UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549


                                  SCHEDULE 13G
                                (Amendment No. 1)


                    Under the Securities Exchange Act of 1934




                                  NANOGEN, INC.
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                                (Name of Issuer)


                    Common Stock, par value $0.001 per share
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                         (Title of Class of Securities)


                                    630075109
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                                 (CUSIP Number)


                               December 31, 2005
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             (Date of Event Which Requires Filing of this Statement)


Check the  appropriate box to designate the rule pursuant to which this Schedule
13G is filed:

                [ ] Rule 13d-1(b)
                [X] Rule 13d-1(c)
                [ ] Rule 13d-1(d)


*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for any  subsequent  amendment  containing  information  which  would  alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions of  the Act  (however, see  the
Notes).





CUSIP No.  630075109
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(1)     Names of Reporting Persons.  I.R.S. Identification Nos. of Above Persons
        (entities only):

                Fort Mason Capital, LLC
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(2)     Check the Appropriate Box if a Member of a Group (See Instructions)

          (a)                            (b)
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(3)     SEC Use Only
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(4)     Citizenship or Place of Organization:  Delaware
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Number of Shares Beneficially Owned
   by Each Reporting Person With       (5) Sole Voting Power:        5,312,660*
                                           -------------------------------------
                                       (6) Shared Voting Power:              0
                                           -------------------------------------
                                       (7) Sole Dispositive Power:   5,312,660*
                                           -------------------------------------
                                       (8) Shared Dispositive Power:         0
                                           -------------------------------------
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(9)     Aggregate Amount Beneficially Owned by Each Reporting Person:
                5,312,660*
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(10)    Check if  the Aggregate Amount  in Row (9) Excludes Certain  Shares (See
        Instructions):   N/A
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(11)    Percent of Class Represented by Amount in Row (9):   9.7%*
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(12)    Type of Reporting Person (See Instructions):    IA
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*  As of December 31, 2005,  Fort Mason  Master,  LP, a Cayman  Islands  limited
partnership  ("Master"),  and  Fort  Mason  Partners,  LP,  a  Delaware  limited
partnership  ("Partners" and,  together with Master,  the "Funds"),  held in the
aggregate  4,547,354 shares of the common stock, par value $0.001 per share (the
"Shares"),  of  Nanogen,  Inc.,  a Delaware  corporation  (the  "Company"),  and
warrants  that  entitle  the Funds to  purchase  up to an  aggregate  of 765,306
additional  Shares at an exercise price of $4.00 per share.  Fort Mason Capital,
LLC, a Delaware limited liability company ("Capital"),  serves as the investment
manager of the Funds and possesses sole power to vote and direct the disposition
of all  securities  of the Company held by the Funds.  Thus,  as of December 31,
2005,  for  the  purposes  of Reg.  Section  240.13d-3,  Capital  is  deemed  to
beneficially  own  5,312,660  Shares,  or 9.7% of the Shares  deemed  issued and
outstanding as of that date.





Item 1(a).  Name Of Issuer.  Nanogen, Inc.

Item 1(b).  Address of Issuer's Principal Executive Offices.
            10398 Pacific Center Court, San Diego, CA 92121


Item 2(a).  Name of Person Filing.  Fort Mason Capital, LLC

Item 2(b).  Address of Principal Business Office or, if None, Residence.
            456 Montgomery Street, 22nd Floor,  San Francisco, CA 94104

Item 2(c).  Citizenship. Fort Mason Capital, LLC is a Delaware limited liability
            company

Item 2(d).  Title of Class of Securities.  Common Stock,  par value  $0.001  per
            share

Item 2(e).  CUSIP No.   630075109


Item 3.     If  This  Statement Is  Filed  Pursuant  to Sections 240.13d-1(b) or
            240.13d-2(b) or (c), Check Whether the Person Filing is a:

            Not Applicable.


Item 4.     Ownership

            (a) Amount Beneficially Owned (as of December 31, 2005)   5,312,660*

            (b) Percent of Class (as of December 31, 2005)             9.7%*

            (c) Number of Shares as to which the person has:

               (i)   sole power to vote or to direct the vote         5,312,660*

               (ii)  shared power to vote or to direct the vote               0*

               (iii) sole power to dispose or to direct the
                     disposition of                                   5,312,660*

               (iv)  shared power to dispose or to direct the
                     disposition of                                           0*


*  As of December 31, 2005,  Fort Mason  Master,  LP, a Cayman  Islands  limited
partnership  ("Master"),  and  Fort  Mason  Partners,  LP,  a  Delaware  limited
partnership  ("Partners" and,  together with Master,  the "Funds"),  held in the
aggregate  4,547,354 shares of the common stock, par value $0.001 per share (the
"Shares"),  of  Nanogen,  Inc.,  a Delaware  corporation  (the  "Company"),  and
warrants  that  entitle  the Funds to  purchase  up to an  aggregate  of 765,306
additional  Shares at an exercise price of $4.00 per share.  Fort Mason Capital,
LLC, a Delaware limited liability company ("Capital"),  serves as the investment
manager of the Funds and possesses sole power to vote and direct the disposition
of all  securities  of the Company held by the Funds.  Thus,  as of December 31,
2005,  for  the  purposes  of Reg.  Section  240.13d-3,  Capital  is  deemed  to
beneficially  own  5,312,660  Shares,  or 9.7% of the Shares  deemed  issued and
outstanding as of that date.





Item 5.  Ownership of Five Percent or Less of a Class.

         Not Applicable.


Item 6.  Ownership of More Than Five Percent on Behalf of Another Person.

         Not Applicable.


Item 7.  Identification  and  Classification  of the  Subsidiary  Which Acquired
         the Security Being Reported on by the Parent Holding Company.

         Not Applicable.


Item 8.  Identification and Classification of Members of the Group.

         Not Applicable.


Item 9.  Notice of Dissolution of Group.

         Not Applicable.


Item 10.  Certification.

          By  signing  below I certify  that,  to the best of my  knowledge  and
belief, the securities  referred to above were not acquired and are not held for
the purpose of or with the effect of changing or influencing  the control of the
issuer of such securities  and were not acquired and are not held in  connection
with or as a participant in any transaction having that purpose or effect.


                                    SIGNATURE


         After reasonable inquiry and to the best of my knowledge and  belief, I
certify that the information  set forth in this statement is  true, complete and
correct.


                                             January 23, 2006


                                             FORT MASON CAPITAL, LLC

                                             By:/s/Dan German
                                                --------------------------------
                                                Name:  Dan German
                                                Title:  Managing Member


      Attention: Intentional misstatements or omissions of fact constitute
                Federal criminal violations (See 18 U.S.C. 1001)