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                                UNITED STATES
                      SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C. 20549

                                 SCHEDULE 13G

                  Under the Securities Exchange Act of 1934
                              (Amendment No. 1)*



                        ALEXION PHARMACEUTICALS, INC.
                               (Name of Issuer)


                                 Common Stock
                        (Title of Class of Securities)


                                  015351109
                                (CUSIP Number)


                              November 30, 2005
           (Date of Event Which Requires Filing of this Statement)


Check the appropriate box to designate the rule pursuant to which this
Schedule is filed:
[ X ] Rule 13d-1(b)
[   ] Rule 13d-1(c)
[   ] Rule 13d-1(d)



*The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which
would alter the disclosures provided in a prior cover page.


The information required in the remainder of this cover page shall not be
deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934 ("Act") or otherwise subject to the liabilities of that section
of the Act but shall be subject to all other provisions of the Act (however,
see the Notes).




     1. Names of Reporting Persons.
I.R.S. Identification Nos. of above persons (entities only).
Federated Investors, Inc.


2.  Check the Appropriate Box if a Member of a Group (See Instructions)


(a)

(b)


3. SEC Use Only


4. Citizenship or Place of Organization
      Pennsylvania


Number of
Shares
Beneficially
Owned by
Each Reporting
Person With
5. Sole Voting Power  2,403


6. Shared Voting Power

7. Sole Dispositive Power  2,403

8. Shared Dispositive Power

9. Aggregate Amount Beneficially Owned by Each Reporting Person  2,403

10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See
Instructions)

11. Percent of Class Represented by Amount in Row (9)  .01%

12. Type of Reporting Person (See Instructions) HC




     1. Names of Reporting Persons.
I.R.S. Identification Nos. of above persons (entities only).

Voting Shares Irrevocable Trust


2.  Check the Appropriate Box if a Member of a Group (See Instructions)


(a)

(b)


3. SEC Use Only


4. Citizenship or Place of Organization
      Pennsylvania


Number of
Shares
Beneficially
Owned by
Each Reporting
Person With
5. Sole Voting Power  2,403


6. Shared Voting Power


7. Sole Dispositive Power  2,403


8. Shared Dispositive Power


9. Aggregate Amount Beneficially Owned by Each Reporting Person  2,403


10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See
Instructions)

11. Percent of Class Represented by Amount in Row (9)  .01%


12. Type of Reporting Person (See Instructions) OO



     1. Names of Reporting Persons.
I.R.S. Identification Nos. of above persons (entities only).

John F. Donahue


2.  Check the Appropriate Box if a Member of a Group (See Instructions)


(a)

(b)


3. SEC Use Only


4. Citizenship or Place of Organization
      United States


Number of
Shares
Beneficially
Owned by
Each Reporting
Person With
5. Sole Voting Power


6. Shared Voting Power  2,403


7. Sole Dispositive Power


8. Shared Dispositive Power  2,403


9. Aggregate Amount Beneficially Owned by Each Reporting Person  2,403


10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See
Instructions)

11. Percent of Class Represented by Amount in Row (9)  .01%


12. Type of Reporting Person (See Instructions) IN



     1. Names of Reporting Persons.
I.R.S. Identification Nos. of above persons (entities only).

Rhodora J. Donahue


2.  Check the Appropriate Box if a Member of a Group (See Instructions)


(a)

(b)


3. SEC Use Only


4. Citizenship or Place of Organization
      United States


Number of
Shares
Beneficially
Owned by
Each Reporting
Person With
5. Sole Voting Power


6. Shared Voting Power  2,403


7. Sole Dispositive Power


8. Shared Dispositive Power  2,403


9. Aggregate Amount Beneficially Owned by Each Reporting Person  2,403


10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See
Instructions)

11. Percent of Class Represented by Amount in Row (9) .01%

12. Type of Reporting Person (See Instructions) IN



     1. Names of Reporting Persons.
I.R.S. Identification Nos. of above persons (entities only).
J. Christopher Donahue


2.  Check the Appropriate Box if a Member of a Group (See Instructions)


(a)

(b)


3. SEC Use Only


4. Citizenship or Place of Organization
      United States


Number of
Shares
Beneficially
Owned by
Each Reporting
Person With
5. Sole Voting Power


6. Shared Voting Power  2,403


7. Sole Dispositive Power


8. Shared Dispositive Power  2,403


9. Aggregate Amount Beneficially Owned by Each Reporting Person  2,403


10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See
Instructions)

11. Percent of Class Represented by Amount in Row (9) .01%


12. Type of Reporting Person (See Instructions) IN


INSTRUCTIONS FOR SCHEDULE 13G

Instructions for Cover Page
(l) Names and I.R.S. Identification Numbers of Reporting Persons-Furnish the
full legal name of each person for whom the report is filed-i.e., each person
required to sign the schedule itself-including each member of a group. Do not
include the name of a person required to be identified in the report but who
is not a reporting person. Reporting persons that are entities are also
requested to furnish their I.R.S. identification numbers, although disclosure
of such numbers is voluntary, not mandatory (see "SPECIAL INSTRUCTIONS FOR
COMPLYING WITH SCHEDULE 13G" below).

(2) If any of the shares beneficially owned by a reporting person are held as
a member of a group and that membership is expressly affirmed, please check
row 2(a). If the reporting person disclaims membership in a group or
describes a relationship with other persons but does not affirm the existence
of a group, please check row 2(b) [unless it is a joint filing pursuant to
Rule 13d1(k)(1) in which case it may not be necessary to check row 2(b)].

(3) The third row is for SEC internal use; please leave blank.

(4) Citizenship or Place of Organization-Furnish citizenship if the named
reporting person is a natural person. Otherwise, furnish place of
organization.

(5)-(9), (11) Aggregate Amount Beneficially Owned By Each Reporting Person,
Etc.-Rows (5) through (9) inclusive, and (11) are to be completed in
accordance with the provisions of Item 4 of Schedule 13G. All percentages are
to be rounded off to the nearest tenth (one place after decimal point).

(10) Check if the aggregate amount reported as beneficially owned in row (9)
does not include shares as to which beneficial ownership is disclaimed
pursuant to Rule 13d-4 (17 CFR 240.13d-4] under the Securities Exchange Act
of 1934.

(12) Type of Reporting Person-Please classify each "reporting person"
according to the following breakdown (see Item 3 of Schedule 13G) and place
the appropriate symbol on the form:
Category Symbol
Broker Dealer  BD
Bank  BK
Insurance Company  IC
Investment Company  IV
Investment Adviser  IA
Employee Benefit Plan, Pension Fund, or Endowment Fund  EP
Parent Holding Company/Control Person  HC
Savings Association  SA
Church Plan  CP
Corporation  CO
Partnership  PN
Individual  IN
Other  OO


Notes: Attach as many copies of the second part of the cover page as are
needed, one reporting person per page.

Filing persons may, in order to avoid unnecessary duplication, answer items
on the schedules (Schedule 13D, 13G or 14D1) by appropriate cross references
to an item or items on the cover page(s). This approach may only be used
where the cover page item or items provide all the disclosure required by the
schedule item. Moreover, such a use of a cover page item will result in the
item becoming a part of the schedule and accordingly being considered as
"filed" for purposes of Section 18 of the Securities Exchange Act or
otherwise subject to the liabilities of that section of the Act.


Reporting persons may comply with their cover page filing requirements by
filing either completed copies of the blank forms available from the
Commission, printed or typed facsimiles, or computer printed facsimiles,
provided the documents filed have identical formats to the forms prescribed
in the Commission's regulations and meet existing Securities Exchange Act
rules as to such matters as clarity and size (Securities Exchange Act Rule
12b-12).


SPECIAL INSTRUCTIONS FOR COMPLYING WITH SCHEDULE 13G

Under Sections 13(d), 13(g), and 23 of the Securities Exchange Act of 1934
and the rules and regulations thereunder, the Commission is authorized to
solicit the information required to be supplied by this schedule by certain
security holders of certain issuers.

Disclosure of the information specified in this schedule is mandatory, except
for I.R.S. identification numbers, disclosure of which is voluntary. The
information will be used for the primary purpose of determining and
disclosing the holdings of certain beneficial owners of certain equity
securities. This statement will be made a matter of public record. Therefore,
any information given will be available for inspection by any member of the
public.

Because of the public nature of the information, the Commission can use it
for a variety of purposes, including referral to other governmental
authorities or securities self-regulatory organizations for investigatory
purposes or in connection with litigation involving the Federal securities
laws or other civil, criminal or regulatory statutes or provisions. I.R.S.
identification numbers, if furnished, will assist the Commission in
identifying security holders and, therefore, in promptly processing
statements of beneficial ownership of securities.

Failure to disclose the information requested by this schedule, except for
I.R.S. identification numbers, may result in civil or criminal action against
the persons involved for violation of the Federal securities laws and rules
promulgated thereunder.

GENERAL INSTRUCTIONS

A. Statements filed pursuant to Rule 13d-1(b) containing the information
required by this schedule shall be filed not later than February 14 following
the calendar year covered by the statement or within the time specified in
Rules 13d-1(b)(2) and 13d2(c). Statements filed pursuant to Rule 13d-1(c)
shall be filed within the time specified in Rules 13d-1(c), 13d-2(b) and
13d-2(d). Statements filed pursuant to Rule 13d-1(d) shall be filed not later
than February 14 following the calendar year covered by the statement
pursuant to Rules 13d-1(d) and 13d-2(b).

B. Information contained in a form which is required to be filed by rules
under section 13(f) (15 U.S.C. 78m(f)) for the same calendar year as that
covered by a statement on this schedule may be incorporated by reference in
response to any of the items of this schedule. If such information is
incorporated by reference in this schedule, copies of the relevant pages of
such form shall be filed as an exhibit to this schedule.

C. The item numbers and captions of the items shall be included but the text
of the items is to be omitted. The answers to the items shall be so prepared
as to indicate clearly the coverage of the items without referring to the
text of the items. Answer every item. If an item is inapplicable or the
answer is in the negative, so state.


Item 1.


(a) Name of Issuer
Alexion Pharmaceuticals,Inc.

(b) Address of Issuer's Principal Executive Offices
352 Knotter Drive
Cheshire, CT 06410

Item 2.

(a) Name of Person Filing SEE ROW 1 OF COVER PAGES


(b) Address of Principal Business Office or, if none, Residence
Federated Investors Tower, Pittsburgh, PA 15222-3779

(c) Citizenship SEE ROWS 1 AND 4 OF COVER PAGES


(d) Title of Class of Securities
Common stock

(e) CUSIP Number 015351109



Item 3. If this statement is filed pursuant to ss.ss.240.13d-1(b) or 
240.13d-2(b) or (c), check whether the person filing is a:

 (a) [   ] Broker or dealer registered under section 15 of the Act (15 U.S.C.
78o).

 (b) [   ] Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c).

 (c) [   ] Insurance company as defined in section 3(a)(19) of the Act (15
U.S.C. 78c).

 (d) [   ] Investment company registered under section 8 of the Investment
Company Act of 1940 (15 U.S.C 80a-8).

 (e) [   ] An investment adviser in accordance with ss.240.13d-1(b)(1)(ii)(E);

 (f) [   ] An employee benefit plan or endowment fund in accordance with
ss.240.13d-1(b)(1)(ii)(F);

 (g) [ X ] A parent holding company or control person in accordance with ss.
240.13d-1(b)(1)(ii)(G);

 (h) [   ] A savings associations as defined in Section 3(b) of the Federal
Deposit Insurance Act (12 U.S.C. 1813);

 (i) [   ] A church plan that is excluded from the definition of an
investment company under section 3(c)(14) of the Investment Company Act of
1940 (15 U.S.C. 80a-3);

 (j) [   ] Group, in accordance with ss.240.13d-1(b)(1)(ii)(J).




Item 4. Ownership.

Provide the following information regarding the aggregate number and
percentage of the class of securities of the issuer identified in Item 1.

A.    Federated Investors, Inc. (See Footnote 1, next page)
 (a) Amount beneficially owned: 2,403

 (b) Percent of class: .01%

 (c) Number of shares as to which the person has:

 (i) Sole power to vote or to direct the vote 2,403

 (ii) Shared power to vote or to direct the vote -0-

 (iii) Sole power to dispose or to direct the disposition of 2,403

 (iv) Shared power to dispose or to direct the disposition of -0-

B.    Voting Shares Irrevocable Trust
 (a) Amount beneficially owned: 2,403

 (b) Percent of class: .01%

 (c) Number of shares as to which the person has:

 (i) Sole power to vote or to direct the vote 2,403

 (ii) Shared power to vote or to direct the vote -0-

 (iii) Sole power to dispose or to direct the disposition of 2,403

 (iv) Shared power to dispose or to direct the disposition of -0-

C.    John F. Donahue
 (a) Amount beneficially owned: 2,403

 (b) Percent of class: .01%

 (c) Number of shares as to which the person has:

 (i) Sole power to vote or to direct the vote -0-

 (ii) Shared power to vote or to direct the vote 2,403

 (iii) Sole power to dispose or to direct the disposition of -0-

 (iv) Shared power to dispose or to direct the disposition of 2,403

D.    Rhodora J. Donahue
 (a) Amount beneficially owned: 2,403

 (b) Percent of class: .01%

 (c) Number of shares as to which the person has:

 (i) Sole power to vote or to direct the vote -0-

 (ii) Shared power to vote or to direct the vote 2,403

 (iii) Sole power to dispose or to direct the disposition of -0-

 (iv) Shared power to dispose or to direct the disposition of 2,403

E.    J. Christopher Donahue
 (a) Amount beneficially owned: 2,403

 (b) Percent of class: .01%

 (c) Number of shares as to which the person has:

 (i) Sole power to vote or to direct the vote -0-

 (ii) Shared power to vote or to direct the vote 2,403

 (iii) Sole power to dispose or to direct the disposition of -0-

 (iv) Shared power to dispose or to direct the disposition of 2,403


Instruction. For computations regarding securities which represent a right to
acquire an underlying security see ss.240.13d3(d)(1).



Item 5. Ownership of Five Percent or Less of a Class

If this statement is being filed to report the fact that as of the date
hereof the reporting person has ceased to be the beneficial owner of more
than five percent of the class of securities, check the following [ X ].

Instruction: Dissolution of a group requires a response to this item.

Item 6. Ownership of More than Five Percent on Behalf of Another Person.
NOT APPLICABLE

Item 7. Identification and Classification of the Subsidiary Which Acquired
the Security Being Reported on By the Parent Holding Company or Control
Person.
SEE EXHIBIT "1" ATTACHED

Item 8. Identification and Classification of Members of the Group
NOT APPLICABLE


Item 9. Notice of Dissolution of Group
NOT APPLICABLE


Item 10. Certification

 (a) The following certification shall be included if the statement is filed
pursuant to ss.240.13d-1(b):

By signing below I certify that, to the best of my knowledge and belief, the
securities referred to above were acquired and are held in the ordinary
course of business and were not acquired and are not held for the purpose of
or with the effect of changing or influencing the control of the issuer of
the securities and were not acquired and are not held in connection with or
as a participant in any transaction having that purpose or effect.

(b) The following certification shall be included if the statement is filed
pursuant to ss.240.13d-1(c):

By signing below I certify that, to the best of my knowledge and belief, the
securities referred to above were not acquired and are not held for the
purpose of or with the effect of changing or influencing the control of the
issuer of the securities and were not acquired and are not held in connection
with or as a participant in any transaction having that purpose or effect.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete
and correct.

Date:  December 9, 2005
By: /s/J. Christopher Donahue
Name/Title:  J. Christopher Donahue, as President of Federated Investors, Inc.

By: /s/John F. Donahue
Name/Title:  John F. Donahue, individually and as Trustee of Voting Shares
Irrevocable Trust, by J. Christopher Donahue, as attorney-in-fact

By: /s/Rhodora J. Donahue
Name/Title:  Rhodora J. Donahue, individually and as Trustee of Voting Shares
Irrevocable Trust, by J. Christopher Donahue, as attorney-in-fact

By: /s/J. Christopher Donahue
Name/Title:  J. Christopher Donahue, individually and as Trustee of Voting
Shares Irrevocable Trust




The original statement shall be signed by each person on whose behalf the
statement is filed or his authorized representative. If the statement is
signed on behalf of a person by his authorized representative other than an
executive officer or general partner of the filing person, evidence of the
representative's authority to sign on behalf of such person shall be filed
with the statement, provided, however, that a power of attorney for this
purpose which is already on file with the Commission may be incorporated by
reference. The name and any title of each person who signs the statement
shall be typed or printed beneath his signature.

NOTE: Schedules filed in paper format shall include a signed original and
five copies of the schedule, including all exhibits. See ss.240.13d-7 for other
parties for whom copies are to be sent.

Attention: Intentional misstatements or omissions of fact constitute Federal
criminal violations
(See 18 U.S.C. 1001)

                                 EXHIBIT "1"

                           ITEM 3 CLASSIFICATION OF
                              REPORTING PERSONS
             Identity and Classification of Each Reporting Person


IDENTITY                                  CLASSIFICATION UNDER ITEM 3

Federated Index Trust                     (d) Investment company registered
                                          under section 8 of the Investment 
                                          Company Act of 1940 (15 U.S.C. 80a-8).

Federated Equity Management Company       (e) Investment Adviser registered
                                          under of Pennsylvania section 203 of 
                                          the Investment Advisers Act of 1940

Federated Global Investment               (e) Investment Adviser registered
                                          under Management Corp. section 203 of
                                          the Investment Advisers Act of 1940

Federated Investors, Inc.                 (g) Parent Holding Company, in
                                          accordance with Section
                                          240.13d-1(b)(ii)(G)

FII Holdings, Inc.                        (g) Parent Holding Company, in
                                          accordance with Section
                                          240.13d-1(b)(ii)(G)

Voting Shares Irrevocable Trust           (g) Parent Holding Company, in
                                          accordance with Section
                                          240.13d-1(b)(ii)(G)

John F. Donahue                           (g) Parent Holding Company, in
                                          accordance with Section
                                          240.13d-1(b)(ii)(G)

Rhodora J. Donahue                        (g) Parent Holding Company, in
                                          accordance with Section
                                          240.13d-1(b)(ii)(G)

J. Christopher Donahue                    (g) Parent Holding Company, in
                                          accordance with Section
                                          240.13d-1(b)(ii)(G)

Federated Investors, Inc. (the "Parent") is filing this Schedule 13G because
it is the parent holding company of Federated Equity Management Company of
Pennsylvania and Federated Global Investment Management Corp. (the
"Investment Advisers"), which act as investment advisers to registered
investment companies and separate accounts that own shares of common stock in
Alexion Pharmaceuticals, Inc. (the "Reported Securities').  The Investment
Advisers are wholly owned subsidiaries of FII Holdings, Inc., which is wholly
owned subsidiary of Federated Investors, Inc., the Parent.  All of the
Parent's outstanding voting stock is held in the Voting Shares Irrevocable
Trust (the "Trust") for which John F. Donahue, Rhodora J. Donahue and J.
Christopher Donahue act as trustees (collectively, the "Trustees").  The
Trustees have joined in filing this Schedule 13G because of the collective
voting control that they exercise over the Parent.  In accordance with Rule
13d-4 under the Securities Act of 1934, as amended, the Parent, the Trust,
and each of the Trustees declare that this statement should not be construed
as an admission that they are the beneficial owners of the Reported
Securities, and the Parent, the Trust, and each of the Trustees expressly
disclaim beneficial ownership of the Reported Securities


                                 EXHIBIT "2"

                        AGREEMENT FOR JOINT FILING OF

                                 SCHEDULE 13G

      The following parties hereby agree to file jointly the statement on
Schedule 13G to which this Agreement is attached and any amendments thereto
which may be deemed necessary pursuant to Regulation 13D-G under the
Securities Exchange Act of 1934:

      1.    Federated Investors, Inc. as parent holding company of the
investment advisers to registered investment companies that beneficially own
the securities.

Voting Shares Irrevocable Trust, as holder of all the voting shares of
Federated Investors, Inc.

John F. Donahue, individually and as Trustee

Rhodora J. Donahue, individually and as Trustee

J. Christopher Donahue, individually and as Trustee

      It is understood and agreed that each of the parties hereto is
responsible for the timely filing of such statement and any amendments
thereto, and for the completeness and accuracy of the information concerning
such party contained therein, but such party is not responsible for the
completeness or accuracy of information concerning the other parties unless
such party knows or has reason to believe that such information is incomplete
or inaccurate.

      It is understood and agreed that the joint filing of Schedule 13G shall
not be construed as an admission that the reporting persons named herein
constitute a group for purposes of Regulation 13D-G of the Securities
Exchange Act of 1934, nor is a joint venture for purposes of the Investment
Company Act of 1940.

Date:       December 9, 2005

By:   /s/J. Christopher Donahue
Name/Title: J. Christopher Donahue, as President of Federated Investors, Inc.

By:   /s/ J. Christopher Donahue
Name/Title: John F. Donahue, individually and as Trustee of Voting Shares
Irrevocable Trust, by J. Christopher Donahue, as attorney-in-fact.

By:   /s/   Rhodora J. Donahue
Name/Title: Rhodora J. Donahue, individually and as Trustee as Voting Shares
Irrevocable Trust, by J. Christopher Donahue, as attorney-in-fact.

By:   /s/   J. Christopher Donahue
Name/Title: J. Christopher Donahue, individually and as Trustee of Voting
Shares Irrevocable Trust

1.    The number of shares indicated represent shares beneficially owned by
      registered investment companies and separate accounts advised by
      subsidiaries of Federated Investors, Inc. that have been delegated the
      power to direct investments and power to vote the securities by the
      registered investment companies' board of trustees or directors and by
      the separate accounts' principals.  All of the voting securities of
      Federated Investors, Inc. are held in the Voting Shares Irrevocable
      Trust ("Trust"), the trustees of which are John F. Donahue, Rhodora J.
      Donahue, and J. Christopher Donahue ("Trustees').  In accordance with
      Rule 13d-4 under the 1934 Act, the Trust, Trustees, and parent holding
      company declare that the filing of this statement should not be
      construed as an admission that any of the investment advisers, parent
      holding company, Trust, and Trustees are beneficial owners (for the
      purposes of Sections 13(d) and/or 13(g) of the Act) of any securities
      covered by this statement, and such advisers, parent holding company,
      Trust, and Trustees expressly disclaim that they are the beneficial
      owners such securities.


                                  EXHIBIT 3

                              POWER OF ATTORNEY

      Each person who signature appears below hereby constitutes and appoints
J. Christopher Donahue their true and lawful attorney-in-fact and agent, with
full power of substitution and resubstitution for them and in their names,
place and stead, in any and all capacities, to sign any and all Schedule 13Ds
and/or Schedule 13Gs, and any amendments thereto, to be filed with the
Securities and Exchange commission pursuant to Regulation 13D-G of the
Securities Exchange Act of 1934, as amended, by means of the Securities and
Exchange Commission's electronic disclosure system known as EDGAR; and to
file the same, with all exhibits thereto and other documents in connection
therewith, with the Securities and Exchange Commission, granting unto said
attorney-in-fact and agent, full power and authority to sign and perform each
and every act and thing requisite and necessary to be done in connection
therewith, as fully to all intents and purposes as each of them might or
could do in person, hereby ratifying and confirming all that said
attorney-in-fact and agent, or their or his substitute or substitutes, may
lawfully do or cause to be done by virtue thereof.


SIGNATURES                               TITLE OR CAPACITY

/s/John F. Donahue                       Individually and as Trustee of
---------------------------------
John F. Donahue                          the Voting Shares Irrevocable Trust

/s/Rhodora J. Donahue                    Individually and as Trustee of
---------------------------------
Rhodora J. Donahue                       the Voting Shares Irrevocable Trust


Sworn to and subscribed before me this 23rd day of September, 2004.

/s/Madaline P. Kelly             
Notary Public
My Commission Expires: February 22, 2008