PROSPECTUS
SUPPLEMENT NO. 1
(to
Prospectus Dated August 30, 2006)
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Filed
Pursuant to Rule 424(b)(3)
File
No. 333-136852
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Shares
Beneficially
Owned
Prior to the Offering
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Shares
Beneficially
Owned
After Completion
Completion
of
the
Offering
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|||||||||||||||||
Selling
Stockholder
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Shares
Subject to Warrants
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Total
Shares Beneficially Owned
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Percentage
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Number
of
Shares
Being
Offered
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Number
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Percentage
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Mallette
Capital Master Fund Ltd. (1)
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0
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504,818
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2.2
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%
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139,160
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365,658
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1.6
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%
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|||||||||||
Mallette
Capital Biotech Fund L.P. (1)
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0
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220,582
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1.0
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%
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60,840
|
159,742
|
*
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||||||||||||
Perceptive
Life Sciences Master Fund,
Ltd.
(2)
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97,500
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597,500
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2.6
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%
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500,000
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97,500
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*
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||||||||||||
Warrant
Strategies Fund LLC (3)
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245,000
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245,000
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1.1
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%
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245,000
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0
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--
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Quogue
Capital LLC (4)
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11,250
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250,000
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1.1
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%
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238,750
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11,250
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*
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||||||||||||
Smithfield
Fiduciary LLC (5)
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87,500
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87,500
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*
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87,500
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0
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--
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