As filed with the Securities and Exchange Commission on August 21, 2001

                                                   REGISTRATION NO. 333-
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                UNITED STATES SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

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                                    FORM S-8
                          REGISTRATION STATEMENT UNDER
                           THE SECURITIES ACT OF 1933

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                                  ARQULE, INC.
             (Exact name of registrant as specified in its charter)

          DELAWARE                                          04-3221586
(State or other jurisdiction                             (I.R.S. Employer
      of incorporation)                                 Identification No.)

                      19 PRESIDENTIAL WAY, WOBURN, MA 01801
                    (Address of Principal Executive Offices)

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                              AMENDED AND RESTATED
                        1996 EMPLOYEE STOCK PURCHASE PLAN
                            (Full Title of the Plan)

                               DR. STEPHEN A. HILL
                      President and Chief Executive Officer
                                  ArQule, Inc.
                               19 Presidential Way
                           Woburn, Massachusetts 01801
                                 (781) 994-0300
            (Name, address and telephone number of agent for service)

                                 with copies to:
                             PAUL M. KINSELLA, ESQ.
                               Palmer & Dodge LLP
                                One Beacon Street
                           Boston, Massachusetts 02108
                                 (617) 573-0100

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                         CALCULATION OF REGISTRATION FEE




----------------------------------- -------------------- -------------------- --------------------- ------------------
                                                          Proposed maximum      Proposed maximum
Title of each class of securities      Amount to be      offering price per    aggregate offering       Amount of
         to be registered            registered (1)(2)          share                price          registration fee
----------------------------------- -------------------- -------------------- --------------------- ------------------
                                                                                        

Common Stock, $0.01 par value         100,000 shares           $12.10 (3)         $1,210,000 (3)         $302.50
----------------------------------- -------------------- -------------------- --------------------- ------------------



(1)  Pursuant to Rule 416 under the Securities Act of 1933, to the extent
     additional shares of our common stock may be issued or issuable as a result
     of a stock split or other distribution declared at any time by the Board of
     Directors while this registration statement is in effect, this registration
     statement is hereby deemed to cover all such additional shares common
     stock.
(2)  This registration statement registers an additional 100,000 shares issuable
     under our Amended and Restated 1996 Employee Stock Purchase Plan. We have
     previously registered 420,000 shares under this plan (File Nos. 333-19469
     and 333-82113).
(3)  Estimated solely for the purpose of determining the registration fee and
     computed pursuant to Rule 457(h)(1). The proposed maximum offering price
     per share indicated equals the last per share sale price of ArQule common
     stock on August 16, 2001 as reported by the Nasdaq National Market.





                                     PART II

               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT


STATEMENT REGARDING INCORPORATION OF INFORMATION BY REFERENCE FROM EFFECTIVE
REGISTRATION STATEMENTS

         This Registration Statement registers additional securities of the same
class as other securities for which a registration statement filed on Form S-8
relating to our Amended and Restated 1996 Employee Stock Purchase Plan is
already effective. Pursuant to General Instruction E of this Form, the contents
of (i) our Registration Statement on Form S-8 (File No. 333-19469) filed with
the Securities and Exchange Commission on January 9, 1997, including exhibits
thereto, relating to the registration of 120,000 shares of our common stock
authorized for issuance under our Amended and Restated 1996 Employee Stock
Purchase Plan, and (ii) our Registration Statement on Form S-8 (Registration No.
333-82113) filed with the Securities and Exchange Commission on July 1, 1999,
including exhibits thereto, relating to the registration of 300,000 shares of
our common stock authorized for issuance under our Amended and Restated 1996
Employee Stock Purchase Plan, are incorporated by reference in their entirety in
this registration statement. This registration statement provides for the
registration of an additional 100,000 shares of our common stock authorized for
issuance under our Amended and Restated 1996 Employee Stock Purchase Plan.


ITEM 8

         See Exhibit Index immediately following the signature page.







                                   SIGNATURES

         Pursuant to the requirements of the Securities Act of 1933, the
Registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-8 and has duly caused this Registration
Statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of Woburn, Commonwealth of Massachusetts, on this 21st
day of August, 2001.

                                        ARQULE, INC.


                                        By: /s/ Stephen A. Hill
                                           -------------------------------------
                                           Stephen A. Hill
                                           President and Chief Executive Officer


                                POWER OF ATTORNEY

         We, the undersigned officers and directors of ArQule, Inc., hereby
severally constitute and appoint Stephen A. Hill, David C. Hastings, and Paul M.
Kinsella, and each of them singly, our true and lawful attorneys-in-fact, with
full power to them in any and all capacities, to sign any and all amendments to
this Registration Statement on Form S-8 (including any post-effective amendments
thereto), and to file the same, with exhibits thereto and other documents in
connection therewith, with the Securities and Exchange Commission, hereby
ratifying and confirming all that each of said attorneys-in-fact may do or cause
to be done by virtue hereof.

         Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed below by the following persons in the
capacities and on the dates indicated:





             SIGNATURE                                       TITLE                              DATE

                                                                                     

/s/  Stephen A. Hill                                Principal Executive                    August 21, 2001
----------------------------------------            Officer and Director
Stephen A. Hill

/s/ David C. Hastings                               Principal Financial and                August 21, 2001
----------------------------------------            Accounting Officer
David C. Hastings

/s/ Laura Avakian                                   Director                               August 21, 2001
----------------------------------------
Laura Avakian

/s/ Werner Cautreels                                Director                               August 21, 2001
----------------------------------------
Werner Cautreels

/s/ Ariel Elia                                      Director  (Chairman)                   August 21, 2001
----------------------------------------
Ariel Elia

/s/ L. Patrick Gage                                 Director                               August 21, 2001
----------------------------------------
L. Patrick Gage

/s/ Tuan Ha-Ngoc                                    Director                               August 21, 2001
----------------------------------------
Tuan Ha-Ngoc

/s/  Michael Rosenblatt                             Director                               August 21, 2001
----------------------------------------
Michael Rosenblatt







                                  EXHIBIT INDEX




      EXHIBIT NUMBER            DESCRIPTION
      --------------            -----------
                         

            5               Opinion of Palmer & Dodge LLP.  Filed herewith.
           23.1             Consent of PricewaterhouseCoopers LLP.  Filed herewith.
           23.2             Consent of Palmer & Dodge LLP (contained in Exhibit 5).
           99.1             Amended and Restated 1996 Employee Stock Purchase Plan.  Filed herewith.