FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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(Print or Type Responses)

1. Name and Address of Reporting Person * KIRK RANDAL J   2. Issuer Name and Ticker or Trading Symbol TRANSGENOMIC INC [TBIO.OB] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director __X__ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) C/O THIRD SECURITY, LLC, 1881 GROVE AVENUE 3. Date of Earliest Transaction (Month/Day/Year) 02/03/2012 (Street) RADFORD, VA 24141 4. If Amendment, Date Original Filed(Month/Day/Year) 6. Individual or Joint/Group Filing(Check Applicable Line) _X_ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 02/03/2012   C   1,200,000 A (1) 1,298,361 I by TS Senior Staff 2008 (2) Common Stock 02/03/2012   C   1,200,000 A (1) 1,298,361 I by TS Staff 2010 (2) Common Stock 02/03/2012   C   600,000 A (1) 649,181 I by TS Incentive 2010 (2)

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)

2. Conversion or Exercise Price of Derivative Security

3. Transaction Date (Month/Day/Year)

3A. Deemed Execution Date, if any (Month/Day/Year)

4. Transaction Code (Instr. 8)

5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)

6. Date Exercisable and Expiration Date (Month/Day/Year)

7. Title and Amount of Underlying Securities (Instr. 3 and 4)

8. Price of Derivative Security (Instr. 5)

9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)

10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)

11. Nature of Indirect Beneficial Ownership (Instr. 4)

Code

V

(A)

(D)

Date Exercisable

Expiration Date

Title

Amount or Number of Shares

Convertible Promissory Note

$ 1 (1)

02/03/2012

C

$ 1,200,000

02/03/2012(1)

(1)

Units (1)

1,200,000

(1)

0

I

by TS Senior Staff 2008 (2)

Convertible Promissory Note

$ 1 (1)

02/03/2012

C

$ 1,200,000

02/03/2012(1)

(1)

Units (1)

1,200,000

(1)

0

I

by TS Staff 2010 (2)

Convertible Promissory Note

$ 1 (1)

02/03/2012

C

$ 600,000

02/03/2012(1)

(1)

Units (1)

600,000

(1)

0

I

by TS Incentive 2010 (2)

Warrant to Purchase Common Stock

$ 1.25 (1)

02/03/2012

C

600,000

(3)

02/02/2017

Common Stock

600,000

(1)

600,000

I

by TS Senior Staff 2008 (2)

Warrant to Purchase Common Stock

$ 1.25 (1)

02/03/2012

C

600,000

(3)

02/02/2017

Common Stock

600,000

(1)

600,000

I

by TS Staff 2010 (2)

Warrant to Purchase Common Stock

$ 1.25 (1)

02/03/2012

C

300,000

(3)

02/02/2017

Common Stock

300,000

(1)

300,000

I

by TS Incentive 2010 (2)

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
KIRK RANDAL J C/O THIRD SECURITY, LLC 1881 GROVE AVENUE RADFORD, VA 24141		X

Signatures

/s/ Randal J. Kirk		02/07/2012
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	The Convertible Promissory Notes (the "Notes") in the amount of $1.2 million, $1.2 million and $600,000 were issued on December 30, 2011 to Third Security Senior Staff 2008 LLC ("TS Senior Staff 2008"), Third Security Staff 2010 LLC ("TS Staff 2010"), and Third Security Incentive 2010 LLC ("TS Incentive 2010"), respectively, at an interest rate of 16% per annum with a maturity date of March 31, 2012. Pursuant to their terms, the Notes automatically converted into Units on February 3, 2012 upon a Qualified Financing, as defined in the Notes, by the issuer. Each Unit consists of one (1) share of Common Stock and a Warrant to Purchase 0.5 shares of Common Stock at an exercise price of $1.25 per share.
(2)	Randal J. Kirk controls each of TS Senior Staff 2008, TS Staff 2010 and TS Incentive 2010. Shares held by these entities may be deemed to be beneficially owned (as defined under Rule 13d-3 promulgated under the Securities Exchange Act of 1934, as amended) by Mr. Kirk. Mr. Kirk disclaims beneficial ownership of such shares, except to the extent of any pecuniary interest therein.
(3)	These warrants are exercisable immediately upon issuance.

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