As filed with the Securities and Exchange Commission on October 1, 2003
                                                     Registration No. 333-_____
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                       Securities and Exchange Commission
                              Washington, DC 20549

                                    Form S-8
                             Registration Statement
                                      Under
                           The Securities Act of 1933

                       ----------------------------------

                         Provectus Pharmaceuticals, Inc.
               (Exact Name of Company as Specified in its Charter)

           Nevada                                      90-0233011
(State or Other Jurisdiction of             (I.R.S. Employer Identification No.)
Incorporation or Organization)

                         7327 Oak Ridge Highway, Suite B
                               Knoxville, TN 37931
          (Address of Principal Executive Offices, including Zip Code)

          ------------------------------------------------------------

                       Consultant Compensation Agreements
                            (Full Title of the Plans)

          ------------------------------------------------------------

                                       with a copy to:
                                       ---------------
Timothy C. Scott, Ph.D.                Wm. Gregory Hall, Jr., Esq.
President                              Baker, Donelson, Bearman & Caldwell, P.C.
Provectus Pharmaceuticals, Inc.        2200 Riverview Tower
7327 Oak Ridge Highway, Suite B        900 South Gay Street
Knoxville, TN 37931                    Knoxville, TN 37902
865/769-4011                           865/549-7000

 (Name, Address and Telephone Number, including Area Code, of Agent for Service)

          -------------------------------------------------------------

                                                                                               

                         Calculation of Registration Fee
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Title of                                                           Proposed maximum
securities                                           Amount            offering       Proposed maximum       Amount of
to be                                                 to be              price       aggregate offering    registration
registered                                         registered        per share (1)        price (1)             fee
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Common shares, par value $.001 per share         300,000 shares         $0.75             $225,000            $18.20
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                                     Part II
               Information Required in the Registration Statement



Item 3.   Incorporation of Documents by Reference.


     The  following  documents  previously  filed with the U.S.  Securities  and
Exchange  Commission  (the "SEC") by Provectus  Pharmaceuticals,  Inc., a Nevada
corporation  formerly known as Provectus  Pharmaceutical,  Inc. (the "Company"),
are incorporated by reference into this Registration Statement on Form S-8:

     1.   The  Company's  Annual Report on Form 10-KSB for the fiscal year ended
          December 31, 2002, as filed with the SEC on April 15, 2003;

     2.   The Company's  Quarterly  Report on Form 10-QSB for the fiscal quarter
          ended March 31, 2003, as filed with the SEC on May 9, 2003;

     3.   The Company's  Quarterly  Report on Form 10-QSB for the fiscal quarter
          ended June 30, 2003, as filed with the SEC on August 14, 2003;

     4.   The Company's  Current  Report on Form 8-K dated December 20, 2002, as
          filed with the SEC on January 3, 2003,  as amended by a filing on Form
          8-K/A filed with the SEC on January 9, 2003;

     5.   The Company's  Current Report on Form 8-K dated May 16, 2003, as filed
          with the SEC on May 22, 2003;

     6.   The Company's Current Report on Form 8-K dated June 16, 2003, as filed
          with the SEC on June 26, 2003; and

     7.   The  description of the Company's  common shares,  par value $.001 per
          share (the "Common  Stock")  contained in the  Company's  Registration
          Statement  on Form S-8 filed with the SEC on April 24,  2003 (File No.
          333-86896),  and any  amendments  and reports filed for the purpose of
          updating that description.

     All documents subsequently filed by the Company pursuant to Sections 13(a),
13(c),  14 and 15(d) of the  Securities  Exchange  Act of 1934,  as amended (the
"Exchange  Act"),  prior  to the  filing  of a  post-effective  amendment  which
indicates  that all the securities  offered have been sold or which  deregisters
all securities then remaining  unsold,  shall be deemed to be incorporated  into
this  Registration  Statement by reference and to be a part hereof from the date
of filing of such documents,  other than the portions of such documents which by
statute,  by  designation  in such  documents or otherwise  are not deemed to be
filed with the SEC or are not required to be incorporated herein by reference.

     Any  statement  contained  in  documents   incorporated  or  deemed  to  be
incorporated by reference into this Registration Statement shall be deemed to be
modified or  superseded,  for purposes of this  Registration  Statement,  to the
extent that a statement  contained  in this  Registration  Statement,  or in any
other  subsequently  filed document that is or is deemed to be  incorporated  by
reference  into  this  Registration  Statement,   modifies  or  supersedes  such
statement.  Any such  statement so modified or  superseded  shall not be deemed,
except as so modified or superseded,  to constitute a part of this  Registration
Statement.

Item 4.  Description of Securities.

     No response is required to this item.

Item 5.  Interests of Named Experts and Counsel.

     No response is required to this item.


                                      II-1


Item 6.  Indemnification of Directors and Officers.

     Nevada law provides that a Nevada  corporation may indemnify any person who
was or is a party or is threatened to be made a party to any threatened, pending
or completed action, suit or proceeding, whether civil, criminal, administrative
or investigative,  other than an action by or in the right of the corporation (a
"non-derivative  proceeding"),  by reason of the fact that he or she is or was a
director, officer, employee or agent of the corporation, or is or was serving at
the  request of the  corporation  as a director,  officer,  employee or agent of
another  corporation,  partnership,  joint venture,  trust or other  enterprise,
against expenses,  including attorneys' fees, judgments,  fines and amounts paid
in settlement  actually and  reasonably  incurred by him in connection  with the
action, suit or proceeding if he or she:

     1.   Is not liable  under  Section  78.138 of the Nevada  Revised  Statutes
          ("NRS  78.138")  for  breach  of his or her  fiduciary  duties  to the
          corporation; or

     2.   Acted  in  good  faith  and in a  manner  which  he or she  reasonably
          believed  to be in or  not  opposed  to  the  best  interests  of  the
          corporation,  and, with respect to any criminal  action or proceeding,
          had no reasonable cause to believe his or her conduct was unlawful.

     In addition,  a Nevada corporation may indemnify any person who was or is a
party  or is  threatened  to be  made a  party  to any  threatened,  pending  or
completed  action or suit by or in the  right of the  corporation  to  procure a
judgment in its favor (a "derivative  proceeding") by reason of the fact that he
or she is or was a director,  officer, employee or agent of the corporation,  or
is or was serving at the  request of the  corporation  as a  director,  officer,
employee or agent of another corporation,  partnership,  joint venture, trust or
other  enterprise  against  expenses,  including  amounts paid in settlement and
attorneys'  fees  actually and  reasonably  incurred by him or her in connection
with the defense or settlement of the action or suit if he:

     1.   Is not liable  under NRS  78.138  for  breach of his or her  fiduciary
          duties to the corporation; or

     2.   Acted  in  good  faith  and in a  manner  which  he or she  reasonably
          believed  to be in or  not  opposed  to  the  best  interests  of  the
          corporation.

     Under Nevada law,  indemnification  may not be made for any claim, issue or
matter  as to which  such a person  has been  adjudged  by a court of  competent
jurisdiction,  after  exhaustion of all appeals  therefrom,  to be liable to the
corporation  or for amounts paid in  settlement to the  corporation,  unless and
only to the  extent  that the court in which the  action or suit was  brought or
other court of competent  jurisdiction  determines upon application that in view
of all the  circumstances  of the case,  the  person is  fairly  and  reasonably
entitled to indemnity for such expenses as the court deems proper.

     To the extent that a director,  officer, employee or agent of a corporation
has been successful on the merits or otherwise in defense of any  non-derivative
proceeding or any derivative  proceeding,  or in defense of any claim,  issue or
matter  therein,  the  corporation  is obligated to indemnify him or her against
expenses,  including  attorneys'  fees,  actually  and  reasonably  incurred  in
connection with the defense.

     Further,  Nevada law permits a Nevada  corporation to purchase and maintain
insurance or to make other financial arrangements on behalf of any person who is
or was a director,  officer, employee or agent of the corporation,  or is or was
serving at the request of the  corporation as a director,  officer,  employee or
agent  of  another  corporation,  partnership,  joint  venture,  trust  or other
enterprise  for any  liability  asserted  against him or her and  liability  and
expenses  incurred by him or her in his or her capacity as a director,  officer,
employee or agent,  or arising out of his or her status as such,  whether or not
the corporation has the authority to indemnify him or her against such liability
and expenses.

     Under the  Company's  Restated  Articles of  Incorporation,  the Company is
obligated  to  indemnify,  to the fullest  extent  permitted  by Nevada law, any
director  or officer who was or is a party or is  threatened  to be made a party
to, or is involved  in, any  threatened,  pending or completed  action,  suit or
proceeding,   whether  civil,  criminal,   administrative  or  investigative  (a
"proceeding"),  by reason of the fact that the director or officer,  or a person
of whom he or she is the legal  representative,  is or was a director or officer

                                      II-2



of the  Company,  or a member of any  committee of the Board of Directors of the
Company,  or is or was  serving  at the  request of the  Company as a  director,
officer,  partner,  trustee,  employee or agent of another corporation,  limited
liability  company,  partnership,  joint  venture,  trust or  other  enterprise,
including  service with respect to employee benefit plans,  whether the basis of
the proceeding is alleged action in an official capacity as a director, officer,
partner,  trustee, employee or agent or in any other capacity while serving as a
director  officer,  partner,  trustee,  employee or agent;  against all expense,
liability and loss (including attorneys' fees, judgments, fines, excise taxes or
penalties and amounts paid or to be paid in settlement)  reasonably  incurred or
suffered  by the  director  or officer in  connection  with the  proceeding.  In
addition,  indemnification is required to continue as to a person who has ceased
to be a director, officer, partner, trustee, employee or agent and inures to the
benefit of his or her heirs, executors and administrators.  However,  subject to
the  exceptions  detailed  below,  the  Company may  indemnify a person  seeking
indemnification  in connection with a proceeding (or part thereof)  initiated by
the person seeking  indemnification only if the proceeding (or part thereof) was
authorized  by the Company's  Board of Directors.  The Company may indemnify any
employee or agent of the Company to an extent  greater than required by law only
if and to the extent that the  Company's  directors,  in their  discretion,  may
determine.

     If a claim for  indemnification  under the Company's  Restated  Articles of
Incorporation  is not paid in full by the Company within 30 days after a written
claim has been received by the Company,  the claimant may at any time thereafter
bring suit against the Company to recover the unpaid amount of the claim and, if
successful  in whole or in part,  the claimant  also will be entitled to be paid
the expense of prosecuting  such claim.  With some  exceptions,  the Company may
defend  against an action brought for this purpose that the claimant has not met
the  standards  of conduct  which make it  permissible  under  Chapter 78 of the
Nevada General Statutes for the Company to indemnify the claimant for the amount
claimed,  but the burden of proving such defense is on the Company.  Neither the
failure of the Company  (including  its Board of  Directors,  independent  legal
counsel  or  its  stockholders)  to  have  made  a  determination  prior  to the
commencement  of such action that  indemnification  of the claimant is proper in
the circumstances  because he or she has met the applicable  standard of conduct
set  forth  in  Chapter  78 of  the  Nevada  General  Statutes,  nor  an  actual
determination  by the Company  (including  its Board of  Directors,  independent
legal counsel or its stockholders) that the claimant has not met such applicable
standard of conduct is a defense to the action or creates a presumption that the
claimant has not met the applicable standard of conduct.

Item 7.  Exemption from Registration Claimed.

     No response is required to this item.

Item 8.  Exhibits.

     See the Exhibit Index at Page X-1 of this Registration Statement.

Item 9.  Undertakings.

     (a)  The Company hereby undertakes:

          (1)  To file,  during  any  period in which  offers or sales are being
               made, a post-effective amendment to this Registration Statement:

               (i)  To include any  prospectus  required by Section  10(a)(3) of
                    the Securities Act;

               (ii) To reflect  in the  prospectus  any facts or events  arising
                    after the effective date of the  Registration  Statement (or
                    the most recent  post-effective  amendment  thereof)  which,
                    individually  or in the  aggregate,  represent a fundamental
                    change  in the  information  set  forth in the  Registration
                    Statement.  Notwithstanding  the foregoing,  any increase or
                    decrease  in  volume  of  securities  offered  (if the total
                    dollar  value of  securities  offered  would not exceed that
                    which was registered) and any deviation from the low or high
                    end of the estimated maximum offering range may be reflected
                    in the form of prospectus filed with the Commission pursuant
                    to Rule 424(b) if, in the  aggregate,  the changes in volume
                    and price represent no more than a 20% change in the maximum
                    aggregate  offering price set forth in the  "Calculation  of
                    Registration  Fee"  table  in  the  effective   Registration
                    Statement;

                                      II-3


               (iii)To include any material information with respect to the plan
                    of distribution not previously disclosed in the Registration
                    Statement or any material change to such  information in the
                    Registration Statement;

     provided, however, that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if
the  Registration  Statement  is on  Form  S-3,  Form  S-8 or  Form  F-3 and the
information  required  to be  included in a  post-effective  amendment  by those
paragraphs is contained in periodic reports filed by the registrant  pursuant to
Section  13 or  Section  15(d) of the  Exchange  Act that  are  incorporated  by
reference in the Registration Statement.

          (2)  That,  for the purpose of  determining  any  liability  under the
               Securities  Act,  each  such  post-effective  amendment  shall be
               deemed  to  be a  new  registration  statement  relating  to  the
               securities  offered therein,  and the offering of such securities
               at that time shall be deemed to be the initial bona fide offering
               thereof.

          (3)  To  remove  from   registration  by  means  of  a  post-effective
               amendment any of the  securities  being  registered  which remain
               unsold at the termination of the offering.

     (b)  The Company  hereby  undertakes  that, for the purposes of determining
          any liability  under the Securities  Act, each filing of the Company's
          annual  report  pursuant  to  Section  13(a) or  Section  15(d) of the
          Exchange  Act (and,  where  applicable,  each  filing  of an  employee
          benefit plan's annual report pursuant to Section 15(d) of the Exchange
          Act) that is incorporated by reference in the  Registration  Statement
          shall be deemed to be a new  registration  statement  relating  to the
          securities  offered  therein,  and the offering of such  securities at
          that  time  shall be  deemed  to be the  initial  bona  fide  offering
          thereof.

     (c)  Insofar  as   indemnification   for  liabilities   arising  under  the
          Securities Act may be permitted to directors, officers and controlling
          persons  of the  Company  pursuant  to the  foregoing  provisions,  or
          otherwise,  the  Company has been  advised  that in the opinion of the
          Commission such  indemnification is against public policy as expressed
          in the Securities Act and is, therefore,  unenforceable.  In the event
          that a claim for indemnification  against such liabilities (other than
          the payment by the Company of expenses incurred or paid by a director,
          officer or controlling person of the Company in the successful defense
          of any action,  suit or  proceeding)  is  asserted  by such  director,
          officer or controlling  person in connection with the securities being
          registered, the Company will, unless in the opinion of its counsel the
          matter has been settled by controlling precedent, submit to a court of
          appropriate  jurisdiction the question whether such indemnification by
          it is against  public  policy as expressed in the  Securities  Act and
          will be governed by the final adjudication of such issue.


                                      II-4



                                   Signatures

     Pursuant to the  requirements of the Securities Act of 1933, the Registrant
certifies  that it has  reasonable  grounds to believe  that it meets all of the
requirements  for  filing on Form S-8,  and has duly  caused  this  Registration
Statement  to be  signed  on its  behalf  by  the  undersigned,  thereunto  duly
authorized,  in the City of Knoxville,  State of Tennessee,  on this 30th day of
September, 2003.

                                        Provectus Pharmaceuticals, Inc.

                                        By:/s/ Timothy C. Scott
                                           ------------------------------------
                                           Timothy C. Scott, Ph.D.
                                           President



                                Power Of Attorney

     Each person whose signature appears below constitutes and appoints H. Craig
Dees, Ph.D.,  Daniel R. Hamilton,  and David L. Morehous,  and each of them, his
true and lawful  attorney-in-fact and agent, with full power of substitution and
resubstitution,  for  him  and in his  name,  place  and  stead,  in any and all
capacities, to sign any and all amendments to the Registration Statement on Form
S-8 filed by  Provectus  Pharmaceuticals,  Inc.  (the  "Company")  with the U.S.
Securities and Exchange  Commission (the "SEC"),  and to file the same, with all
exhibits  thereto,  and other documents in connection  therewith,  with the SEC;
granting unto said  attorneys-in-fact  and agents,  and each of them, full power
and  authority  to do and  perform  each and every act and thing  requisite  and
necessary  fully to all intents  and  purposes as he might or could do in person
thereby ratifying and confirming all that said  attorneys-in-fact  and agents or
any of them, or their or his substitutes or substitute, may lawfully do or cause
to be done by virtue hereof.

     Pursuant  to  the   requirements  of  the  Securities  Act  of  1933,  this
Registration  Statement  has  been  signed  by  the  following  persons  in  the
capacities indicated on September 30, 2003:

         Signatures
         ----------
                                                 Title
                                                 -----

/s/ H. Craig Dees                  Chief Executive Officer and a Director
-----------------------------      (Principal executive officer)
H. Craig Dees


/s/ Daniel R. Hamilton             Chief Financial Officer (Principal financial
-----------------------------      officer and principal accounting officer)
Daniel R. Hamilton


/s/ Timothy C. Scott               Director
-----------------------------
Timothy C. Scott, Ph.D.


/s/ Eric A. Wachter                Director
-----------------------------
Eric A. Wachter


/s/ Stuart Fuchs                   Director
-----------------------------
Stuart Fuchs

                                      II-5






                                  Exhibit Index


Exhibit No.                           Description
-----------                           -----------

     4.1      Consulting Agreement dated September 1, 2003
              between the Company and Dr. Phillip A. Baker.

     4.2      Consulting Agreement dated September 4, 2003
              between the Company and Bruce A. Cosgrove.

     4.3      Consulting Agreement dated September 4, 2003
              between the Company and George F. Matin.

     5.1      Opinion of Baker, Donelson, Bearman, Caldwell & Berkowitz, P.C.

     23.1     Consent of Baker, Donelson, Bearman, Caldwell & Berkowitz, P.C.
              (included in Exhibit 5.1).

     23.2     Consent of BDO Seidman LLP.

     24.1     Power of Attorney (included on Page II-5 of this Registration
              Statement).

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                                      X-1