UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                  SCHEDULE 14A
                                 (Rule 14a-101)

                     INFORMATION REQUIRED IN PROXY STATEMENT
                            SCHEDULE 14A INFORMATION
                Proxy Statement Pursuant to Section 14(a) of the
                Securities Exchange Act of 1934 (Amendment No. )


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              |_| Soliciting Material Pursuant to Section 240.14a-12


                         PROVECTUS PHARMACEUTICALS, INC.

                (Name of Registrant as Specified in Its Charter)


                                 Not Applicable
    (Name of Person(s) Filing Proxy Statement, if Other Than the Registrant)

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Date filed: April 21, 2005


[PROVECTUS PHARMACEUTICALS, INC. LOGO]           7327 Oak Ridge Highway, Suite A
                                                             Knoxville, TN 37931

                                                              phone 865/769-4011
                                                                fax 865/769-4013


                  Notice of 2005 Annual Meeting of Stockholders
                           To Be Held on May 19, 2005

To Our Stockholders:

         We will hold the 2005 annual  meeting of the  stockholders  of  
Provectus  Pharmaceuticals,  Inc. on  Thursday,  May 19, 2005, beginning at 
3:00 p.m.  Eastern time, at the offices of Baker,  Donelson,  Bearman,  Caldwell
& Berkowitz  located at Riverview  Tower, Suite 2200, 900 South Gay Street, 
Knoxville, Tennessee 37902.  The annual meeting is being held for the following 
purposes:

        1.  To elect four directors to serve on our Board of Directors for a 
            one-year term;

        2.  To approve an  amendment to our Amended and  Restated  2002 Stock 
            Plan to increase the number of shares  reserved for issuance from 
            3,000,000 to 5,000,000; and

        3.  To transact any other business that properly comes before the annual
            meeting.

        Only  stockholders of record as of the close of  business  on April 13, 
2005 will be entitled to notice of and to vote at the annual meeting.

        You are  cordially  invited to attend the  annual  meeting.  Regardless
of whether  you plan to attend the annual  meeting in person, please complete, 
sign and date the enclosed proxy card and return it promptly in the accompanying
postage-paid envelope.

                                   By order of the Board of Directors,

                                    /s/ Peter R. Culpepper

                                   Peter R. Culpepper
                                   Secretary

April 21, 2005


                             YOUR VOTE IS IMPORTANT

TO ENSURE THAT YOU ARE REPRESENTED AT THE ANNUAL MEETING, PLEASE  COMPLETE,  
SIGN, DATE AND PROMPTLY RETURN THE ENCLOSED PROXY IN THE ACCOMPANYING  ENVELOPE,
REGARDLESS OF WHETHER YOU PLAN TO ATTEND THE ANNUAL MEETING IN PERSON.  NO 
ADDITIONAL  POSTAGE IS NECESSARY IF THE PROXY IS MAILED IN THE UNITED STATES.  
YOU MAY REVOKE YOUR PROXY AT ANY TIME BEFORE IT IS VOTED AT THE MEETING.



 [PROVECTUS PHARMACEUTICALS, INC. LOGO]          7327 Oak Ridge Highway, Suite A
                                                             Knoxville, TN 37931

                                                              phone 865/769-4011
                                                                fax 865/769-4013


                               PROXY STATEMENT FOR
                       2005 ANNUAL MEETING OF STOCKHOLDERS
                           TO BE HELD ON MAY 19, 2005


         We are delivering these proxy materials to solicit proxies on behalf of
the Board of Directors of Provectus Pharmaceuticals, Inc., for the annual 
meeting of stockholders to be held on Thursday, May 19, 2005, beginning at 3:00 
p.m. Eastern time, at Riverview Tower, Suite 2200, 900 South Gay Street, 
Knoxville, Tennessee.

         We are mailing this proxy statement, together with a form of proxy and 
our annual report on Form 10-KSB for the year ended December 31, 2004, beginning
on April 21, 2005.

        About the Annual Meeting

        What is the purpose of the Annual Meeting?

                 At the annual meeting, stockholders will act upon the following
                 matters:

                        -   The election of four directors to serve on our Board
                            of Directors for a one-year term.

                        -   The approval of an increase in the number of shares 
                            reserved for issuance under our 2002 Stock Plan from
                            3,000,000 to 5,000,000.

        Who is entitled to vote?

        Only stockholders of record at the close of business on April 13, 2005, 
the record date for the annual meeting, are entitled to receive notice of the 
annual meeting and to vote the shares of common stock that they held on that 
date at the annual meeting. Each outstanding share of common stock entitles its 
holder to cast one vote on each matter to be voted on at the annual meeting.

        What constitutes a quorum?

        The presence at the annual meeting, in person or by proxy, of the 
holders of a majority of the shares of the common stock outstanding on the 
record date will constitute a quorum.  As of the record date, there were 
16,644,275 outstanding shares of common stock.  Shares held by stockholders 
present at the annual meeting who elect to abstain from voting nonetheless will
be included in the calculation of the number of shares considered present at the
annual meeting.

        How do I vote?

        If you complete and properly sign the accompanying proxy card and return
it to us, the proxy holders named on the proxy card will vote your shares as you
direct.  If you are a registered stockholder and attend the annual meeting, you 
may deliver your completed proxy card or vote in person at the meeting.  If you 
hold your shares in a brokerage account or in "street name" and you wish to vote
at the annual meeting, you will need to obtain a proxy from the broker or other 
nominee who holds your shares.

                                       1


        Can I change my vote after I return my proxy card?

        Yes.  Even after you have submitted your proxy card, you may change your
vote at any time before the proxy is exercised by filing with the Secretary 
either a notice of revocation or a duly executed proxy card bearing a later 
date.  "Street name" stockholders must contact your broker or other nominee and
follow its instructions if they wish to change their votes.  The powers of the 
proxy holders will be suspended if you attend the annual meeting in person and 
so request, although your attendance at the annual meeting will not by itself 
revoke a previously granted proxy.

        What are the Board's recommendations?

        Unless you give other instructions on your proxy card, the persons named
as proxies on the proxy card will vote your shares in accordance with the 
recommendations of the Board of Directors.  The Board recommends a vote FOR
 election of each of the four candidates nominated to serve on our Board of 
Directors for a one-year term and FOR approval of the proposed amendment 
to our Amended and Restated 2002 Stock Plan to increase the number of shares 
reserved for issuance from 3,000,000 to 5,000,000.

        If any other business is properly brought before the annual meeting, the
proxies will vote your shares as the Board of Directors recommends.  If the 
Board does not give a recommendation, the proxies will vote your shares as they 
may determine in their own discretion.

        What vote is required to approve each item?

                Election of Directors

        The affirmative vote of a plurality of the votes cast at the annual 
meeting is required for the election of directors.  If you are present at the 
meeting and you abstain from voting for one or more directors, your shares will 
not be counted in the vote for any nominee, although they will be counted for 
the purpose of determining whether there is a quorum present.  A properly 
executed proxy card marked "WITHHOLD AUTHORITY" with respect to the election of 
one or more directors will not be voted with respect to the director or 
directors indicated and will be treated as an abstention with respect to voting 
on the director or directors.

                Approval of the Amendment to the Amended and Restated 2002 Stock
                Plan and Other Items

        For approval of the amendment to the Amended and Restated 2002 Stock 
Plan and any other item of business that properly comes before the annual 
meeting, the affirmative vote of the holders of a majority of the common stock 
present at the annual meeting, in person or by proxy, and entitled to vote will 
be required for approval.  The shares of any stockholder present at the meeting 
who abstains from voting on the proposed ratification or on any other item will 
not be counted in the vote, although they will be counted for the purpose of 
determining whether there is a quorum at the annual meeting.  An abstention, 
therefore, will have the effect of a negative vote.  A properly executed proxy 
card marked "ABSTAIN" with respect to any such matter will not be voted and will
be treated as an abstention with respect to that matter.

        In general, if you hold shares of common stock in "street name" through 
a broker or other nominee, and if your broker or other nominee is not instructed
or otherwise empowered to vote your shares at a meeting with respect to a 
particular matter, then your shares will constitute "broker non-votes" as to the
matter.  In the election of directors, brokers generally have discretion to vote
your shares even in the absence of express instructions from you.  As to all 
matters, a broker non-vote will have the same effect as an abstention.


                                       2



                                 STOCK OWNERSHIP

        The table below shows the amount of our common stock beneficially owned 
as of April 13, 2005 by each of our directors and officers, each person whom we 
believe beneficially owns more than 5% of our outstanding voting stock, and all 
executive officers and directors as a group.



                                                                                                                
                                                                   Amount and Nature of           Percentage
                     Name and Address (1)                        Beneficial Ownership (2)        of Class (3)

H. Craig Dees.................................................         1,654,109       (4)             9.8%

Timothy C. Scott..............................................         1,653,769       (5)             9.8%

Eric A. Wachter...............................................         1,666,349       (6)             9.9%

Peter R. Culpepper............................................           100,000       (7)             0.6%

Stuart Fuchs..................................................           851,418       (8)             5.1%

Richard Smithline.............................................         4,166,665       (9)            20.0%
   830 Third Avenue, 14th Floor
   New York, NY 10022

Thomas E. Sandell.............................................         1,614,462      (10)             8.8%
   40 West 57th Street, 26th Floor
   New York, NY 10019

Gryffindor Capital Partners I, L.L.C..........................         1,152,919      (11)             6.6%
   150 North Wacker Drive, Suite 800
   Chicago, IL 60606

John Smolik...................................................           897,339      (12)             5.4%
   119 Tanasi Court
   Loudon, TN 37774
                                                                                    
All directors and executive officers as a group                        
  (5 persons)................................................          5,925,645      (13)            33.7%


---------------------------------------

(1)     If no address is given, the named individual is an executive officer or 
     director of Provectus Pharmaceuticals, Inc., whose business address is 7327
     Oak Ridge Highway, Suite A, Knoxville, TN 37931.

(2)     Shares of common stock that a person has the right to acquire within 60 
     days of April 13, 2005 are deemed outstanding for computing the percentage 
     ownership of the person having the right to acquire such shares, but are 
     not deemed outstanding for computing the percentage ownership of any other 
     person.  Except as indicated by a note, each stockholder listed in the 
     table has sole voting and investment power as to the shares owned by that 
     person.

(3)     As of April 13, 2005, there were 16,644,275 shares of common stock 
     issued and outstanding.

(4)     Dr. Dees' beneficial ownership includes 536 shares held by Dees Family 
     Foundation, an entity established for the benefit of Dr. Dees' family, and 
     256,250 shares subject to options which are exercisable within 60 days.

(5)     Dr. Scott's beneficial ownership includes 55,996 shares held by Scott 
     Family Investment Limited Partnership, a limited partnership established 
     for the benefit of Dr. Scott's family, and 256,250 shares subject to 
     options which are exercisable within 60 days.

                                       3


(6)      Dr. Wachter's beneficial ownership includes 4,867 shares held by the 
     Eric A. Wachter 1998 Charitable Remainder Unitrust and 256,250 shares 
     subject to options which are exercisable within 60 days.

(7)      Mr. Culpepper's beneficial ownership includes 100,000 shares subject to
     options which are exercisable within 60 days.

(8)      Mr. Fuchs's beneficial ownership includes 226,459 shares held by SFF 
     Limited Partnership, a limited partnership of which Mr. Fuchs is the 
     general partner; 348,499 shares an IRA of Mr. Fuch; 50,000 shares subject 
     to options which are exercisable within 60 days and 226,460 shares held by 
     Gryffindor Capital Partners I, L.L.C., a Delaware limited liability company
     of which Mr. Fuchs is the managing principal ("Gryffindor").

(9)     Mr. Smithline's beneficial ownership includes 4,166,665 shares of Common
     Stock comprised of 1,333,333 shares of Common Stock underlying Convertible 
     Debentures held by DCOFI Master LDC, of which Mr. Smithline is a director, 
     2,266,666 shares of Common Stock underlying Warrants held by DCOFI Master 
     LDC, of which Mr. Smithline is a director, and 566,666 shares of Common 
     Stock underlying Warrants held by DC Asset Management, LLC, of which Mr. 
     Smithline is the Managing Member.

(10)    Mr. Sandell's beneficial ownership includes 1,614,462 shares of Common 
     Stock comprised of 962,962 shares of Common Stock, and warrants exercisable
     for 651,500 shares of Common Stock.  Mr. Sandell beneficially owns this 
     Common Stock jointly with Castlerigg Master Investments, Castlerigg 
     International, Castlerigg Holdings, and Sandell Asset Management Corp., 
     each of which Mr. Sandell is a Director, and together with Mr. Sandell are 
     referred to as "The Reporting Persons."  The Reporting Persons disclaim 
     beneficial ownership of 311,462 shares of Common Stock.

(11)    Gryffindor's beneficial ownership includes 226,460 shares directly held
     and 226,459 shares held by SFF Limited Partnership, a limited partnership
     of which Stuart Fuchs, one of our directors, is the general partner.  
     Gryffindor disclaims beneficial ownership of the shares held by SFF Limited
     Partnership. Gryffindor's beneficial ownership also includes 700,000 shares
     of Common Stock underlying Warrants.

(12)    Mr. Smolik's beneficial ownership includes 48,666 shares held by Smolik 
     Family LLP.

(13)    Includes 918,750 shares subject to options which are exercisable within 
     60 days.

             Section 16(a) Beneficial Ownership Reporting Compliance

The federal securities laws require our directors and executive officers and 
persons who beneficially own more than 10% of a registered class of our equity 
securities to file with the SEC initial reports of ownership and reports of 
changes in ownership of our securities.  Based solely on our review of the 
copies of these forms received by us or representations from certain reporting
persons, we believe that SEC beneficial ownership reporting requirements for 
2004 were met.

                                       4


                                Proposal 1:
                                  -------------  
                              Election of Directors

        The persons listed below have been nominated by the Board of Directors 
to serve as directors for a one-year term expiring at the annual meeting of 
stockholders occurring in 2006.  Each nominee has consented to serve on the 
Board of Directors.  If any nominee were to become unavailable to serve as a 
director, the Board of Directors may designate a substitute nominee.  In that 
case, the persons named as proxies on the accompanying proxy card will vote for 
the substitute nominee designated by the Board of Directors.

        H. Craig Dees, Ph.D., 53, has served as our Chief Executive 
Officer and as a member of our Board of Directors since we acquired PPI on April
23, 2002. Before joining us, from 1997 to 2002 he served as senior member of the
management team of Photogen Technologies, Inc., including serving as a member of
the Board of Directors of Photogen from 1997 to 2000.  Prior to joining 
Photogen, Dr. Dees served as a Group Leader at the Oak Ridge National 
Laboratory, and as a senior member of the management teams of LipoGen Inc., a 
medical diagnostic company which used genetic engineering technologies to 
manufacture and distribute diagnostic assay kits for auto-immune diseases, and 
TechAmerica Group Inc., now a part of Boehringer Ingelheim Vetmedica, Inc., the 
U.S. animal health subsidiary of Boehringer Ingelhem GmbH, an international 
chemical and pharmaceutical company headquartered in Germany.  He earned a
Ph.D. in Molecular Virology from the University of Wisconsin - Madison in 1984.

        Timothy C. Scott, Ph.D., 47, has served as our President and as a
member of our Board of Directors since we acquired PPI on April 23, 2002.  Prior
to joining us, Dr. Scott was as a senior member of the Photogen management team 
from 1997 to 2002, including serving as Photogen's Chief Operating Officer from 
1999 to 2002, as a director of Photogen from 1997 to 2000, and as interim CEO 
for a period in 2000.  Before joining Photogen, he served as senior management 
of Genase LLC, a developer of enzymes for fabric treatment, and held senior 
research and management positions at Oak Ridge National Laboratory.  Dr. Scott 
earned a Ph.D. in Chemical Engineering from the University of Wisconsin - 
Madison in 1985.

        Eric A. Wachter, Ph.D., 42, has served as our Vice President - 
Pharmaceuticals and as a member of our Board of Directors since we acquired PPI 
on April 23, 2002.  Prior to joining us, from 1997 to 2002 he was a senior 
member of the management team of Photogen, including serving as Secretary and a 
director of Photogen since 1997 and as Vice President and Secretary and a 
director of Photogen since 1999.  Prior to joining Photogen, Dr. Wachter served 
as a senior research staff member with Oak Ridge National Laboratory.  He earned
a Ph.D. in Chemistry from the University of Wisconsin - Madison in 1988.

        Stuart Fuchs, 58, has served as a member of our Board of 
Directors since January 23, 2003.  He is the co-founder and managing principal 
of Gryffindor since January 2000, a Chicago-based venture capital firm. Before 
joining Gryffindor, he was a founding stockholder of several biotech companies, 
including Angiogen LLC (since 1998), which develops combinations of drugs to
stimulate in vivo production of factors that inhibit the growth of blood vessels
in tumors, and Nace Pharma LLC (since 1996), which develops drugs that employ 
novel drug delivery technologies.  Through Nace Resources Inc., a Delaware 
corporation providing strategic and financial advice to companies in the 
technology sector, Mr. Fuchs has formed or participated in groups of investors 
on behalf of several companies, including Miicro Inc., Celsion Corp. and 
Photogen.  Before founding Nace Resources Inc., he served for 19 years as
an investment banker with Goldman, Sachs & Co., where he co-managed the firm's 
public finance activities for the Midwest region. Before joining Goldman, Sachs 
& Co., Mr. Fuchs was a lawyer in private practice with Barrett Smith Schapiro & 
Simon in New York.  Mr. Fuchs holds an A.B. degree from Harvard College and a 
J.D. from Harvard Law School and is a member of the Association of the Bar of
the City of New York.

        The Board of Directors recommends that the stockholders vote FOR each
of the nominees for election to the Board of Directors named above.

                                       5


                                 Proposal 2:
                                    -----------
              Amendment to the Amended and Restated 2002 Stock Plan

        The Board of Directors has approved an amendment to our Amended and 
Restated 2002 Stock Plan, subject to stockholder approval to increase the number
of shares reserved for issuance under the Plan from 3,000,000 shares to 
5,000,000.  The Plan was approved by the stockholders at the annual meeting in 
2003 and was amended at the annual meeting in 2004.  Our Board has determined
that an increase in the reserve of shares is necessary, especially in light of 
the fact that as of April 13, 2005, only 75,000 shares remain in the reserve.  
The Board believes that we must offer a competitive equity compensation program 
if we are to continue to successfully attract and retain the most qualified 
candidates as employees, directors and consultants.  The Board expects that the
Plan, as amended, will be an important factor in attracting and retaining the 
personnel essential to our success and in motivating these individuals to strive
to enhance our growth and profitability.  The opportunity to acquire an equity 
interest will align the economic interest of these individuals with those of 
other stockholders, thereby benefiting all of our stockholders.  The Plan
remains unchanged in all other respects.

        The Plan provides for the grant of stock options, stock appreciation 
rights, rights to purchase restricted stock and long-term performance awards.  
Our employees, consultants and directors who are not employees whose present and
potential contributions are important to our continued success are eligible to 
receive awards.  The Plan is administered by the Board of Directors which has 
the power to authorize awards and determine their terms and conditions.  The 
Plan will remain in effect until all awards under the Plan have been issued, 
expired or otherwise terminated or the Plan is terminated by the Board of 
Directors. However, no award may be granted more than ten years after the date 
of the Plan's approval (2013).  Generally, a participant's awards issued under 
the Plan are not transferable except by will or by the laws of descent and 
distribution.

        The Board of Directors recommends that the stockholders vote FOR the 
adoption of this proposal.

                                       6


                 Information about the Board of Directors

        How often did the Board of Directors meet in 2004?

        The Board of Directors met once and took action by unanimous written 
consent 8 times during 2004.  Each Board member attended more than 75% of the 
total number of meetings of the Board and its committees on which he served.  
Members of the Board of Directors are encouraged to attend the annual meeting.  
All members of our Board attended the 2004 annual meeting of stockholders.

        How does the Board of Directors operate?

        Because the Board of Directors consists of only four members and our 
operations remain amenable to oversight by a limited number of directors, the 
Board has not delegated any of its functions to committees.   None of the 
members of our Board of Directors is considered independent.  The Board has not 
adopted either a nominating or audit committee charter.

        The entire Board of Directors acts as our audit committee as permitted 
under Section 3(a)(58)(B) of the Securities Exchange Act of 1934 and as our 
nominating committee. The Board views its duties as an audit committee as 
follows:

        -    Review recommendations of independent auditors concerning our 
             accounting principles, internal controls and accounting
             procedures and practices;

        -    Review the scope of the annual audit;

        -    Approve or disapprove each professional service or type of service 
             other than standard auditing services to be provided by the 
             auditors; and

        -    Review and discuss with the independent auditors the audited 
             financial statements.

     The entire Board of Directors acts as our nominating  committee.  The Board
has no set  procedures  or policy on the  selection of nominees or evaluation of
shareholder  recommendations  and will consider  these issues on a  case-by-case
basis. The Board will consider shareholder recommendations for director nominees
that are  properly  received in  accordance  with our bylaws and the  applicable
rules and  regulations  of the  Securities  and Exchange  Commission.  The Board
screens all  potential  candidates in the same manner.  The Board's  review will
typically be based on all  information  provided  with respect to the  potential
candidate.  The Board has not established  specific minimum  qualifications that
must be met by a nominee for a position on the Board or specific  qualities  and
skills for a director.  For more  information,  please see the section  entitled
"Stockholder   Proposals  for  2006  Annual  Meeting  of  Stockholders"   below.
Stockholders who wish to contact the members of the Board of Directors may do so
by sending an e-mail addressed to them at info@pvct.com.

        How are directors compensated?

        Three of our four  directors,  Drs.  Dees,  Scott and Wachter,  are also
full-time  employees.  As discussed  below under the heading 

                                       7


     "EXECUTIVE OFFICER COMPENSATION," they are compensated for their service in
those roles. They are not separately compensated for their service as directors.

     Mr. Fuchs does not receive cash compensation for his service as a member of
the Board of  Directors,  although he is  reimbursed  for  expenses  incurred in
fulfilling his duties as a director, including attending meetings.

     On the date of each  annual  meeting of  shareholders,  each  member of the
Board receives options exercisable for 25,000 shares of our common stock.





                                       8


                        Executive Officer Compensation

        The table below shows the  compensation  for services in all capacities 
we paid during the year ended December 31, 2004 to our Chief Executive Officer 
and the other executive officers during the year ended December 31, 2004 who 
received more than $100,000:

                                                                            

                                                      Summary Compensation Table
                                                                    Long Term                                       
                                    Annual Compensation            Compensation         
                                    -------------------            ------------         
                                                                 Securities Underlying   All Other Compensation(1)            
   Name and Position      Year    Salary ($)       Bonus($)        Options/SARs(#)       ----------------------                  
   -----------------      ----    ----------       --------      ---------------------              
    
H. Craig Dees...........  2004     175,000            --             325,000                     $91,666
Chief Executive Officer   2003     131,250            --             100,000                        --
                          2002      18,750            --               --                         18,750
Timothy C. Scott........  2004     175,000            --             325,000                     $77,083
President                 2003     131,250            --             100,000                        --
                          2002      18,750            --               --                         18,750
Eric A. Wachter.........  2004     175,000            --             325,000                     $70,833
Vice                      2003     131,250            --             100,000                        --
President-Pharmaceuticals 2002      18,750            --               --                         18,750
Peter R. Culpepper......  2004     118,750            --             400,000                        --
Chief Financial Officer   2003      --                --               --                           --
                          2002      --                --               --                           --

-------------------

(1)  Drs.  Dees,  Scott and Wachter  served  without  salary from April 23, 2002
     until November 16, 2002.  Beginning November 16, 2002, we began paying them
     their respective  regular salaries.  From November 16, 2002 to December 31,
     2002,  we also paid them an amount equal to their salary for that period as
     compensation for their earlier service without salary.  During 2004 we paid
     them a portion of their accrued  compensation  relating to the period April
     23, 2002 until November 16, 2002.

     Other Executive Officer

     Serving as an executive  officer in addition to those listed above is Peter
R.  Culpepper  who was  appointed  to serve as our Chief  Financial  Officer  in
February 2004.  Previously,  Mr. Culpepper served as Chief Financial Officer for
Felix  Culpepper  International,  Inc.  from  2001  to  2004;  was a  Registered
Representative  with AXA  Advisors,  LLC from 2002 to 2003;  has served as Chief
Accounting Officer and Corporate  Controller for Neptec, Inc. from 2000 to 2001;
has served in various  Senior  Director  positions  with  Metromedia  Affiliated
Companies  from 1998 to 2000;  has served in various  Senior  Director and other
financial positions with Paging Network,  Inc. from 1993 to 1998; and has served
in a variety of financial  roles in public  accounting and industry from 1982 to
1993.  He  earned a Masters  in  Business  Administration  in  Finance  from the
University of Maryland - College Park in 1992 and an  undergraduate  degree from
the  College of  William  and Mary -  Williamsburg,  Virginia  in 1982.  He is a
licensed  Certified  Public  Accountant in both  Tennessee and Maryland and is a
faculty member with the University of Phoenix.


                                                                 
                                                   Option Grants in Last Fiscal Year
                                                           % of total options                                
                                     Number of shares     granted to employees        Exercise     Expiration
               Name                 underlying options       in fiscal year         price ($/sh)      Date
               ----                 ------------------     -------------------      ------------    ---------

H. Craig Dees..................           300,000               21.8                    1.10          2014
                                          25,000                1.8                     0.95          2014
Timothy C. Scott...............           300,000               21.8                    1.10          2014
                                          25,000                1.8                     0.95          2014
Eric A. Wachter................           300,000               21.8                    1.10          2014
                                          25,000                1.8                     0.95          2014
Peter R. Culpepper.............           300,000               21.8                    1.10          2014
                                          100,000               7.3                     1.25          2014



                                       9


             Aggregated Option/SAR Exercises in Last Fiscal Year And
                        Fiscal Year-End Option/SAR Values


        The following table discloses information regarding stock options held 
at the end of or exercised in the year 2004 for each of the executive officers 
listed in the Summary Compensation Table above.


                                                                                  

                             Shares                       Securities underlying           Value of unexercised
                          acquired on       Value          Unexercised options            in-the-money options
         Name             exercise (1)   realized (1)      at December 31, 2004         at December 31, 2004 (2)
         ----             ------------   ------------     ----------------------        ------------------------
                                                       Exercisable   Unexercisable    Exercisable    Unexercisable
                                                       -----------   -------------    -----------    ------------- 
H. Craig Dees........         ---            ---         162,500        262,500         $19,875         $16,125
Timothy C. Scott ....         ---            ---         162,500        262,500         $19,875         $16,125
Eric A. Wachter......          --             --         162,500        262,500         $19,875         $16,125
Peter R. Culpepper...          --             --          25,000        375,000           --              --

----------------
(1)  As of December  31, 2004,  no options have been  exercised by the executive
     officers  under the Amended and Restated  2002 Stock Option Plan.

(2)  Based on the closing price of the OTCC Bulletin Board of $0.75 per share as
     of April 13, 2005.

     Employment Agreements

        As a condition to the loan we obtained from Gryffindor which we 
described above under the section entitled "Certain Relationships and Related 
Transactions," we entered into Confidentiality, Inventions and Non-Competition 
Agreements with Drs. Dees, Scott, and Wachter.  These agreements prohibit Drs. 
Dees, Scott, and Wachter each from disclosing our confidential information at 
any time while he is employed by us or during the five-year period after his 
employment ends for any reason.  These agreements also provide that any 
invention or development that Dr. Dees, Dr. Scott, or Dr. Wachter may invent as 
a result of the work he does for us during his employment or during the one-year
period after his employment ends for any reason belongs to us.  Finally, these
agreements prevent each of Drs. Dees, Scott, or Wachter from engaging in certain
kinds of competition with us for a period of 18 months after his employment ends
for any reason.  We believe that these provisions are prudent practice for 
technology-intensive businesses such as ours, and similar provisions are 
included in the employment agreements of executive officers of most
biopharmaceutical companies.

        Drs. Dees, Scott, Wachter and Mr. Culpepper each entered into an 
employment contract with the company on January 4th, 2005 for a period of one 
year with automatic annual renewals.

        Equity Compensation Plan Information

        The table below sets forth  certain  information  regarding  shares 
available as of December 31, 2004 for issuance  under our equity compensation 
plans: 

                                                                                       

                                                  (a)                    (b)                      (c)
                                                                                            Number of securities
                                                                                           remaining available for
                                             Number of securities                           future issuance under
                                              to be issued upon       Weighted-average             equity
                                                 exercise of         exercise price of        compensation plans
                                             outstanding options,   outstanding options,    (excluding securities
Category                                     warrants and rights    warrants and rights   reflected in column (a))
--------                                    ---------------------   --------------------  ------------------------
                                                                                                                    
Equity compensation plans approved by                                                                               
     stockholders........................... 1,725,000              $        0.97            1,275,000                
                                                                                                                    
Equity compensation plans not approved by                                                                           
     stockholders...........................         0              $         --              ________                
                                                                                                                    
         Total.............................. 1,725,000                                       1,275,000                

                                       10


        Report of the Board of Directors Acting as the audit committee

         The Board of Directors  serves as our audit committee.  None of the 
members of the Board are independent.  The Board acting as audit committee 
reviews our financial reporting process.   In this context, the Board

        -    has reviewed and discussed with management the audited financial 
             statements for the year ended December 31, 2004.

        -    has discussed with BDO Seidman, LLP, our independent auditors, the 
             matters required to be discussed by Statement on auditing
             Standards No. 61, as modified or supplemented.

        -    has received the written disclosures and the letter from BDO 
             Seidman, LLP, required by Independence Standards Board Standard
             No. 1 ("Independence Discussions with Audit Committees"), as 
             modified or supplemented, and has discussed with BDO Seidman, LLP, 
             the independent accountant's independence.

        Based on this review and the discussions  referred to above,  the Board
determined that the audited  financial  statements be included  in our Annual 
Report on Form 10-KSB for the year ended  December  31,  2004,  for filing with 
the  Securities  and  Exchange Commission.  The Board also appointed BDO 
Seidman, LLP, as our independent auditor for 2005.

        This report is submitted on behalf of the members of the Board of 
Directors acting as the Audit Committee:

                      H. Craig Dees             Timothy C. Scott
                      Eric A. Wachter           Stuart Fuchs

        The  Report of the Board  acting as the Audit  Committee  set out above
shall not be deemed  "soliciting  material" or to be "filed" with the Securities
and Exchange Commission,  nor shall it be incorporated by any general statement
incorporating by reference this proxy  statement  into any filing under the  
Securities  Act of 1933,  as amended,  or the  Securities  Exchange  Act of 
1934, as amended,  except to the extent that we specifically  incorporate  this 
information by reference and shall not otherwise be deemed filed under these 
Acts.

        We do not currently  have an "audit  committee  financial  expert," as 
defined  under the rules of the SEC.  Because the Board consists of only four  
members and  operations  remain  amendable  to oversight  by a limited  number 
of  directors,  the Board has not delegated any of its functions to committees.
The entire Board acts as our audit committee as permitted  under Section  3(a)
(58)(B) of the  Securities  Exchange Act of 1934.  We believe that all members 
of our Board are  qualified to serve as the  committee and have the experience 
and knowledge to perform the duties required of the committee.  We do not have 
any  independent  directors who would qualify as an audit committee  financial 
expert, as defined.  We believe that it has been, and may continue to be,  
impractical to recruit such a director unless and until we are significantly 
larger.

                                Audit Fees

        The firm of BDO Seidman, LLP, served as our independent auditors and 
audited our financial statements for 2004.  We expect that representatives of 
BDO Seidman, LLP, will be present at the annual meeting.  They will be given an 
opportunity to make a statement if they so desire and will be available to 
respond to appropriate questions. The table below sets out the fees we paid to
BDO Seidman, LLP, our independent auditors for 2003 and 2004.


                                                                                                        

                                                                                                2003        2004
                   Audit fees...........................................................       $53,400       $98,300
                   Audit-related fees...................................................            --            --
                   Tax fees.............................................................            --            --
                   All other fees.......................................................            --            --
                            Total.......................................................       $53,400       $98,300


        It is the  policy of the Board of  Directors  to  pre-approve  all audit
and  non-audit  services  provided  by the  Company's independent  auditor.  The

                                       11

Board of Directors has  considered  whether the provision by BDO Seidman,  LLP, 
of services of the varieties described  above is compatible  with  maintaining  
the  independence  of BDO Seidman,  LLP. In view of the fact that BDO Seidman,  
LLP, provides no services  to us other than audit  services,  the Board of  
Directors  believes  that such  services do not  jeopardize  the independence of
BDO Seidman, LLP.

     Investment by Gryffindor

     On November  26,  2002,  Gryffindor  purchased  our $1 million  Convertible
Secured  Promissory Note dated November 26, 2002. This Note bears interest at 8%
per annum,  payable  quarterly  in  arrears,  and is due and  payable in full on
November 26, 2004. Subject to certain  exceptions,  the Note is convertible into
shares of our common  stock on or after  November  26,  2003,  at which time the
principal amount of the Note is convertible into common stock at the rate of one
share for each  $0.737 of  principal  so  converted  and any  accrued but unpaid
interest on the Note is  convertible  at the rate of one share for each $0.55 of
accrued but unpaid  interest so converted.  Our  obligations  under the Note are
secured by a first priority  security  interest in all of our assets,  including
the capital  stock of our wholly owned  subsidiary  Xantech.  In  addition,  our
obligations to Gryffindor are guaranteed by Xantech,  and Xantech's guarantee is
secured  by a first  priority  security  interest  in all of  Xantech's  assets.
Pursuant to our agreement with  Gryffindor,  we also issued to Gryffindor and to
Stuart  Fuchs,  the managing  principal  of  Gryffindor,  Common Stock  Purchase
Warrants  dated  November  26,  2002,   entitling  Gryffindor  and  SFF  Limited
Partnership, a limited partnership of which Mr. Fuchs is the general partner, to
purchase,  in the aggregate,  up to 452,919 shares of common stock at a price of
$0.001 per share.  Simultaneously with the completion of the these transactions,
Gryffindor and SFF Limited Partnership exercised the warrants in their entirety,
and we issued  226,460  shares of our common  stock to  Gryffindor  and  226,459
shares to SFF  Limited  Partnership.  On January  23,  2003,  as required by our
agreement with  Gryffindor,  Mr. Fuchs became one of our  directors.  We believe
that the terms of these  transactions  were obtained by  arms-length  bargaining
prior to the time Mr. Fuchs became one of our directors.

     The Convertible  Secured Promissory Note was amended on January 31, 2003 by
Senior Secured Convertible Note in the principal amount of $1,025,959.  Pursuant
to an agreement dated November 26, 2004 between the Company and Gryffindor,  the
Company  amended the Senior  Secured  Convertible  Note and issued  Gryffindor a
Second Amended and Restated Senior Secured  Convertible  Note dated November 26,
2004 in the amended  principal  amount of $1,185,959 which included the original
note principal  plus accrued  interest.  The Second Amended and Restated  Senior
Secured  Convertible Note bears interest at 8% per annum,  payable  quarterly in
arrears,  is due and  payable  in full on  November  26,  2005,  and  amends and
restates the Senior Secured Convertible Note in its entirety. Subject to certain
exceptions, the Note is convertible into shares of the Company's common stock on
or after  November 26, 2004, at which time the  principal  amount of the Note is
convertible  into  common  stock at the rate of one  share  for each  $0.737  of
principal  so  converted  and any  accrued  but unpaid  interest  on the Note is
convertible  at the rate of one  share  for each  $0.55 of  accrued  but  unpaid
interest so converted.  The Company issued warrants to Gryffindor to purchase up
to 525,000  shares of the Company's  common stock at an exercise  price of $1.00
per share as  consideration  for  extending  the maturity date and accepting the
Second Amended and Restated Senior Secured  Convertible  Note dated November 26,
2004 in substitution thereof.

     The Second Amended and Restated  Senior Secured  Convertible  Note provides
that the Company  will issue  Gryffindor  warrants to purchase  common stock for
each calendar  month the Second  Amended and Restated  Note remains  outstanding
after  March 1, 2005.  On March 26,  2005,  pursuant  to the terms of the Second
Amended and  Restated  Senior  Secured  Convertible  Note,  the  Company  issued
warrants to Gryffindor to purchase  100,000 shares of the Company's common stock
at an exercise  price of $1.00 per share and warrants to purchase  75,000 shares
of the Company's common stock at an exercise price of $1.25 per share.

          Loan by Wachter

     During 2002,  Eric A.  Wachter,  Vice-President  of  Pharmaceuticals  and a
Director of the  Company,  loaned the Company  $109,000.  During  2003,  Wachter
loaned the Company an additional $40,000. Interest on the loan is 5%, compounded
monthly. Principal is due on December 31, 2009 and interest is payable quarterly
in arrears  beginning June 30, 2003.  Accrued interest was $15,434 and $7,431 at
December 31, 2004 and 2003 respectively.  Interest expense was $8,003 and $7,431
at December 31, 2004 and 2003, respectively.

                                       12


                              Other Matters

        As of the date of this proxy  statement,  we know of no other business 
that will be presented for  consideration at the annual meeting other than the 
items  referred to above.  If any other matter  properly is brought  before the 
annual meeting for action by the stockholders,  the persons  named in the 
proxies will vote the shares of common stock  represented  by proxies as  
recommended  by the Board of Directors or, if the Board gives no recommendation,
as they may determine in their own discretion.


                          Additional Information

        Solicitation of Proxies and Cost

        We will bear the cost of soliciting proxies for the annual meeting.  In 
addition to solicitation of proxies by use of the mails, our employees, without 
extra remuneration, may solicit proxies personally or by telecommunications.  We
will reimburse brokerage firms, nominees, custodians and fiduciaries for their 
out-of-pocket expenses for forwarding proxy materials to beneficial owners and 
seeking instruction with respect thereto.

      Stockholder Proposals for 2006 Annual Meeting of Stockholders

        Stockholders interested in presenting a proposal for consideration at 
our annual meeting of stockholders in 2006 may do so by following the procedures
prescribed in Rule 14a-8 under the Securities Exchange Act of 1934 and our 
bylaws.  To be eligible for inclusion, stockholder proposals must be received by
our Secretary no later than December 31, 2005.

                                 By Order of the Board of Directors

                                  /s/ Peter R. Culpepper

                                 Peter R. Culpepper
                                 Secretary





Knoxville, Tennessee
April 21, 2005

                                       13

                       Provectus Pharmaceuticals, Inc.

                       2005 ANNUAL MEETING OF STOCKHOLDERS
                           TO BE HELD ON MAY 19, 2005

         THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS

        The 2005 Annual Meeting of Stockholders of Provectus  Pharmaceuticals,  
Inc. a Nevada corporation (the "Company") will be held at the offices of Baker, 
Donelson,  Bearman,  Caldwell & Berkowitz,  the Company's counsel, located at 
Riverview Tower, Suite 2200, 900 South Gay Street,  Knoxville,  Tennessee 37902,
on Thursday,  May 19, 2005, beginning at 3:00 p.m. Eastern time. The undersigned
hereby acknowledges  receipt of the  combined  Notice of 2005  Annual  Meeting 
of  Stockholders  and Proxy  Statement  dated  April 21,  2005, accompanying  
this  proxy,  to which  reference  is hereby  made for further  information  
regarding  the meeting and the matters to be considered and voted on by the 
stockholders at the meeting.

        The undersigned  hereby  appoints Peter R. Culpepper and Linda M. 
Crouch-McCreadie,  and each of them,  attorneys and agents, with full power of  
substitution,  to vote as proxy all shares of common stock of the Company owned 
of record by the  undersigned as of the record date and otherwise to act on 
behalf of the  undersigned  at the meeting and any  postponement  or  
adjournment  thereof,  in accordance with the instructions  set forth herein and
with  discretionary  authority with respect to any other business,  not known or
determined at the time of the  solicitation of this proxy,  that properly comes 
before such meeting or any  postponement or adjournment thereof.

        The undersigned  hereby revokes any proxy  heretofore  given and directs
said attorneys and agents to vote or act as indicated on the reverse side 
hereof.  If no instruction is given, this proxy will be voted FOR proposals 1 
and 2.

                           (continued on reverse side)
--------------------------------------------------------------------------------
                              FOLD AND DETACH HERE

[Provectus Pharmaceuticals, Inc. Logo            7327 Oak Ridge Highway, Suite A
                                                            Knoxville, TN 37931

                                                              phone 865/769-4011
                                                                fax 865/769-4013

                                                  April 21, 2005
        Dear Stockholder:

                It is a great  pleasure to have this  opportunity  to provide 
        you with our 2004 Annual  Report and the Proxy Statement for our 2005 
        Annual Meeting of  Stockholders.  The Annual Report  discusses our  
        performance in fiscal 2004 as well as our business strategy for the 
        future.  The Proxy Statement  provides you with information  relating to
        the business to be conducted at our annual meeting on May 19, 2005.

                         YOUR VOTE IS IMPORTANT!

                You can vote by completing, signing, dating, and returning your 
        proxy card in the accompanying envelope.

        Thank you for your continued interest in, and ownership of, Provectus 
        Pharmaceuticals, Inc.

                                             Sincerely,

                                             /s/ H. Craig Dees

                                             H. Craig Dees, Ph.D.
                                             Chief Executive Officer

                                       14


        This  proxy is  solicited  on  behalf  of the Board of  Directors  of 
the  Company  and will be voted in  accordance  with the undersigned's  
instructions  set forth herein.  If no  instructions  are  provided,  this proxy
will be voted FOR each of the proposals described below.  THE BOARD OF 
DIRECTORS RECOMMENDS THAT YOU VOTE FOR THE PROPOSALS.

    As to the election to the Board of Directors of the nominees named in the
       proxy statement delivered in connection with the Annual Meeting of
             Stockholders, each for a one-year term expiring at the
                      2005 Annual Meeting of Stockholders:

     |_| FOR all nominees listed below:
                  H. Craig Dees, Ph.D.                  Timothy C. Scott, Ph.D.
                  Stuart Fuchs                          Eric A. Wachter, Ph.D.

     |_| WITHHOLD AUTHORITY for all nominees
                  Instruction: To withhold authority to vote for any director 
                  nominee, mark this box and draw a line through the name
                  of the nominee in the list above.

      As to the approval of the amendment to the Amended and Restated 2002
              Stock Plan to increase the number of shares reserved
                   under the Plan from 3,000,000 to 5,000,000:

            |_| FOR          |_| AGAINST            |_| ABSTAIN

        With respect to any other item of business that properly  comes before 
the meeting,  the proxy holders are  authorized to vote the undersigned's shares
in accordance with their best judgment.

                        Date:                                             , 2005
                              -------------------------------------------

     |X| Please mark your votes as indicated in this
         example.

                              -------------------------------------------
                              Signature of stockholder


                              -------------------------------------------
                              Signature of stockholder, if held jointly

                                  Please sign your name as it appears on this 
                              proxy.  Joint owners each should  sign.  When  
                              signing as  trustee,  administrator,  executor,  
                              attorney, etc.,  please  indicate  your full title
                              as such.  Corporations  should sign in full  
                              corporate  name by President or other  authorized 
                              officer.  Partnerships should sign in full 
                              partnership name by authorized partner.
--------------------------------------------------------------------------------
                              FOLD AND DETACH HERE

                                  Vote by Mail

       Mark, sign, and date your proxy card and return it in the enclosed
                             postage-paid envelope.



                              THANK YOU FOR VOTING.


                                       15