Illumina Inc.
 

     
Prospectus Supplement
  Filed Pursuant to Rule 424(b)(7)
(To Prospectus Dated August 13, 2007)
  File No. 333-145408
(ILLUMINA LOGO)
$400,000,000 Principal Amount of 0.625% Convertible Senior Notes due 2014
and
Shares of Common Stock Issuable on Conversion of the Notes
This prospectus supplement covers resales of our 0.625% convertible senior notes due 2014, and the shares of our common stock issuable upon the conversion of the notes, by the holders of those securities. We will not receive any proceeds from the resale of the notes or shares.
This prospectus supplement supplements, and must be read in conjunction with, the prospectus, dated August 13, 2007.
Investing in the notes or the underlying shares of our common stock involves a high degree of risk. Before buying any notes or shares, you should read the discussion of material risks of investing in the notes and our common stock under the heading “Risk Factors” beginning on page 8 of the prospectus.
Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or passed upon the adequacy or accuracy of this prospectus supplement or the related prospectus. Any representation to the contrary is a criminal offense.
The date of this prospectus supplement is September 5, 2007

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Selling Securityholders
The information in the table below should be considered in addition to the information appearing in the related prospectus under the heading “Selling Securityholders” and is based on information provided to us by the selling securityholders as of September 5, 2007. If any selling securityholder identified in the table below is also identified in the table appearing in the related prospectus under the heading “Selling Securityholders,” then the information relating to that selling securityholder in the table and notes below supersedes in the corresponding information in the prospectus.
The table below sets forth information about the beneficial ownership of the notes and shares of our common stock by each holder who has timely provided us with a completed and executed notice and questionnaire stating its intent to use this prospectus supplement and the related prospectus to sell or otherwise dispose of notes or shares of our common stock that may be issuable upon conversion of the notes.
We have prepared this table using information furnished to us by or on behalf of the selling securityholders. Except as otherwise indicated below, to our knowledge, no selling securityholder or any of its affiliates, officers, directors or principal equity holders (5% or more) has held any position or office or has had any other material relationship with us or our predecessors or affiliates during the three years prior to the date of this prospectus supplement.
Our registration of the notes and the shares of our common stock that may be issued upon conversion of the notes does not mean that the selling securityholders identified below will sell all or any of these securities. In addition, the selling securityholders may have sold, transferred or disposed of all or a portion of their notes since the date on which they provided us with the information regarding their holdings, including in transactions exempt from the registration and prospectus delivery requirements of the Securities Act of 1933, as amended. The identity and holdings of the selling securityholders may change from time to time.
                                         
                    Number of     Number of Shares of  
    Principal     Number of     Shares of     Common Stock Beneficially  
    Amount of     Shares of     Common     Owned After this Offering  
    Notes     Common     Stock                
    Beneficially     Stock     Issuable             As a  
    Owned     Beneficially     upon             Percentage of  
    Before this     Owned     Conversion             Common  
    Offering that     Before this     that May be             Stock  
Name   May Be Sold     Offering1     Sold2     Number3     Outstanding4  
Argent Classic Convertible Arbitrage Fund L.P.5
  $ 1,250,000       28,628       28,628             *  
Argent Classic Convertible Arbitrage Fund Ltd.5
    9,370,000       214,600       214,600             *  
Argent Classic Convertible Arbitrage Fund II, L.P.5
    280,000       6,412       6,412             *  
Argent LowLev Convertible Arbitrage Fund Ltd.5
    1,800,000       41,225       41,225             *  
Argent LowLev Convertible Arbitrage Fund II, LLC5
    80,000       1,832       1,832             *  
Argentum Multi-Strategy Fund LP — Classic5
    60,000       1,374       1,374             *  
Argentum Multi-Strategy Fund Ltd — Classic5
    240,000       5,496       5,496             *  
Arkansas Pers6
    650,000       14,886       14,886             *  
Boilermakers Blacksmith Pension Trust6
    700,000       16,032       16,032             *  
CASAM Context Offshore Advantage Fund Ltd.7
    2,300,000       52,676       52,676             *  
Citadel Equity Fund, Ltd.8, 16, 17
    35,000,000       1,667,956       801,601       866,355       1.6 %
Class C Trading Company, Ltd5
    1,090,000       24,964       24,964             *  
Elite Classic Convertible Arbitrage Ltd.5
    600,000       13,741       13,741             *  
Forest Global Convertible Master Fund L.P.9
    3,637,000       83,297       83,297             *  

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                    Number of     Number of Shares of  
    Principal     Number of     Shares of     Common Stock Beneficially  
    Amount of     Shares of     Common     Owned After this Offering  
    Notes     Common     Stock                
    Beneficially     Stock     Issuable             As a  
    Owned     Beneficially     upon             Percentage of  
    Before this     Owned     Conversion             Common  
    Offering that     Before this     that May be             Stock  
Name   May Be Sold     Offering1     Sold2     Number3     Outstanding4  
Forest Multi Strategy Master Fund SPC, on behalf of its Multi Strategy Segregated Portfolio9
    405,000       9,275       9,275             *  
FPL Group Employees Pension Plan6
    350,000       8,016       8,016             *  
Froley Revy Alternative Strategies6
    500,000       11,451       11,451             *  
Goldman Sachs10, 15, 17
    23,550,000       539,363       539,363             *  
HFR CA Global Opportunity Master Trust9
    1,230,000       28,170       28,170             *  
HFR CA Global Select Master Trust Account5
    470,000       10,764       10,764             *  
HFR RVA Select Performance Master Trust9
    363,000       8,313       8,313             *  
Institutional Benchmarks Master Fund9
    790,000       18,093       18,093             *  
LLT Limited
    481,000       11,016       11,016             *  
Lyxor/Forest Fund Limited9
    6,324,000       144,837       144,837             *  
Lyxor Master Fund Ref: Argent/LowLev CB c/o Argent5
    820,000       18,780       18,780             *  
Partners Group Alternative Strategies PCC LTD5
    1,000,000       22,902       22,902             *  
Radcliffe SPC, Ltd. for and on behalf of the Class A Segregated Portfolio11
    12,500,000       286,286       286,286             *  
Silvercreek Limited Partnership12
    8,000,000       183,223       183,223             *  
Silvercreek II Limited12
    4,500,000       103,063       103,063             *  
Topaz Fund13, 16, 17
    2,525,000       57,829       57,829             *  
UBS O’Connor LLC F/B/O: O’Connor Global Convertible Arbitrage Master Limited14
    5,849,000       133,959       133,959             *  
UBS O’Connor LLC F/B/O: O’Connor Global Convertible Arbitrage II Master Limited14
    151,000       3,458       3,458             *  
Xavex Convertible Arbitrage 2 Fund5
    240,000       5,496       5,496             *  
Xavex Convertible Arbitrage 10 Fund5
    1,200,000       27,483       27,483             *  
 
*   Less than 1%.
 
(1)   Includes shares issuable upon conversion of the notes indicated next to such selling securityholder. See note (2) below.
 
(2)   Assumes conversion of the full amount of notes held by the selling securityholder at the rate of 22.9029 shares of our common stock per $1,000 in principal amount of the notes. This represents the theoretical maximum number of shares issuable upon conversion of the notes, disregarding the effects of any events that result in an adjustment to the conversion rate. The conversion rate and the number of shares of common stock issuable upon conversion of the notes may be adjusted under the circumstances described in the prospectus under “Description of the Notes—Conversion Rights—Conversion Rate Adjustments” and “—Adjustment to Shares Delivered upon Conversion upon Fundamental Change.” Accordingly, the number of shares of our common stock issuable upon conversion of the notes may increase or decrease from time to time. Holders will receive a cash adjustment for any fractional share amount resulting from conversion of the notes, as described in the prospectus under “Description of the Notes—Conversion Rights—Payment upon Conversion.”
 
(3)   Assumes that the selling securityholder has sold all the shares of our common stock shown as being issuable upon conversion of the notes listed next to such securityholder’s name.
 
(4)   Calculated based on 53,952,776 shares of our common stock outstanding as of July 18, 2007. In calculating this amount for a particular selling securityholder, we treated as outstanding the number of shares of our common stock issuable upon conversion of all of that holder’s notes. However, we did not assume the conversion of any other holder’s notes.
 
(5)   Nathaniel Brown and Robert Richardson share voting or dispositive powers over these securities.
 
(6)   Ann Houlihan shares voting or dispositive powers over these securities.
 
(7)   Michael S, Rosen and William D. Fertig of Context Capital Management, LLC, Investment Advisor to this selling securityholder, share voting or dispositive powers over these securities.
 
(8)   Citadel Limited Partnership (“CLP”) is the trading manager of Citadel Equity Fund Ltd. and consequently has investment discretion over securities held by Citadel Equity Fund Ltd. Citadel Investment Group, L.L.C. (“CIG”) controls CLP. Kenneth C. Griffin controls CIG and therefore has the ultimate investment discretion over securities held by Citadel Equity Fund Ltd. CLP, CIG and Mr. Griffin each disclaim beneficial ownership of the shares held by Citadel Equity Fund Ltd.
 
(9)   Forest Investment Management LLC exercises voting or dispositive power with respect to these notes and the common stock underlying the notes. Forest Investment Management LLC is wholly owned by Forest Partners II LP, the sole general partner of which is Michael A. Boyd Inc., which is controlled by Michael Boyd.
 
(10)   The Goldman Sachs Group, Inc. is the parent of Goldman Sachs & Co. Goldman, Sachs & Co. is not an affiliate of Illumina, Inc. (the term “affiliate” as used here means a person that directly or indirectly, through one or more intermediaries, controls or is controlled by or is under common control with, Illumina, Inc.). Goldman Sachs & Co. makes no other representation about any of its officers, directors or principal equity holders (5% or more) as to whether any of such persons holds or has held positions or offices in, or has or has had any material relationship with, Illumina Inc. or its predecessors or affiliates. Please see the publicly filed reports for Goldman Sachs Group, Inc. available at www.sec.gov for a list of its directors and its executive officers. Except as otherwise specifically identified in the related prospectus under the heading “Incorporation of Certain Documents by Reference,” we have not incorporated by reference into this prospectus supplement or the related prospectus the information contained in, or that can be accessed through, such website (including, without limitation, the publicly filed reports for Goldman Sachs Group, Inc.), and you should not consider it to be a part of this prospectus supplement or the related prospectus.
 
(11)   Pursuant to an investment management agreement, RG Capital Management, L.P. (“RG Capital”) serves as the investment manager of Radcliffe SPC. Ltd.’s Class A Segregated Portfolio. RGC Management Company, LLC (“Management”) is the general partner of RG Capital. Steve Katznelson and Gerald Stahlecker serve as the managing members of Management. Each of RG Capital, Management and Messrs. Katznelson and Stahlecker disclaims beneficial ownership of the securities owned by Radcliffe SPC, Ltd. for and on behalf of the Class A Segregated Portfolio.
 
(12)   Louise Morwick, Bryn Joynt and Chris Witkowski share voting or dispositive powers over these securities.
 
(13)   Robert Marx (SG Americas Securities LLC Investment Advisor) shares voting or dispositive powers over these securities.
 
(14)   This selling securityholder is a fund which cedes investment control to UBS O’Connor LLC (the Investment Manager). The Investment

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    Manager makes all the investment voting decisions. UBS O’Connor LLC is a wholly owned subsidiary of UBS AG, which is listed and traded on the NYSE.
 
(15)   This selling securityholder has identified itself as a broker-dealer that is registered under the Securities Act of 1934, as amended.
 
(16)   This selling securityholder has identified itself as an affiliate of a broker-dealer that is registered under the Securities Act of 1934, as amended.
 
(17)   This selling securityholder has represented to us that, at the time it acquired the securities, it did not have any agreements or understandings, directly or indirectly, with any person to distribute the securities.

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