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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                    FORM 8-K

                                 CURRENT REPORT
     Pursuant to Section 13 OR 15(d) of the Securities Exchange Act of 1934

        Date of Report (Date of earliest event reported) April 21, 2005

                             MIDSOUTH BANCORP, INC.
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             (Exact name of registrant as specified in its charter)

         Louisiana                    1-11826                   72-1020809
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(State or other jurisdiction        (Commission              (I.R.S. Employer
      of incorporation)             File Number)            Identification No.)

        102 Versailles Boulevard, Lafayette, Louisiana            70501
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           (Address of principal executive offices)             (Zip Code)

Registrant's telephone number, including area code    337-237-8343


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         (Former name or former address, if changed since last report.)

Check the appropriate box below if the Form 8-K filing is intended to
simultaneously satisfy the filing obligation of the registrant under any of the
following provisions:

[ ]  Written communications pursuant to Rule 425 under the Securities
     Act (17 CFR 230.425)

[ ]  Soliciting material pursuant to Rule 14a-12 under the Exchange
     Act (17 CFR 240.14a-12)

[ ]  Pre-commencement communications pursuant to Rule 14d-2(b) under the
     Exchange Act (17 CFR 240.14d-2(b))

[ ]  Pre-commencement communications pursuant to Rule 13e-4(c) under the
     Exchange Act (17 CFR 240.13e-4(c))

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ITEM 2.02. RESULTS OF OPERATIONS AND FINANCIAL CONDITION

     On April 21, 2005, MidSouth Bancorp, Inc. (the "Company") issued a press
release regarding the Company's earnings for the quarter ending March 31, 2005.
The Company's earnings release, including financial highlights, is attached as
Exhibit 99.1.

ITEM 9.01. FINANCIAL STATEMENTS AND EXHIBITS

(c)      Exhibits

99.1     Press Release dated April 21, 2005.



                                    SIGNATURE

     Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.

                                                 MidSouth Bancorp, Inc

Date   April 21, 2005
                                                 /s/ C. R. Cloutier
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                                                 C. R. Cloutier
                                                 President & CEO