SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON, DC 20549

                                  SCHEDULE 13G
                                 (Rule 13d-102)

             INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT
           TO RULES 13d-1(b)(c), AND (d) AND AMENDMENTS THERETO FILED
                            PURSUANT TO RULE 13d-2(b)

                                (Amendment No. 1)

                               EPIX Medical, Inc.
--------------------------------------------------------------------------------
                                (Name of Issuer)

                          Common Stock, $.01 par value
--------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                    26881Q101
--------------------------------------------------------------------------------
                                 (CUSIP Number)

                                December 31, 2003
--------------------------------------------------------------------------------
             (Date of Event Which Requires Filing of this Statement)

     Check the  appropriate  box to  designate  the rule  pursuant to which this
Schedule is filed:

          [_] Rule 13d-1(b)

          [X] Rule 13d-1(c)

          [_] Rule 13d-1(d)

----------
(1)  The  remainder  of this  cover  page  shall be filled  out for a  reporting
     person's  initial  filing on this form with respect to the subject class of
     securities,  and for any subsequent amendment containing  information which
     would alter the disclosures provided in a prior cover page.

     The  information  required in the remainder of this cover page shall not be
deemed to be "filed"  for the purpose of Section 18 of the  Securities  Exchange
Act of 1934 or otherwise  subject to the  liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).


CUSIP No. 26881Q101
          ---------

1.   NAME OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

     Deerfield Capital, L.P.

2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a) [_]
                                                                 (b) [X]

3.   SEC USE ONLY

4.   CITIZENSHIP OR PLACE OF ORGANIZATION

     Delaware

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH

5.   SOLE VOTING POWER

6.   SHARED VOTING POWER

     487,188

7.   SOLE DISPOSITIVE POWER

8.   SHARED DISPOSITIVE POWER

     487,188

9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     487,188

10.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

                                                                          [_]

11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

     2.21%

12.  TYPE OF REPORTING PERSON*

     PN


CUSIP No. 26881Q101
          ---------

1.   NAME OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

     Deerfield Partners, L.P.

2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a) [_]
                                                                 (b) [X]

3.   SEC USE ONLY

4.   CITIZENSHIP OR PLACE OF ORGANIZATION

     Delaware

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH

5.   SOLE VOTING POWER

6.   SHARED VOTING POWER

     487,188

7.   SOLE DISPOSITIVE POWER

8.   SHARED DISPOSITIVE POWER

     487,188

9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     487,188

10.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

                                                                          [_]

11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

     2.21%

12.  TYPE OF REPORTING PERSON*

     PN


CUSIP No. 26881Q101
          ---------

1.   NAME OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

     Deerfield Management Company

2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a) [_]
                                                                 (b) [X]

3.   SEC USE ONLY

4.   CITIZENSHIP OR PLACE OF ORGANIZATION

     New York

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH

5.   SOLE VOTING POWER

6.   SHARED VOTING POWER

     449,712

7.   SOLE DISPOSITIVE POWER

8.   SHARED DISPOSITIVE POWER

     449,712

9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     449,712

10.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

                                                                          [_]

11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

     2.04%

12.  TYPE OF REPORTING PERSON*

     PN


CUSIP No. 26881Q101
          ---------

1.   NAME OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

     Deerfield International Limited

2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a) [_]
                                                                 (b) [X]

3.   SEC USE ONLY

4.   CITIZENSHIP OR PLACE OF ORGANIZATION

     British Virgin Islands

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH

5.   SOLE VOTING POWER

6.   SHARED VOTING POWER

     449,712

7.   SOLE DISPOSITIVE POWER

8.   SHARED DISPOSITIVE POWER

     449,712

9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     449,712

10.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

                                                                          [_]

11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

     2.04%

12.  TYPE OF REPORTING PERSON*

     CO


CUSIP No. 26881Q101
          ---------

1.   NAME OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

     Arnold H. Snider

2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a) [_]
                                                                 (b) [X]

3.   SEC USE ONLY

4.   CITIZENSHIP OR PLACE OF ORGANIZATION

     United States

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH

5.   SOLE VOTING POWER

6.   SHARED VOTING POWER

     936,900

7.   SOLE DISPOSITIVE POWER

8.   SHARED DISPOSITIVE POWER

     936,900

9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     936,900

10.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

                                                                          [_]

11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

     4.25%

12.  TYPE OF REPORTING PERSON*

     IN


CUSIP No. 26881Q101
          ---------

Item 1(a).  Name of Issuer:

            EPIX Medical, Inc.

            --------------------------------------------------------------------

Item 1(b).  Address of Issuer's Principal Executive Offices:

            71 Rogers Street
            Cambridge, Massachusetts 02142

            --------------------------------------------------------------------

Item 2(a).  Name of Person Filing:

            Arnold H. Snider, Deerfield Capital, L.P., Deerfield Partners, L.P.
            Deerfield Management Company, Deerfield International Limited

            --------------------------------------------------------------------

Item 2(b).  Address of Principal Business Office, or if None, Residence:

            Arnold H. Snider, Deerfield Capital, L.P., Deerfield Partners, L.P.
            Deerfield Management Company, 780 Third Avenue, 37th Floor, New
            York, NY 10017

            Deerfield International Limited, c/o Hemisphere Management (B.V.I.)
            Limited, Bison Court, Columbus Centre, P.O. Box 3460, Road Town,
            Tortola, British Virgin Islands

            --------------------------------------------------------------------

Item 2(c).  Citizenship:

            Mr. Snider - United States citizen

            Deerfield Capital, L.P. and Deerfield Partners,
            L.P. - Delaware limited partnerships

            Deerfield Management Company - New York limited
            partnership

            Deerfield International Limited - British Virgin
            Islands corporation

            --------------------------------------------------------------------

Item 2(d).  Title of Class of Securities:

            Common Stock, $.01 par value

            --------------------------------------------------------------------

Item 2(e).  CUSIP Number:

            26881Q101

            --------------------------------------------------------------------

Item 3.     If This Statement is Filed Pursuant to Rule 13d-1(b), or 13d-2(b) or
            (c), Check Whether the Person Filing is a:

     (a)    [_]   Broker or dealer registered under Section 15 of the Exchange
                  Act.

     (b)    [_]   Bank as defined in Section 3(a)(6) of the Exchange Act.

     (c)    [_]   Insurance company as defined in Section 3(a)(19) of the
                  Exchange Act.

     (d)    [_]   Investment company registered under Section 8 of the
                  Investment Company Act.

     (e)    [_]   An investment adviser in accordance with Rule
                  13d-1(b)(1)(ii)(E);

     (f)    [_]   An employee benefit plan or endowment fund in accordance with
                  Rule 13d-1(b)(1)(ii)(F);

     (g)    [_]   A parent holding company or control person in accordance with
                  Rule 13d-1(b)(1)(ii)(G);

     (h)    [_]   A savings association as defined in Section 3(b) of the
                  Federal Deposit Insurance Act;

     (i)    [_]   A church plan that is excluded from the definition of an
                  investment company under Section 3(c)(14) of the Investment
                  Company Act;

     (j)    [_]   Group, in accordance with Rule 13d-1(b)(1)(ii)(J).

Item 4.     Ownership.

      Provide the following information regarding the aggregate number and
percentage of the class of securities of the issuer identified in Item 1.

      (a)   Amount beneficially owned:

            Deerfield Capital, L.P. and Deerfield Partners, L.P. - 487,188
            shares; Deerfield Management Company and Deerfield International
            Limited - 449,712 shares; Arnold H. Snider - 936,900 shares.

          ----------------------------------------------------------------------

      (b)   Percent of class:

            Deerfield Capital, L.P. and Deerfield Partners, L.P. - 2.21%;
            Deerfield Management Company and Deerfield International Limited -
            2.04%; Arnold H. Snider - 4.25%

            --------------------------------------------------------------------

      (c)   Number of shares as to which such person has:

            (i)   Sole power to vote or to direct the vote        0
                                                            -------------------,

            (ii)  Shared power to vote or to direct the      Deerfield Capital,
                  vote                                       L.P. and Deerfield
                                                             Partners, L.P. -
                                                             487,188;
                                                             Deerfield
                                                             Management Company
                                                             and Deerfield
                                                             International
                                                             Limited -
                                                             449,712;
                                                             Arnold H. Snider -
                                                             936,900.
                                                            -------------------,
            (iii) Sole power to dispose or to direct the          0
                  disposition of                            -------------------,

            (iv)  Shared power to dispose or to direct
                  the disposition of                         Deerfield Capital,
                                                             L.P. and Deerfield
                                                             Partners, L.P. -
                                                             487,188;
                                                             Deerfield
                                                             Management Company
                                                             and Deerfield
                                                             International
                                                             Limited  -
                                                             449,712;
                                                             Arnold H. Snider -
                                                             936,900.
                                                            -------------------.

      The Reporting Persons specifically disclaim beneficial ownership in the
securities reported herein except to the extent of their pecuniary interest
therein.

Item 5. Ownership of Five Percent or Less of a Class.

      If this statement is being filed to report the fact that as of the date
hereof the reporting person has ceased to be the beneficial owner of more than
five percent of the class of securities check the following [X].

            --------------------------------------------------------------------

Item 6. Ownership of More Than Five Percent on Behalf of Another Person.

      If any other person is known to have the right to receive or the power to
direct the receipt of dividends from, or the proceeds from the sale of, such
securities, a statement to that effect should be included in response to this
item and, if such interest relates to more than five percent of the class, such
person should be identified. A listing of the shareholders of an investment
company registered under the Investment Company Act of 1940 or the beneficiaries
of employee benefit plan, pension fund or endowment fund is not required.

            N/A

            --------------------------------------------------------------------

Item 7.     Identification and Classification of the Subsidiary Which Acquired
            the Security Being Reported on by the Parent Holding Company or
            Control Person.

      If a parent holding company or Control person has filed this schedule,
pursuant to Rule 13d-1(b)(1)(ii)(G), so indicate under Item 3(g) and attach an
exhibit stating the identity and the Item 3 classification of the relevant
subsidiary. If a parent holding company or control person has filed this
schedule pursuant to Rule 13d-1(c) or Rule 13d-1(d), attach an exhibit stating
the identification of the relevant subsidiary.

            N/A

            --------------------------------------------------------------------

Item 8. Identification and Classification of Members of the Group.

      If a group has filed this schedule pursuant to ss.240.13d-1(b)(1)(ii)(J),
so indicate under Item 3(j) and attach an exhibit stating the identity and Item
3 classification of each member of the group. If a group has filed this schedule
pursuant to ss.240.13d-1(c) or ss.240.13d-1(d), attach an exhibit stating the
identity of each member of the group.

            N/A

            --------------------------------------------------------------------

Item 9. Notice of Dissolution of Group.

      Notice of dissolution of a group may be furnished as an exhibit stating
the date of the dissolution and that all further filings with respect to
transactions in the security reported on will be filed, if required, by members
of the group, in their individual capacity. See Item 5.

            N/A

            --------------------------------------------------------------------

Item 10. Certifications.

            "By signing below I certify that, to the best of my knowledge and
            belief, the securities referred to above were not acquired and are
            not held for the purpose of or with the effect of changing or
            influencing the control of the issuer of the securities and were not
            acquired and are not held in connection with or as a participant in
            any transaction having such purpose or effect."

                                    SIGNATURE

      After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

DEERFIELD CAPITAL, L.P.

By:  Snider Capital Corp.,
     General Partner

By:  /s/ Arnold H. Snider
         ---------------------------
         Arnold H. Snider, President


DEERFIELD PARTNERS, L.P.

By:  Deerfield Capital, L.P.

By:  Snider Capital Corp.,
     General Partner

By:  /s/ Arnold H. Snider
         ---------------------------
         Arnold H. Snider, President


DEERFIELD MANAGEMENT COMPANY

By:  Snider Management Company,
     General Partner

By:  /s/ Arnold H. Snider
         ---------------------------
         Arnold H. Snider, President


DEERFIELD INTERNATIONAL LIMITED

By:  Deerfield Management Company

By:  Snider Management Company,
     General Partner

By:  /s/ Arnold H. Snider
         ----------------------------
         Arnold H. Snider, President


ARNOLD H. SNIDER

     /s/ Arnold H. Snider
         -------------------------

Date:  January 16, 2004


                                    Exhibit A

                                    Agreement

          The undersigned agree that this Schedule 13G dated January 16, 2004
relating to the Common Stock, $.01 par value of EPIX Medical, Inc. shall be
filed on behalf of the undersigned.

DEERFIELD CAPITAL, L.P.

By:  Snider Capital Corp.,
     General Partner

By:  /s/ Arnold H. Snider
         ---------------------------
         Arnold H. Snider, President


DEERFIELD PARTNERS, L.P.

By:  Deerfield Capital, L.P.

By:  Snider Capital Corp.,
     General Partner

By:  /s/ Arnold H. Snider
         ---------------------------
         Arnold H. Snider, President


DEERFIELD MANAGEMENT COMPANY

By:  Snider Management Company
     General Partner

By:  /s/ Arnold H. Snider
         ---------------------------
         Arnold H. Snider, President


DEERFIELD INTERNATIONAL LIMITED

By:  Deerfield Management Company

By:  Snider Management Company,
     General Partner

By:  /s/ Arnold H. Snider
         ---------------------------
         Arnold H. Snider, President


ARNOLD H. SNIDER

     /s/ Arnold H. Snider

00871.0001 #453781