacturers could delay supply or manufacture of component products required to be integrated or sold with its products.  There are no assurances ThermoGenesis will be successful in locating an alternative supplier or manufacturer to meet product shipment or launch deadlines.  As a result, our sales, contractual commitments and financial forecasts may be significantly affected by any such delays.

Dependence On Suppliers For Disposable Products And Custom Components May Impact the Production Schedule.

ThermoGenesis obtains certain disposable products and custom components from a limited number of suppliers.  If the supplier raises the price or discontinues production, ThermoGenesis may have to find another qualified supplier to provide the item or re-engineer the item.   In the event that it becomes necessary for ThermoGenesis to find another supplier, it would first be required to qualify the quality assurance systems and product quality of that alternative supplier.  Any operational issues with re-engineering or the alternative qualified supplier may impact the production schedule, therefore delaying revenues, and this may cause the cost of disposables or key components to increase.
ThermoGenesis’ AXP Revenue Is Indirectly Subject to Customer And Distributor Inventory Requirements And Continuity Of Inventory Purchasing.

On August 26, 2013, ThermoGenesis sent a 90 day notice of termination of the GE Healthcare (“GEHC”) AXP distribution agreement.  This termination will cause the sale of AXP disposable product inventory by GEHC, which would result in a surplus of product availability in the market.  During the sell-off of product inventory by GEHC, ThermoGenesis’ revenues could decline significantly, which would have a material adverse effect on its financial performance during those periods.  ThermoGenesis estimates the amount of such a revenue decline could be up to $1.8 million over two consecutive quarters, beginning in the quarter ended June 30, 2013.   ThermoGenesis is attempting to mitigate this potential financial impact on working capital requirements by seeking other distribution partners, modifying customer contracts or seeking additional debt or equity financing.

Failure To Meet Certain Financial Covenants Could Decrease ThermoGenesis’ AXP Revenues.

Under certain license and escrow agreements, if ThermoGenesis fails to meet certain financial covenants, other companies may take possession of the escrowed intellectual property and initiate manufacturing of the applicable device and disposables. If this were to occur, ThermoGenesis’ revenues would be negatively impacted.

Failure To Retain Or Hire Key Personnel May Adversely Affect ThermoGenesis’ Ability to Sustain or Grow its Business.

ThermoGenesis’ ability to operate successfully and manage its potential future growth depends significantly upon retaining key research, technical, clinical, regulatory, sales, marketing and managerial personnel.  ThermoGenesis’ future success partially depends upon the continued services of key technical and senior management personnel.  ThermoGenesis’ future success also depends on its continuing ability to attract, retain and motivate highly qualified managerial and technical personnel.  The inability to retain or attract qualified personnel could have a significant negative effect upon ThermoGenesis’ efforts and thereby materially harm its business and future financial condition.

All Of ThermoGenesis’ Operations Are Conducted At A Single Location.  Any Disruption At ThermoGenesis’ Facility Could Delay Revenues Or Increase Our Expenses.

All of ThermoGenesis’ operations are conducted at a single location although ThermoGenesis contracts the manufacturing of certain devices, disposables and components.  ThermoGenesis takes precautions to safeguard its facility, through insurance, health and safety protocols, and off-site storage of computer data.  However, a natural disaster, such as a fire, flood or earthquake, could cause substantial delays in ThermoGenesis’ operations, damage or destroy its manufacturing equipment or inventory, and cause ThermoGenesis to incur additional expenses.  The insurance ThermoGenesis’ maintains against fires, floods, and other natural disasters may not be adequate to cover ThermoGenesis’ losses in any particular case.

Risks Related to ThermoGenesis’ Industry

ThermoGenesis’ Business Is Heavily Regulated, Resulting In Increased Costs of Operations And Delays In Product Sales.

Many of ThermoGenesis’ products require FDA approval or clearance to sell in the U.S. and will require approvals from comparable agencies to sell in foreign countries.  These authorizations may limit the U.S. or foreign markets in which ThermoGenesis’ products may be sold.  Further, ThermoGenesis’ products must be manufactured under requirements of ThermoGenesis’ quality system for continued CE-Marking so they can continue to be marketed and sold in Europe.  These requirements are similar to the QSR of both the FDA and California Department of Public Health.  Failure to comply with or inappropriately interpret these quality system requirements and regulations may subject the ThermoGenesis to delays in production while it corrects deficiencies found by the FDA, the State of California, or the ThermoGenesis’ notifying body as a result of any audit of its quality system.  If ThermoGenesis is found to be out of compliance, ThermoGenesis could receive a warning letter or an untitled letter from the FDA or even be temporarily shut down in manufacturing and product sales while the non-conformances are rectified.  Also, ThermoGenesis may have to recall products and temporarily cease their manufacture and distribution, which would increase its costs and reduce its revenues.  The FDA may also invalidate ThermoGenesis’ premarket application (PMA) or 510(k) if appropriate regulations relative to the PMA or 510(k) product are not met.  The notified bodies may elect to not renew CE-Mark certification.  Any of these events would negatively impact ThermoGenesis’ revenues and costs of operations.
Changes In Governmental Regulations May Reduce Demand For ThermoGenesis’ Products Or Increase ThermoGenesis’ Expenses.

ThermoGenesis competes in many markets in which ThermoGenesis and its customers must comply with federal, state, local and international regulations, such as environmental, health and safety and food and drug regulations. ThermoGenesis develops, configures and markets its products to meet customer needs created by those regulations.  Any significant change in regulations could reduce demand for ThermoGenesis’ products or increase its expenses.  For example, many of ThermoGenesis’ instruments are marketed to the industry for enabling new regenerative therapies.  Changes in the U.S. FDA’s regulation of the devices and products directed at regenerative medicine, and development process for new therapeutic applications could have an adverse effect on the demand for these products.

To Sell In International Markets, ThermoGenesis Will Be Subject to Regulation in Foreign Countries.

In cooperation with its distribution partners, ThermoGenesis intends to market our current and future products both domestically and in many foreign markets.  A number of risks are inherent in international transactions.  In order for ThermoGenesis to market its products in certain non-U.S. jurisdictions, ThermoGenesis needs to obtain and maintain required regulatory approvals or clearances and must comply with extensive regulations regarding safety, manufacturing processes and quality.  These regulations, including the requirements for approvals or clearances to market, may differ from the FDA regulatory scheme.  International sales also may be limited or disrupted by political instability, price controls, trade restrictions and changes in tariffs.  Additionally, fluctuations in currency exchange rates may adversely affect demand for its products by increasing the price of ThermoGenesis’ products in the currency of the countries in which the products are sold.

There Can Be No Assurance That ThermoGenesis Will Obtain Regulatory Approvals Or Clearances In All Of The Countries Where ThermoGenesis Intends To Market Our Products, Or That ThermoGenesis Will Not Incur Significant Costs In Obtaining Or Maintaining Foreign Regulatory Approvals Or Clearances, Or That ThermoGenesis Will Be Able To Successfully Commercialize Current Or Future Products In Various Foreign Markets.

Delays in receipt of approvals or clearances to market our products in foreign countries, failure to receive such approvals or clearances or the future loss of previously received approvals or clearances could have a substantial negative effect on ThermoGenesis’ results of operations and financial condition.

Competition In ThermoGenesis’ Industry Is Intense And Will Likely Involve Companies With Greater Resources Than It Has.

ThermoGenesis hopes to develop a competitive advantage in the medical applications of its products, but there are many competitors that are substantially larger and possess greater financial resources and more personnel than ThermoGenesis does.  ThermoGenesis’ current principal market is cord blood banks, and with regards to the BioArchive and AXP Systems, numerous larger and better-financed medical device manufacturers may choose to enter this market as it develops.
Influence By The Government And Insurance Companies May Adversely Impact Sales Of ThermoGenesis’ Products.

ThermoGenesis’ business may be materially affected by continuing efforts by government, third-party payers such as Medicare, Medicaid, and private health insurance plans, to reduce the costs of healthcare.  For example, in certain foreign markets the pricing and profit margins of certain healthcare products are subject to government controls.  In addition, increasing emphasis on managed care in the U.S. will continue to place pressure on the pricing of healthcare products.  As a result, continuing efforts to contain healthcare costs may result in reduced sales or price reductions for ThermoGenesis’ products.  To date, ThermoGenesis is not aware of any direct impact on its pricing or product sales due to such efforts by governments to contain healthcare costs, and ThermoGenesis does not anticipate any impact in the near future.

Product Liability And Uninsured Risks May Adversely Affect ThermoGenesis’ Continuing Operations.

ThermoGenesis operates in an industry susceptible to significant product liability claims.  ThermoGenesis may be liable if any of its products cause injury, illness, or death.  These claims may be brought by individuals seeking relief or by groups seeking to represent a class.  ThermoGenesis also may be required to recall certain of its products should they become damaged or if they are defective.  ThermoGenesis is not aware of any material product liability claims against it.  However, product liability claims may be asserted against ThermoGenesis in the future based on events ThermoGenesis is not aware of at the present time.  ThermoGenesis maintains a product liability policy for $3,000,000 and a general liability policy that includes product liability coverage of $1,000,000 per occurrence and $2,000,000 per year in the aggregate.  However, a product liability claim against ThermoGenesis could have a material adverse effect on its business or future financial condition.

Risks Related to Operating Results and Financial Markets

ThermoGenesis Has Incurred Net Losses Since its Inception And Losses May Continue.

Except for net income of $11,000 for fiscal 1994, ThermoGenesis has not been profitable since its inception.  For the fiscal year ended June 30, 2013, ThermoGenesis had a net loss of $3,086,000 and an accumulated deficit at June 30, 2013, of $114,191,000.  ThermoGenesis will continue to incur significant costs as it develops and markets its current products and related applications.  Although ThermoGenesis is executing its business plan to develop, market and launch new products, continuing losses may impair its ability to fully meet its objectives for new product sales.

Demand For Most Of ThermoGenesis’ Products Depends On Capital Spending Policies Of Its Customers And On Government Funding Policies.

ThermoGenesis’ customers include stem cell banks (both private and non-profit), laboratories, universities, healthcare providers, government agencies and public and private research institutions.  Many factors, including public policy spending priorities, available resources and product and economic cycles, have a significant effect on the capital spending policies of these entities.  These policies in turn can have a significant effect on the demand for ThermoGenesis’ products.  Further, the current economic crisis heightens the risk that its customers may lack the funding or credit facilities that they may have previously used for acquiring its products.  Such credit or funding restrictions could delay or lower ThermoGenesis’ future revenues.

Risks Related to ThermoGenesis Common Stock

Trading Prices For ThermoGenesis’ Common Stock Have Been, And May Continue To Be, Volatile.

The trading price of ThermoGenesis’ common stock has been subject to wide fluctuations and may continue to be volatile in the future.  Trading price fluctuations can be caused by a variety of factors, many of which are beyond its control, including, among other things:

· Variations in operating results;
· ThermoGenesis’ common stock is thinly traded;
· Regulatory actions, such as product recalls;
· Governmental regulatory acts;
· Biological or medical discoveries;
· Changes in earnings estimates by securities analysts; and
· Market conditions in ThermoGenesis’ industry and the economy as a whole.

If ThermoGenesis’ revenues or operating results fall below the expectations of securities analysts and investors, the price of its common stock would likely decline.  In the last few years, the stock market experienced extreme price and volume fluctuations due to the unprecedented turmoil and upheaval of the credit markets and the financial services industry, which have particularly affected the market prices for emerging biotechnology and medical device companies, and has adversely affected the market price of ThermoGenesis common stock.

ThermoGenesis Common Stock Per Share Price Does Not Currently Meet the Requirements of the NASDAQ Capital Market Stock Exchange and ThermoGenesis Has Received Notice that Its Common Stock may be Delisted.  Our Ability to Sell Our Equity Securities and the Liquidity of Our Common Stock Could be Adversely Affected if We Are Delisted.

The listing standards of NASDAQ Capital Market provide, among other things, that a company’s securities may be delisted if the bid price of its stock drops below $1.00 for a period of 30 consecutive business days.  On December 11, 2013, ThermoGenesis received notice from the NASDAQ Listing Qualifications Department informing it that ThermoGenesis failed to maintain the minimum bid listing requirement and must regain compliance with listing requirements or face delisting. In order to become compliant, the bid price of ThermoGenesis common stock must close at a price of at least $1.00 per share for a minimum of 10 consecutive business days at any time before June 9, 2014.

Delisting from NASDAQ could adversely affect ThermoGenesis’ability to raise additional financing through the sale of equity securities, could significantly affect the ability of investors to trade its securities and could negatively affect the value and liquidity of its common stock.  Delisting could also have other negative results, including the potential loss of confidence by employees, the loss of institutional investor interest and fewer business development opportunities.

ThermoGenesis Has Never Paid Cash Dividends.

ThermoGenesis has never paid any cash dividends on its common stock and does intend to pay cash dividends in the future.  Instead, ThermoGenesis intends to apply earnings, if any, to the expansion and development of its business.

Risks Related to the Business and Operations of TotipotentRX

TotipotentRX’s Limited Operating History In the Emerging Regenerative Medicine Industry May Make It Difficult to Evaluate Its Business.

TotipotentRX is in the business of research, development and commercialization of autologous cell-based therapeutics for use in the emerging regenerative medicine industry, and, although it has experience in developing clinical protocols and conducting clinical trials through its relationship with Fortis, it has a limited operating history in the new and emerging regenerative medicine industry on which to base an evaluation of its business and prospects.  TotipotentRX will be subject to the risks inherent in the operation of a company in an emerging industry such as regulatory setbacks and delays, fluctuations in expenses, competition, and governmental regulation.  Any failure to successfully address these risks and uncertainties could seriously harm TotipotentRX’s business and prospects.

TotipotentRX Has Incurred Losses Since Inception and Anticipates That It Will Continue To Incur Losses For The Foreseeable Future.

TotipotentRX has incurred losses since its inception and expects to continue to incur losses for the foreseeable future.  These losses may increase as TotipotentRX continues its research and development activities, seeks regulatory approvals for its product candidates and commercializes any approved products.
TotipotentRX’s Potential Products And Technologies Are In Early Stages Of Development.

The development of new cell therapy combination products (pharmaceutical products) is a highly risky undertaking, and there can be no assurance that any future research and development efforts TotipotentRX might undertake will be successful.  TotipotentRX’s potential products in cardiovascular, orthopedic and wound care indications will require extensive additional research and development and regulatory approval before any commercial introduction.  There can be no assurance that any future research, development and clinical trial efforts will result in viable products or meet efficacy standards.

TotipotentRX Is Subject To Substantial Government Regulation Which Could Materially Adversely Affect TotipotentRX’s Business.

The production and marketing of TotipotentRX’s products and potential products and its ongoing research and development, pre-clinical testing and clinical trial activities are currently subject to extensive regulation and review by numerous governmental authorities in the United States and will face similar regulation and review for overseas approval and sales from governmental authorities outside of the United States.  All of the products TotipotentRX is currently developing must undergo rigorous clinical testing and an extensive regulatory approval process before they can be marketed.  This process makes it longer, harder and more costly to bring TotipotentRX’s potential products to market, and TotipotentRX cannot guarantee that any of its potential products will be approved.  If TotipotentRX or its collaboration partners do not comply with applicable regulatory requirements, such violations could result in non-approval, suspensions of regulatory approvals, civil penalties and criminal fines, product seizures and recalls, operating restrictions, injunctions, and criminal prosecution.

To Operate In Foreign Jurisdictions, TotipotentRX Is Subject to Regulation by Non-U.S. Authorities.

TotipotentRX has operations in India, and as such is subject to Indian regulatory agencies.  A number of risks are inherent in conducting business and clinical operations overseas.  In order for TotipotentRX to operate as a majority owned foreign corporation in India, it is subject to financial regulations imposed by the Reserve Bank of India.  This includes the rules specific to the capital funding, repatriation of funds and payment of dividends from and to the foreign subsidiaries from and to the parent in the U.S.

In order for TotipotentRX to manufacture and/or market its services and products in India, TotipotentRX needs to obtain and maintain required regulatory approvals or clearances and must comply with extensive regulations regarding safety, manufacturing processes and quality.  These regulations, including the requirements for approvals or clearances to market, and/or export may differ from the U.S. FDA regulatory scheme.

In order for TotipotentRX to complete clinical trials, clinical trial services and cell banking in India, and other foreign jurisdictions, TotipotentRX needs to obtain and maintain approvals and licenses which comply with extensive regulations of the appropriate regulatory body.

International sales also may be limited or disrupted by political instability, price controls, trade restrictions and changes in tariffs as ordered by various governmental agencies.  Additionally, fluctuations in currency exchange rates may adversely affect demand for its products by increasing the price of ThermoGenesis’ products in the currency of the countries in which the products are sold.

TotipotentRX Intends To Rely On Third Parties For Certain Functions In Conducting Clinical Trials Of Its Product Candidates.

TotipotentRX relies on third parties for clinical trial activities of its products.  In this regard, TotipotentRX has entered into a collaborative agreement with Fortis Healthcare Limited, a hospital chain networked throughout India and Asia, where TotipotentRX acts as an exclusive regenerative medicine service provider to Fortis Healthcare and which arrangement expires in May 2016.  Additionally, TotipotentRX receives certain discounts from Fortis Healthcare for clinical and hospital services specific to conducting early clinical trials in their organization.  If the agreement is not renewed or is terminated by Fortis, TotipotentRX will have to find other entities or organizations to fulfill Fortis’ favorable cost structure thus jeopardizing or delaying development of TotipotentRX’s products.
TotipotentRX relies on other third parties for various miscellaneous clinical trial activities.  Any one of these third-party contractors may fail to comply with regulatory requirements or meet their contractual obligations to TotipotentRX in a timely manner or at all.

Delays In The Commencement Or Completion Of Clinical Testing Of TotipotentRX’s Products Could Result In Increased Costs To TotipotentRX And Delay Its Ability To Generate Revenues.

Delays in the commencement or completion of clinical testing could significantly impact TotipotentRX’s product development costs.  TotipotentRX does not know whether current or planned clinical trials will begin on time or be completed on schedule, if at all.  The commencement of clinical trials can be delayed for a variety of reasons, including delays in:

· obtaining regulatory approval to commence a clinical trial;
· reaching agreement on acceptable terms with prospective contract research organizations and clinical trial sites for Phase II and III trials;
· obtaining proper devices for any or all of the combination product candidates;
· obtaining institutional review board approval to conduct a clinical trial at a prospective site; and
· recruiting participants for a clinical trial.

In addition, once a clinical trial has begun, it may be suspended or terminated by TotipotentRX or the FDA or other regulatory authorities due to a number of factors, including:

· failure to conduct the clinical trial in accordance with regulatory requirements;
· inspection of the clinical trial operations or clinical trial site by the FDA or other regulatory authorities resulting in the imposition of a clinical hold;
· failure to achieve certain efficacy and/or safety standards;
· reports of serious adverse events or adverse events including but not limited to death of trial subjects; or
· lack of adequate funding to continue the clinical trial.

TotipotentRX’s clinical therapy candidates may produce negative or inconclusive results, and TotipotentRX may decide, or regulators may require, to conduct additional clinical trials or abandon product development programs that it expects to be pursuing.

TotipotentRX Does Not Have Commercial-Scale Manufacturing Capability And It Lacks Commercial Manufacturing Experience.

TotipotentRX operates GMP manufacturing facilities for both devices and cellular production; however, they are not of sufficient size for medium to large commercial production of product candidates.  TotipotentRX will not have large scale experience in cell-drug formulation or manufacturing, and it will lack the resources and the capability to manufacture any of the combined company’s product candidates on a clinical or commercial scale.  Accordingly, TotipotentRX expects to depend on third-party contract manufacturers for the foreseeable future.  Any performance failure on the part of TotipotentRX’s contract manufacturers could delay clinical development, regulatory approval or commercialization of its current or future products, depriving it of potential product revenues and resulting in additional losses.

TotipotentRX Is Subject To Complex Regulations, And Is Unable To Predict Future Regulatory Requirements.

TotipotentRX may be subject to a more complex regulatory process since stem cell therapies are relatively new and regulatory agencies have less experience with them than with traditional pharmaceutical products and medical devices.  Additionally, TotipotentRX believes many of its therapies will be subject to the U.S. FDA Office of Combination Products, and there have not been any cellular biological-device combinations approved to date by this office.
If TotipotentRX Fails To Obtain Acceptable Prices Or Appropriate Reimbursement For Its Products, Its Ability To Successfully Commercialize Its Products Will Be Impaired.

Government and insurance reimbursements for healthcare expenditures play an important role for all healthcare providers, including physicians and pharmaceutical companies such as TotipotentRX that plan to offer various products in the United States and other countries in the future.  TotipotentRX’s ability to earn sufficient returns on its products and potential products will depend in part on the extent to which reimbursement for the costs of such products will be available from government health administration authorities, private health coverage insurers, managed care organizations, and other organizations.  In the United States, TotipotentRX’s ability to have its products eligible for Medicare, Medicaid or private insurance reimbursement will be an important factor in determining the ultimate success of its products.  If, for any reason, Medicare, Medicaid or the insurance companies decline to provide reimbursement for TotipotentRX’s products, its ability to commercialize its products would be adversely affected.

TotipotentRX Has Limited Sales, Marketing and Distribution Experience.

TotipotentRX has limited experience in the sales, marketing, and distribution of pharmaceutical products.  There can be no assurance that TotipotentRX will be able to establish sales, marketing, and distribution capabilities or make arrangements with its current collaborators or others to perform such activities or that such efforts will be successful.  If TotipotentRX decides to market any of its new products directly, it must either partner, acquire or internally develop a marketing and sales force with technical expertise and with supporting distribution capabilities.  The acquisition or development of a sales, marketing and distribution infrastructure would require substantial resources, which may not be available to the combined company or, even if available, divert the attention of its management and key personnel, and have a negative impact on further product development efforts.

TotipotentRX May Seek To Enter Into Collaborative Arrangements To Develop and Commercialize Its Products Which May Not Be Successful.

TotipotentRX may seek to enter into collaborative arrangements to develop and commercialize some of its potential products both in North America and international markets.  There can be no assurance that TotipotentRX will be able to negotiate collaborative arrangements on favorable terms or at all or that its current or future collaborative arrangements will be successful.

If TotipotentRX’s Competitors Develop And Market Products That Are More Effective Than TotipotentRX’s Product Candidates Or Obtain Regulatory And Marketing Approval For Similar Products Before TotipotentRX does, TotipotentRX’s Commercial Opportunity May Be Reduced Or Eliminated.

The development and commercialization of new pharmaceutical products which target cardiovascular, orthopedic, chronic dermal wounds and other conditions addressed by the current and future products of TotipotentRX is competitive, and the combined company will face competition from numerous sources, including major biotechnology and pharmaceutical companies worldwide.  Many of TotipotentRX’s competitors have substantially greater financial and technical resources, and development, production and marketing capabilities than TotipotentRX does.  In addition, many of these companies have more experience than TotipotentRX in pre-clinical testing, clinical trials and manufacturing of compounds, as well as in obtaining FDA and foreign regulatory approvals.  As a result, there is a risk that one of the competitors will develop a more effective product for the same indications for which TotipotentRX is developing a product or, alternatively, bring a similar product to market before TotipotentRX can do so.

If TotipotentRX Suffers Negative Publicity Concerning The Safety Of Its Products In Development, Its Sales May Be Harmed And TotipotentRX May Be Forced To Withdraw Such Products In Development.

If concerns should arise about the safety of TotipotentRX’s products that are in development or marketed,   regardless of whether or not such concerns have a basis in generally accepted science or peer-reviewed scientific research, such concerns could adversely affect the market for its products.
Product Liability And Uninsured Risks May Adversely Affect TotipotentRX’s Continuing Operations.

TotipotentRX operates in an industry susceptible to significant product liability claims.  TotipotentRX may be liable if any of its services, products or clinical trials cause injury, illness, or death.  These claims may be brought by individuals seeking relief or by groups seeking to represent a class.  TotipotentRX also may be required to recall certain of its products should they become damaged, if they are defective, or if they are adulterated.  TotipotentRX is not aware of any material services, product or clinical trial liability claims against it.  However, services, product or clinical trial liability claims may be asserted against TotipotentRX in the future based on events TotipotentRX is not aware of at the present time.  TotipotentRX maintains a commercial general liability and professional liability policy for $5,000,000 and a product liability policy inclusive of completed operations liability coverage of $2,000,000 per occurrence and $2,000,000 per year in the aggregate.  However, any liability claim against TotipotentRX could have a material adverse effect on its business or future financial condition.

The Loss of Either Mr. Kenneth L. Harris, Mr. Mitchel Sivilotti or Dr. Venkatesh Ponemone Will Adversely Affect TotipotentRX.

The loss of the services of any principal member of TotipotentRX’s management and research, development and clinical teams, and especially Mr. Kenneth Harris, Mr. Mitchel Sivilotti or Dr. Venkatesh Ponemone could adversely affect TotipotentRX and the combined company.  TotipotentRX does not maintain “key person” life insurance on any of its officers, employees or consultants.

TotipotentRX’s Principal Stockholders Have Significant Influence Over TotipotentRX and Will Have Significant Influence Over the Combined Company.

As of the date of this proxy statement/prospectus/consent solicitation, the Principal Stockholders beneficially own 74.7% of TotipotentRX common stock and will beneficially own approximately 32.0% of the outstanding common stock of the combined company.  As a result, the Principal Stockholders will be able to exert a significant degree of influence or actual control over the combined company’s management and affairs after the Merger and over matters requiring stockholder approval, including the election of directors, any merger, consolidation or sale of all or substantially all of the combined company’s assets, and any other significant corporate transaction.  The interests of the Principal Stockholders may not always coincide with the interests of the combined company or its other stockholders.

TotipotentRX Is A Private Company And Has Not Been Subject to the Sarbanes-Oxley Act Of 2002, the Rules and Regulations of the SEC or Other Corporate Governance Requirements.

TotipotentRX is a private company and has not been subject to the Sarbanes-Oxley Act of 2002, the rules and regulations of the SEC, or other corporate governance requirements to which public reporting companies may be subject. During the audit of TotipotentRX’s financial statements for the year ended December 31, 2012, TotipotentRX’s independent registered public accounting firm determined that a material weakness existed in its internal control over financial reporting as TotipotentRX did not have adequate personnel and information systems in place to prepare financial statements on a timely basis, including accrual accounting, non-routine data processes and estimation processes. If the Merger is completed, ThermoGenesis will be required to implement the appropriate internal control processes and procedures over financial accounting and reporting. However, there is a risk that the combined company may incur significant legal, accounting and other expenses to ensure that TotipotentRX meets these requirements. Such requirements include, but are not limited to, that the combined company will be required to report on the effectiveness of its internal control of over financial reporting. Implementing the controls and procedures required to comply with the various applicable laws and regulations may place a significant burden on the combined company’s management and internal resources. The diversion of management’s attention and any difficulties encountered in such an implementation could result in delays in the combined company’s clinical trials and product development programs and could otherwise harm the combined company’s business, financial condition and operating results.

TotipotentRX Has Never Paid Cash Dividends On Its Common Stock.

TotipotentRX has never declared or paid cash dividends on its common stock and does not anticipate to pay any cash dividends in the future.

CAUTIONARY STATEMENT REGARDING FORWARD-LOOKING STATEMENTS
 
This proxy statement/prospectus/consent solicitation contains “forward-looking statements” of ThermoGenesis within the meaning of the Private Securities Litigation Reform Act of 1995, which is applicable to ThermoGenesis because ThermoGenesis is a public company subject to the reporting requirements of the Exchange Act, but is not applicable to TotipotentRX because TotipotentRX is not a public company and is not currently subject to the reporting requirements of the Exchange Act. These forward-looking statements include:
 
· the potential value created by the proposed Merger for ThermoGenesis’ and TotipotentRX’s stockholders;
· the conduct and results of TotipotentRX’s research, discovery and preclinical efforts and clinical trials;
· anticipated timelines for product development efforts;
· the amount of time required to obtain regulatory approvals for TotipotentRX or the combined company’s product candidates;
· TotipotentRX’s plans regarding future research, discovery and preclinical efforts and clinical activities, and ThermoGenesis and TotipotentRX’s collaborative, intellectual property and regulatory activities;
· information concerning possible future or assumed results of the combined company;
· the period in which ThermoGenesis and TotipotentRX expect cash to be available to fund their current operating plans, both before and after giving effect to the Merger;
· future required funding needs;
· the benefits of Merger;
· each of ThermoGenesis’ and TotipotentRX’s results of operations, financial condition and businesses, and products and drug candidates under development and the expected impact of the proposed Merger on the combined company’s financial and operating performance; and
· estimates concerning future revenues and other future financial and other results that are contained in the section of this proxy statement/prospectus/consent solicitation entitled “Certain Projected Financial Information Concerning TotipotentRX.”

Words such as “anticipates,” “believes,” “forecast,” “potential,” “contemplates,” “expects,” “intends,” “plans,” “believes,” “seeks,” “estimates,” “could,” “would,” “will,” “may,” “can” and similar expressions identify forward-looking statements. These forward-looking statements are not guarantees of future performance and are subject to risks and uncertainties that could cause actual results to differ materially from the results contemplated by the forward-looking statements, including the following:

· ThermoGenesis and TotipotentRX may not be able to complete the Merger;
· TotipotentRX’s product candidates that appear promising in early research and clinical trials but may not demonstrate safety and efficacy in subsequent clinical trials;
· revenues and income from TotipotentRX’s anticipated future products may not meet expectations;
· the combined company may not be able to obtain the equity or debt financing necessary to support its anticipated level of operations;
· risks associated with reliance on collaborative partners for further clinical trials and other development activities; and
· risks involved with development and commercialization of product candidates.

Many of the important factors that will determine these results and values are beyond ThermoGenesis’ and TotipotentRX’s ability to control or predict.  You are cautioned not to put undue reliance on any forward-looking statements.  Except as otherwise required by law, ThermoGenesis and TotipotentRX do not assume any obligation to update any forward-looking statements.  In evaluating the Merger, you should carefully consider the discussion of risks and uncertainties in the section entitled “Risk Factors” in this proxy statement/prospectus/consent solicitation.
THE SPECIAL MEETING OF THERMOGENESIS STOCKHOLDERS

Date, Time and Place

The special meeting of ThermoGenesis stockholders will be held on Thursday, February 13, 2014, at the law office of Weintraub Tobin, 400 Capitol Mall, Suite 1100, Sacramento, CA  95814 commencing at 10:00 a.m. (local time).  ThermoGenesis is sending this proxy statement/prospectus/consent solicitation to its stockholders in connection with the solicitation of proxies by the ThermoGenesis board of directors for use at the ThermoGenesis special meeting and any adjournments or postponements of such meeting. This proxy statement/prospectus/consent solicitation is first being furnished to stockholders of ThermoGenesis on or about December 26, 2013.

Purposes of the ThermoGenesis Special Meeting

The purposes of the ThermoGenesis special meeting are:

1.   To consider and vote upon a proposal to approve and adopt the Agreement and Plan of Merger and Reorganization dated July 15, 2013, by and among ThermoGenesis Corp., TotipotentRX Corporation, Kenneth Harris and Mitchel Sivilotti,  and related transactions therein, pursuant to which among other things  ThermoGenesis will issue shares of common stock to the shareholders of TotipotentRX Corporation and TotipotentRX Corporation will merge with and into ThermoGenesis, with ThermoGenesis surviving the merger;

2.  To consider and vote upon a proposal to adjourn the special meeting, if necessary, if a quorum is present, to solicit additional proxies if there are not sufficient votes in favor to approve the Merger Agreement; and

3.  To consider and act upon such other business and matters or proposal as may properly come before the Meeting, including adjournment.

The board of directors of ThermoGenesis has fixed December 20, 2013 as the record date for determining which stockholders have the right to receive notice of and to vote at the ThermoGenesis special meeting or any adjournments or postponements thereof.  Only holders of record of shares of ThermoGenesis common stock at the close of business on the record date have the right to receive notice of and to vote at the ThermoGenesis special meeting.  At the close of business on the record date, ThermoGenesis had 16,677,909 shares of common stock outstanding and entitled to vote.

Your vote is important.  The affirmative vote of the holders of a majority of the outstanding shares of ThermoGenesis common stock having voting power on the record date for the ThermoGenesis special meeting is required for approval of Proposal No. 1.  The affirmative vote of the holders of a majority of the shares of ThermoGenesis common stock having voting power present in person or represented by proxy at the ThermoGenesis special meeting is required for approval of Proposal No. 2, if necessary.

Whether or not you plan to attend the ThermoGenesis special meeting, please complete, sign and date the enclosed proxy and return it promptly in the enclosed postage-paid return envelope.  You may revoke the proxy at any time before its exercise in the manner described in this accompanying proxy statement/prospectus/consent solicitation.  Any stockholder present at the ThermoGenesis special meeting, including any adjournment or postponement of the meeting, may revoke such stockholder’s proxy and vote personally on the matters to be considered at the ThermoGenesis special meeting.  Executed proxies with no instructions indicated thereon will be voted “FOR” each of the proposals outlined above.

Recommendation of ThermoGenesis’ Board of Directors

THE THERMOGENESIS BOARD OF DIRECTORS HAS DETERMINED THAT THE MERGER AS DESCRIBED IN THIS PROXY STATEMENT/PROSPECTUS/CONSENT SOLICITATION, IS ADVISABLE AND IN THE BEST INTERESTS OF THERMOGENESIS AND ITS STOCKHOLDERS AND HAS APPROVED SUCH PROPOSAL.  THE THERMOGENESIS BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS THAT THERMOGENESIS STOCKHOLDERS VOTE “FOR” THERMOGENESIS PROPOSAL NO. 1.
THE THERMOGENESIS BOARD OF DIRECTORS HAS DETERMINED THAT ADJOURNING THE THERMOGENESIS SPECIAL MEETING, IF NECESSARY, TO SOLICIT ADDITIONAL PROXIES IF THERE ARE NOT SUFFICIENT VOTES IN FAVOR OF THE THERMOGENESIS PROPOSAL NUMBER 1 OUTLINED ABOVE IS ADVISABLE AND IN THE BEST INTERESTS OF THERMOGENESIS AND ITS STOCKHOLDERS AND HAS APPROVED SUCH PROPOSAL.  THE THERMOGENESIS BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS THAT THERMOGENESIS STOCKHOLDERS VOTE “FOR” THERMOGENESIS PROPOSAL NO. 2 TO ADJOURN THE THERMOGENESIS SPECIAL MEETING, IF NECESSARY, TO SOLICIT ADDITIONAL PROXIES IF THERE ARE NOT SUFFICIENT VOTES IN FAVOR OF THE MERGER AGREEMENT PROPOSAL OUTLINED ABOVE.

Record Date and Voting Power
 
Only holders of record of ThermoGenesis common stock at the close of business on the record date, December 20, 2013, are entitled to notice of, and to vote at, the ThermoGenesis special meeting or any adjournments or postponements thereof.  At the close of business on the record date, 16,677,909 shares of ThermoGenesis common stock were issued and outstanding and entitled to vote.  Each share of ThermoGenesis common stock entitles the holder thereof to one vote on each matter submitted for stockholder approval.  See the section entitled “Principal Stockholders of ThermoGenesis” in this proxy statement/prospectus/consent solicitation for information regarding persons known to the management of ThermoGenesis to be the principal stockholders of ThermoGenesis.

Voting and Revocation of Proxies

The ThermoGenesis proxy accompanying this proxy statement/prospectus/consent solicitation is solicited on behalf of the board of directors of ThermoGenesis for use at the ThermoGenesis special meeting.

If you are a stockholder of record of ThermoGenesis as of the applicable record date referred to above, you may vote in person at the ThermoGenesis special meeting or vote by proxy using the enclosed proxy card.  Whether or not you plan to attend the ThermoGenesis special meeting, ThermoGenesis urges you to vote by proxy to ensure your vote is counted.  You may still attend the ThermoGenesis special meeting and vote in person if you have already voted by proxy.

Ÿ To vote in person, come to the ThermoGenesis special meeting and ThermoGenesis will give you a ballot when you arrive.
Ÿ To vote using the proxy card, simply mark, sign and date your proxy card and return it promptly in the postage-paid envelope provided.  If you return your signed proxy card to ThermoGenesis before the ThermoGenesis special meeting, ThermoGenesis will vote your shares as you direct.

All properly executed ThermoGenesis proxies that are not revoked will be voted at the ThermoGenesis special meeting and at any adjournments or postponements of the ThermoGenesis special meeting in accordance with the instructions contained in the proxy.  If a holder of ThermoGenesis common stock executes and returns a proxy and does not specify otherwise, the shares represented by that proxy will be voted  “FOR” ThermoGenesis Proposal No. 1 to approve and adopt the Merger Agreement, and “FOR” ThermoGenesis Proposal No. 2 to adjourn the ThermoGenesis special meeting, if necessary, to solicit additional proxies if there are not sufficient votes in favor of the ThermoGenesis proposal number 1 outlined above in accordance with the recommendation of the ThermoGenesis board of directors.

A ThermoGenesis stockholder of record as of the applicable record date described above who has submitted a proxy may revoke it at any time before it is voted at the ThermoGenesis special meeting by executing and returning a proxy bearing a later date, filing written notice of revocation with the Secretary of ThermoGenesis stating that the proxy is revoked, or attending the ThermoGenesis special meeting and voting in person.

Required Vote

The presence, in person or represented by proxy, at the ThermoGenesis special meeting of the holders of a majority of the shares of ThermoGenesis common stock outstanding and entitled to vote at the ThermoGenesis special meeting is necessary to constitute a quorum at the special meeting.  Abstentions and broker non-votes will be counted towards a quorum.  Approval of ThermoGenesis Proposal No. 1 requires the affirmative vote of holders of a majority of the ThermoGenesis common stock having voting power outstanding on the record date for the ThermoGenesis special meeting.  Approval of each of ThermoGenesis Proposal No. 2 requires the affirmative vote of the holders of a majority of the ThermoGenesis common stock having voting power present in person or represented by proxy at the ThermoGenesis special meeting.

Votes will be counted by the inspector of election appointed for the special meeting, who will separately count “FOR”, “WITHHOLD,” and “AGAINST” votes, and abstentions and broker non-votes.  Broker non-votes and abstentions will have the same effect as “AGAINST” votes for ThermoGenesis Proposal No. 1.  For ThermoGenesis Proposal No. 2, broker non-votes will not be counted towards the vote total.

At the record date for the ThermoGenesis special meeting, the directors and executive officers of ThermoGenesis beneficially owned approximately 3.5% of the outstanding shares of ThermoGenesis common stock entitled to vote at the ThermoGenesis special meeting.

Solicitation of Proxies

In addition to soliciting proxies through the mail, ThermoGenesis may solicit proxies through its directors, officers and employees in person and by email, telephone or facsimile.  ThermoGenesis may also request broker, bank or other nominees to forward proxy materials to the beneficial owners of shares held of record by them.  ThermoGenesis will pay all expenses incurred in connection with the solicitation of proxies.  In addition, ThermoGenesis has retained Georgeson Inc. to assist in the solicitation for an estimated fee of $8,500.  ThermoGenesis also agreed to reimburse Georgeson for reasonable out-of-pocket expenses and disbursements incurred in connection with the proxy solicitation and to indemnify ThermoGenesis against certain losses, costs and expenses.

Other Matters

As of the date of this proxy statement/prospectus/consent solicitation, the ThermoGenesis board of directors does not know of any other business to be presented at the ThermoGenesis special meeting other than as set forth in the notice accompanying this proxy statement/prospectus/consent solicitation.  If any other matters should properly come before the ThermoGenesis special meeting, it is intended that the shares represented by proxies will be voted with respect to such matters in accordance with the judgment of the persons voting the proxies.

SOLICITATION OF TOTIPOTENTRX WRITTEN CONSENT

TotipotentRX Shareholder Action by Written Consent

The TotipotentRX board of directors is providing this proxy statement/prospectus/consent solicitation to its shareholders. TotipotentRX shareholders are being asked to execute and deliver the written consent furnished with this proxy statement/prospectus/consent solicitation to adopt and approve the Merger Agreement, including the Merger and transactions contemplated thereby.

Shares Entitled to Consent and Consent Required

Only TotipotentRX shareholders of record at the close of business on December 20, 2013, will be notified of and be entitled to execute and deliver a written consent.  On the record date, the outstanding securities of TotipotentRX eligible to consent with respect to the Merger Agreement proposal consists of 401,563 shares of TotipotentRX common stock.  Each holder of common stock is entitled to one vote for each share of common stock held of record.

Approval of the adoption and approval of the Merger Agreement including the Merger and transactions contemplated thereby requires the approval by the holders owning a majority of the shares of TotipotentRX common stock outstanding on the record date.

On the record date, the directors and executive officers of TotipotentRX were beneficial owners of 91.52% of the outstanding shares of TotipotentRX common stock entitled to execute and deliver the written consent.

Submission of Consents

You may consent to the Merger Agreement proposal with respect to your shares of common stock of TotipotentRX by completing and signing the written consent furnished with this proxy statement/prospectus/consent solicitation and returning it to TotipotentRX on or before January 31, 2014, the date the TotipotentRX board of directors has set as the targeted final date for receipt of written consents.  TotipotentRX reserves the right to extend the final date for receipt of written consents beyond January 31, 2014, in the event that consents adopting and approving the Merger Agreement, including the Merger and transactions contemplated thereby have not been obtained by that date from holders of a sufficient number of shares of TotipotentRX common stock to satisfy the conditions to the Merger.  Any such extension may be made without notice to shareholders.  Once TotipotentRX has received written consents from holders owning more than a majority of outstanding shares of common stock of TotipotentRX, the consent solicitation will conclude.

If you hold shares of TotipotentRX common stock as of the record date and you wish to give your written consent, you must complete the enclosed written consent, date and sign it, and promptly return it to TotipotentRX. Once you have completed, dated and signed your written consent, deliver it to TotipotentRX by faxing it, by emailing a pdf copy of your written consent to proxyvote@totipotentrx.com, or by mailing your written consent to TotipotentRX Corporation, 548 S. Spring Street, Suite 210, Los Angeles, CA 90013, Phone:  (213) 221-7373 Fax: (213) 341-2415; attention: Kenneth L. Harris.

Executing Consents; Revocation of Consents

With respect to the Merger Agreement proposal for which the shares of TotipotentRX common stock that you hold allow you to give consent, you may execute a written consent to approve the Merger Agreement proposal (which is equivalent to a vote for the proposal) or disapprove the Merger Agreement proposal (which is equivalent to a vote against the proposal).  If you do not return your written consent, it will have the same effect as a vote against the Merger Agreement.  If you are a record holder and you return a signed written consent without indicating your decision on the Merger Agreement proposal, you will have given your consent to adopt and approve the Merger Agreement including the Merger and transactions contemplated thereby.

Your consent to the Merger Agreement proposal may be changed or revoked at any time before the consents of a sufficient number of shares to approve and adopt such proposal have been filed with TotipotentRX’s corporate secretary.  If you wish to change or revoke a previously delivered consent before that time, you may do so by delivering a notice of revocation to TotipotentRX’s corporate secretary or by delivering a new written consent with a later date.
Solicitation of Consents; Expense

The expense of preparing, printing and mailing these consent solicitation materials is being borne by TotipotentRX.  Officers and employees of TotipotentRX may solicit consents by telephone and personally, in addition to solicitation by mail. These persons will receive their regular salaries but no special compensation for soliciting consents.

Recommendation of the TotipotentRX Board

THE TOTIPOTENTRX BOARD OF DIRECTORS RECOMMENDS THAT TOTIPOTENTRX SHAREHOLDERS ADOPT AND APPROVE THE MERGER AGREEMENT INCLUDING THE MERGER AND TRANSACTIONS CONTEMPLATED THEREBY BY EXECUTING AND DELIVERING THE WRITTEN CONSENT FURNISHED WITH THIS PROXY STATEMENT/PROSPECTUS/CONSENT SOLICITATION.

The TotipotentRX board of directors believes the Merger Agreement, including the merger consideration to be received by TotipotentRX stockholders is fair, advisable and in the best interests of TotipotentRX and its shareholders.  The TotipotentRX board of directors, after careful study and evaluation of the economic, financial, legal and other factors, also believe the Merger could provide the combined company with increased opportunity for profitable expansion of its business, which in turn should benefit TotipotentRX shareholders who become stockholders of ThermoGenesis. See “The Merger—Reasons for the Merger— TotipotentRX’s Reasons for the Merger” on page 39 of this proxy statement/prospectus/consent solicitation.

THE MERGER

This section and the section entitled “The Merger Agreement” in this proxy statement/prospectus/consent solicitation describe the material aspects of the Merger, including the Merger Agreement.  While ThermoGenesis and TotipotentRX believe that this description covers the material terms of the Merger and the Merger Agreement, it may not contain all of the information that is important to you.  You should read carefully this entire proxy statement/prospectus/consent solicitation for a more complete understanding of the Merger and the Merger Agreement, including the Merger Agreement attached as Annex A to this proxy statement/prospectus/consent solicitation.

Reasons for the Merger

The following discussion of the parties’ reasons for the Merger contains a number of forward-looking statements that reflect the current views of ThermoGenesis and/or TotipotentRX with respect to future events that may have an effect on their future financial performance.  Forward-looking statements are subject to risks and uncertainties.  Actual results and outcomes may differ materially from the results and outcomes discussed in the forward-looking statements.  Cautionary statements that identify important factors that could cause or contribute to differences in results and outcomes include those discussed in the sections entitled “Risk Factors” and “Forward-Looking Statements” in this proxy statement/prospectus/consent solicitation.

Mutual Reasons for the Merger

In reaching the decision to adopt the Merger and recommend the Merger Agreement for approval by the stockholders of ThermoGenesis and shareholders of TotipotentRX, each board of directors consulted with its respective management as well as legal and financial advisors.  As discussed in greater detail below, these consultations included discussions regarding TotipotentRX’s and ThermoGenesis’ strategic business plan, the costs and risks of executing that business plan as an independent company, post and current business operations and financial condition, future prospects, the strategic rationale for the potential transaction, and the terms and conditions of the Merger Agreement.

ThermoGenesis and TotipotentRX believe that the combined company will have the following potential advantages:

One of the First Integrated Regenerative Medicine Companies.  The combined company will be one of the first companies to bring together cell-therapy-related devices, patented platform technology, proprietary cell formulations and treatment protocols and a cell-therapy-specific clinical research organization increasing the likelihood that a safe and effective therapy can reach full commercialization.
Practical, Commercializable Cell Therapies.  The combined company will offer safe and effective therapies backed by clinical evidence, including eight clinical trials in osteoarthritis, avascular necrosis, cardiac and critical limb ischemia, among others, using patient and regulator friendly autologous cells and at the bedside, 60-90 minute protocol.
Ability to Rapidly and Cost-Effectively Implement New Clinical Trials.  The combined company will have the ability to rapidly initiate early clinical development of new cell therapies at its U.S. FDA-registered clinical research organization in India and generate high quality data at a fraction of the cost of clinical trials undertaken in the U.S. or Europe.
Positioned to Commercialize in Both Developed and Emerging Markets. The combined company's existing U.S. and Asian footprints uniquely position it to meet the needs of patients, hospitals and physicians across the globe. This footprint allows flexibility to meet the variable market demands in service and price.
Significant Value Creation.  The combined company should support a higher valuation than either company alone, with the potential to create additional, near and long-term shareholder value through the development of new protocols in major therapeutic areas.
Background of the Merger

Historical Background for ThermoGenesis

In early 2012, ThermoGenesis management began a formal assessment of the near and long-term prospects of its cord blood business in response to the unexpected slow-down of automated cord blood processing and storage units beginning in 2011 in the U.S. and Europe. In connection with the appointment of a new Chief Executive Officer and a management restructuring in February of 2012, the board of directors and management undertook to evaluate the state of ThermoGenesis’ business, including its organization and product capabilities in light of the evolving economic and regulatory environments. As a result of its assessment of the cord blood, bone marrow and peripheral blood processing markets, management concluded:

· demand for cord blood services outside of Asia was stagnant due to continuing weak economic conditions; Annual unit volume collections in public banks had declined due to a lack of government funding and of the units being collected, units qualifying for storage declined due to higher minimum cell yield requirements established by the U.S. Health Resources and Services Administration (HRSA).
· the competitive landscape had increased as a result of the entrance of new companies in the cord blood cell processing space.
· the regulatory landscape was rapidly changing, requiring safety and efficacy data to be submitted to the FDA for marketing approval, meaning a more onerous and costly pre-market approval (PMA) pathway for in-vivo stem cell device products rather than the previous 510(k) approval pathway.
· per FDA issued guidance, future cellular therapies to be approved by the FDA will be as “combination products”, which they broadly define as the combination of co-labeled, optimized “cell friendly” devices, effective cell/biological formulations and cell dose.
· the FDA position on combination products punctuated the critical role of ThermoGenesis’ cell collection, separation and concentration technologies for point-of-care, large patient population clinical indications. At the same time, the need to further improve the system intelligence of its processing platforms to better meet these requirements, including more flexible harvest volumes and greater cell characterization capabilities through on-line diagnostics became apparent.
· shifting the burden of proof for safety and efficacy to medical device manufacturers substantially increases the organizational clinical and scientific capability requirements as well as greater direct point-of-care experience for ThermoGenesis.

Given the above conclusions, coupled with ThermoGenesis’ trading volume, stock price, and available working capital, ThermoGenesis’ board of directors and management determined that the time period for shareholders to realize the full value of ThermoGenesis’ business plan as a stand-alone device design and manufacturing company could be significantly protracted. Therefore, the Company determined to explore opportunities in adjacent markets and potential strategic alliances to expand its capabilities and market position, to address broader markets for its current and proposed technologies in the regenerative medicine space, thereby repositioning ThermoGenesis to provide greater near and long-term shareholder value.

Accordingly, the board of directors authorized management to further streamline the base business to grow its share in the cord blood market and develop the capabilities to more fully address the new, large market opportunities in the regenerative medicine space. This plan included:

· executing on its current stand-alone operating plan with a focus on (i) increasing revenues from the cord blood market through competitive share gains in Europe and North America (ii) further adoption of the AXP System in new markets including China and India via commercial partnerships and joint ventures; and (iii) disposing of non-key operations including its ThermoLine and CryoSeal product lines;
· pursuing a growth strategy within the cord blood industry through strategic acquisitions and/or mergers; and
· extending its reach into the regenerative medicine industry by developing greater internal clinical and scientific expertise and point-of-care experience or by entering into a merger or combination with an existing company operating in the regenerative medicine industry.
As discussed below in the section entitled “Market Review and Discussions with Certain Other Entities, during this time, the ThermoGenesis board considered several alternatives, including some unsolicited offers and proposals by third parties, which the board ultimately concluded were not in the best interest of ThermoGenesis and its shareholders.

Strategic Discussions with TotipotentRX

On March 28, 2012, Matthew Plavan had initial discussions with Kenneth Harris and Mitchel Sivilotti, TotipotentRX’s Chief Executive Officer and President, respectively, regarding a potential strategic combination between ThermoGenesis and TotipotentRX.  TotipotentRX is engaged in the research, development, and commercialization of cell-based therapeutics for use in regenerative medicine.  ThermoGenesis had an existing business relationship with TotipotentRX whereby TotipotentRX sold various ThermoGenesis products and also used various ThermoGenesis products in their clinical procedures and trials.   ThermoGenesis’ management understood TotipotentRX possesses deep experience in developing point-of care clinical applications in the regenerative medicine industry, has extensive experience in running cell-based human FDA clinical trials and has an exclusive relationship with Fortis Healthcare. As such, management believed a merger or partnership with TotipotentRX would bring to ThermoGenesis the ideal scientific and biological capabilities to complement its engineering, cell processing, and commercialization know-how to produce a fully integrated regenerative medicine company to target the regenerative medicine market opportunity and increase near-term shareholder value.

Subsequent to the March 28, 2012 meeting, Messrs. Plavan, Harris and Sivilotti met again in June and July 2012 in addition to holding several conference calls to conduct due diligence,  discuss the potential for combining the companies, and to discuss relative valuation.  Effective April 4, 2012, ThermoGenesis and TotipotentRX entered into a mutual non-disclosure agreement and on June 21, 2012, in connection with further due diligence efforts, ThermoGenesis granted TotipotentRX access to a data room.  Based on further conversations among Messrs. Plavan, Harris and Sivilotti, management of TotipotentRX proposed a merger that would result in a substantially greater than 50.0% ownership position by Totipotent’s shareholders in the combined company. During the same conversations Mr. Plavan communicated that he did not believe a greater than 50.0% ownership by TotipotentRX shareholders in the combined company would be acceptable to ThermoGenesis and its shareholders.

On July 22 and 23, 2012 Mr. Plavan traveled to India with Messrs. Harris and Sivilotti to tour TotipotentRX’s India facilities and perform due diligence on TotipotentRX’s operations, including diligence sessions on their Clinical Research Organization, clinical trial process and the Fortis hospital.  Additionally, Mr. Plavan interviewed key personnel at TotipotentRX and met with the clinical department heads employed by the Fortis Healthcare System.

Further, and in light of the different views of the relative values of each company, on August 1, 2012, ThermoGenesis signed a letter of understanding with Roth Capital Partners, LLC to provide ThermoGenesis with valuation and strategic advisory services in connection with its various strategic merger or acquisition activities.

During the first two weeks of August 2012, Messrs. Plavan, Harris and Sivilotti held conference calls and in-person meetings to conduct due diligence on one another and prepare a business plan and  preliminary financial information for the combined company for valuation purposes.   On August 8, 2012, Messrs. Plavan, Harris and Sivilotti made a presentation of the business plan and preliminary financial information for the combined company to Roth for the purposes of obtaining input and guidance on the relative valuations of each company.  Also, during the first two weeks of August, 2012, management of TotipotentRX reaffirmed its position that TotipotentRX would not accept an ownership share of less than 50.0% of the combined company.

On August 22, 2012, ThermoGenesis’ board of directors held a special meeting.  At the meeting Mr. Plavan reviewed the status of the strategic alternatives the ThermoGenesis’ board of directors and management had been considering including the status and progress of discussions with TotipotentRX.  Although the ThermoGenesis board of directors indicated that it continued to believe that a greater than 50.0% ownership by TotipotentRX was not in the best interests of ThermoGenesis and its shareholders, the board authorized senior management to continue discussions with TotipotentRX.
During late August and early September of 2012, Messrs. Plavan, Harris and Sivilotti continued to have conference calls to discuss the business plan for the combined company, due diligence and relative valuation.  On September 12, 2012, Messrs. Plavan, Harris and Sivilotti had a conference call with Roth to discuss the combined business plan, preliminary financial information and relative valuation.   Roth’s preliminary view did not support a greater than 50.0% ownership in the combined company by TotipotentRX.  On September 13, 2012, ThermoGenesis’ board of directors held a special meeting wherein Mr. Plavan presented the results of Roth’s preliminary view noting that it did not support ownership percentage of greater than 50.0% by TotipotentRX.  After discussion, the ThermoGenesis board agreed to continue to pursue a strategic combination with TotipotentRx under the condition that ThermoGenesis would maintain greater than 50.0% ownership of the combined company.

During September and October of 2012, Messrs. Plavan, Harris and Sivilotti continued to discuss a potential merger between ThermoGenesis and TotipotentRX wherein ThermoGenesis would retain greater than 50.0% ownership.  Additionally, further discussion ensued regarding the management and board of director structures of the combined company.

On October 26, 2012, ThermoGenesis held a regularly scheduled board of directors meeting. During the meeting Mr. Plavan provided an update on the status of the discussions with TotipotentRX, including the valuation impasse as well complications in discussions brought about by the public announcement on October 25, 2012 that Harvest Technologies had filed a lawsuit alleging ThermoGenesis’ Res-Q product infringes two Harvest patents. Based upon the uncertainty introduced by the lawsuit, and the continued inability to agree on relative valuations, Mr. Plavan recommended an indefinite deferral of merger discussions with TotipotentRX. In lieu of merger discussion, The ThermoGenesis Board authorized management to focus on opportunities to expand its commercial partnership with TotipotentRX.

During the process of pursuing a new commercial relationship with TotipotentRX, in early November 2012, Messrs. Harris and Sivilotti commenced discussions with Mr. Plavan regarding the potential for a three-way merger between ThermoGenesis, TotipotentRX and another medical device oriented company operating in the cord blood sector (Company A) with a strategic focus of producing cell separation tools and accessories to support regenerative medicine.  During the period November 2012 through March 7, 2013, Messrs. Plavan, Harris and Sivilotti explored a three-way merger with Company A, however on March 7, 2013, Mr. Plavan and Messrs. Harris and Sivilotti terminated negotiations with Company A and agreed to focus on a merger between ThermoGenesis and TotipotentRX.  For additional information regarding discussion and negotiations between ThermoGenesis, TotipotentRX and Company A, please see the section “Strategic Discussions with Company A” below.

On March 8 and March 10, 2013, Messrs. Plavan and Harris met at ThermoGenesis’ offices to continue discussing a possible merger.  From March 31 through April 23, 2013, management from both ThermoGenesis and TotipotentRX held various meetings to discuss the combined business plan and related preliminary financial information, conduct due diligence on each other and discuss relative valuations.   On April 23, 2013, counsel for ThermoGenesis distributed the first draft of the Merger Agreement and a timeline of the proposed merger to the parties.

On April 26, 2013, the ThermoGenesis board of directors held a regularly scheduled meeting.  In addition to Messrs. Plavan and Mr. Bessey ThermoGenesis Chief Financial Officer, also in attendance were Messrs. Harris and Sivilotti.  Messrs. Harris and Sivilotti introduced themselves and provided their relevant professional background and experience.  Messrs. Harris and Sivilotti made a presentation to the ThermoGenesis board of directors outlining the nature of TotipotentRX’s operations, long-term business plan and related financial information.  Discussion ensued regarding TotipotentRX’s partnership with Fortis Healthcare, its Clinical Research Organization and the status and future of their clinical trials program.  Both ThermoGenesis and TotipotentRX then presented the proposed business plan and related financial information for the combined company.  After further discussion, the ThermoGenesis board of directors agreed to engage an independent accounting firm to conduct financial due diligence on TotipotentRX.  Roth, the financial advisor to ThermoGenesis’ board of directors also made a presentation on the timing and steps associated with the merger timeline with additional discussion on a potential future equity financing.
From April 26, 2013, through signing of the Merger Agreement on July 15, 2013, ThermoGenesis management met on a weekly basis with TotipotentRX management to finalize the business operating plan and associated long-term financial information, complete due diligence and negotiate the final relative ownership percentages in the combined company.   Also during this time period, ThermoGenesis and TotipotentRX and their respective representatives entered into numerous discussions regarding management structure and board of director composition of the combined company, employment agreements for Messrs. Harris and Sivilotti, lock-up agreements, assumption of certain TotipotentRX debt and certain India tax issues that may affect the shareholders of TotipotentRX. Based on the review and analysis of ThermoGenesis’ management as well as input and guidance from ThermoGenesis’ financial advisor, ThermoGenesis management determined that an exchange ratio whereby ThermoGenesis would own 57.0% of the combined company and Totipotent would own 43.0% of the combined company would be in the best interest of ThermoGenesis shareholders.

Also during the period from April 26, 2013 through the signing of the Merger Agreement, the ThermoGenesis board of directors met 15 times to monitor the status of discussions, evaluate the progress and discuss and analyze the terms of the Merger and related issues.

On July 14, 2013, the ThermoGenesis board of directors held a meeting to review the final terms of the Merger Agreement, including the associated lock-up agreement, non-compete agreement and employment agreements for Messrs. Harris and Sivilotti.  The board of directors was also provided a draft copy of Roth’s valuation analysis which supported the ThermoGenesis merger consideration of 43.0% relative shareholder ownership by TotipotentRX.  On July 15, 2013, Roth made its formal presentation of its valuation analysis to the ThermoGenesis’ board of directors followed later that day in a separate board of directors meeting in which Roth issued its fairness opinion regarding the Merger Consideration of 43.0% of the combined company to the shareholders of TotipotentRX.  Following the issuance of the fairness opinion and further discussion, including discussion with counsel, ThermoGenesis’ board of directors approved the Merger Agreement of ThermoGenesis with TotipotentRX.

Alternative Strategic Discussions with Company A

During discussions with TotipotentRX, ThermoGenesis also had other discussions with another company (Company A) with respect to a potential business combination.  The following is a summary of discussions which were subsequently terminated.

Early in 2012, the CEO of a privately-backed company that was developing a cell processing device for use in the cord blood industry contacted Mr. Plavan and indicated that Company A was interested discussing a potential business combination between ThermoGenesis and Company A. Company A made an unsolicited proposal to acquire ThermoGenesis in a merger that would result in Company A obtaining an ownership interest in ThermoGenesis significantly greater than 50.0%, and thus resulting in a change of control. Company A requested a response to their proposal within 10 days of delivery. On March 20, 2012, ThermoGenesis’ board of directors held a meeting and discussed Company A’s proposal.  Following discussion, the ThermoGenesis board of directors determined that the proposed transaction structure significantly undervalued ThermoGenesis, lacked sufficient capital to execute the combination and relinquished control of the combined company to Company A. Therefore, on behalf of its stockholder, ThermoGenesis rejected the proposal.

There were no substantive discussions between ThermoGenesis and Company A with respect to a potential business combination from March 2012 to July 2012.  In early August of 2012, the CEO of Company A again contacted Mr. Plavan to discuss a potential business combination between ThermoGenesis and Company A.  On August 10, 2012 and August 21, 2012, Mr. Plavan met with the CEO of Company A to revisit the potential of a business combination with ThermoGenesis and Company A, with the prospect of an infusion of capital from a private equity firm invested in Company A (PE firm A) and to revisit ways to better align the two managements’ strategic plans.

On August 22, 2012, ThermoGenesis’ board of directors held a special meeting wherein Mr. Plavan reviewed the status of the potential strategic relationship with Company A coupled with funding from PE firm A.    Based on a review and recommendation by Mr. Plavan, the board of directors authorized senior management to continue conversations with Company A to develop a business plan with a focus on driving stockholder value in the regenerative medicine markets leveraging a growth capital infusion from PE firm A.
During September and October of 2012, Mr. Plavan had several meetings with Company A’s senior management to discuss a combined business plan, attempting to drive alignment in strategic direction towards regenerative medicine, building on the base cord blood business.

On October 11, 2012, the ThermoGenesis board of directors held a special meeting wherein Mr. Plavan provided an update on the discussions with Company A regarding a possible strategic merger. Based on review, discussion and recommendation by Mr. Plavan, the ThermoGenesis board of directors agreed to cease merger conversations with Company A given the lack of progress in bridging the substantial valuation and strategic vision gaps between the two companies.

During the process of pursuing a strategic relationship with TotipotentRX, in early November 2012, Messrs. Harris and Sivilotti commenced discussions with Mr. Plavan regarding the potential for a three-way merger among ThermoGenesis, TotipotentRX and Company A and a capital infusion from a private equity firm, with a strategic focus on producing cell separation tools and accessories to support regenerative medicine.  On November 27, 2012, representatives of ThermoGenesis, TotipotentRX and Company A met to discuss the possibility of such a combination. The parties believed that potential and existing products offered by Company A and ThermoGenesis could further enhance TotipotentRX’s services in the regenerative medicine market.  Further due diligence for all parties occurred over the holidays and during the month of December 2012, leading to a discussion of terms of a proposed standstill agreement and non-disclosure agreement.

From January 10th to the 27th of 2013, all three parties continued to conduct due diligence on each other and met to have further discussions regarding the business plan of the combined entity and the relative valuation of each party to the proposed merger.

On January 25, 2013, the ThermoGenesis board of directors held a regularly scheduled meeting wherein Mr. Plavan reviewed a previously circulated draft non-binding letter of intent whereby ThermoGenesis would acquire 100.0% of the outstanding shares of common stock of both TotipotentRX and Company A with the surviving entity continuing as a public company.  The proposed exchange rate would result in each of the three entities owning 33.0% of the combined company, but in no circumstances would any of the three entities own more than 40.0% or less than 25.0%. In addition, PE firm A was expected to lead an approximate $20 million financing in conjunction with the approved transaction.

On January 30, 2013, Messrs. Plavan, Harris, Sivilotti and the CEO of Company A signed the non-binding letter of intent.  On February 15, 2013, Messrs. Plavan, Harris, and Sivilotti and Company A’s CEO held a meeting to negotiate the terms of the proposed three-way merger.  The discussions were primarily focused on the valuations of each of the companies and each company’s percentage ownership of the combined company.  From February 15, 2013 through March 5, 2013, the parties further negotiated ownership of each respective company in the combined company, management of the combined company, product development strategies and strategic marketing.  Strong alignment in each of these areas developed between TotipotentRX and ThermoGenesis; however, after continued discussion and negotiation, management of Company A remained misaligned to these strategic imperatives.

Accordingly, on March 7, 2013 Messrs. Plavan, Harris and Sivilotti notified Company A in writing that ThermoGenesis and TotipotentRX were terminating the letter of intent for a three-way merger because the parties could not agree on a number of fundamental strategic initiatives.

Subsequent to March 7, 2013, certain members of ThermoGenesis and TotipotentRX met with Company A and PE firm A to discuss the possibility of reviving discussions. Despite numerous attempts these meetings did not result in resolution of significant structural and valuation issues.  On April 18, 2013, ThermoGenesis’ board of directors agreed to abandon the proposed merger involving Company A as they could not substantially bridge the gap in expectations for ownership of each respective company in the combined company, management of the combined company, product development strategies and strategic marketing. In addition, based on review and recommendation by senior management, including Messrs. Plavan and Bessey, the board of directors agreed to move forward with a proposed merger with TotipotentRX where significant alignment of fundamental, strategic imperatives existed.
Market Review and Discussions with Certain Other Entities

In addition, during discussions with TotipotentRX and prior thereto, ThermoGenesis took certain steps and had certain inquiries regarding possible strategic relationships.

ThermoGenesis’ board of directors and senior management reviewed from time-to-time potential industry shifts, and assessed strategic alternatives in an effort to strategically position ThermoGenesis.    During 2011, the board engaged a financial advisor to assist with strategic prospects, and to perform limited inquiries to gauge interest by third-party entities interested in strategic alternatives.  The outcome from these efforts did not result in any meaningful opportunities.

During 2011 a large publicly-traded company operating in the regenerative medicine industry made an unsolicited offer to purchase ThermoGenesis.  The ThermoGenesis board of directors reviewed the offer and determined that it was not complete, and lacked sufficient terms to evaluate meaningfully, and therefore did not pursue the unsolicited offer.

During the period March 2012 through August 2012, a privately-held company operating in the cell based practice of medicine sector made a series of unsolicited inquiries to ThermoGenesis as to whether ThermoGenesis would be interested in being acquired.  However, because this company was unwilling to make a firm offer in order for the ThermoGenesis board to make an initial determination, and because this company did not appear to have the financial resources or ability to close any proposed transaction, ThermoGenesis did not further pursue discussions.

ThermoGenesis’ Reasons for the Merger

For more than fifteen years, ThermoGenesis has been a leading supplier of enabling technologies to the global cord blood market, having more recently entered the bone marrow and platelet rich plasma processing markets.  Expectations for high growth in the cord blood markets have not been fulfilled due to a number of macro-market factors, none more influential than the lack of funding to demonstrate the clinical potential of cord blood therapies (beyond a bone marrow blood transfusion substitute).  Therefore, the world-wide cord blood processing and storage market has not met the expectations for high growth.  Although a relatively small overall addressable market, in the near term, serving the cord blood market remains ThermoGenesis’ essential base business.

Seeking larger addressable market opportunities, beginning in 2009, ThermoGenesis expanded into adjacent markets where its automation platforms can process cells sourced from bone marrow and peripheral blood to treat damaged or diseased tissues at the bedside. Since that time, cells derived from bone marrow have become a leading candidate source for regenerative medicine therapies, a market estimated to exceed $6 billion by 2020.

Targeting the global market for regenerative medicine has become ThermoGenesis’ primary strategy for growth and enhancing shareholder value. The isolation and capture of specific stem cell formulations, in the right quantities and highest viability, quickly, safely, consistently and at the point of care is essential for successful regenerative medicine therapies.   ThermoGenesis’ “smart” processing technologies meet these essential requirements, having been used in over 20,000 hematopoietic stem cell transplant processing applications since 2009. Coupled with these processing capabilities, ThermoGenesis believes the speed, versatility and cost effectiveness of its processing platforms make bedside autologous cell therapy delivery highly affordable and commercially viable. Additionally, in 2010, the FDA clarified its position with regard to the in-vivo use of cells derived from a patient, used either to treat the same or unrelated patient.  Such therapies will be approved by the FDA as “combination products”, which they broadly define as the combination of co-labeled, optimized “cell friendly” devices, effective cell/biological formulations and cell dose. Therefore, applicants seeking FDA approval of cell therapies to treat large patient populations must possess a broad range of capabilities to effectively progress a combination product from initial application through to final PMA approval.

Although ThermoGenesis possesses extensive cell processing and storage device design, development and commercialization know-how, it lacks the depth of clinical, scientific and biological engineering experience at the bedside necessary to fully engineer and effectively navigate the evolving regulatory pathways necessary to commercialize approved blockbuster cell therapies.
ThermoGenesis is committed to acquiring the additional capabilities necessary to fully exploit the regenerative market opportunity and fulfill its growth and value creation goals. Management believes the Merger with TotipotentRX is highly complementary and immediately fills the skillset and point-of-care experience gaps existing within ThermoGenesis today.  Furthermore, ThermoGenesis’ and TotipotentRX’s respective management teams share a consistent vision for the market potential of individualized autologous cell therapies.  If delivered safely and effectively in a single procedure at the bedside, both companies believe Cesca Therapeutics has the potential to substantially change the cost and quality of care delivered today. Cesca’s primary therapies target the root cause of disease or illness which is curative.  In addition, the target cost of Cesca’s autologous treatments are less than the current standard of care and the clinical applications are numerous, creating meaningful opportunities for cost reductions.

ThermoGenesis believes the primary advantages of the Merger to ThermoGenesis are:

Cell Therapy Clinical Research Organization (CTCRO) – To ThermoGenesis’ management’s knowledge, the TotipotentRX CTCRO is the only clinical research organization (CRO) specializing in cell therapy clinical trials having full capability for processing, cryostoring and treating patients in a state-of-the art tertiary care research hospital.  This combination adds to ThermoGenesis a world class cell therapy clinical data generation capability, embedded within the Fortis Hospital network.  Fortis Healthcare is one of the premier private healthcare organizations globally, and operates 72 hospital facilities in 6 countries worldwide (India, UAE, Hong Kong, Singapore, Mauritius, and Canada).  Within the CTCRO, TotipotentRX employs 18 clinical scientists, including PhDs, MDs and MScs, who work with Fortis surgeons managing clinical trials and providing cell therapy treatments in the operating theater.  During the early phase of clinical trials, management of the operating room clinicians and technicians facilitates that ThermoGenesis’ tools and clinical protocols are being consistently applied ensuring our cell formulations and dosing are optimized during each procedure.  In addition, having a presence in the operating room or procedure theater ensures an invaluable feedback loop for process improvement and new product development.

Human stem cell clinical data – With the Merger, ThermoGenesis inherits one of the world’s most comprehensive autologous human stem clinical data sets.  TotipotentRX has over five years of clinical experience using stem cells in approximately 600 human procedures, mostly performed through the TotipotentRX/Fortis Healthcare cell therapy partnership.  TotipotentRX has engaged in Pilot and Phase I/Ib clinical trials in ten specific clinical indications targeting vascular, orthopedic and neurological diseases or conditions.   ThermoGenesis sees tremendous value in the safety and early efficacy results shown in these trials.  Given this baseline, the combined company is poised to begin Phase 1b, Phase II/IIb or Phase II/III clinical trials in Cardiac, critical limb ischemia (CLI) and Avascular Necrosis indications within the initial year following the Merger.

Cell Therapy Clinical Protocols – TotipotentRX’s extensive clinical trial experience has yielded eight cell therapy clinical protocols, each containing a proprietary cell formulation and optimized instructions for use at the point of care to ensure optimal clinical outcomes.  These proprietary protocols are essential to controlling the many variables at the point of care, ensuring consistent application of the therapies and clinical outcomes. These protocols are protected by intellectual property filings and ThermoGenesis intends for them to be embedded in the approved cell therapies, ensuring the combined company maintains a proprietary marketing position.

Hospital Network – TotipotentRX is the exclusive provider of cell therapy services to Fortis Healthcare.  This provides the combined company access to excellent clinical staff and world class secondary and tertiary care hospitals, along with access to more than 15,000 patients per day.  This translates into the ability to enroll patients faster into the combined company’s clinical trial initiatives, and each patient receiving treatment in state-of-the art facilities with first-in-class diagnostics and imaging systems.   ThermoGenesis believes that this will provide it the ability to rapidly test new therapies for safety and early efficacy through ThermoGenesis’ CTCRO for the combined company as well as ThermoGenesis’ potential license or marketing partners, and represents an opportunity to provide contract CTCRO services.
Low cost, high quality Asian infrastructure – TotipotentRX has an experienced clinical, scientific and professional staff of approximately 51 full time employees based in New Delhi, India. TotipotentRX’s staff maintains the ability to run high quality cell therapy clinical trials, manage global regulatory filings and perform proprietary clinical product development initiatives.  ThermoGenesis has found that the average professional wage rate in New Delhi to be less than 50.0% of U.S. wages for comparable positions.  Thus, ThermoGenesis is filling its clinical and scientific skills gap most economically through this combination.  In addition, New Delhi represents a vast pool of cost effective, highly educated and experienced resources to further grow ThermoGenesis’ capabilities as needed.  Moreover, ThermoGenesis’ management estimates the cost savings achieved by TotipotentRX in performing their ten pilot, Phase I or Phase Ib clinical trials through their India CTCRO has saved in excess of $12 million in the past five years as compared to performing the same trials in the U.S.   ThermoGenesis expects its upcoming Phase I trial work planned for the combined company through its India CTCRO to generate an equivalent level of savings or better, as compared to U.S. trial costs, over the next 24 to 36 months.

The combined company also gains the benefit of high quality, low cost cell manufacturing.  The TotipotentRX cell laboratory facility within the Fortis New Delhi facility is U.S. FDA registered, ISO certified, and accredited for Good Manufacturing Practices, Good Clinical Practices, and Good Laboratory Practices by the British Standards Group (BSI).

In addition to considering the factors outlined above, the ThermoGenesis board of directors considered the following factors in reaching its conclusion to approve the Merger and to recommend that the ThermoGenesis stockholders approve the Merger Agreement and the Merger and transactions contemplated thereby including the issuance of shares of ThermoGenesis common stock in the Merger:

· ThermoGenesis will have access to TotipotentRX’s extensive human clinical trial portfolio;
· ThermoGenesis will have access to TotipotentRX’s highly valuable low cost clinical research organization;
· ThermoGenesis believes that by merging with TotipotentRX, ThermoGenesis will be able to participate in the potentially lucrative regenerative medicine industry which may provide for potentially higher margins than through the sale its products;
· TotipotentRX’s expertise in clinical trials and its existing relationship with Fortis Healthcare;
· the results of the due diligence review of TotipotentRX’s business and operations by ThermoGenesis’ management, which confirmed, among other things, that TotipotentRX met the criteria set by ThermoGenesis’ board for a potential merger candidate and that the assets and liabilities of TotipotentRX were substantially as represented by TotipotentRX management;
· the fact that the Merger Agreement would be submitted to the ThermoGenesis stockholders for approval;
· the future prospects for ThermoGenesis’ business, and the costs of attempting to continue as an independent company;
· the terms and conditions of the Merger Agreement, including the following related factors:
o the percentage of the combined company that the ThermoGenesis stockholders will maintain  in the transaction;
o the fact that the exchange ratio will not fluctuate based upon changes in the price of ThermoGenesis common stock or the value of TotipotentRX common stock prior to completion of the Merger;
o ThermoGenesis’ rights under the Merger Agreement to consider certain unsolicited acquisition proposals under certain circumstances should ThermoGenesis receive a superior proposal;
o the conclusion of ThermoGenesis’ board of directors that the potential termination fee of $500,000, and the circumstances when such fee may be payable, were reasonable;
o the no-solicitation provisions governing TotipotentRX’s ability to engage in negotiations with, provide any confidential information or data to, and otherwise have discussions with, any person relating to an acquisition proposal;
o the belief that the terms of the Merger Agreement, including the parties’ representations, warranties and covenants, and the conditions to their respective obligations, are reasonable under the circumstances; and
o the expectation that the Merger will be treated as a reorganization for U.S. federal income tax purposes, with the result that in the Merger, the ThermoGenesis stockholders will not recognize taxable gain or loss for U.S. federal income tax purposes.
· ThermoGenesis’ understanding of TotipotentRX’s business, including its product candidates, TotipotentRX’s experienced management team, and the prospects for value creation for ThermoGenesis stockholders in connection with the Merger;
· the fairness opinion issued to the board of directors by Roth Capital Partners, LLC on July 15, 2013, analyzing the fairness of the consideration provided for in the Merger, as more fully described in Annex C;
· the likelihood that the Merger will be consummated on a timely basis, including the likelihood that the Merger will receive all necessary approvals; and
· the possibility that the combined entity would be able to take advantage of the potential benefits resulting from the combination.

In the course of its deliberations, ThermoGenesis’ board of directors also considered a variety of risks and other countervailing factors related to entering into the Merger Agreement, including:
 
· the risks related to TotipotentRX and the combined company as described in the risk factors set forth elsewhere in this proxy statement/prospectus/consent solicitation, including the risk that the combined company will not benefit from the Merger as anticipated;
· the fact that the shares of ThermoGenesis common stock to be issued in the Merger will represent forty-three percent (43.0%) of the outstanding shares of common stock of the combined company immediately after completion of the Merger, thus causing ThermoGenesis stockholders to experience immediate and significant dilution in their equity interests and voting power upon completion of the Merger;
· the $500,000 termination fee payable to TotipotentRX upon the occurrence of certain events and the potential effect of such termination fee in deterring other potential acquirers from proposing an alternative transaction that may be more advantageous to ThermoGenesis stockholders;
· the risks, challenges and costs inherent in combining the operations of the two companies and the substantial expenses to be incurred in connection with the Merger, including the possibility that delays or difficulties in completing the integration could adversely affect the combined company’s operating results and preclude the achievement of some of the benefits anticipated from the Merger;
· the risk of diverting the attention of ThermoGenesis’ management from other strategic priorities to implement the Merger and make arrangements for the integration of each company’s operations and infrastructure following the Merger;
· the possible volatility, at least in the short term, of the trading price of ThermoGenesis’ common stock resulting from the Merger announcement;
· the risk that the Merger might not be consummated in a timely manner or at all;
· the possibility that the anticipated benefits of the Merger may not be realized or they may be lower than expected;
· the risk to ThermoGenesis’ business, operations and financial results in the event that the Merger is not consummated;
· the restrictions on the conduct of ThermoGenesis’ business prior to completion of the Merger, which require ThermoGenesis to carry on its business in the ordinary course and consistent with past practice, subject to specific additional restrictions, which may delay or prevent ThermoGenesis from pursuing business opportunities that otherwise would be in it best interests as an independent, stand-alone company;
· the substantial transaction costs and expenses that have been incurred to date and likely will be incurred in connection with the Merger; and
· various other risks associated with the combined company and the Merger, including those described in the section entitled “Risk Factors” in this proxy statement/prospectus/consent solicitation.

After evaluating the proposed transaction with TotipotentRX and taking into account all of the factors previously discussed and considered by the board, the board unanimously approved the Merger with TotipotentRX and authorized management to negotiate and enter into definitive agreements on terms consistent in material respects with the terms presented to the board.  In making its determination, the board considered the percentage of the combined company that would be held by ThermoGenesis stockholders, the existing business and future business prospects of the combined company, the overall structure of the transaction, the terms of the Merger Agreement and the factors and considerations described above.
The foregoing information and factors considered by ThermoGenesis’ board of directors are not intended to be exhaustive but are believed to include all of the material factors considered by ThermoGenesis’ board of directors.  The ThermoGenesis board of directors viewed its recommendation to approve the Merger as being based upon its business judgment in light of the totality of the information presented and considered, and the overall effect of the transaction on the stockholders of ThermoGenesis compared to other alternatives.  In view of the wide variety of factors considered in connection with its evaluation of the Merger and the complexity of these matters, ThermoGenesis’ board of directors did not find it useful, and did not attempt, to quantify, rank or otherwise assign relative weights to these factors.  In considering the factors described above, individual members of ThermoGenesis’ board of directors may have given different weight to different factors.  ThermoGenesis’ board of directors conducted an overall analysis of the factors described above, including discussions with, and questioning of, ThermoGenesis’ management and ThermoGenesis’ financial and legal advisors, and considered the factors overall to be favorable to, and to support, its determination.

Historical Background for TotipotentRX

The TotipotentRX Corporation five year plan as presented to its Board of Directors in December 2011 and again updated in March 2013 outlined the prospects for, and TotipotentRX’s gaps in, further advancing its autologous cellular therapies, disposable cellular medical devices, and cellular clinical trials services business verticals.  TotipotentRX's management advised the Board that the regulatory agencies, and most specifically the U.S. FDA were coming to a concentric opinion that “approvable” cellular therapies would require a combination product within an integrated approach to product development and the regulatory application; meaning that all devices, diagnostics, and cellular biologicals used in the preparation of autologous cell therapies would require optimization, testing, and approval as an integrated product.  Therefore, for TotipotentRX to advance the commercialization of its clinical intellectual property, it would require partnering, licensing or acquisition of several key technologies, and the access to funding to complete the related technical agreements and subsequent clinical trials.  TotipotentRX’s Board was apprised of these requirements, and subsequently the management was authorized to license technology and raise the appropriate equity investment(s) to fund the programs.  The sequence that followed was:

· The first and most urgent technology necessary was the mechanical means to purify a desired cell formulation from a heterogeneous bone marrow mixture within a short and highly controlled time period.  In 2011 there were two commercially available platforms and one early development stage platform.  Using an internal technological vetting process the prospective list was shortened to two.  TotipotentRX had an existing distribution relationship with one of the manufacturers of a commercially available device, ThermoGenesis, and initial discussions were started which led to a collaborative Phase 1b clinical trial.  At that time ThermoGenesis was not ready for licensing the technology exclusively in the cardiovascular space and had existing contractual limitations in the orthopedic space.  Simultaneously, TotipotentRX pursued the product still in development and completed a global exclusive license agreement for intracoronary delivery of cells, but the option for orthopedic applications had already been licensed to another third-party.  The licensed product ultimately failed in repeated laboratory experiments throughout 2011 and 2012.
· The second requirement of TotipotentRX was to raise the necessary capital to expand its clinical intellectual property and clinical trials organization, and a Series B funding was completed in January 2012 to advance the pilot trial clinical programs in cardiovascular and orthopedic indications.

Having limited access to a commercializable cell processing technology and planning to do another substantial capital raise for advancing several of its high impact clinical therapies, TotipotentRX’s management approached ThermoGenesis’ new Chief Executive Officer in March 2012 to consider a merger of the two companies.

TotipotentRX’s management felt the synergies between the two companies were obvious:
 
· ThermoGenesis required significant leaps in clinical capability to catch-up and to recognize the value of their processing platform,
· Thermogenesis had engineering strength to execute on the design changes required by TotipotentRX,
· TotipotentRX has the clinical competence to provide the clinical leap required by ThermoGenesis, and
· ThermoGenesis and TotipotentRX jointly could create a company that would have considerable synergy value.

On March 28, 2012 Messrs. Harris and Sivilotti held an initial meeting with Matt Plavan, ThermoGenesis
CEO to discuss the concept of combining the companies.

Subsequent to the March 28, 2012 meeting, Messrs. Plavan, Harris and Sivilotti met again in June and July 2012 in addition to holding several conference calls to conduct due diligence, discuss the potential for combining the companies, and to discuss relative valuation.  Effective April 4, 2012, ThermoGenesis and TotipotentRX entered into a mutual non-disclosure agreement and on June 21, 2012, in connection with further due diligence efforts, MK Alliance and TotipotentRX granted ThermoGenesis access to a data room created on OneHub.  Jointly on behalf of both Boards, MK Alliance and TotipotentRX, Mr. Harris presented a rationale for majority ownership position by MK Alliance’s and Totipotent’s shareholders in the combined company. The rationale was that ThermoGenesis stock price was severally depressed and in the opinion of Mr. Harris and Mr. Sivilotti the private cord blood business would face serious headwinds.  During the same conversations Mr. Plavan communicated that he did not believe a greater than 50.0% ownership by MK Alliance and TotipotentRX shareholders in the combined company would be acceptable to ThermoGenesis and its shareholders, however all parties agreed that it was too early to fully assess each other without deeper diligence.

On June 20, 2012, Mr. Harris and Sivilotti presented an initial update to the Board of MK Alliance and subsequently to the Board of TotipotentRX.   Both Boards approved expanding the diligence process even though the valuation concerns remained.

On July 22 and 23, 2012 Mr. Harris and Sivilotti traveled with Mr. Plavan to tour TotipotentRX’s India facilities and perform assess the GMP medical device operations of MK Alliance and the cellular GMP and clinical trial operations of TotipotentRX, including diligence sessions on their Clinical Research Organization, clinical trial process and the Fortis hospital.  Mr. Plavan was given full access to staff, records, doctors, and facilities.

During the first two weeks of August 2012, Messrs. Harris, Sivilotti and Plavan held conference calls and in-person meetings to conduct due diligence on one another and prepare a business plan and  preliminary financial information for the combined company for valuation purposes.

On August 8, 2012, Messrs. Plavan, Harris and Sivilotti made a presentation of the business plan and preliminary financial information for the combined company to Roth in their headquarters in Newport Beach, California for the purposes of obtaining input and guidance on the relative valuations of each company.

Discussions and diligence with ThermoGenesis continued in the months of September and October 2012, however the challenges remained per Mr. Plavan that the valuation splits were likely unacceptable to ThermoGenesis.

The discussions with ThermoGenesis slowed by the second week in October 2012, and both the Board of MK Alliance and TotipotentRX felt the potential for reaching an agreeable valuation was becoming challenging.

During the third week in October 2012, TotipotentRX research team continued diligence on another pre-production lot of the licensed technology, and the results were extremely discouraging.

On November 17, 2012, TotipotentRX served a breach of contract notice to the licensor of the early stage cell processing device.  The Board of TotipotentRX considered it options of litigation, and retained counsel to pursue the licensor for breach of contract.  The Board of TotipotentRX authorized management to approach ThermoGenesis for a development collaboration and potential license to ThermoGenesis’ MXP platform.

During the process of pursuing a new commercial relationship for potential access to ThermoGenesis MXP processing Mr. Harris and Mr. Sivilotti commenced discussions with Mr. Plavan regarding the potential for a three-way merger between ThermoGenesis, TotipotentRX/MK Alliance (in combination) plus another medical device early development company (Company A) with a strategic focus of producing cell separation tools and accessories to support regenerative medicine.  Company A had a venture capital firm (VC A) interested in options for combining the companies.
On December 22, 2012 the Boards of TotipotentRX and subsequently MK Alliance authorized Mr. Harris to enter into full diligence and discussions with ThermoGenesis, Company A and VC A.

During the period November 2012 through March 2013, Messrs. Plavan, Harris and Sivilotti explored a three-way merger with Company A however the parties could not agree on the proper split.   On February 20, 2012 Mr. Harris and Mr. Plavan met and jointly discussed the impasse with Company A and VCA.

On March 1, 2013 the TotipotentRX Board and subsequently MK Alliance Board was updated on the recommendation of Mr. Harris and Mr. Sivilotti that the three way merger was no longer practical due to unreasonable demands of Company A and VC A on devaluing all other parties, i.e. ThermoGenesis, TotipotentRX and MK Alliance.  The Boards of TotipotentRX and MK Alliance authorized the termination of further merger discussions.

On March 7, 2013, Mr. Plavan and Messrs. Harris and Sivilotti terminated negotiations with Company A and VCA and agreed to focus on a merger between ThermoGenesis and TotipotentRX/MK Alliance.

On March 8 and March 10, 2013, Messrs. Plavan and Harris met at ThermoGenesis’ offices to continue discussing a possible merger.  From March 31 through April 23, 2013, management from both ThermoGenesis and TotipotentRX held various meetings to discuss the combined business plan and related preliminary financial information, conduct due diligence on each other and discuss relative valuations.   On April 23, 2013, counsel for ThermoGenesis distributed the first draft of the Merger Agreement and a timeline of the proposed merger to the parties.

On March 24, 2013 MK Alliance, Inc.’s corporate counsel presented a notice that the Board of MK Alliance should consider a potential conflict as follows:

· Mr. Harris and Mr. Sivilotti potentially be employees of a joint company with ThermoGenesis;
· MK Alliance and TotipotentRX have the same corporate counsel; and
· Mr. Harris, Mr. Sivilotti and Mr. Rehra are on both the MK Alliance and TotipotentRX boards.

The Boards deferred all authority to accept the conflict or hire a second legal firm, to the independent directors, Dr. Gary Cohan for MK Alliance, and Mr. Michaal Rhein for TotipotentRX.  Both independent directors considered the cost of doubling up the legal fees, and felt that both MK Alliance and TotipotentRX shared the same desires and goals.  The decision by Dr. Cohan and Mr. Rhein was to waive the conflict and appoint Troy Gould to represent both companies was signed on March 24, 2013 and presented into the records of both Boards on May 26, 2013.

Discussions and diligence between ThermoGenesis, MK Alliance (represented by Mitchel Sivilotti), and TotipotentRX (represented by Ken Harris) continued in April and May.  Also during this time period, ThermoGenesis and TotipotentRX and their respective representatives entered into numerous discussions regarding management structure and board of director composition of the combined company, employment agreements for Messrs. Harris and Sivilotti, lock-up agreements, assumption of certain TotipotentRX debt and certain India tax issues that may affect the shareholders of TotipotentRX.

Mr. Harris and Mr. Sivilotti updated the Board of MK Alliance and TotipotentRX on June 2, 2013 that the anticipated valuation split with ThermoGenesis would be 43.0% to 45.0% of the combined company to be held by MK Alliance and TotipotentRX.  The Boards discussed the near term dilutive effect to the shareholders, but the Directors agreed the opportunity for medium term appreciation outweighed the short term dilution and risk that further negotiation for incremental ownership could create a walk away by ThermoGenesis.

The Boards of MK Alliance and TotipotentRX met five more times between June 2, 2013 and July 15, 2013.
The shareholders of MK Alliance and TotipotentRX unanimously approved through written consent the merger of the companies.  The consents were gathered from July 3 to July 9, 2013.  MK Alliance (surviving as TotipotentRX) also approved the appointment of Mr. Michael Rhein, former independent director from TotipotentRX, to its board.

On July 15, 2013, the TotipotentRX board held a meeting to review the final terms of the Merger Agreement, including the associated lock-up agreement, non-compete agreement and employment agreements for Messrs. Harris and Sivilotti,. The management valuation report and the due diligence final reports were also presented.  After careful consideration the Board unanimously approved the merger agreement with ThermoGenesis.

TotipotentRX’s Reasons for the Merger; Recommendation of the TotipotentRX Board of Directors

The TotipotentRX board of directors has determined that the terms of the Merger are fair and in the best interests of TotipotentRX and its shareholders.  Accordingly, the board of directors approved the Merger Agreement including the Merger and related transactions contemplated thereby, and recommended that TotipotentRX’s shareholders consent vote FOR the Merger Agreement including the Merger and related transactions contemplated thereby.

The TotipotentRX board considered a number of factors in reaching its decision, without assigning any specific or relative weight to such factors.  The material factors considered included:

· ThermoGenesis processing technology in all fields of use;
· ThermoGenesis’ engineering competency;
· ThermoGenesis’ scaled cell processing device manufacturing which was approaching Six Sigma quality;
· information concerning the business, operations, net worth, liabilities, cash assets and needs, and future business prospects of TotipotentRX and ThermoGenesis, both individually and on a combined basis;
· the belief that by combining operations, the combined company would have better opportunities for future growth than TotipotentRX would have on its own;
· the current and prospective economic and competitive environments facing TotipotentRX as a stand-alone company;
· the fact that the holders of TotipotentRX common stock would own 43.0% of the outstanding common stock of the combined company;
· the belief that the Merger would provide TotipotentRX with additional management and financial resources;
· the opportunity for TotipotentRX’s shareholders to benefit from potential appreciation in the value of the combined company’s common stock; and
· the expectation that the Merger would be accomplished on a tax-free basis for United States federal income tax purposes for TotipotentRX shareholders, except for taxes payable on cash received by TotipotentRX stockholders in lieu of fractional shares and holders who exercise their dissenters rights.

In addition to considering the factors outlined above, the TotipotentRX board of directors considered the following factors in reaching its conclusion to approve the Merger and to recommend that the TotipotentRX stockholders approve the Merger Agreement, all of which it viewed as supporting its decision to approve the business combination with ThermoGenesis:

· the results of the due diligence review of ThermoGenesis’ business and operations by TotipotentRX’s management confirmed that the assets and liabilities of ThermoGenesis were substantially as represented by ThermoGenesis management;
· the terms and conditions of the Merger Agreement, including the following related factors:
o the number of shares of the combined company that the TotipotentRX shareholders will receive in the transaction;
o the fact that the exchange ratios will not fluctuate based upon changes in the price of ThermoGenesis common stock or the value of TotipotentRX common stock prior to completion of the Merger;
o the conclusion of TotipotentRX’s board of directors that the potential termination fee of $500,000, and the circumstances when such fee may be payable, were reasonable;
o the no-solicitation provisions governing ThermoGenesis’ ability to engage in negotiations with, provide any confidential information or data to, and otherwise have discussions with, any person relating to an acquisition proposal; and
o the belief that the terms of the Merger Agreement, including the parties’ representations, warranties and covenants, and the conditions to their respective obligations, are reasonable under the circumstances; and
o the opportunity for TotipotentRX shareholders to hold shares of a publicly traded company;
· the likelihood that the Merger will be consummated on a timely basis, including the likelihood that the merger will receive all necessary approvals;
· the possibility that the combined entity would be able to take advantage of the potential benefits resulting from the combination of ThermoGenesis and TotipotentRX; and
· the TotipotentRX board of directors’ consideration of strategic alternatives to the Merger.

The TotipotentRX board also considered a number of risks and potentially negative factors in its deliberations concerning the Merger, including the risk factors described elsewhere in this proxy statement/prospectus/consent solicitation, and in particular:
 
· the risk that the Merger would not be completed in a timely manner or at all;
· the substantial expenses to be incurred in connection with the Merger;
· the fact that TotipotentRX’s shareholders will not receive the full benefit of any future growth in the value of their equity that TotipotentRX may have achieved as an independent company;
· the restrictions on the ability of the Principal Stockholders to freely trade their shares of ThermoGenesis common stock for a certain period of time following the effective date of the Merger;
· the risks associated with the existing operations of ThermoGenesis;
· the limitations on TotipotentRX, as set forth in the Merger Agreement, from engaging in discussions and negotiations with any party, other than ThermoGenesis, concerning a business combination involving TotipotentRX;
· the possibility that TotipotentRX will be required to pay the termination fee provided for in the Merger Agreement;
· the risk that the potential benefits of the Merger may not be realized;
· the risks, challenges and costs inherent in combining the operations of the two companies and the substantial expenses to be incurred in connection with the Merger, including the possibility that delays or difficulties in completing the integration could adversely affect the combined company’s operating results and preclude the achievement of some of the benefits anticipated from the Merger;
· the restrictions on the conduct of TotipotentRX’s business prior to completion of the Merger, which require TotipotentRX to carry on its business in the ordinary course and consistent with past practice, subject to specific additional restrictions, which may delay or prevent TotipotentRX from pursuing business opportunities that otherwise would be in it best interests as an independent, stand-alone company;
· the possible volatility, at least in the short term, of the trading price of ThermoGenesis’ common stock following the Merger;
· the risk of diverting management’s attention from other strategic priorities to implement Merger integration efforts;
· the risk that the Merger might not be consummated in a timely manner or at all and the potential adverse effect of the public announcement of the announcing the delay or non-consummation of the Merger on TotipotentRX’s reputation;
· the risk to TotipotentRX’s business, operations and financial results in the event that the Merger is not consummated; and
· various other risks associated with the combined company and the Merger, including those described in the section entitled “Risk Factors” in this proxy statement/prospectus/consent solicitation.
The board of directors of TotipotentRX determined that the Merger is preferable to the other alternatives which might be available to TotipotentRX, such as remaining independent and attempting to grow organically using equity or debt financings, or engaging in a transaction with another party.  The TotipotentRX board made that determination because it believes that the Merger will unite two companies with complementary needs, assets and board members, thereby creating a combined company with greater capital strength and profitability potential than TotipotentRX possesses on a stand-alone basis or that TotipotentRX might be able to achieve through other alternatives.
 
For the reasons set forth above, the board of directors of TotipotentRX recommends that holders of TotipotentRX common stock vote to approve the Merger Agreement, including Merger and transactions contemplated thereby.
 
Opinion of Roth Capital Partners

The ThermoGenesis board of directors retained Roth Capital Partners, LLC (Roth) to render an opinion as to the fairness, from a financial point of view, of the consideration to be paid in the Merger by ThermoGenesis.

On July 15, 2013, Roth rendered its oral opinion to the board of directors of ThermoGenesis (which was subsequently confirmed in writing by delivery of Roth’s written opinion dated the same date) to the effect that, based upon and subject to the assumptions, factors, qualifications and limitations set forth in the written opinion described herein, as of July 15, 2013, the total consideration to be paid by ThermoGenesis in connection with the Merger, including the Merger Consideration, is fair to ThermoGenesis from a financial point of view.

Roth’s opinion was prepared solely for the information of the board of directors of ThermoGenesis and only addressed the fairness, from a financial point of view, of the total consideration to be paid by ThermoGenesis in connection with the Merger, including the Merger Consideration.  Roth was not requested to opine as to, and Roth’s opinion does not address, the relative merits of the Merger Agreement or the Merger or any alternatives to such transactions, ThermoGenesis’ underlying decision to proceed with or effect the Merger, or any other aspect of the Merger.  The summary of Roth’s opinion in this proxy statement/prospectus/consent solicitation is qualified in its entirety by reference to the full text of its written opinion, which is included as Annex C to this proxy statement/prospectus/consent solicitation and sets forth the procedures followed, assumptions made, qualifications and limitations on the review undertaken and other matters considered by Roth in preparing its opinion.  However, neither Roth’s written opinion nor the summary of its opinion and the related analyses set forth in this proxy statement/prospectus/consent solicitation are intended to be, and they do not constitute, advice or a recommendation to any stockholder as to how such stockholder should act or vote with respect to any matter relating to the Merger.

The terms of the Merger, the Merger Consideration, and the related transactions were determined through arm’s length negotiations between ThermoGenesis and TotipotentRX and were approved unanimously by ThermoGenesis’ board of directors.  Roth did not determine the consideration to be paid by ThermoGenesis to TotipotentRX shareholders in connection with the Merger.

The full text of Roth’s opinion, which sets forth the assumptions made, general procedures followed, factors considered and limitations on the review undertaken by Roth in rendering its opinion is attached as Annex C and is incorporated herein by reference.  ThermoGenesis urges you to read the opinion in its entirety.  The summary of the opinion of Roth set forth below is qualified in its entirety by reference to the full text of the opinion.  Roth’s opinion, based upon and subject to the procedures followed, assumptions made, qualifications and limitations on the review undertaken and the other factors Roth deemed relevant, is that the total consideration to be paid by ThermoGenesis in connection with the Merger, including the Merger Consideration, is fair to ThermoGenesis, from a financial point of view.

In connection with rendering the opinion described above and performing its related financial analyses, Roth, among other things:

· reviewed the financial terms of a draft of the Merger Agreement dated July 15, 2013;
· reviewed certain financial information regarding ThermoGenesis provided to Roth by senior management of ThermoGenesis;
· reviewed certain publicly available financial statements and other information concerning ThermoGenesis;
· reviewed certain financial projections prepared by senior management of ThermoGenesis;
· participated in certain discussions among members of senior management of ThermoGenesis and TotipotentRX;
· discussed the past and current operations and financial condition and the prospects of the Merger with ThermoGenesis’ senior management members;
· compared certain financial terms of the Merger to the financial terms, to the extent publicly available, of certain other acquisition transactions that Roth deemed to be comparable to the Merger; and
· reviewed such other financial studies and analyses and conducted such other investigations as Roth deemed necessary or appropriate for the purpose of rendering its opinion.

The following is a summary of the material financial analyses performed by Roth in connection with the preparation of its fairness opinion, which opinion was rendered orally to the board of directors of ThermoGenesis (and subsequently confirmed in writing by delivery of Roth’s written opinion dated the same date) on July 15, 2013.  The preparation of analyses and a fairness opinion is a complex analytic process involving various determinations as to the most appropriate and relevant methods of financial analysis and the application of those methods to the particular circumstances and, therefore, such an opinion is not readily susceptible to summary description and this summary does not purport to be a complete description of the analyses performed by Roth or the delivery of Roth’s opinion to the board of directors of ThermoGenesis.

This summary includes information presented in tabular format.  In order to fully understand the financial analyses presented by Roth, the tables must be read together with the text of each analysis summary and considered as a whole.  The tables alone do not constitute a complete summary of the financial analyses.  Considering any portion of such analyses and of the factors considered, without considering all analyses and factors, could create a misleading or incomplete view of the process underlying Roth’s opinion.

In arriving at its opinion, Roth assumed and relied upon, without independent verification, the accuracy and completeness of the information that was publicly available or supplied or otherwise made available to Roth by ThermoGenesis and TotipotentRX and further relied upon the assurances of ThermoGenesis that it is not aware of any facts that would make any of the information reviewed by Roth inaccurate, incomplete or misleading in any material respect.  Roth expressed no opinion with respect to the fairness of the amount or nature of the compensation to any of TotipotentRX’s officers, directors or employees, or any class of such persons and the assumption by ThermoGenesis of certain TotipotentRX debt due to the Principal Stockholders, relative to the consideration to be paid to the holders of shares of TotipotentRX common stock in the Merger.

With respect to the financial forecasts relating to ThermoGenesis prepared by the management of ThermoGenesis, Roth assumed that they had been reasonably prepared reflecting the best currently available estimates and good faith judgments of ThermoGenesis’ management as to the future financial performance of ThermoGenesis.  Roth was not engaged to assess the achievability of any projections or the assumptions on which they were based, and Roth expressed no view as to such projections or assumptions.  In addition, Roth did not assume any responsibility for any independent valuation or appraisal of the assets or liabilities of ThermoGenesis, nor was Roth furnished with any such valuation or appraisal. Roth did not assume any obligation to conduct, and did not conduct, any physical inspection of the properties or facilities of ThermoGenesis.

Roth assumed that the Merger will be consummated in accordance with the terms set forth in the Merger Agreement.  Roth also assumed that the representations and warranties of each party in the Merger Agreement are true and correct, that each party will perform on a timely basis all covenants and agreements required to be performed by it under the Merger Agreement and that all conditions to the consummation of the Merger will be satisfied without waiver thereof.  Roth further assumed that the draft of the Merger Agreement provided to Roth will conform in all material respects to the Merger Agreement and that the Merger will be consummated in all material respects as described in the draft of the Merger Agreement provided to Roth. Finally, Roth also assumed that all governmental, regulatory and other consents and approvals contemplated by the Merger Agreement will be obtained and that, in the course of obtaining any of those consents and approvals, no modification, delay, limitation, restriction or condition will be imposed or waivers made that would have an adverse effect on ThermoGenesis or TotipotentRX or on the contemplated benefits of the Merger. Roth is not a legal, tax or regulatory advisor. Roth's fairness opinion was approved by its fairness committee.
Roth's opinion is necessarily based on economic, market and other conditions as they existed and the information made available to Roth as of July 15, 2013, which is the date of the Roth opinion. Although subsequent developments may affect the opinion, Roth does not have any obligation to update, revise or reaffirm its opinion and Roth expressly disclaims any responsibility to do so. Roth did not express any opinion as to the underlying valuation, future performance or long-term viability of ThermoGenesis or as to what the value of the shares of ThermoGenesis actually will be when issued to holders of TotipotentRX pursuant to the Merger or the prices at which shares of ThermoGenesis common stock will trade at any time.

The Merger Consideration was determined through arm's length negotiations between ThermoGenesis and TotipotentRX and was approved by the ThermoGenesis and TotipotentRX boards of directors.  Although Roth provided advice to ThermoGenesis' board of directors during these negotiations, the decision to enter into the Merger was solely that of ThermoGenesis' board of directors.  Roth's opinion and its presentation to ThermoGenesis' board of directors was one of many factors taken into consideration by the ThermoGenesis board of directors in deciding to approve, adopt and authorize the Merger Agreement.  Consequently, the analyses as described herein should not be viewed as determinative of the opinion of ThermoGenesis' board of directors with respect to the Merger Consideration or of whether ThermoGenesis' board of directors would have been willing to agree to different consideration. The following is a brief summary of each of the material analyses performed by Roth in connection with its opinion letter dated July 15, 2013.

In furnishing its opinion, Roth does not admit that it is an expert within the meaning of the term “expert” as used in the Securities Act of 1933 and the rules and regulations thereunder, nor does it admit that its opinion constitutes a report or valuation within the meaning of Section 11 of the Securities Act of 1933. Roth did not attempt to combine the analyses described herein into one composite valuation range, nor did Roth assign any quantitative weight to any of the analyses or the other factors considered.  Furthermore, in arriving at its opinion, Roth did not attribute any particular weight to any analysis or factor considered by it, but rather made qualitative judgments as to the significance and relevance of each analysis and factor in light of one another.  Accordingly, Roth has stated that it believes that its analyses must be considered as a whole and that considering any portion of its analyses, without considering all of the analyses, could create a misleading or incomplete view of the process underlying its opinion or the conclusions to be drawn therefrom.

In conducting the analysis as to the fairness to ThermoGenesis, from a financial point of view, of the consideration to be paid by ThermoGenesis pursuant to the terms of the Merger Agreement, Roth conducted a stand-alone valuation of ThermoGenesis.  Roth then conducted a valuation of ThermoGenesis and TotipotentRX as a pro-forma combined entity, against which Roth compared the pro-forma ThermoGenesis ownership based on the Merger Agreement, with ThermoGenesis’ stand-alone valuation.

The results of the application by Roth of each of the valuation methodologies utilized in connection with its fairness opinion is summarized below.

Stand-Alone Valuation

Roth conducted an analysis of the value of ThermoGenesis on a stand-alone basis.  In determining the value, Roth reviewed and conducted:
 
· Comparable Companies Analysis;
· Precedent M&A Transactions Analysis;
· Discounted Cash Flow Analysis of the projected operations of ThermoGenesis; and
· Market valuation Analysis.

Utilizing the various valuation methodologies listed above and based on ThermoGenesis’ fiscal year end 2013 projected revenues of $18.2 million, Roth estimated a valuation of ThermoGenesis utilizing the Comparable Companies Analysis of $23.7 million to $25.7 million; Precedent M&A Transactions Analysis of $32.2 million to $40.4 million; Discounted Cash Flow Analysis of $30.6 million to $39.3 million; and Market Valuation Analysis of $21.7 million to $23.4 million.  Roth then determined the average of these four methodologies which ranged from $27.0 million to $32.2 million, leading to a $29.6 million stand-alone average value.
The results of these analyses are summarized as follows:

 
 
   
EV/2013 Revenue
Multiple
   
Implied Enterprise
Value
 
Methodology
 
2013 Projected Revenue
   
Low
   
High
   
Low
   
High
 
Comparable Companies Analysis
 
$
18,227
     
1.3
x
   
1.4
x
 
$
23,697
   
$
25,704
 
Precedent M&A Transactions(a)
 
$
18,227
     
1.8
x
   
2.2
x
 
$
32,230
   
$
40,400
 
DCF (Revenue Multiple Method)(b)(c)(d)(e)
 
$
18,227
     
1.7
x
   
2.2
x
 
$
30,649
   
$
39,256
 
ThermoGenesis Market Valuation(f)
 
$
18,227
     
1.2
x
   
1.3
x
 
$
21,716
   
$
23,370
 
Average
 
$
18,227
     
1.5
x
   
1.8
x
 
$
27,073
   
$
32,182
 
 

Notes:
High and low ranges are based on mean and median values.
 
(a)
Based on selected transactions from January 1, 2008 to July 12, 2013.
(b)
Based on Max and Min values.
(c)
DCF calculated with median discount rate of 17.0% and median terminal revenue multiple of 1.5x.
(d)
EBITDA used a proxy for free cash flow.
(e)
Based on projections from 2013 to 2020.
(f)
Based on 52 week high/low as of July 12, 2013.

Comparable Companies Analysis

The comparable companies’ analysis uses data from comparable guideline companies to develop a measure of current value for ThermoGenesis based on its current and estimated sales, operating income and earnings per share. The theory underlying the comparable companies’ valuation is that companies in the same industry with similar operating characteristics should have certain valuation benchmarks in common. The goal of the analysis is to develop a premise for relative value, which when coupled with other valuation approaches, presents a foundation for determining a range of firm value.

Under this analysis, Roth assembled a peer group of comparable companies among clinical technologies companies based on the following criteria: lines of business, maturity of business, business model and risks, size and scale of operations, growth prospects and other relevant characteristics.  Roth examined and compared each company’s performance, profitability, leverage and business trends. Based on these analyses, a number of financial multiples and ratios are calculated to gauge each company’s relative performance and valuation.

The following companies were included in Roth’s comparable companies’ analysis:

China Cord Blood Corporation:

China Cord Blood Corporation, together with its subsidiaries, primarily engages in the provision of umbilical cord blood storage and ancillary services in the People’s Republic of China. The company provides cord blood testing, processing, and storage services under the direction of subscribers; laboratory testing and hematopoietic stem cell services; and tests, processes, and stores donated cord blood, as well as offers matching services. As of March 31, 2013, it had three operating cord blood banks in the Beijing municipality, the Guangdong province, and the Zhejiang province. China Cord Blood Corporation is based in Central, Hong Kong. (Source: Capital IQ)

Rochester Medical Corporation:

Rochester Medical Corporation engages in the development, manufacture, and marketing of PVC-free and latex-free urinary continence and urine drainage care products for the home and acute care markets. Its home care products include silicone male external catheters (MECs) under the UltraFlex, Pop-On, Wide Band, Natural, Clear Advantage, Transfix, and Spirit names for managing male urinary incontinence; latex MECs under the Freedom and Freedom Plus names for managing male urinary incontinence; intermittent catheters, such as standard, antibacterial, hydrophilic, and antibacterial personal catheters in various diameters for male, female, and pediatric use; and the FemSoft Insert, a liquid-filled urethral insert for managing stress urinary incontinence in adult females. The company’s acute care products comprise standard and StrataSI silicone Foley catheters, as well as StrataNF catheter, an antibacterial Foley catheter that reduces the incidence of hospital acquired urinary tract infection. It also distributes ostomy, and wound and scar care products and accessories; anti-decubitis mattresses; and other branded urological products. Rochester Medical Corporation offers its products to distributors, individual hospitals, healthcare institutions, and extended care facilities. The company markets its products primarily under the Rochester Medical brand name through a direct sales force in the United States, the United Kingdom, and the Netherlands; and supplies to various medical product companies and group purchasing organizations, as well as markets through independent distributors in other international markets. Rochester Medical Corporation was founded in 1988 and is headquartered in Stewartville, Minnesota. (Source: Capital IQ)
Cryo-Cell International:

Cryo-Cell International, Inc. engages in cellular processing and cryogenic cellular storage, with a focus on the collection and preservation of umbilical cord (U-Cord) blood stem cells for family use. Its Menstrual Stem Cell technology allows women to store their own menstrual stem cells, which regenerative capabilities as stem cells from umbilical cord blood or bone marrow. The company offers menstrual stem cell service to capture self-renewing stem cells, and processes and cryopreserves them for cellular therapies and potential treatment of various life threatening diseases, such as stroke, heart disease, diabetes, neurodegenerative diseases, and ischemic wounds. Its services also include reproductive tissue storage service, which includes storage of cryopreserved embryos, oocyctes, and sperm; and cord tissue service, which stores a section of the umbilical cord tissue for use in regenerative medicine research of potential therapies for various conditions, including heart disease, stroke, multiple sclerosis, and diabetes. The company markets its cord blood stem cell preservation services directly to expectant parents, as well as by distributing information through obstetricians, pediatricians, childbirth educators, certified nurse-midwives, and other related healthcare professionals. It stores approximately 275,000 cord blood specimens worldwide. The company holds research and development agreement with Saneron CCEL Therapeutics, Inc. to collaborate on research utilizing the company’s menstrual stem cell technology in pre-clinical models for certain neurological diseases and disorders. Cryo-Cell International, Inc. was founded in 1989 and is headquartered in Oldsmar, Florida. (Source: Capital IQ)

Cord Blood America:

Cord Blood America, Inc., through its subsidiaries, provides private cord blood stem cell preservation services to families in the United States, Puerto Rico, Germany, Spain, Italy, Argentina, Uruguay, and Paraguay. It services include collection of materials, physician and customer support, transportation, and comprehensive testing. The company is headquartered in Las Vegas, Nevada. (Source: Capital IQ)

Roth concluded that the enterprise value for ThermoGenesis on a comparable company basis ranged from $23.7 million to $25.7 million which compared favorably to the enterprise value represented by the consideration to be paid by ThermoGenesis in the Merger, including the Merger Consideration. This enterprise value range was calculated using the relative valuation metric of ThermoGenesis estimated 2013 revenue multiplied by the mean and median enterprise value/revenue multiples of the comparable companies.  The comparable company metrics were based off of trading multiples as of July 12, 2013.
This analysis yielded the following (in millions):

Blood Banking/Consumables Comps
   
 
($ in millions, except per share data)
   
 
Company
 
7/12/13
Price
   
52
week
Low
   
52
week
High
   
(3 Mo)
Avg
Daily
Value
Traded
   
Market
Cap.
   
Enterprise
Value
   
Cash
   
Debt
   
LTM
Revenue
   
EV/Rev.
LTM
 
China Cord Blood Corporation
 
$
3.39
   
$
2.21
   
$
3.50
   
$
0.000
   
$
247.5
   
$
136.8
   
$
240.4
   
$
129.0
   
$
87.8
     
1.6
x
Rochester Medical Corporation
 
$
15.14
   
$
9.11
   
$
15.80
   
$
0.552
   
$
186.8
   
$
164.0
   
$
22.8
   
$
0.0
   
$
67.8
     
2.4
x
Cryo-Cell International, Inc.
 
$
1.94
   
$
1.80
   
$
2.60
   
$
0.013
   
$
21.0
   
$
18.1
   
$
2.9
   
$
0.0
   
$
18.8
     
1.0
x
Cord Blood America Inc.
 
$
0.00
   
$
0.00
   
$
0.02
   
$
0.033
   
$
1.6
   
$
3.4
   
$
0.4
   
$
1.5
   
$
5.8
     
0.6
x
Mean
                         
$
0.150
   
$
114.2
   
$
80.6
   
$
66.6
   
$
32.6
   
$
45.1
   
$
1.4
x
Median
                         
$
0.023
   
$
103.9
   
$
77.4
   
$
12.8
   
$
0.8
   
$
43.3
   
$
1.3
x

Precedent M&A Transactions Analysis

The precedent transaction analysis uses data based on the values acquirers have previously placed on comparable companies in a merger or acquisition to develop a measure of current value for ThermoGenesis.

Roth examined precedent transactions, from January 1, 2008 through July 12, 2013, involving clinical technologies companies that it viewed as similar to ThermoGenesis which included companies involved in the blood banking / consumables space.
These entities were selected on the basis of the nature of their businesses, their size and operating characteristics.  The data available on these transactions, due in part to their size, is limited.  Roth examined the data points set out in the table below for the selected precedent transactions.

Closing Date
Target
Buyers
 
Total
Transaction
Value (M)
   
TTM
Revenue
(Target)
   
Revenue
Multiple
 
03/08/2013
Goodman Co., Ltd.
Nipro Corporation
 
$
184.2
   
$
173.6
     
1.1
x
02/24/2013
HemoCue AB
Radiometer Medical ApS
 
$
300.00
   
$
115.4
     
2.6
x
10/04/2012
Stellacure GmbH
MediVision Trägergesellschaft mbH
 
$
117.0
   
NA
   
NA
 
08/10/2012
Lifebank Corp.
Insception Biosciences Inc.
 
$
4.9
   
$
3.1
     
1.6
x
07/25/2012
Aspen Surgical Products, Inc.
Hill-Rom, Inc.
 
$
400.0
   
$
120.0
     
3.3
x
1/27/2012
Florida’s Blood Centers, Inc.
OneBlood, Inc.
 
NA
   
NA
   
NA
 
12/02/2011
RESORBA Wundversorgung
Advanced Medical Solutions Group plc
 
$
85.4
   
$
26.9
     
3.2
x
8/15/2011
Attends Healthcare Products, Inc.
Domtar Corporation
 
$
300.0
   
$
200.0
     
1.5
x
08/02/2011
Byrne Medical, Inc.
Medivators Inc.
 
$
109.8
   
$
38.6
     
2.8
x
07/11/2011
Coral Blood Services, Inc.
The American National Red Cross
 
$
3.0
   
NA
   
NA
 
06/30/2011
Blood Bank Of  The Redwoods Inc.
Blood Centers Of The Pacific
 
NA
   
NA
   
NA
 
04/30/2011
NeoCells, Inc.
Cord Blood America Inc.
 
$
0.3
   
NA
   
NA
 
03/01/2011
Pac-Kit Safety Equipment Co., Inc.
Acme United Corp.
 
$
3.4
   
$
5.4
     
0.6
x
02/24/2011
Reproductive Genetics Institute, Inc.
Cord Blood America Inc.
 
$
0.1
   
NA
   
NA
 
01/05/2011
Elastic Therapy, Inc.
DJO, LLC
 
$
45.8
   
$
26.0
     
1.8
x
07/31/2010
Central Illinois Community Blood Center
Mississippi Valley Regional Blood Center , Inc.
 
NA
   
NA
   
NA
 
04/19/2010
BioCells, Inc.
Cord Blood America Inc.
 
$
2.1
   
$
1.2
     
1.8
x
04/09/2010
Sorin Group USA, Inc.
Cytomedix, Inc.
 
$
11.0
   
$
9.6
     
1.2
x
03/07/2010
York S/A. Indústria E Comércio
Hypermarcas SA
 
$
54.3
   
$
35.6
     
1.5
x
12/31/2009
Vista Cord LLC
Family Cord, Inc.
 
NA
   
NA
   
NA
 
07/28/2009
Power Medical Interventions, Inc.
United States Surgical Corporation
 
$
60.8
   
$
9.6
     
6.3
x
11/25/2008
Distrex Ibérica S.A.
Cederroth Distrex, S.A.
 
$
7.1
   
$
11.7
     
0.6
x
10/04/2008
Life Sera Inc.
Octapharma AG
 
$
60.0
   
$
30.5
     
2.0
x
03/10/2008
Specialized Health Products
CR Bard Inc.
 
$
68.4
   
$
18.9
     
3.6
x
 
 
 
                              
 
  Mean
$
90.9
$
51.6
2.2
x
 
Median
 
$
57.2
    
$
26.5
     
1.8
x

Roth also examined enterprise value/LTM (last twelve months) revenue multiples for the selected precedent transactions, which yielded multiples ranging from 1.8x – 2.2x.  The median enterprise value/LTM revenue multiple for the selected precedent transactions was 1.8x.  The mean enterprise value/LTM revenue multiple for the selected precedent transactions was 2.2x.  This implied a valuation range of $32.2 million to $40.4 million for ThermoGenesis.  Roth believed that this analysis is very imprecise due to its lack of fundamental valuation based on the future cash flow generation capabilities of ThermoGenesis.  Roth applied LTM revenue multiples from the precedent transactions to ThermoGenesis’ projected revenue for 2013.

This analysis yielded the following relative valuation range (in millions):

 
 
Revenue Multiple
   
Relative Value
 
Mean
   
2.2
x
 
$
40.4
 
Median
   
1.8
x
 
$
32.2
 

Discounted Cash Flow Analysis

The discounted cash flow analysis is a “forward looking” methodology and is based on projected future cash flows to be generated by ThermoGenesis which are then discounted back to the present.  This methodology has three primary components: (1) the present value of projected unlevered cash flows for a determined period; (2) the present value of the terminal value of cash flows (representing firm value beyond the time horizon on the projections); and (3) the weighted average cost of capital (WACC) used to discount such future cash flows and terminal value back to the present.  In the discounted cash flow analysis, Roth used EBITDA as a proxy for free cash flow.  The future cash flows plus the terminal value of such cash flows are discounted by the company’s risk-adjusted cost of capital, the WACC, to derive a present value.
In conducting its discounted cash flow analysis for the purpose of determining the enterprise value of ThermoGenesis, Roth calculated the EBITDA (used as a proxy for free cash flow) that ThermoGenesis is expected to generate during fiscal years 2013 to 2020 based upon financial projections prepared by ThermoGenesis’ management.  Terminal values based on terminal revenue multiples of 1.3x to1.7x were applied to management’s revenue estimates in year 2020 to complete the basis for calculating the present value of future free cash flows.  The future free cash flows are then discounted by the company’s risk-adjusted cost of capital rate, to derive a present value.  In selecting an appropriate discount rate, Roth took into account ThermoGenesis’ unlevered equity beta, ThermoGenesis’ debt to equity ratio, ThermoGenesis’ tax rate assumption (which applied ThermoGenesis’ net operating losses to eliminate taxes through 2020), the risk free rate of 3.2% based on Bloomberg (July 1, 2013), the equity risk premium of 18.4% based on Ibbotson Associates SBBI 2013 representing the long-term historical equity risk premium as of year-end 2012 of 6.7%, and a small stock premium of 11.65% based on Ibbotson Associates SBBI 2013 representing the micro-cap premium for the bottom 10th decile of companies on the NYSE/AMEX/NASDAQ.  Application of the foregoing principles resulted in a 16.6% WACC.  Roth performed a sensitivity analysis using discount rates from 16.0% to 18.0% to arrive at a range of present values.

Based on the foregoing, Roth computed an enterprise value range of $30.6 million to $39.3 million which compared favorably to the enterprise value implied by the consideration to be paid by ThermoGenesis in the Merger, including the Merger Consideration.  Applying the range of enterprise values obtained from the discounted cash flow analysis, compared to ThermoGenesis’ expected 2013 revenue, Roth arrived at a range of EV/2013 revenue multiples of 1.7x to 2.2x.  In evaluating the foregoing, it should be noted that the WACC does not take into consideration the specific firm risks such as bankruptcy.  As a result, ThermoGenesis’ true WACC may be higher when taking into consideration the risks of default and negative operating profit history of the business which would have the effect of reducing the enterprise value range.  By conducting an analysis of a range of discount rates rather than relying one specific WACC, Roth is comfortable that the analysis is appropriate.

Market Valuation Analysis

The market valuation analysis is based on the 52-week high and low of a company’s market capitalization on its respective market exchange.  Applying ThermoGenesis’ 52-week high and low trading prices Roth arrive at an implied enterprise valuation range of $21.7 million to $23.4 million which translates into 2013 revenue multiples ranging from 1.2x to 1.3x.

Combined Entity-Enterprise Value

In evaluating the value of ThermoGenesis and TotipotentRX as a combined company, Roth performed the following analyses:
 
· public comparable company enterprise valuations; and
· discounted cash flow analysis of the projected therapeutic and non-therapeutic operations of the combined company.

Under a combined entity analysis, a public comparable company analysis attempts to provide an implied value of a company by comparing it to similar companies that are publicly traded.  Roth assembled a peer group of comparable public companies.  The criteria for selecting comparable companies included line of business, business model and risks, growth prospects, maturity of business, size and scale of operations, and other relevant characteristics.  Based on its analysis, Roth estimated that the implied enterprise value of the combined company was between $73.9 million and $118.8 million.

For a combined entity analysis, the discounted cash flow analysis, as described in further detail above, is designed to provide insight into the estimated value of a company’s equity as a function of the company’s estimated future free cash flows.  This methodology is a forward looking approach which discounts expected future cash flows by the firm’s risk-adjusted cost of capital.  In utilizing the discounted cash flow analysis, Roth used EBITDA as a proxy for free cash flow, and risk adjusted therapeutic EBITDA for probability of success.  Roth also used a declining growth method for the terminal value associated with therapeutic EBITDA and a terminal revenue multiple of 1x-2x for the non-therapeutic EBITDA.  Based on the discounted cash flow analysis, Roth estimated a combined enterprise value of the combined company ranging from $41.5 million to $93.2 million.
The results of these analyses are summarized as follows:

 
 
Implied Enterprise Value
 
Methodology
 
Low
   
High
 
Comparable Company Analysis(a)
 
$
73,880
   
$
118,767
 
Combined DCF(b) (c)
 
$
41,469
   
$
93,219
 
Average
 
$
57,674
   
$
105,993
 
 

Notes:
Dollars in thousands.
High and low ranges are based on mean and median values.
 
(a)
Based low and high based on Mean and Median values, comps updated as of July 12, 2013.
 
(b)
Discounted cash flow (DCF) uses EBITDA as a proxy for free cash flow; therapeutic EBITDA is adjusted for probability of success.
 
(c)
DCF uses the declining growth method for therapeutic EBITDA terminal value and multiple of 1x-2x for the non-therapeutic EBITDA terminal value.

Roth then calculated the average of the combined company enterprise value utilizing the comparable companies’ analysis and combined discounted cash flow analysis to determine a range of $57.7 million to $106.0 million to derive an average enterprise value of $81.8 million for the combined company.  Roth then applied the 57.0% ThermoGenesis and 43.0% TotipotentRX pro-forma equity ownership percentages based on the Merger Agreement, which would attribute $47.5 million of the combined company value to ThermoGenesis.

Roth noted that the $47.5 million in value attributed to ThermoGenesis using the combined entity-enterprise value is greater than ThermoGenesis stand-alone equity value of $29.6 million.

As discussed above, Roth performed a variety of financial and comparative analyses for purposes of rendering its opinion. While the preceding summary describes several analyses and examinations that Roth deems material to its evaluation and opinion, they are not a comprehensive description of all analyses and examinations actually conducted by Roth.

General

Roth is a nationally recognized investment banking firm that provides financial advisory services and is continually engaged in the valuation of businesses and their securities in connection with mergers and acquisitions, negotiated underwritings, secondary distributions of listed and unlisted securities, private placements and valuations for estate, corporate and other purposes. The ThermoGenesis board of directors retained Roth to render an opinion as to the fairness, from a financial point of view, of the consideration to be received in the Merger by ThermoGenesis and its stockholders based upon the foregoing qualifications, experience and expertise.

Roth has acted as valuation and strategic advisor to ThermoGenesis in connection with the Merger for which it received a fee for its services of $150,000 that was paid upon engagement.  ThermoGenesis also paid Roth a fee of $200,000 for rendering its fairness opinion delivered in connection with the Merger. The $200,000 opinion fee was not contingent in whole or in part on the success of the Merger and related transactions, or on the conclusions reached in the opinion.  ThermoGenesis has also agreed to indemnify Roth against certain liabilities and other items that arise out of the ThermoGenesis' engagement of Roth.  ThermoGenesis' board of directors did not limit Roth in any way in the investigations it made or the procedures it followed in rendering its opinion.

Roth in the past has provided and may in the future provide investment banking and other financial services to ThermoGenesis and its affiliates for which Roth and its affiliates have received or may receive compensation.  Roth is a full service securities firm engaged in securities trading and brokerage activities, as well as providing investment banking and other financial services.  In the ordinary course of business, Roth and its affiliates may acquire, hold or sell, for their own accounts and for the accounts of customers, equity, debt and other securities and financial instruments (including bank loans and other obligations) of ThermoGenesis, and, accordingly, Roth and its affiliates may at any time hold a long or a short position in such securities.

Interests of TotipotentRX Directors and Executive Officers in the Merger

In considering the recommendation of the TotipotentRX board of directors with respect to adopting the Merger Agreement, TotipotentRX shareholders should be aware that certain members of the board of directors and executive officers of TotipotentRX have interests in the Merger that may be different from, or in addition to, interests they may have as TotipotentRX stockholders.  For example, following the consummation of the Merger, Kenneth L. Harris will serve as President and Mitchel Sivilotti will serve as Chief Biologist, Senior Vice President of the combined company.   In addition, the combined company will assume certain TotipotentRX debt in the approximate aggregate amount of $336,000 due to the Principal Stockholders through the payment of $150,000 in cash in the aggregate with the balance payable through the issuance of the combined company’s common stock.
 
For a description of the terms of Messrs. Harris’s and Sivilotti’s employment contracts, see the section entitled “Agreements Related to the Merger Agreement” on page 78.
 
TotipotentRX’s board of directors was aware of these potential conflicts of interest and considered them, among other matters, in reaching its decision to approve the Merger Agreement including the Merger and transactions contemplated thereby and to recommend that its shareholders consent to the approval of the Merger Agreement proposal contemplated by this proxy statement/prospectus/consent solicitation.
 
Effective Date of the Merger

The Merger Agreement requires the parties to consummate the Merger after all of the conditions to the consummation of the Merger contained in the Merger Agreement are satisfied or waived, including the approval of the Merger Agreement by the stockholders of ThermoGenesis and shareholders TotipotentRX.  The Merger will become effective upon the filing of a certificate of merger with the Secretary of State of the State of Delaware or at such later time as is agreed by ThermoGenesis and TotipotentRX and specified in the certificate of merger.  Neither ThermoGenesis nor TotipotentRX can predict the exact timing of the consummation of the Merger.

Regulatory Approvals

ThermoGenesis must comply with applicable federal and state securities laws in connection with the issuance of shares of ThermoGenesis common stock in the Merger and the filing of this proxy statement/prospectus/consent solicitation with the SEC.

ThermoGenesis and TotipotentRX must comply with applicable Reserve Bank of India laws specific to the Foreign Exchange Management Act in connection with the transfer of shares from a nonresident shareholder (TotipotentRX) to another nonresident shareholder (ThermoGenesis).

Tax Treatment of the Merger

ThermoGenesis and TotipotentRX intend the Merger to qualify as a reorganization within the meaning of Section 368(a) of the Internal Revenue Code of 1986, as amended, or the Code.  Each of ThermoGenesis and TotipotentRX will use its commercially reasonable best efforts to cause the Merger to qualify as a reorganization within the meaning of Section 368(a) of the Code, and not to permit or cause any affiliate or any subsidiary of ThermoGenesis or TotipotentRX to take any action or cause any action to be taken which would cause the Merger to fail to qualify as a reorganization under Section 368(a) of the Code.  For a description of the material United States federal tax consequences of the Merger, see the section entitled “Material United States Federal Income Tax Consequences of the Merger” below.
 
Material United States Federal Income Tax Consequences of the Merger

General

The following general discussion summarizes the material United States federal income tax consequences of the Merger to ThermoGenesis, TotipotentRX, and holders of TotipotentRX common stock who are “United States persons” (as defined in Section 7701(a)(30) of the Code) and who hold their TotipotentRX common stock as a capital asset within the meaning of Section 1221 of the Code.  The term “non-United States person” means a person or holder other than a “United States person.” If a partnership or other flow-through entity is a beneficial owner of TotipotentRX common stock, the tax treatment of a partner in the partnership or an owner of the entity will depend upon the status of the partner or other owner and the activities of the partnership or other entity.
This section does not discuss all of the United States federal income tax consequences that may be relevant to a particular shareholder in light of his or her individual circumstances or to shareholders subject to special treatment under the federal income tax laws, including, without limitation:

· brokers or dealers in securities or foreign currencies;
· shareholders who are subject to the alternative minimum tax provisions of the Code;
· tax-exempt organizations;
· shareholders who are “non-United States persons”;
· expatriates;
· shareholders that have a functional currency other than the United States dollar;
· banks, financial institutions or insurance companies;
· shareholders who acquired TotipotentRX stock in connection with stock option or stock purchase plans or in other compensatory transactions; or
· shareholders who hold TotipotentRX stock as part of an integrated investment, including a straddle, hedge, or other risk reduction strategy, or as part of a conversion transaction or constructive sale.

Assuming the Merger is completed according to the terms of the Merger Agreement and this proxy statement/prospectus/consent solicitation, and based upon customary assumptions and certain representations as to factual matters by ThermoGenesis and TotipotentRX, it is the opinion of Weintraub Tobin Chediak Coleman Grodin that the Merger will be treated for United States federal income tax purposes as a reorganization within the meaning of Section 368(a) of the Code.  No ruling has been or will be sought from the Internal Revenue Service, or the IRS, as to the United States federal income tax consequences of the Merger, and the following summary is not binding on the IRS or the courts.  This discussion is based upon the Code, laws, regulations, rulings and decisions in effect as of the date of this proxy statement/prospectus/consent solicitation, all of which are subject to change, possibly with retroactive effect.  This summary does not address the tax consequences of the Merger under state, local and foreign laws or under United States federal tax law other than income tax law.  There can be no assurance that the IRS will not challenge one or more of the tax consequences described herein.

TotipotentRX shareholders are urged to consult their own tax advisors as to the specific tax consequences to them of the Merger, including any applicable federal, state, local and foreign tax consequences.

The following summary sets forth the material federal income tax consequences for the TotipotentRX shareholders and the corporate parties to the Merger assuming that the Merger will constitute a “reorganization” within the meaning of Section 368(a) of the Code.

· TotipotentRX shareholders will not recognize any gain or loss upon the receipt of ThermoGenesis common stock in exchange for TotipotentRX stock in connection with the Merger (except to the extent of cash received in lieu of a fractional share of ThermoGenesis common stock, as discussed below).
· cash payments received by a TotipotentRX stockholder for a fractional share of ThermoGenesis common stock will be treated as if such fractional share had been issued in connection with the Merger and then redeemed by ThermoGenesis for cash.  TotipotentRX shareholders will recognize capital gain or loss with respect to such cash payment, measured by the difference, if any, between the amount of cash received and the tax basis in such fractional share.
· the aggregate tax basis of the ThermoGenesis common stock received by a TotipotentRX stockholder in connection with the Merger will be the same as the aggregate tax basis of the TotipotentRX stock surrendered in exchange for ThermoGenesis common stock, reduced by any amount allocable to a fractional share of ThermoGenesis common stock for which cash is received.
· the holding period of the ThermoGenesis common stock received by a TotipotentRX shareholder in connection with the Merger will include the holding period of the TotipotentRX stock surrendered in connection with the Merger.
· a dissenting shareholder who perfects appraisal rights will generally recognize gain or loss with respect to his or her shares of the TotipotentRX stock equal to the difference between the amount of cash received and his or her basis in such stock.  Such gain or loss will generally be long term capital gain or loss, provided the shares were held for more than one year before the disposition of the shares.  Interest, if any, awarded in an appraisal proceeding by a court would be included in such stockholder’s income as ordinary income.
· ThermoGenesis and TotipotentRX will not recognize gain or loss solely as a result of the Merger.

Backup Withholding

If you are a non-corporate holder of TotipotentRX stock you may be subject to information reporting and backup withholding on any cash payments received in lieu of a fractional share interest in ThermoGenesis common stock or cash payments for perfecting appraisal rights.  You will not be subject to backup withholding, however, if you:

· furnish a correct taxpayer identification number and certify that you are not subject to backup withholding on the substitute Form W-9 or successor form included in the letter of transmittal to be delivered to you following the completion of the merger (or the appropriate Form W-8, as applicable); or
· are otherwise exempt from backup withholding.

Any amounts withheld under the backup withholding rules will be allowed as a refund or credit against your United States federal income tax liability, provided you furnish the required information to the IRS.

Tax Return Reporting Requirements

If you receive ThermoGenesis common stock as a result of the Merger, you will be required to retain records pertaining to the Merger, and you will be required to file with your United States federal income tax return for the year in which the Merger takes place a statement setting forth certain facts relating to the Merger as provided in Treasury Regulations Section 1.368-3(b).

Taxable Acquisition

The failure of the Merger to qualify as a reorganization within the meaning of Section 368(a) of the Code would result in a TotipotentRX shareholder recognizing gain or loss with respect to the shares of TotipotentRX stock surrendered by such shareholder equal to the difference between the shareholder’s basis in the shares and the fair market value, as of the effective date of the Merger, of the ThermoGenesis stock received in exchange for the TotipotentRX stock (and the cash received in lieu of a fractional share of TotipotentRX stock).  In such event, a shareholder’s aggregate basis in the ThermoGenesis common stock so received would equal its fair market value and such shareholder’s holding period would begin the day after the Merger.  A dissenting shareholder who receives cash will be required to recognize gain or loss in the same manner as described above (see discussion of dissenters in a reorganization above).

The foregoing discussion is not intended to be a complete analysis or description of all potential United States federal income tax consequences of the Merger.   In addition, the discussion does not address tax consequences which may vary with, or are contingent on, your individual circumstances.  Moreover, the discussion does not address any non-income tax or any foreign, state or local tax consequences of the Merger.  Accordingly, TotipotentRX shareholders are urged to consult with their own tax advisor to determine the particular United States federal, state, local or foreign income or other tax consequences to them of the merger.

Appraisal and Dissenters’ Rights

Appraisal Rights of ThermoGenesis Stockholders

Because ThermoGenesis common stock is listed on the NASDAQ Capital Market, a National Securities Exchange, under Delaware law, holders of shares of ThermoGenesis common stock are not entitled to appraisal rights.

Dissenters’ Rights of TotipotentRX Shareholders

The following is a summary of Chapter 13 of the California General Corporate Law (CGCL), which sets forth the procedures for TotipotentRX shareholders to dissent from the Merger and to demand statutory dissenters’ rights under the CGCL, including a brief description of the procedures to be followed if a holder of TotipotentRX common stock desires to exercise dissenters’ rights. The record holders of TotipotentRX common stock who have perfected their dissenters’ rights in accordance with Chapter 13 of the CGCL and have not withdrawn their demands or otherwise lost their rights to exercise their dissenters’ rights with respect to the Merger are referred to herein as “Dissenting Shareholders,” and the shares of TotipotentRX common stock with respect to which they exercise dissenters’ rights are referred to herein as “Dissenting Shares.” This summary does not purport to be a complete statement of the provisions of California law relating to the rights of TotipotentRX shareholders to an appraisal of the value of their shares and is qualified in its entirety by reference to Chapter 13 of the CGCL, the full text of which is attached as Annex B hereto.  Please note that failure to follow the procedures required by the CGCL could result in the loss of dissenters’ rights.

If the Merger Agreement is approved by the required vote of TotipotentRX shareholders and is not abandoned or terminated, holders of TotipotentRX common stock who did not approve the Merger may, by complying with Sections 1300 through 1313 of the CGCL, be entitled to dissenters’ rights as described herein and receive cash for the fair market value of their Dissenting Shares.

Dissenting Shareholders of TotipotentRX common stock must satisfy each of the following requirements to qualify as Dissenting Shares under California law:

the Dissenting Shares must have been outstanding on December 20, 2013;
the TotipotentRX shareholder must not have voted in favor of the Merger Agreement and any proxy card submitted must have been marked to be either voted “Against” or “Abstain.”  If the TotipotentRX shareholder returns a signed proxy card without voting instructions or with instructions to vote “FOR” the Merger Agreement, his or her shares were automatically voted in favor of the Merger Agreement and they have lost their dissenters’ rights;
the Dissenting Shareholder must make a written demand that TotipotentRX repurchase the Dissenting Shares at fair market value (as described below); and
the Dissenting Shareholder must submit the Dissenting Shares certificates for endorsement (as described below).

Refusal to approve the Merger Agreement by written consent does not in and of itself constitute a demand for appraisal under California law.

Pursuant to Sections 1300 through 1313 of the CGCL, holders of Dissenting Shares may require TotipotentRX  to repurchase their Dissenting Shares at a price equal to the fair market value of such shares which shall be determined as of, and immediately prior to,  the first announcement of the terms of the proposed Merger, excluding any appreciation or depreciation in consequence of the proposed Merger, as adjusted for any stock split, reverse stock split or stock dividend that becomes effective thereafter.

Within ten days following approval of the Merger Agreement by the TotipotentRX shareholders, TotipotentRX will mail a dissenters’ notice to each person who did not vote or abstained from voting in favor of or voted against the Merger Agreement. The TotipotentRX dissenters’ notice must contain the following:
notice of the approval of the Merger Agreement;
a statement of the price determined by TotipotentRX to represent the fair market value of Dissenting Shares (which shall constitute an offer by TotipotentRX to purchase such Dissenting Shares at a stated price unless such shares lose their status as “Dissenting Shares” under Section 1309 of the CGCL);
a brief description of the procedures for Dissenting Shareholders to exercise their rights; and
a copy of Sections 1300 through 1304 of Chapter 13 of the CGCL.

Within 30 days after the date on which the dissenters’ notice was mailed by TotipotentRX to each person who did not vote or abstained from voting in favor of, or voted against, the Merger Agreement, a Dissenting Shareholder must:

demand that TotipotentRX  repurchase such shareholder’s Dissenting Shares;
include in that demand the number and class of Dissenting Shares held of record that the Dissenting Shareholder demands that TotipotentRX  purchase;
state that the Dissenting Shareholder is demanding purchase of the shares and payment of their fair market value.  The statement of fair market value constitutes an offer by the Dissenting Shareholder to sell the Dissenting Shares at such price within such 30-day period; and
submit to TotipotentRX  certificates representing any Dissenting Shares that the Dissenting Shareholder demands TotipotentRX purchase, so that such Dissenting Shares may either be stamped or endorsed with the statement that the shares are Dissenting Shares or exchanged for certificates of appropriate denomination so stamped or endorsed. The demand statement and TotipotentRX certificates should be delivered to:

TotipotentRX Corporation
Attn: Kenneth L. Harris, Chief Executive Officer
548 South Spring Street, Suite 210
Los Angeles, CA 90013

If upon the Dissenting Shareholder’s surrender of the certificates representing the Dissenting Shares, TotipotentRX and a Dissenting Shareholder agree upon the price to be paid for the Dissenting Shares and agree that such shares are Dissenting Shares, then the agreed price is required by law to be paid (with interest thereon at the legal rate on judgments from the date of the agreement) to the Dissenting Shareholder within the later of 30 days after the date of such agreement or 30 days after any statutory or contractual conditions to the completion of the Merger are satisfied.

If TotipotentRX and a Dissenting Shareholder disagree as to the price for such Dissenting Shares or disagree as to whether such shares are entitled to be classified as Dissenting Shares, such Dissenting Shareholder has the right to bring an action in California Superior Court of the proper county, within six months after the date on which the notice of the shareholders’ approval of the Merger is mailed, to resolve such dispute.  In such action, the court will determine whether the shares of TotipotentRX common stock held by such shareholder are Dissenting Shares or as to the fair market value of the holder’s shares, or both, or may intervene in any action pending on such a complaint. If the complaint is not filed or intervention in a pending action is not made within the specified six-month period, the dissenters’ rights are lost.

In determining the fair market value of the dissenting TotipotentRX shares, the court may appoint one or more impartial appraisers to make the determination. Within a time fixed by the court, the appraiser, or a majority of them, will make and file a report with the court. If the appraisers cannot determine the fair market value within ten days of their appointment, or within a longer time determined by the court, or the court does not confirm their report, then the court will determine the fair market value. The costs of the appraisal action, including reasonable compensation to the appraisers appointed by the court, will be allocated between TotipotentRX and Dissenting Shareholder as the court deems equitable.  However, if the appraisal of the fair market value of TotipotentRX shares exceeds the price offered by TotipotentRX in the notice of approval, then TotipotentRX shall pay the costs. If the fair market value of the shares awarded by the court exceeds 125.0% of the price offered by TotipotentRX, then the court may in its discretion impose additional costs on TotipotentRX, including attorneys’ fees, fees of expert witnesses and interest.
TotipotentRX shareholders considering whether to exercise dissenters’ rights should consider that the fair market value of their TotipotentRX common stock determined under Chapter 13 of the CGCL could be more than, the same as or less than the value of Merger Consideration to be paid in connection with the Merger, as set forth in the Merger Agreement. Also, TotipotentRX reserves the right to assert in any appraisal proceedings that, for purposes thereof, the fair market value of TotipotentRX common stock is less than the value of the Merger Consideration to be issued and paid in connection with the Merger, as set forth in the Merger Agreement.

Strict compliance with certain technical prerequisites is required to exercise dissenters’ rights. TotipotentRX shareholders wishing to exercise dissenters’ rights should consult with their own legal counsel in connection with compliance with Chapter 13 of the CGCL. Any TotipotentRX shareholder who fails to comply with the requirements of Chapter 13 of the CGCL, attached as Annex B to this proxy statement/prospectus/consent solicitation, will forfeit the right to exercise dissenters’ rights and will, instead, receive the Merger Consideration to be issued and paid in connection with the Merger, as set forth in the Merger Agreement.

TotipotentRX shareholders should be aware that California law provides, among other things, that a Dissenting Shareholder may not withdraw the demand for payment of the fair market value of Dissenting Shares unless TotipotentRX consents to such request for withdrawal.

IN VIEW OF THE COMPLEXITY OF THE PROVISIONS OF CALIFORNIA LAW RELATING TO DISSENTERS’ RIGHTS, ALL TOTIPOTENTRX SHAREHOLDERS THAT WISH TO EXERCISE DISSENTERS’ RIGHTS OR THAT WISH TO PRESERVE THEIR RIGHT TO DO SO SHOULD CAREFULLY REVIEW CHAPTER 13 OF THE CALIFORNIA CORPORATIONS CODE, BECAUSE FAILURE TO COMPLY WITH THE PROCEDURES SET FORTH THEREIN WILL RESULT IN THE LOSS OF SUCH RIGHTS. THOSE WISHING TO DISSENT SHOULD CONSULT WITH THEIR OWN LEGAL COUNSEL IN CONNECTION WITH COMPLIANCE UNDER CHAPTER 13.

THE MERGER AGREEMENT

The following is a summary of selected provisions of the Merger Agreement.  While ThermoGenesis and TotipotentRX believe that this description covers the material terms of the Merger Agreement, it may not contain all of the information that is important to you.  The Merger Agreement has been attached as Annex A to this proxy statement/prospectus/consent solicitation to provide you with information regarding its terms.  It is not intended to provide any other factual information about ThermoGenesis or TotipotentRX.  The following description does not purport to be complete and is qualified in its entirety by reference to the Merger Agreement.  You should refer to the full text of the Merger Agreement for details of the Merger and the terms and conditions of the Merger.

The Merger Agreement contains representations and warranties that ThermoGenesis, on the one hand, and TotipotentRX and the Principal Stockholders, on the other hand, have made to the other as of specific dates.  In your review of the representations and warranties contained in the Merger Agreement and described in this summary, it is important to bear in mind that the representations and warranties were made solely for the benefit of the parties to the Merger Agreement, and were negotiated with the principal purpose of allocating risk between the parties to the Merger Agreement, rather than establishing matters as facts. The representations and warranties may also be subject to a contractual standard of materiality that may be different from that generally relevant to stockholders or applicable to reports and documents filed with the SEC, and in some cases are qualified by confidential disclosures that were made by each party to the other, which disclosures are not reflected in the Merger Agreement or otherwise publicly disclosed. The representations and warranties in the Merger Agreement will not survive the completion of the Merger. Moreover, information concerning the subject matter of the representations and warranties may have changed since the date of the Merger Agreement and subsequent developments or new information qualifying a representation or warranty may have been included or incorporated by reference into this proxy statement/prospectus/consent solicitation. For the foregoing reasons, the representations, warranties and covenants or any descriptions of those provisions should not be read alone, but instead should be read together with the information provided elsewhere in this proxy statement/prospectus.

The Merger and Effective Date of the Merger

The Merger Agreement provides that TotipotentRX will merge with and into ThermoGenesis, with ThermoGenesis surviving the Merger.  The closing of the Merger will occur at a date as ThermoGenesis and TotipotentRX agree, but no later than the third business day after the satisfaction or waiver of the last to be satisfied or waived of the closing conditions set forth in the Merger Agreement, or at such other time, date and place as ThermoGenesis and TotipotentRX mutually agree in writing.  As soon as practicable after the closing, ThermoGenesis and TotipotentRX will fil