To better its services in structure determination of macromolecules, cells and tissues, Creative Biostructure, an uprising server in structural biology and membrane protein technologies, has recently updated its Cryo-EM services.
Shirley, United States - August 1, 2019 /MarketersMedia/ —
Creative Biostructure, a prominent supplier of cost-effective contract services in the field of structural biology, has enlarged the portfolio of its featured Cryo-EM services to better serve its global clients. Now the company is capable to provide relatively high-resolution structure samples of membrane proteins, large proteins, virions, ribosomes, complex compounds and etc.
Single crystal X-ray disffraction (SC-XRD), nuclear magnetic resonance (NMR) and cryo-electron microscopy (Cryo-EM) are three main research techniques for structural biology. According to the Protein Data Bank (PDB), although the former two techniques account for over 99% resolved protein structures, respectively over 120,000 protein structures by SC-XRD and 12,000 protein structures by NMR, Cryo-EM earns its irreplaceable place with the explosive growth of resolved structures in recent years. In a word, there is no “all-in-one” method for structure determination since all three techniques have their own advantages as well as limitations.
To better support scientists’ ultrastructure study, Creative Biostructure provides a clear work flow of Cryo-EM service process for many a hot sample types, including but are not limited: challenging membrane proteins, small proteins, virus particles, biological tissues, virus-like particles (VLP), nanomaterials, filaments, and etc. Take membrane protein as an example, the company starts from effective pasmid design, protein expression and purification, easy sample preparation, EM imaging and data processing, manual model building, to accurate refinement between the model and collected data, so as to get a closer-to-native state of protein structure.
“We could conduct a rapid freeze treatment for the prepared sample.” Says Flora Jones, Chief Research Scientist of Creative Biostrcture, “Usually we use a very small amount of sample, about 0.1 milligram, to achieve a relatively high-resolution protein 3D structure. There is no need for the proteins to crystallize.”
The company has set up an EM platform for its Cryo-EM services. The platform is facilitated with the most advanced electron microscopes equipped with direct electron detectors. Combined with its expertise in membrane protein production, the company is capable to realize the structure determination of a broad spectrum of membrane proteins such as GPCRs, within their native environment and in a variety of conformational states, even for protein targets considered as intractable for crystal studies.
Online inquiry on Creative Biostructure’s official website is available now. Please visit https://www.creative-biostructure.com/cryo-em-services_4.htm for more information. The company also welcome customized request via email or by phone.
About Creative Biostructure
The company is a credited US-based yet worldwide-radiated supplier of membrane proteins and membrane protein technologies. In supporting the development of drug discovery and development, it has set up a variety of cost-effective platforms as well as comprehensive strategies to satisfy the increasing needs of high-quality membrane proteins and high-resolution protein structures. Except for Cryo-EM sevices, the company also features in NMR services, protein crystallization and membrane protein expression.
Contact Info:
Name: Vivian Gray
Email: Send Email
Organization: Creative Biostructure
Address: 45-1 Ramsey Road, Shirley, NY 11967, USA
Phone: 6316197922
Website: https://www.creative-biostructure.com/
Source: MarketersMedia
Release ID: 88902753
