Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
SHROTRIYA RAJESH C MD
   2. Issuer Name and Ticker or Trading Symbol
SPECTRUM PHARMACEUTICALS INC [SPPI] 		5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
__X__ Director __X__ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
Chairman & CEO
(Last)
(First)
(Middle)
11500 S. EASTERN AVE., SUITE 240		 3. Date of Earliest Transaction (Month/Day/Year)
12/22/2015
(Street)

HENDERSON, NV 89052		 4. If Amendment, Date Original Filed(Month/Day/Year)
 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)		 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)		 4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		 5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)		 6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)		 7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock, $0.001 par value 12/22/2015   M   90,750 A $ 4.23 101,426 I By Shrotriya Gift Trust
Common Stock, $0.001 par value 12/22/2015   F   65,732 (1) D $ 5.84 35,694 I By Shrotriya Gift Trust
Common Stock, $0.001 par value 12/22/2015   M   38,498 A $ 4.23 38,498 I By Shrotriya Annuity Trust
Common Stock, $0.001 par value 12/22/2015   F   27,885 (1) D $ 5.84 10,613 I By Shrotriya Annuity Trust
Common Stock, $0.001 par value               1,766,740 D  
Common Stock, $0.001 par value               498,894 I By CS Family Trust
Common Stock, $0.001 par value               26,128 I By 401(k) Plan
Common Stock, $0.001 par value               9,523 I By Spouse
Common Stock, $0.001 par value               78,089 I By Shrotriya Family Foundation

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)		 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)		 5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)		 6. Date Exercisable and Expiration Date
(Month/Day/Year)		 7. Title and Amount of Underlying Securities
(Instr. 3 and 4)		 8. Price of Derivative Security
(Instr. 5)		 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)		 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)		 11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Stock Option Exercise (Right to Buy) $ 4.23 12/22/2015   M     90,750 01/01/2009 01/01/2016 Common Stock 90,750 $ 0 0 I By Shrotriya Gift Trust
Stock Option Exercise (Right to Buy) $ 4.23 12/22/2015   M     38,498 01/01/2009 01/01/2016 Common Stock 38,498 $ 0 0 I Shrotriya Annuity Trust

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
SHROTRIYA RAJESH C MD
11500 S. EASTERN AVE.
SUITE 240
HENDERSON, NV 89052		   X   X   Chairman & CEO  

Signatures

 /s/ Kurt A. Gustafson, attorney-in-fact for Rajesh C. Shrotriya   12/23/2015
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Represents shares withheld by Spectrum to satisfy the Reporting Person's payment of the exercise price. The shares have not been sold by the Reporting Person or by Spectrum. The shares have been cancelled by the transfer agent.

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