SCHEDULE 13G


                       SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON, DC 20549


                    Under the Securities Exchange Act of 1934
                                (Amendment No. )*

                              Genomic Health, Inc.
--------------------------------------------------------------------------------
                                (Name of Issuer)

                    Common Stock, par value $0.0001 per share
--------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                    37244C101
          ------------------------------------------------------------
                                 (CUSIP Number)

                                September 8, 2006
          ------------------------------------------------------------
             (Date of Event which Requires Filing of this Statement)

      Check the appropriate box to designate the rule pursuant to which this
Schedule is filed:

      [ ] Rule 13d-1(b)

      [X] Rule 13d-1(c)

      [ ] Rule 13d-1(d)

      *The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which would
alter disclosures provided in a prior cover page.

      The information required on the remainder of this cover page shall not be
deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934 (the "Act") or otherwise subject to the liabilities of that section
of the Act, but shall be subject to all other provisions of the Act (however,
see the Notes).

                               Page 1 of 8 Pages


CUSIP No.  37244C101
--------------------------------------------------------------------------------
  1     NAMES OF REPORTING PERSONS
        I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (entities only)

        Felix J. Baker
--------------------------------------------------------------------------------
  2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
        (a) |_|
        (b) |X|
--------------------------------------------------------------------------------
  3     SEC USE ONLY
--------------------------------------------------------------------------------
  4     CITIZENSHIP OR PLACE OF ORGANIZATION
        United States
--------------------------------------------------------------------------------
                           5    SOLE VOTING POWER
       NUMBER OF                -0-
         SHARES            -----------------------------------------------------
      BENEFICIALLY         6    SHARED VOTING POWER
        OWNED BY                1,489,099
          EACH             -----------------------------------------------------
       REPORTING           7    SOLE DISPOSITIVE POWER
         PERSON                 -0-
          WITH             -----------------------------------------------------
                           8    SHARED DISPOSITIVE POWER
                                1,489,099
--------------------------------------------------------------------------------
  9     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
        1,489,099
--------------------------------------------------------------------------------
  10    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
        |_|  (See Instructions)
--------------------------------------------------------------------------------
  11    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
        6.1%
--------------------------------------------------------------------------------
  12    TYPE OF REPORTING PERSON (See Instructions)
        IN
--------------------------------------------------------------------------------

                               Page 2 of 8 Pages


CUSIP No.  37244C101
--------------------------------------------------------------------------------
  1     NAMES OF REPORTING PERSONS
        I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (entities only)

        Julian C. Baker
--------------------------------------------------------------------------------
  2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
        (a) |_|
        (b) |X|
--------------------------------------------------------------------------------
  3     SEC USE ONLY
--------------------------------------------------------------------------------
  4     CITIZENSHIP OR PLACE OF ORGANIZATION
        United States
--------------------------------------------------------------------------------
                      5    SOLE VOTING POWER
     NUMBER OF             -0-
      SHARES          ----------------------------------------------------------
   BENEFICIALLY       6    SHARED VOTING POWER
     OWNED BY              1,489,099
       EACH           ----------------------------------------------------------
     REPORTING        7    SOLE DISPOSITIVE POWER
      PERSON               -0-
       WITH           ----------------------------------------------------------
                      8    SHARED DISPOSITIVE POWER
                           1,489,099
--------------------------------------------------------------------------------
  9     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
        1,489,099
--------------------------------------------------------------------------------
  10    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
        |_| (See Instructions)
--------------------------------------------------------------------------------
  11    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
        6.1%
--------------------------------------------------------------------------------
  12    TYPE OF REPORTING PERSON (See Instructions)
        IN
--------------------------------------------------------------------------------

                               Page 3 of 8 Pages


Item 1(a)    Name of Issuer:

             Genomic Health, Inc.

Item 1(b)    Address of Issuer's Principal Executive Offices:

             301 Penobscot Drive
             Redwood City, California 94063

Item 2(a)    Name of Person Filing:

             This Schedule 13G is being filed jointly by Felix J. Baker and
             Julian C. Baker (the "Reporting Persons").

Item 2(b)    Address of Principal Business Office or, if None, Residence:

             Name                             Business Address
             ----                             ----------------

             Felix J. Baker                   667 Madison Avenue
                                              New York, NY 10021

             Julian C. Baker                  667 Madison Avenue
                                              New York, NY 10021

Item 2(c)    Citizenship:

             Each of the Reporting Persons is a United States citizen.

Item 2(d)    Title of Class of Securities:

             Common Stock, par value $0.0001 per share

Item 2(e)    CUSIP Number:

             37244C101

Item 3.      If this statement is filed pursuant to ss.ss.240.13d-1(b) or
             (c), check whether the person filing is a:   N/A

         (a) [ ] Broker or dealer registered under Section 15 of the Exchange
Act.

         (b) [ ] Bank as defined in section 3(a)(6) of the Exchange Act.

         (c) [ ] Insurance company as defined in section 3(a)(19) of the
Exchange Act.

         (d) [ ] Investment company registered under section 8 of the Investment
Company Act of 1940.

         (e) [ ] An investment adviser in accordance with Rule
13d-1(b)(1)(ii)(E).

                               Page 4 of 8 Pages


         (f) [ ] An employee benefit plan or endowment fund in accordance with
Rule 13d-1(b)(1)(ii)(F).

         (g) [ ] A parent holding company or control person in accordance with
Rule 13d-1(b)(1)(ii)(G).

         (h) [ ] A savings association as defined in Section 3(b) of the Federal
Deposit Insurance Act.

         (i) [ ] A church plan that is excluded from the definition of an
investment company under section 3(c)(14) of the Investment Company Act of 1940.

         (j) [ ] Group, in accordance with Rule 13d-1(b)(1)(ii)(J).

Item 4.      Ownership.

             Set forth below is the aggregate number of shares of Common Stock,
held as of the date hereof by each of the following, together with the
percentage of the outstanding shares of Common Stock that such number represents
based upon 24,512,947 shares outstanding as reported on the company's SEC Form
10Q filed on August 14, 2006.

                                                               Percent of Class
      Name                                 Number of Shares      Outstanding
      --------------------------------     ----------------    ----------------
      Baker Bros. Investments, L.P.               173,897             0.7%
      Baker Bros. Investments II, L.P.             15,314             0.1%
      Baker Biotech Fund I, L.P.                  233,732             0.9%
      Baker Brothers Life Sciences, L.P.          713,044             2.9%
      14159, L.P.                                   5,318             0.1%
      FBB Associates                              173,897             0.7%
      Baker/Tisch Investments, L.P.               173,897             0.7%
      --------------------------------     --------------           ------
      Total                                     1,489,099             6.1%

             By virtue of their ownership of entities that have the power
to control the investment decisions of the limited partnerships listed in the
table above, Felix J. Baker and Julian C. Baker may each be deemed to be
beneficial owners of shares owned by such entities and may be deemed to have
shared power to vote or direct the vote of and shared power to dispose or direct
the disposition of such securities.

Item 5.      Ownership of Five Percent or Less of a Class.

             If this statement is being filed to report the fact that as of
the date hereof the reporting person has ceased to be the beneficial owner of
more than five percent of the class of securities, check the following [ ]. N/A

Item 6.      Ownership of More than Five Percent on Behalf of Another Person.

             The entities listed in Item 4 above are investment funds the
investors in which have the right to receive dividends, interest and the
proceeds of sale of securities owned by such funds.

                               Page 5 of 8 Pages


Item 7.      Identification and Classification of the Subsidiary Which Acquired
             the Security Being Reported on by the Parent Holding Company or
             Control Person.

             N/A

Item 8.      Identification and Classification of Members of the Group.

             N/A

Item 9.      Notice of Dissolution of Group.

             N/A

Item 10.     Certification.

             By signing below I certify that, to the best of my knowledge
and belief, the securities referred to above were not acquired and are not held
for the purpose of or with the effect of changing or influencing the control of
the issuer of the securities and were not acquired and are not held in
connection with or as a participant in any transaction having that purpose or
effect.

                               Page 6 of 8 Pages




                                    SIGNATURE

             After reasonable inquiry and to the best of my knowledge and
belief, I hereby certify that the information set forth in this statement is
true, complete and correct.

September 12, 2006

                                      /s/ Felix J. Baker
                                      ----------------------------------
                                      Felix J. Baker


                                      /s/ Julian C. Baker
                                      ----------------------------------
                                      Julian C. Baker




















                               Page 7 of 8 Pages





                                    AGREEMENT


                  In accordance with Rule 13d-1(k)(1) under the Securities
Exchange Act of 1934, as amended, the undersigned hereby agree that this
Statement on Schedule 13G relating to the Common Stock of Genomic Health, Inc.
is being filed with the Securities and Exchange Commission on behalf of each of
them.

September 12, 2006



                                      /s/ Felix J. Baker
                                      ----------------------------------
                                      Felix J. Baker


                                      /s/ Julian C. Baker
                                      ----------------------------------
                                      Julian C. Baker






























                               Page 8 of 8 Pages