UNITED STATES
                      SECURITIES AND EXCHANGE COMMISSION
                           WASHINGTON, D.C. 20549

                             __________________


                                  FORM 8-K

                               CURRENT REPORT

                    Pursuant to Section 13 or 15(d) of the
                       Securities Exchange Act of 1934


Date of report (Date of earliest event reported)     September 18, 2006
                                                     -------------------------

                           First Bancshares, Inc.
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             (Exact Name of Registrant as Specified in Charter)

          Missouri                 0-22842                    43-1654695
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(State or Other Jurisdiction    (Commission                 (I.R.S. Employer
     of Incorporation)          File Number)               Identification No.)

 142 East First Street, Mountain Grove, Missouri                 65711
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     (Address of Principal Executive Offices)                  (Zip Code)

Registrant's telephone number, including area code   (417) 926-5151
                                                     -------------------------

Check the appropriate box below if the Form 8-K filing is intended to
simultaneously satisfy the filing obligation of the registrant under any of
the following provisions.

[ ]  Written communications pursuant to Rule 425 under the Securities Act (17
     CFR 230.425)

[ ]  Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17
     CFR 240.14a-12)

[ ]  Pre-commencement communications pursuant to Rule 14d-2(b) under the
     Exchange Act (17 CFR 240.14d-2(b))

[ ]  Pre-commencement communications pursuant to Rule 13e-4(c) under the
     Exchange Act (17 CFR 240.13e-4(c))






Item 5.02 Departure of Directors or Principal Officers; Election of Directors;
Appointment of Principal Officers.

On September 19, 2006, First Bancshares, Inc. ("Company") issued a press
release regarding the departure of Susan J. Uchtman, Chief Financial Officer
of the Company and its financial institution subsidiary, First Home Savings
Bank ("Bank"), effective immediately.  James W. Duncan will serve as the
interim Chief Financial Officer of the Company and the Bank until a qualified
replacement for Ms. Uchtman is found by the Boards of Directors of the Company
and the Bank. For further information see the Company's press release attached
hereto as Exhibit 99.1, which is incorporated herein by reference.


Item 9.01. Financial Statements and Exhibits.

      (c) Exhibits

            99.1  News Release of First Bancshares, Inc. dated September 19,
                  2006.






                                  SIGNATURES

     Pursuant to the requirements of the Securities Exchange Act of 1934, the
Registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.


Date: September 19, 2006           FIRST BANCSHARES, INC.

                                   James W. Duncan
                                   --------------------------------------
                                   James W. Duncan
                                   President and Chief Executive Officer






                                 Exhibit 99.1

                     News Release Dated September 19, 2006






                          **FOR IMMEDIATE RELEASE**

                            FIRST BANCSHARES, INC.
                   ANNOUNCES RESIGNATION OF SENIOR OFFICER

Mountain Grove, Missouri (September 19, 2006)   First Bancshares, Inc. (Nasdaq
- FstBksh: "FBSI") (the "Company"), the parent company of First Home Savings
Bank, Mountain Grove, Missouri ("Bank"), today announced that Susan J.
Uchtman, Chief Financial Officer of the Company and of the Bank has left her
positions with the Company, the Bank and its affiliated entities effective
immediately.  A qualified replacement for Ms. Uchtman is being sought by the
Boards of Directors of the Company and the Bank.   Until a qualified
replacement is found, James W. Duncan will assume Ms. Uchtman's management
duties and responsibilities.

First Home Savings Bank is an FDIC-insured savings bank chartered by the State
of Missouri that conducts business from its home office in Mountain Grove,
Missouri and tene full service branch facilities in Marshfield, Ava,
Gainesville, Sparta, Theodosia, Crane, Galena, Kissee Mills, Rockaway Beach
and Springfield, Missouri.

At June 30, 2006, First Bancshares, Inc. had consolidated total assets of
$228.4 million and stockholders' equity of $26.3 million.

Forward-looking statements:
Certain matters discussed in this press release may contain forward-looking
statements within the meaning of the Private Securities Litigation Reform Act
of 1995 and are made pursuant to the safe harbors of the PSLRA. Any such
forward-looking statements are subject to various risks and uncertainties and
are therefore qualified by First Bancshares, Inc.'s cautionary statements
contained in its filings with the Securities and Exchange Commission,
including, but not limited to Annual Reports on Form 10-KSB, Quarterly Reports
on Form 10-QSB and Current Reports on Form 8-K.   Accordingly, these factors
should be considered in evaluating forward-looking statements, and undue
reliance should not be placed on such statements.  The Company undertakes no
responsibility to update or revise any forward-looking statements.


For additional information contact James W. Duncan at (417) 926-5151.